Reviewed,
UniProtKB/Swiss-Prot Q8K2Z8 (UB2Q2_MOUSE)
Last modified
June 16, 2009.
Version 63.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ubiquitin-conjugating enzyme E2 Q2 EC=6.3.2.19 Alternative name(s): Ubiquitin-protein ligase Q2 Ubiquitin carrier protein Q2 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 378 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the covalent attachment of ubiquitin to other proteins By similarity. |
| Catalytic activity | ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. |
| Pathway | |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the ubiquitin-conjugating enzyme family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ubl conjugation pathway |
| Cellular component | Cytoplasm |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW post-translational protein modificationInferred from electronic annotation. Source: InterPro regulation of protein metabolic processInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-protein ligase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8K2Z8-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8K2Z8-2) The sequence of this isoform differs from the canonical sequence as follows: 1-123: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 378 | 378 | Ubiquitin-conjugating enzyme E2 Q2 | PRO_0000223880 | |||||
Regions | |||||||||
| Compositional bias | 41 – 56 | 16 | Pro-rich | ||||||
| Compositional bias | 138 – 181 | 44 | Glu-rich | ||||||
Sites | |||||||||
| Active site | 307 | 1 | Glycyl thioester intermediate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 372 | 1 | Phosphothreonine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 123 | 123 | Missing in isoform 2. | VSP_017300 | |||||
| Natural variant | 235 | 1 | I → T in strain: FVB/N. Ref.2 | ||||||
Experimental info | |||||||||
| Sequence conflict | 246 | 1 | L → Q in BAC38813. Ref.1 | ||||||
Sequences
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References
| [1] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6J. Tissue: Bone marrow, Fetal head, Hippocampus and Thymus. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-235. Strain: FVB/N. Tissue: Mammary tumor. |
Cross-references
Sequence databases | |
|---|---|
| AK083216 mRNA. Translation: BAC38813.1. AK076148 mRNA. Translation: BAC36218.1. AK042515 mRNA. Translation: BAE20633.1. AK150776 mRNA. Translation: BAE29841.1. BC029111 mRNA. Translation: AAH29111.1. | |
| IPI | IPI00345026. IPI00719933. |
| RefSeq | NP_850931.1. |
| UniGene | Mm.207894 |
3D structure databases | |
| SMR | Q8K2Z8. Positions 204-365. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q8K2Z8. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000032307. Mus musculus. [Contig view] |
| GeneID | 109161. |
| KEGG | mmu:109161. |
Organism-specific databases | |
| MGI | MGI:2388672. Ube2q2. |
Phylogenomic databases | |
| HOGENOM | Q8K2Z8. |
| HOVERGEN | Q8K2Z8. |
| OMA | Q8K2Z8. YKAGIYS. |
Enzyme and pathway databases | |
| BRENDA | 6.3.2.19. 244. |
Gene expression databases | |
| ArrayExpress | Q8K2Z8. |
| Bgee | Q8K2Z8. |
| CleanEx | MM_UBE2Q2. |
| GermOnline | ENSMUSG00000032307. Mus musculus. |
Family and domain databases | |
| InterPro | IPR006575. RWD. IPR016135. UBQ-conjugat/RWD-like. IPR000608. UBQ-conjugat_E2. [Graphical view] |
| Gene3D | G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit. |
| Pfam | PF05773. RWD. 1 hit. PF00179. UQ_con. 1 hit. [Graphical view] |
| ProDom | PD000461. UBQ_conjugat. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00591. RWD. 1 hit. SM00212. UBCc. 1 hit. [Graphical view] |
| PROSITE | PS00183. UBIQUITIN_CONJUGAT_1. False negative. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 361712. |
| SOURCE | Search... |
Entry information
| Entry name | UB2Q2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8K2Z8 Secondary accession number(s): Q3UBX3 Q8BVX5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


