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Q8K301 (DDX52_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ATP-dependent RNA helicase DDX52

EC=3.6.4.13
Alternative name(s):
ATP-dependent RNA helicase ROK1-like
DEAD box protein 52
Gene names
Name:Ddx52
Synonyms:Rok1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length598 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + H2O = ADP + phosphate.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Ontologies

Keywords
   Cellular componentNucleus
   LigandATP-binding
Nucleotide-binding
RNA-binding
   Molecular functionHelicase
Hydrolase
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent helicase activity

Inferred from electronic annotation. Source: InterPro

RNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 598598Probable ATP-dependent RNA helicase DDX52
PRO_0000055061

Regions

Domain197 – 375179Helicase ATP-binding
Domain386 – 547162Helicase C-terminal
Nucleotide binding210 – 2178ATP By similarity
Motif166 – 19429Q motif
Motif319 – 3224DEAD box
Compositional bias86 – 927Poly-Lys

Amino acid modifications

Modified residue151N6-acetyllysine By similarity
Modified residue391Phosphoserine By similarity

Experimental info

Sequence conflict751Q → E in AAH29094. Ref.4
Sequence conflict811R → K in BAC38014. Ref.1
Sequence conflict1031F → L in AAH29094. Ref.4
Sequence conflict1191D → E in AAH29094. Ref.4
Sequence conflict3121N → S in AAH29094. Ref.4
Sequence conflict3731V → I in AAH29094. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q8K301 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: B4C89C522C4A79A9

FASTA59867,474
        10         20         30         40         50         60 
MDSYDLFRRL GAGAKFDVKR FSADATRFQV GKRKFDSESL EVLKGLDFFG NKKSVSDECG 

        70         80         90        100        110        120 
ALQIHQEPPN EEKTQGVLLE RSKEPKKKKR KKMTSEVPAQ EDFDGGIQWT SSVEAKLQDE 

       130        140        150        160        170        180 
KVSGEKKLTS GKLEHLRKEK VNFFRNKHKI HVQGTDLPDP IATFQQLDQE YKINSRLLQN 

       190        200        210        220        230        240 
ILDAGFQVPT PIQMQAIPVM LHGRELLASA PTGSGKTLAF SIPILMQLKQ PTNKGFRALV 

       250        260        270        280        290        300 
ISPTRELASQ IHRELIKISE GTGFRIHMIH KAAIAAKKFG PKSSKKFDIL VTTPNRLIYL 

       310        320        330        340        350        360 
LKQDPPGIDL TNVEWLVVDE SDKLFEDGKT GFREQLASIF LACTSPKVRR AMFSATFAYD 

       370        380        390        400        410        420 
VEQWCKLNLD NVVSVSIGAR NSAVETVEQE LLFVGSETGK LLAMRELVKK GFKPPVLVFV 

       430        440        450        460        470        480 
QSIERAKELF HELIYEGINV DVIHAERTQQ QRDNTVHSFR AGKIWVLICT ALLARGIDFK 

       490        500        510        520        530        540 
GVNLVINYDF PTSSVEYIHR IGRTGRAGNR GKAVTFFTED DKPLLRSVAN VIQQAGCPVP 

       550        560        570        580        590 
EYIKGFQKLL SKQKKKMIKK PLERESICTT PKYFLEQAKQ KKVAGQNSKK KETLKEKS 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Retina and Xiphoid cartilage.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK080767 mRNA. Translation: BAC38014.1.
AK133545 mRNA. Translation: BAE21716.1.
AL645615 Genomic DNA. Translation: CAI25508.1.
CH466556 Genomic DNA. Translation: EDL15728.1.
BC029094 mRNA. Translation: AAH29094.1.
RefSeqNP_084372.2. NM_030096.2.
UniGeneMm.280544.

3D structure databases

ProteinModelPortalQ8K301.
SMRQ8K301. Positions 140-516.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000048802.

PTM databases

PhosphoSiteQ8K301.

Proteomic databases

PaxDbQ8K301.
PRIDEQ8K301.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049257; ENSMUSP00000048802; ENSMUSG00000020677.
GeneID78394.
KEGGmmu:78394.
UCSCuc007kpz.2. mouse.

Organism-specific databases

CTD11056.
MGIMGI:1925644. Ddx52.

Phylogenomic databases

eggNOGCOG0513.
GeneTreeENSGT00550000074863.
HOGENOMHOG000242486.
HOVERGENHBG051332.
InParanoidQ3UZY9.
KOK14779.
OMAVMKQSGC.
OrthoDBEOG7H1JKD.
TreeFamTF314448.

Gene expression databases

ArrayExpressQ8K301.
BgeeQ8K301.
CleanExMM_DDX52.
GenevestigatorQ8K301.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio348796.
PROQ8K301.
SOURCESearch...

Entry information

Entry nameDDX52_MOUSE
AccessionPrimary (citable) accession number: Q8K301
Secondary accession number(s): Q3UZY9, Q8BV29
Entry history
Integrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot