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Q8K2X8

- TF2H5_MOUSE

UniProt

Q8K2X8 - TF2H5_MOUSE

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Protein

General transcription factor IIH subunit 5

Gene

Gtf2h5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Component of the TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell (By similarity).By similarity

GO - Molecular functioni

  1. rDNA binding Source: MGI

GO - Biological processi

  1. cellular response to gamma radiation Source: MGI
  2. nucleotide-excision repair Source: MGI
  3. nucleotide-excision repair, preincision complex assembly Source: MGI
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. rRNA processing Source: MGI
  6. transcription elongation from RNA polymerase I promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 5
Alternative name(s):
General transcription factor IIH polypeptide 5
TFB5 ortholog
TFIIH basal transcription factor complex TTD-A subunit
Gene namesi
Name:Gtf2h5
Synonyms:D17Wsu155e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:107227. Gtf2h5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. core TFIIH complex Source: InterPro
  2. nucleolus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7171General transcription factor IIH subunit 5PRO_0000119257Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8K2X8.
PRIDEiQ8K2X8.

PTM databases

PhosphoSiteiQ8K2X8.

Expressioni

Gene expression databases

BgeeiQ8K2X8.
CleanExiMM_GTF2H5.
GenevestigatoriQ8K2X8.

Interactioni

Subunit structurei

Subunit of the TFIIH basal transcription factor complex that contains ERCC2, ERCC3, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, MNAT1, CDK7 and CCNH.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8K2X8.
SMRiQ8K2X8. Positions 1-71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB5 family.Curated

Phylogenomic databases

eggNOGiNOG278168.
GeneTreeiENSGT00390000004028.
HOGENOMiHOG000199698.
HOVERGENiHBG055393.
InParanoidiQ8K2X8.
KOiK10845.
OMAiKDLDDTH.
OrthoDBiEOG7BGHPM.
PhylomeDBiQ8K2X8.
TreeFamiTF319487.

Family and domain databases

Gene3Di3.30.70.1220. 1 hit.
InterProiIPR009400. TFIIH_TTDA/Tfb5.
[Graphical view]
PfamiPF06331. Tbf5. 1 hit.
[Graphical view]
SUPFAMiSSF142897. SSF142897. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K2X8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVNVLKGVLI ECDPAMKQFL LYLDEANALG KKFIIQDIDD THVFVIAELV
60 70
NVLQERVGEL MDQNAFSLTQ K
Length:71
Mass (Da):8,037
Last modified:October 1, 2002 - v1
Checksum:i940B4D3C9BED9A8F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71G → R in BAC25398. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003547 mRNA. Translation: BAC25038.1.
AK003579 mRNA. Translation: BAC25043.1.
AK011281 mRNA. Translation: BAC25328.1.
AK012257 mRNA. Translation: BAC25362.1.
AK013225 mRNA. Translation: BAC25398.1.
BC029238 mRNA. Translation: AAH29238.1.
CCDSiCCDS37423.1.
RefSeqiNP_852057.2. NM_181392.3.
XP_006523302.1. XM_006523239.1.
XP_006523303.1. XM_006523240.1.
UniGeneiMm.303441.

Genome annotation databases

EnsembliENSMUST00000039487; ENSMUSP00000040355; ENSMUSG00000034345.
ENSMUST00000100955; ENSMUSP00000098515; ENSMUSG00000034345.
GeneIDi66467.
KEGGimmu:66467.
UCSCiuc008aga.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003547 mRNA. Translation: BAC25038.1 .
AK003579 mRNA. Translation: BAC25043.1 .
AK011281 mRNA. Translation: BAC25328.1 .
AK012257 mRNA. Translation: BAC25362.1 .
AK013225 mRNA. Translation: BAC25398.1 .
BC029238 mRNA. Translation: AAH29238.1 .
CCDSi CCDS37423.1.
RefSeqi NP_852057.2. NM_181392.3.
XP_006523302.1. XM_006523239.1.
XP_006523303.1. XM_006523240.1.
UniGenei Mm.303441.

3D structure databases

ProteinModelPortali Q8K2X8.
SMRi Q8K2X8. Positions 1-71.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8K2X8.

Proteomic databases

MaxQBi Q8K2X8.
PRIDEi Q8K2X8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039487 ; ENSMUSP00000040355 ; ENSMUSG00000034345 .
ENSMUST00000100955 ; ENSMUSP00000098515 ; ENSMUSG00000034345 .
GeneIDi 66467.
KEGGi mmu:66467.
UCSCi uc008aga.2. mouse.

Organism-specific databases

CTDi 404672.
MGIi MGI:107227. Gtf2h5.

Phylogenomic databases

eggNOGi NOG278168.
GeneTreei ENSGT00390000004028.
HOGENOMi HOG000199698.
HOVERGENi HBG055393.
InParanoidi Q8K2X8.
KOi K10845.
OMAi KDLDDTH.
OrthoDBi EOG7BGHPM.
PhylomeDBi Q8K2X8.
TreeFami TF319487.

Miscellaneous databases

ChiTaRSi GTF2H5. mouse.
NextBioi 321774.
PROi Q8K2X8.
SOURCEi Search...

Gene expression databases

Bgeei Q8K2X8.
CleanExi MM_GTF2H5.
Genevestigatori Q8K2X8.

Family and domain databases

Gene3Di 3.30.70.1220. 1 hit.
InterProi IPR009400. TFIIH_TTDA/Tfb5.
[Graphical view ]
Pfami PF06331. Tbf5. 1 hit.
[Graphical view ]
SUPFAMi SSF142897. SSF142897. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-69, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiTF2H5_MOUSE
AccessioniPrimary (citable) accession number: Q8K2X8
Secondary accession number(s): Q8BT75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3