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Q8K2X8

- TF2H5_MOUSE

UniProt

Q8K2X8 - TF2H5_MOUSE

Protein

General transcription factor IIH subunit 5

Gene

Gtf2h5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell By similarity.By similarity

    GO - Molecular functioni

    1. rDNA binding Source: MGI

    GO - Biological processi

    1. cellular response to gamma radiation Source: MGI
    2. nucleotide-excision repair Source: MGI
    3. nucleotide-excision repair, preincision complex assembly Source: MGI
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. rRNA processing Source: MGI
    6. transcription elongation from RNA polymerase I promoter Source: MGI

    Keywords - Biological processi

    DNA damage, DNA repair, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General transcription factor IIH subunit 5
    Alternative name(s):
    General transcription factor IIH polypeptide 5
    TFB5 ortholog
    TFIIH basal transcription factor complex TTD-A subunit
    Gene namesi
    Name:Gtf2h5
    Synonyms:D17Wsu155e
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:107227. Gtf2h5.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. core TFIIH complex Source: InterPro
    2. nucleolus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7171General transcription factor IIH subunit 5PRO_0000119257Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei69 – 691Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ8K2X8.

    PTM databases

    PhosphoSiteiQ8K2X8.

    Expressioni

    Gene expression databases

    BgeeiQ8K2X8.
    CleanExiMM_GTF2H5.
    GenevestigatoriQ8K2X8.

    Interactioni

    Subunit structurei

    Subunit of the TFIIH basal transcription factor complex that contains ERCC2, ERCC3, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, MNAT1, CDK7 and CCNH.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K2X8.
    SMRiQ8K2X8. Positions 1-71.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TFB5 family.Curated

    Phylogenomic databases

    eggNOGiNOG278168.
    GeneTreeiENSGT00390000004028.
    HOGENOMiHOG000199698.
    HOVERGENiHBG055393.
    InParanoidiQ8K2X8.
    KOiK10845.
    OMAiKDLDDTH.
    OrthoDBiEOG7BGHPM.
    PhylomeDBiQ8K2X8.
    TreeFamiTF319487.

    Family and domain databases

    Gene3Di3.30.70.1220. 1 hit.
    InterProiIPR009400. TFIIH_TTDA/Tfb5.
    [Graphical view]
    PfamiPF06331. Tbf5. 1 hit.
    [Graphical view]
    SUPFAMiSSF142897. SSF142897. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8K2X8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNVLKGVLI ECDPAMKQFL LYLDEANALG KKFIIQDIDD THVFVIAELV   50
    NVLQERVGEL MDQNAFSLTQ K 71
    Length:71
    Mass (Da):8,037
    Last modified:October 1, 2002 - v1
    Checksum:i940B4D3C9BED9A8F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71G → R in BAC25398. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003547 mRNA. Translation: BAC25038.1.
    AK003579 mRNA. Translation: BAC25043.1.
    AK011281 mRNA. Translation: BAC25328.1.
    AK012257 mRNA. Translation: BAC25362.1.
    AK013225 mRNA. Translation: BAC25398.1.
    BC029238 mRNA. Translation: AAH29238.1.
    CCDSiCCDS37423.1.
    RefSeqiNP_852057.2. NM_181392.3.
    XP_006523302.1. XM_006523239.1.
    XP_006523303.1. XM_006523240.1.
    UniGeneiMm.303441.

    Genome annotation databases

    EnsembliENSMUST00000039487; ENSMUSP00000040355; ENSMUSG00000034345.
    ENSMUST00000100955; ENSMUSP00000098515; ENSMUSG00000034345.
    GeneIDi66467.
    KEGGimmu:66467.
    UCSCiuc008aga.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003547 mRNA. Translation: BAC25038.1 .
    AK003579 mRNA. Translation: BAC25043.1 .
    AK011281 mRNA. Translation: BAC25328.1 .
    AK012257 mRNA. Translation: BAC25362.1 .
    AK013225 mRNA. Translation: BAC25398.1 .
    BC029238 mRNA. Translation: AAH29238.1 .
    CCDSi CCDS37423.1.
    RefSeqi NP_852057.2. NM_181392.3.
    XP_006523302.1. XM_006523239.1.
    XP_006523303.1. XM_006523240.1.
    UniGenei Mm.303441.

    3D structure databases

    ProteinModelPortali Q8K2X8.
    SMRi Q8K2X8. Positions 1-71.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8K2X8.

    Proteomic databases

    PRIDEi Q8K2X8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000039487 ; ENSMUSP00000040355 ; ENSMUSG00000034345 .
    ENSMUST00000100955 ; ENSMUSP00000098515 ; ENSMUSG00000034345 .
    GeneIDi 66467.
    KEGGi mmu:66467.
    UCSCi uc008aga.2. mouse.

    Organism-specific databases

    CTDi 404672.
    MGIi MGI:107227. Gtf2h5.

    Phylogenomic databases

    eggNOGi NOG278168.
    GeneTreei ENSGT00390000004028.
    HOGENOMi HOG000199698.
    HOVERGENi HBG055393.
    InParanoidi Q8K2X8.
    KOi K10845.
    OMAi KDLDDTH.
    OrthoDBi EOG7BGHPM.
    PhylomeDBi Q8K2X8.
    TreeFami TF319487.

    Miscellaneous databases

    ChiTaRSi GTF2H5. mouse.
    NextBioi 321774.
    PROi Q8K2X8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K2X8.
    CleanExi MM_GTF2H5.
    Genevestigatori Q8K2X8.

    Family and domain databases

    Gene3Di 3.30.70.1220. 1 hit.
    InterProi IPR009400. TFIIH_TTDA/Tfb5.
    [Graphical view ]
    Pfami PF06331. Tbf5. 1 hit.
    [Graphical view ]
    SUPFAMi SSF142897. SSF142897. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-69, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiTF2H5_MOUSE
    AccessioniPrimary (citable) accession number: Q8K2X8
    Secondary accession number(s): Q8BT75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3