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Protein

Ubiquitin-conjugating enzyme E2 Q2

Gene

Ube2q2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination.By similarity

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei307Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 Q2 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme Q2
Ubiquitin carrier protein Q2
Ubiquitin-protein ligase Q2
Gene namesi
Name:Ube2q2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2388672 Ube2q2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002238801 – 378Ubiquitin-conjugating enzyme E2 Q2Add BLAST378

Post-translational modificationi

Auto-ubiquitinated in vitro.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ8K2Z8
PaxDbiQ8K2Z8
PeptideAtlasiQ8K2Z8
PRIDEiQ8K2Z8

PTM databases

iPTMnetiQ8K2Z8
PhosphoSitePlusiQ8K2Z8

Expressioni

Gene expression databases

BgeeiENSMUSG00000032307
CleanExiMM_UBE2Q2
ExpressionAtlasiQ8K2Z8 baseline and differential
GenevisibleiQ8K2Z8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059798

Structurei

3D structure databases

ProteinModelPortaliQ8K2Z8
SMRiQ8K2Z8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 56Pro-richAdd BLAST16
Compositional biasi138 – 181Glu-richAdd BLAST44

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0897 Eukaryota
ENOG410XRET LUCA
GeneTreeiENSGT00390000018573
HOGENOMiHOG000007757
HOVERGENiHBG061368
InParanoidiQ8K2Z8
KOiK10582
OMAiIPTGQNG
OrthoDBiEOG091G0LGG
PhylomeDBiQ8K2Z8
TreeFamiTF313338

Family and domain databases

Gene3Di3.10.110.10, 2 hits
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 2 hits
PROSITEiView protein in PROSITE
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K2Z8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPPPPPGSS
60 70 80 90 100
LSPPPPLTLH CNITESYPSS SPIWFVDSDD PNLTSVLERL EDTKNNSSLR
110 120 130 140 150
QQLKWLICDL CRLYNLPKHL DVEMLDQPLP TGQNGTTEEV TSEEEEEEEM
160 170 180 190 200
AEDIEDLDHY EMKEEEPING KKSEDEGIEK ENLAILEKIR KTQRQDHLNG
210 220 230 240 250
AVSGSVQASD RLMKELRDVY RSQSYKAGIY SVELINDSLY DWHVKLHKVD
260 270 280 290 300
SDSPLHSDLQ ILKEKEGIEY ILLNFSFKDN FPFDPPFVRV VLPVLSGGYV
310 320 330 340 350
LGGGALCMEL LTKQGWSSAY SIESVIMQIN ATLVKGKARV QFGANKNQYN
360 370
LARAQQSYNS IVQIHEKNGW YTPPKEDG
Length:378
Mass (Da):42,935
Last modified:February 21, 2006 - v2
Checksum:i4A81D0AC4BD302E3
GO
Isoform 2 (identifier: Q8K2Z8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.
Show »
Length:255
Mass (Da):28,916
Checksum:i2F5077B3FAC2D6DF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246L → Q in BAC38813 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti235I → T in strain: FVB/N. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0173001 – 123Missing in isoform 2. 1 PublicationAdd BLAST123

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083216 mRNA Translation: BAC38813.1
AK076148 mRNA Translation: BAC36218.1
AK042515 mRNA Translation: BAE20633.1
AK150776 mRNA Translation: BAE29841.1
BC029111 mRNA Translation: AAH29111.1
CCDSiCCDS23201.1 [Q8K2Z8-1]
CCDS85678.1 [Q8K2Z8-2]
RefSeqiNP_001333587.1, NM_001346658.1 [Q8K2Z8-2]
NP_850931.2, NM_180600.3 [Q8K2Z8-1]
UniGeneiMm.207894

Genome annotation databases

EnsembliENSMUST00000059555; ENSMUSP00000059798; ENSMUSG00000032307 [Q8K2Z8-1]
ENSMUST00000122441; ENSMUSP00000112745; ENSMUSG00000032307 [Q8K2Z8-2]
GeneIDi109161
KEGGimmu:109161
UCSCiuc009psb.2 mouse [Q8K2Z8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUB2Q2_MOUSE
AccessioniPrimary (citable) accession number: Q8K2Z8
Secondary accession number(s): Q3UBX3
, Q3V3A5, Q8BUN2, Q8BVX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 21, 2006
Last modified: May 23, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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