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Q8K2Z8

- UB2Q2_MOUSE

UniProt

Q8K2Z8 - UB2Q2_MOUSE

Protein

Ubiquitin-conjugating enzyme E2 Q2

Gene

Ube2q2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (21 Feb 2006)
      Previous versions | rss
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    Functioni

    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination By similarity.By similarity

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei307 – 3071Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. ubiquitin-protein transferase activity Source: UniProtKB

    GO - Biological processi

    1. protein K48-linked ubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 Q2 (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein Q2
    Ubiquitin-protein ligase Q2
    Gene namesi
    Name:Ube2q2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2388672. Ube2q2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 378378Ubiquitin-conjugating enzyme E2 Q2PRO_0000223880Add
    BLAST

    Proteomic databases

    MaxQBiQ8K2Z8.
    PaxDbiQ8K2Z8.
    PRIDEiQ8K2Z8.

    PTM databases

    PhosphoSiteiQ8K2Z8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K2Z8.
    BgeeiQ8K2Z8.
    CleanExiMM_UBE2Q2.
    GenevestigatoriQ8K2Z8.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000059798.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K2Z8.
    SMRiQ8K2Z8. Positions 204-365.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi41 – 5616Pro-richAdd
    BLAST
    Compositional biasi138 – 18144Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG320521.
    GeneTreeiENSGT00390000018573.
    HOGENOMiHOG000007757.
    HOVERGENiHBG061368.
    InParanoidiQ8K2Z8.
    KOiK10582.
    OMAiSYKAGIY.
    OrthoDBiEOG76DTSS.
    PhylomeDBiQ8K2Z8.
    TreeFamiTF313338.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR006575. RWD-domain.
    IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF05773. RWD. 1 hit.
    PF00179. UQ_con. 1 hit.
    [Graphical view]
    SMARTiSM00591. RWD. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 2 hits.
    PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8K2Z8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPPPPPGSS    50
    LSPPPPLTLH CNITESYPSS SPIWFVDSDD PNLTSVLERL EDTKNNSSLR 100
    QQLKWLICDL CRLYNLPKHL DVEMLDQPLP TGQNGTTEEV TSEEEEEEEM 150
    AEDIEDLDHY EMKEEEPING KKSEDEGIEK ENLAILEKIR KTQRQDHLNG 200
    AVSGSVQASD RLMKELRDVY RSQSYKAGIY SVELINDSLY DWHVKLHKVD 250
    SDSPLHSDLQ ILKEKEGIEY ILLNFSFKDN FPFDPPFVRV VLPVLSGGYV 300
    LGGGALCMEL LTKQGWSSAY SIESVIMQIN ATLVKGKARV QFGANKNQYN 350
    LARAQQSYNS IVQIHEKNGW YTPPKEDG 378
    Length:378
    Mass (Da):42,935
    Last modified:February 21, 2006 - v2
    Checksum:i4A81D0AC4BD302E3
    GO
    Isoform 2 (identifier: Q8K2Z8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-123: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:255
    Mass (Da):28,916
    Checksum:i2F5077B3FAC2D6DF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti246 – 2461L → Q in BAC38813. (PubMed:16141072)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti235 – 2351I → T in strain: FVB/N. 1 Publication

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 123123Missing in isoform 2. 1 PublicationVSP_017300Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK083216 mRNA. Translation: BAC38813.1.
    AK076148 mRNA. Translation: BAC36218.1.
    AK042515 mRNA. Translation: BAE20633.1.
    AK150776 mRNA. Translation: BAE29841.1.
    BC029111 mRNA. Translation: AAH29111.1.
    CCDSiCCDS23201.1. [Q8K2Z8-1]
    RefSeqiNP_850931.2. NM_180600.3. [Q8K2Z8-1]
    XP_006510831.1. XM_006510768.1. [Q8K2Z8-2]
    UniGeneiMm.207894.

    Genome annotation databases

    EnsembliENSMUST00000059555; ENSMUSP00000059798; ENSMUSG00000032307. [Q8K2Z8-1]
    ENSMUST00000122441; ENSMUSP00000112745; ENSMUSG00000032307. [Q8K2Z8-2]
    GeneIDi109161.
    KEGGimmu:109161.
    UCSCiuc009psb.2. mouse. [Q8K2Z8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK083216 mRNA. Translation: BAC38813.1 .
    AK076148 mRNA. Translation: BAC36218.1 .
    AK042515 mRNA. Translation: BAE20633.1 .
    AK150776 mRNA. Translation: BAE29841.1 .
    BC029111 mRNA. Translation: AAH29111.1 .
    CCDSi CCDS23201.1. [Q8K2Z8-1 ]
    RefSeqi NP_850931.2. NM_180600.3. [Q8K2Z8-1 ]
    XP_006510831.1. XM_006510768.1. [Q8K2Z8-2 ]
    UniGenei Mm.207894.

    3D structure databases

    ProteinModelPortali Q8K2Z8.
    SMRi Q8K2Z8. Positions 204-365.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000059798.

    PTM databases

    PhosphoSitei Q8K2Z8.

    Proteomic databases

    MaxQBi Q8K2Z8.
    PaxDbi Q8K2Z8.
    PRIDEi Q8K2Z8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000059555 ; ENSMUSP00000059798 ; ENSMUSG00000032307 . [Q8K2Z8-1 ]
    ENSMUST00000122441 ; ENSMUSP00000112745 ; ENSMUSG00000032307 . [Q8K2Z8-2 ]
    GeneIDi 109161.
    KEGGi mmu:109161.
    UCSCi uc009psb.2. mouse. [Q8K2Z8-1 ]

    Organism-specific databases

    CTDi 92912.
    MGIi MGI:2388672. Ube2q2.

    Phylogenomic databases

    eggNOGi NOG320521.
    GeneTreei ENSGT00390000018573.
    HOGENOMi HOG000007757.
    HOVERGENi HBG061368.
    InParanoidi Q8K2Z8.
    KOi K10582.
    OMAi SYKAGIY.
    OrthoDBi EOG76DTSS.
    PhylomeDBi Q8K2Z8.
    TreeFami TF313338.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    NextBioi 361712.
    PROi Q8K2Z8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K2Z8.
    Bgeei Q8K2Z8.
    CleanExi MM_UBE2Q2.
    Genevestigatori Q8K2Z8.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR006575. RWD-domain.
    IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF05773. RWD. 1 hit.
    PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SMARTi SM00591. RWD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 2 hits.
    PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Bone marrow, Fetal head, Hippocampus and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-235.
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiUB2Q2_MOUSE
    AccessioniPrimary (citable) accession number: Q8K2Z8
    Secondary accession number(s): Q3UBX3
    , Q3V3A5, Q8BUN2, Q8BVX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: February 21, 2006
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3