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Protein

Matrin-3

Gene

Matr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri800 – 831Matrin-typePROSITE-ProRule annotationAdd BLAST32

GO - Molecular functioni

GO - Biological processi

  • heart valve development Source: MGI
  • posttranscriptional regulation of gene expression Source: MGI
  • ventricular septum development Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Matrin-3
Gene namesi
Name:Matr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1298379. Matr3.

Subcellular locationi

  • Nucleus matrix PROSITE-ProRule annotation

GO - Cellular componenti

  • membrane Source: MGI
  • nuclear matrix Source: UniProtKB-SubCell
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000816232 – 846Matrin-3Add BLAST845

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei3N6-acetyllysine; alternateBy similarity1
Cross-linki3Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei4PhosphoserineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei22PhosphoserineBy similarity1
Modified residuei41PhosphoserineBy similarity1
Modified residuei118PhosphoserineBy similarity1
Modified residuei126PhosphoserineBy similarity1
Cross-linki146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei150PhosphothreonineCombined sources1
Modified residuei157PhosphoserineBy similarity1
Modified residuei158PhosphotyrosineBy similarity1
Modified residuei164PhosphoserineBy similarity1
Modified residuei188PhosphoserineCombined sources1
Modified residuei195PhosphoserineCombined sources1
Modified residuei202PhosphotyrosineBy similarity1
Modified residuei206PhosphoserineBy similarity1
Modified residuei208PhosphoserineBy similarity1
Modified residuei211PhosphoserineBy similarity1
Modified residuei219PhosphotyrosineBy similarity1
Modified residuei234PhosphoserineBy similarity1
Modified residuei264PhosphoserineBy similarity1
Modified residuei275PhosphoserineBy similarity1
Cross-linki487Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki491Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei509PhosphoserineBy similarity1
Modified residuei511PhosphoserineBy similarity1
Modified residuei522N6-acetyllysineBy similarity1
Modified residuei533PhosphoserineCombined sources1
Cross-linki554Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei571N6-acetyllysineBy similarity1
Modified residuei596PhosphoserineBy similarity1
Modified residuei598PhosphoserineCombined sources1
Modified residuei604PhosphoserineCombined sources1
Modified residuei606PhosphoserineBy similarity1
Cross-linki616Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei653PhosphoserineBy similarity1
Modified residuei670PhosphoserineBy similarity1
Modified residuei672PhosphoserineBy similarity1
Modified residuei673PhosphoserineBy similarity1
Modified residuei678PhosphothreonineBy similarity1
Modified residuei688PhosphoserineBy similarity1
Cross-linki718Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki735Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei740PhosphothreonineBy similarity1
Modified residuei746PhosphoserineBy similarity1
Modified residuei758PhosphoserineBy similarity1
Modified residuei835N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8K310.
MaxQBiQ8K310.
PaxDbiQ8K310.
PRIDEiQ8K310.

PTM databases

iPTMnetiQ8K310.
PhosphoSitePlusiQ8K310.
SwissPalmiQ8K310.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037236.
CleanExiMM_MATR3.
ExpressionAtlasiQ8K310. baseline and differential.
GenevisibleiQ8K310. MM.

Interactioni

Subunit structurei

Part of a complex consisting of SFPQ, NONO and MATR3. Interacts with AGO1 and AGO2 (By similarity). Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, MATR3, MKI67, CCAR2, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (By similarity). Interacts with TARDBP (By similarity).By similarity

Protein-protein interaction databases

BioGridi201324. 11 interactors.
IntActiQ8K310. 12 interactors.
MINTiMINT-4101305.
STRINGi10090.ENSMUSP00000125761.

Structurei

Secondary structure

1846
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi399 – 404Combined sources6
Beta strandi408 – 410Combined sources3
Helixi411 – 416Combined sources6
Turni417 – 419Combined sources3
Helixi420 – 422Combined sources3
Beta strandi425 – 430Combined sources6
Beta strandi432 – 435Combined sources4
Beta strandi437 – 443Combined sources7
Helixi444 – 456Combined sources13
Beta strandi467 – 471Combined sources5
Beta strandi497 – 502Combined sources6
Helixi511 – 514Combined sources4
Turni515 – 520Combined sources6
Beta strandi524 – 529Combined sources6
Turni530 – 533Combined sources4
Beta strandi534 – 538Combined sources5
Helixi542 – 554Combined sources13
Beta strandi559 – 562Combined sources4
Beta strandi565 – 569Combined sources5
Beta strandi573 – 576Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4DNMR-A390-478[»]
1X4FNMR-A478-576[»]
ProteinModelPortaliQ8K310.
SMRiQ8K310.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8K310.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini398 – 473RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini496 – 571RRM 2PROSITE-ProRule annotationAdd BLAST76

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi709 – 717Nuclear localization signalSequence analysis9

Sequence similaritiesi

Contains 1 matrin-type zinc finger.PROSITE-ProRule annotation
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri800 – 831Matrin-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGPC. Eukaryota.
ENOG410XSPB. LUCA.
GeneTreeiENSGT00850000132320.
HOVERGENiHBG057347.
InParanoidiQ8K310.
KOiK13213.
OMAiEQEPSML.
OrthoDBiEOG091G0QCV.
PhylomeDBiQ8K310.
TreeFamiTF333921.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
PS50171. ZF_MATRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSFQQSSL GRDSQGHGRD LSAAGIGLLA AATQSLSMPA SLGRMNQGTA
60 70 80 90 100
RLASLMNLGM SSSLNQQGAH SALSSASTSS HNLQSIFNIG SRGPLPLSSQ
110 120 130 140 150
HRGDTDQASN ILASFGLSAR DLDELSRYPE DKITPENLPQ ILLQLKRRRT
160 170 180 190 200
EEGPTLSYGR DGRSATREPP YRVPRDDWEE KRHFRRDSFD DRGPSLNPVL
210 220 230 240 250
DYDHGSRSQE SGYYDRMDYE DDRLRDGERC RDDSFFGETS HNYHKFDSEY
260 270 280 290 300
ERMGRGPGPL QERSLFEKKR GAPPSSNIED FHGLLPKGYP HLCSICDLPV
310 320 330 340 350
HSNKEWSQHI NGASHSRRCQ LLLEIYPEWN PDNDTGHTMG DPFMLQQSTN
360 370 380 390 400
PAPGILGPPP PSFHLGGPAV GPRGNLGAGN GNLQGPRHMQ KGRVETSRVV
410 420 430 440 450
HIMDFQRGKN LRYQLLQLVE PFGVISNHLI LNKINEAFIE MATTEDAQAA
460 470 480 490 500
VDYYTTTPAL VFGKPVRVHL SQKYKRIKKP EGKPDQKFDQ KQELGRVIHL
510 520 530 540 550
SNLPHSGYSD SAVLKLAEPY GKIKNYILMR MKSQAFIEME TREDAMAMVD
560 570 580 590 600
HCLKKALWFQ GRCVKVDLSE KYKKLVLRIP NRGIDLLKKD KSRKRSYSPD
610 620 630 640 650
GKESPSDKKS KTDAQKTESP AEGKEQEEKS GEDGEKDTKD DQTEQEPSML
660 670 680 690 700
LESEDELLVD EEEAAALLES GSSVGDETDL ANLGDVSSDG KKEPSDKAVK
710 720 730 740 750
KDPSASATSK KKLKKVDKIE ELDQENEAAL ENGIKNEENT EPGAESAENA
760 770 780 790 800
DDPNKDTSEN ADGQNDENKE DYTIPDEYRI GPYQPNVPVG IDYVIPKTGF
810 820 830 840
YCKLCSLFYT NEEVAKNTHC SSLPHYQKLK KFLNKLAEER RQKKET
Length:846
Mass (Da):94,630
Last modified:October 1, 2002 - v1
Checksum:i59C30E63D55093AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK087939 mRNA. Translation: BAC40050.1.
BC029070 mRNA. Translation: AAH29070.1.
CCDSiCCDS29142.1.
RefSeqiNP_034901.2. NM_010771.6.
UniGeneiMm.215034.

Genome annotation databases

EnsembliENSMUST00000166793; ENSMUSP00000125761; ENSMUSG00000037236.
ENSMUST00000187389; ENSMUSP00000139745; ENSMUSG00000037236.
ENSMUST00000190029; ENSMUSP00000140846; ENSMUSG00000037236.
GeneIDi17184.
KEGGimmu:17184.
UCSCiuc008emg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK087939 mRNA. Translation: BAC40050.1.
BC029070 mRNA. Translation: AAH29070.1.
CCDSiCCDS29142.1.
RefSeqiNP_034901.2. NM_010771.6.
UniGeneiMm.215034.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4DNMR-A390-478[»]
1X4FNMR-A478-576[»]
ProteinModelPortaliQ8K310.
SMRiQ8K310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201324. 11 interactors.
IntActiQ8K310. 12 interactors.
MINTiMINT-4101305.
STRINGi10090.ENSMUSP00000125761.

PTM databases

iPTMnetiQ8K310.
PhosphoSitePlusiQ8K310.
SwissPalmiQ8K310.

Proteomic databases

EPDiQ8K310.
MaxQBiQ8K310.
PaxDbiQ8K310.
PRIDEiQ8K310.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000166793; ENSMUSP00000125761; ENSMUSG00000037236.
ENSMUST00000187389; ENSMUSP00000139745; ENSMUSG00000037236.
ENSMUST00000190029; ENSMUSP00000140846; ENSMUSG00000037236.
GeneIDi17184.
KEGGimmu:17184.
UCSCiuc008emg.2. mouse.

Organism-specific databases

CTDi9782.
MGIiMGI:1298379. Matr3.

Phylogenomic databases

eggNOGiENOG410IGPC. Eukaryota.
ENOG410XSPB. LUCA.
GeneTreeiENSGT00850000132320.
HOVERGENiHBG057347.
InParanoidiQ8K310.
KOiK13213.
OMAiEQEPSML.
OrthoDBiEOG091G0QCV.
PhylomeDBiQ8K310.
TreeFamiTF333921.

Miscellaneous databases

ChiTaRSiMatr3. mouse.
EvolutionaryTraceiQ8K310.
PROiQ8K310.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037236.
CleanExiMM_MATR3.
ExpressionAtlasiQ8K310. baseline and differential.
GenevisibleiQ8K310. MM.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
PS50171. ZF_MATRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMATR3_MOUSE
AccessioniPrimary (citable) accession number: Q8K310
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.