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Q8K2Z8

- UB2Q2_MOUSE

UniProt

Q8K2Z8 - UB2Q2_MOUSE

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Protein

Ubiquitin-conjugating enzyme E2 Q2

Gene
Ube2q2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei307 – 3071Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. protein K48-linked ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 Q2 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein Q2
Ubiquitin-protein ligase Q2
Gene namesi
Name:Ube2q2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2388672. Ube2q2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Ubiquitin-conjugating enzyme E2 Q2PRO_0000223880Add
BLAST

Proteomic databases

MaxQBiQ8K2Z8.
PaxDbiQ8K2Z8.
PRIDEiQ8K2Z8.

PTM databases

PhosphoSiteiQ8K2Z8.

Expressioni

Gene expression databases

ArrayExpressiQ8K2Z8.
BgeeiQ8K2Z8.
CleanExiMM_UBE2Q2.
GenevestigatoriQ8K2Z8.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059798.

Structurei

3D structure databases

ProteinModelPortaliQ8K2Z8.
SMRiQ8K2Z8. Positions 204-365.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 5616Pro-richAdd
BLAST
Compositional biasi138 – 18144Glu-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG320521.
GeneTreeiENSGT00390000018573.
HOGENOMiHOG000007757.
HOVERGENiHBG061368.
InParanoidiQ8K2Z8.
KOiK10582.
OMAiSYKAGIY.
OrthoDBiEOG76DTSS.
PhylomeDBiQ8K2Z8.
TreeFamiTF313338.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR006575. RWD-domain.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF05773. RWD. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view]
SMARTiSM00591. RWD. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 2 hits.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8K2Z8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPPPPPGSS    50
LSPPPPLTLH CNITESYPSS SPIWFVDSDD PNLTSVLERL EDTKNNSSLR 100
QQLKWLICDL CRLYNLPKHL DVEMLDQPLP TGQNGTTEEV TSEEEEEEEM 150
AEDIEDLDHY EMKEEEPING KKSEDEGIEK ENLAILEKIR KTQRQDHLNG 200
AVSGSVQASD RLMKELRDVY RSQSYKAGIY SVELINDSLY DWHVKLHKVD 250
SDSPLHSDLQ ILKEKEGIEY ILLNFSFKDN FPFDPPFVRV VLPVLSGGYV 300
LGGGALCMEL LTKQGWSSAY SIESVIMQIN ATLVKGKARV QFGANKNQYN 350
LARAQQSYNS IVQIHEKNGW YTPPKEDG 378
Length:378
Mass (Da):42,935
Last modified:February 21, 2006 - v2
Checksum:i4A81D0AC4BD302E3
GO
Isoform 2 (identifier: Q8K2Z8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.

Show »
Length:255
Mass (Da):28,916
Checksum:i2F5077B3FAC2D6DF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti235 – 2351I → T in strain: FVB/N. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 123123Missing in isoform 2. VSP_017300Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti246 – 2461L → Q in BAC38813. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK083216 mRNA. Translation: BAC38813.1.
AK076148 mRNA. Translation: BAC36218.1.
AK042515 mRNA. Translation: BAE20633.1.
AK150776 mRNA. Translation: BAE29841.1.
BC029111 mRNA. Translation: AAH29111.1.
CCDSiCCDS23201.1. [Q8K2Z8-1]
RefSeqiNP_850931.2. NM_180600.3. [Q8K2Z8-1]
XP_006510831.1. XM_006510768.1. [Q8K2Z8-2]
UniGeneiMm.207894.

Genome annotation databases

EnsembliENSMUST00000059555; ENSMUSP00000059798; ENSMUSG00000032307. [Q8K2Z8-1]
ENSMUST00000122441; ENSMUSP00000112745; ENSMUSG00000032307. [Q8K2Z8-2]
GeneIDi109161.
KEGGimmu:109161.
UCSCiuc009psb.2. mouse. [Q8K2Z8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK083216 mRNA. Translation: BAC38813.1 .
AK076148 mRNA. Translation: BAC36218.1 .
AK042515 mRNA. Translation: BAE20633.1 .
AK150776 mRNA. Translation: BAE29841.1 .
BC029111 mRNA. Translation: AAH29111.1 .
CCDSi CCDS23201.1. [Q8K2Z8-1 ]
RefSeqi NP_850931.2. NM_180600.3. [Q8K2Z8-1 ]
XP_006510831.1. XM_006510768.1. [Q8K2Z8-2 ]
UniGenei Mm.207894.

3D structure databases

ProteinModelPortali Q8K2Z8.
SMRi Q8K2Z8. Positions 204-365.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000059798.

PTM databases

PhosphoSitei Q8K2Z8.

Proteomic databases

MaxQBi Q8K2Z8.
PaxDbi Q8K2Z8.
PRIDEi Q8K2Z8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000059555 ; ENSMUSP00000059798 ; ENSMUSG00000032307 . [Q8K2Z8-1 ]
ENSMUST00000122441 ; ENSMUSP00000112745 ; ENSMUSG00000032307 . [Q8K2Z8-2 ]
GeneIDi 109161.
KEGGi mmu:109161.
UCSCi uc009psb.2. mouse. [Q8K2Z8-1 ]

Organism-specific databases

CTDi 92912.
MGIi MGI:2388672. Ube2q2.

Phylogenomic databases

eggNOGi NOG320521.
GeneTreei ENSGT00390000018573.
HOGENOMi HOG000007757.
HOVERGENi HBG061368.
InParanoidi Q8K2Z8.
KOi K10582.
OMAi SYKAGIY.
OrthoDBi EOG76DTSS.
PhylomeDBi Q8K2Z8.
TreeFami TF313338.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

NextBioi 361712.
PROi Q8K2Z8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8K2Z8.
Bgeei Q8K2Z8.
CleanExi MM_UBE2Q2.
Genevestigatori Q8K2Z8.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR006575. RWD-domain.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF05773. RWD. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view ]
SMARTi SM00591. RWD. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 2 hits.
PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Bone marrow, Fetal head, Hippocampus and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-235.
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiUB2Q2_MOUSE
AccessioniPrimary (citable) accession number: Q8K2Z8
Secondary accession number(s): Q3UBX3
, Q3V3A5, Q8BUN2, Q8BVX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 21, 2006
Last modified: September 3, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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