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Q8K301

- DDX52_MOUSE

UniProt

Q8K301 - DDX52_MOUSE

Protein

Probable ATP-dependent RNA helicase DDX52

Gene

Ddx52

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi210 – 2178ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. helicase activity Source: UniProtKB-KW
    3. RNA binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ATP-dependent RNA helicase DDX52 (EC:3.6.4.13)
    Alternative name(s):
    ATP-dependent RNA helicase ROK1-like
    DEAD box protein 52
    Gene namesi
    Name:Ddx52
    Synonyms:Rok1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1925644. Ddx52.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 598598Probable ATP-dependent RNA helicase DDX52PRO_0000055061Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei15 – 151N6-acetyllysineBy similarity
    Modified residuei39 – 391PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ8K301.
    PRIDEiQ8K301.

    PTM databases

    PhosphoSiteiQ8K301.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K301.
    BgeeiQ8K301.
    CleanExiMM_DDX52.
    GenevestigatoriQ8K301.

    Interactioni

    Protein-protein interaction databases

    BioGridi219368. 1 interaction.
    STRINGi10090.ENSMUSP00000048802.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K301.
    SMRiQ8K301. Positions 140-544.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini197 – 375179Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini386 – 547162Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi166 – 19429Q motifAdd
    BLAST
    Motifi319 – 3224DEAD box

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi86 – 927Poly-Lys

    Sequence similaritiesi

    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0513.
    GeneTreeiENSGT00550000074863.
    HOGENOMiHOG000242486.
    HOVERGENiHBG051332.
    InParanoidiQ3UZY9.
    KOiK14779.
    OMAiNVDCLHA.
    OrthoDBiEOG7H1JKD.
    TreeFamiTF314448.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view]
    PfamiPF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K301-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSYDLFRRL GAGAKFDVKR FSADATRFQV GKRKFDSESL EVLKGLDFFG    50
    NKKSVSDECG ALQIHQEPPN EEKTQGVLLE RSKEPKKKKR KKMTSEVPAQ 100
    EDFDGGIQWT SSVEAKLQDE KVSGEKKLTS GKLEHLRKEK VNFFRNKHKI 150
    HVQGTDLPDP IATFQQLDQE YKINSRLLQN ILDAGFQVPT PIQMQAIPVM 200
    LHGRELLASA PTGSGKTLAF SIPILMQLKQ PTNKGFRALV ISPTRELASQ 250
    IHRELIKISE GTGFRIHMIH KAAIAAKKFG PKSSKKFDIL VTTPNRLIYL 300
    LKQDPPGIDL TNVEWLVVDE SDKLFEDGKT GFREQLASIF LACTSPKVRR 350
    AMFSATFAYD VEQWCKLNLD NVVSVSIGAR NSAVETVEQE LLFVGSETGK 400
    LLAMRELVKK GFKPPVLVFV QSIERAKELF HELIYEGINV DVIHAERTQQ 450
    QRDNTVHSFR AGKIWVLICT ALLARGIDFK GVNLVINYDF PTSSVEYIHR 500
    IGRTGRAGNR GKAVTFFTED DKPLLRSVAN VIQQAGCPVP EYIKGFQKLL 550
    SKQKKKMIKK PLERESICTT PKYFLEQAKQ KKVAGQNSKK KETLKEKS 598
    Length:598
    Mass (Da):67,474
    Last modified:July 27, 2011 - v2
    Checksum:iB4C89C522C4A79A9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 751Q → E in AAH29094. (PubMed:15489334)Curated
    Sequence conflicti81 – 811R → K in BAC38014. (PubMed:16141072)Curated
    Sequence conflicti103 – 1031F → L in AAH29094. (PubMed:15489334)Curated
    Sequence conflicti119 – 1191D → E in AAH29094. (PubMed:15489334)Curated
    Sequence conflicti312 – 3121N → S in AAH29094. (PubMed:15489334)Curated
    Sequence conflicti373 – 3731V → I in AAH29094. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK080767 mRNA. Translation: BAC38014.1.
    AK133545 mRNA. Translation: BAE21716.1.
    AL645615 Genomic DNA. Translation: CAI25508.1.
    CH466556 Genomic DNA. Translation: EDL15728.1.
    BC029094 mRNA. Translation: AAH29094.1.
    CCDSiCCDS25180.1.
    RefSeqiNP_084372.2. NM_030096.2.
    UniGeneiMm.280544.

    Genome annotation databases

    EnsembliENSMUST00000049257; ENSMUSP00000048802; ENSMUSG00000020677.
    GeneIDi78394.
    KEGGimmu:78394.
    UCSCiuc007kpz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK080767 mRNA. Translation: BAC38014.1 .
    AK133545 mRNA. Translation: BAE21716.1 .
    AL645615 Genomic DNA. Translation: CAI25508.1 .
    CH466556 Genomic DNA. Translation: EDL15728.1 .
    BC029094 mRNA. Translation: AAH29094.1 .
    CCDSi CCDS25180.1.
    RefSeqi NP_084372.2. NM_030096.2.
    UniGenei Mm.280544.

    3D structure databases

    ProteinModelPortali Q8K301.
    SMRi Q8K301. Positions 140-544.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 219368. 1 interaction.
    STRINGi 10090.ENSMUSP00000048802.

    PTM databases

    PhosphoSitei Q8K301.

    Proteomic databases

    PaxDbi Q8K301.
    PRIDEi Q8K301.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049257 ; ENSMUSP00000048802 ; ENSMUSG00000020677 .
    GeneIDi 78394.
    KEGGi mmu:78394.
    UCSCi uc007kpz.2. mouse.

    Organism-specific databases

    CTDi 11056.
    MGIi MGI:1925644. Ddx52.

    Phylogenomic databases

    eggNOGi COG0513.
    GeneTreei ENSGT00550000074863.
    HOGENOMi HOG000242486.
    HOVERGENi HBG051332.
    InParanoidi Q3UZY9.
    KOi K14779.
    OMAi NVDCLHA.
    OrthoDBi EOG7H1JKD.
    TreeFami TF314448.

    Miscellaneous databases

    NextBioi 348796.
    PROi Q8K301.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K301.
    Bgeei Q8K301.
    CleanExi MM_DDX52.
    Genevestigatori Q8K301.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view ]
    Pfami PF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Retina and Xiphoid cartilage.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiDDX52_MOUSE
    AccessioniPrimary (citable) accession number: Q8K301
    Secondary accession number(s): Q3UZY9, Q8BV29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 9, 2003
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3