Reviewed,
UniProtKB/Swiss-Prot Q8K2X1 (AT10D_MOUSE)
Last modified
May 5, 2009.
Version 62.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Probable phospholipid-transporting ATPase VD Short name=ATPVD EC=3.6.3.1 Alternative name(s): ATPase class V type 10D | ||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 1416 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | ATP + H2O + phospholipid(In) = ADP + phosphate + phospholipid(Out). |
| Subcellular location | Membrane; Multi-pass membrane protein Potential. |
| Tissue specificity | Expressed in placenta and kidney. Ref.1 |
| Polymorphism | In strain C57BL/6, a polymorphism generates a premature stop codon at position 764. Ref.1 |
| Sequence similarities | Belongs to the cation transport ATPase (P-type) family. Type IV subfamily. |
| Sequence caution | The sequence AAH29551.1 differs from that shown. Reason: Frameshift at position 1136. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Transmembrane |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Hydrolase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | ATP biosynthetic process Inferred from electronic annotation. Source: InterPro cation transport Ref.1Non-traceable author statement. Source: UniProtKB phospholipid transportInferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Ref.1 Non-traceable author statement. Source: UniProtKB |
| Molecular function | ATP binding Ref.1 Non-traceable author statement. Source: UniProtKB ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanismInferred from electronic annotation. Source: InterPro magnesium ion binding Ref.1Non-traceable author statement. Source: UniProtKB phospholipid-translocating ATPase activity Ref.1Non-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8K2X1-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8K2X1-2) The sequence of this isoform differs from the canonical sequence as follows: 1120-1135: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1416 | 1416 | Probable phospholipid-transporting ATPase VD | PRO_0000046384 | |||||
Regions | |||||||||
| Topological domain | 1 – 97 | 97 | Cytoplasmic Potential | ||||||
| Transmembrane | 98 – 118 | 21 | Potential | ||||||
| Topological domain | 119 – 120 | 2 | Extracellular Potential | ||||||
| Transmembrane | 121 – 141 | 21 | Potential | ||||||
| Topological domain | 142 – 321 | 180 | Cytoplasmic Potential | ||||||
| Transmembrane | 322 – 342 | 21 | Potential | ||||||
| Topological domain | 343 – 365 | 23 | Extracellular Potential | ||||||
| Transmembrane | 366 – 386 | 21 | Potential | ||||||
| Topological domain | 387 – 1110 | 724 | Cytoplasmic Potential | ||||||
| Transmembrane | 1111 – 1131 | 21 | Potential | ||||||
| Topological domain | 1132 – 1142 | 11 | Extracellular Potential | ||||||
| Transmembrane | 1143 – 1163 | 21 | Potential | ||||||
| Topological domain | 1164 – 1192 | 29 | Cytoplasmic Potential | ||||||
| Transmembrane | 1193 – 1213 | 21 | Potential | ||||||
| Topological domain | 1214 – 1221 | 8 | Extracellular Potential | ||||||
| Transmembrane | 1222 – 1242 | 21 | Potential | ||||||
| Topological domain | 1243 – 1252 | 10 | Cytoplasmic Potential | ||||||
| Transmembrane | 1253 – 1273 | 21 | Potential | ||||||
| Topological domain | 1274 – 1289 | 16 | Extracellular Potential | ||||||
| Transmembrane | 1290 – 1310 | 21 | Potential | ||||||
| Topological domain | 1311 – 1416 | 106 | Cytoplasmic Potential | ||||||
| Nucleotide binding | 993 – 1000 | 8 | ATP Potential | ||||||
| Nucleotide binding | 1361 – 1368 | 8 | ATP Potential | ||||||
Sites | |||||||||
| Active site | 438 | 1 | 4-aspartylphosphate intermediate By similarity | ||||||
| Metal binding | 1053 | 1 | Magnesium By similarity UniProtKB Q9P241 | ||||||
| Metal binding | 1057 | 1 | Magnesium By similarity UniProtKB Q9P241 | ||||||
Natural variations | |||||||||
| Alternative sequence | 1120 – 1135 | 16 | Missing in isoform 2. | VSP_006959 | |||||
| Natural variant | 700 | 1 | V → A in strain: CAST, MAI, MBT and PWK. Ref.1 | ||||||
| Natural variant | 716 | 1 | S → L in strain: CAST, MAI, MBT and PWK. Ref.1 | ||||||
Experimental info | |||||||||
| Sequence conflict | 1239 | 1 | L → F in AAH29551. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of a putative type IV aminophospholipid transporter P-type ATPase." Flamant S., Pescher P., Lemercier B., Clement-Ziza M., Kepes F., Fellous M., Milon G., Marchal G., Besmond C. Mamm. Genome 14:21-30(2003) [PubMed: 12532265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS ALA-700 AND LEU-716. Strain: BALB/c, C57BL/6, CAST, MAI, MBT and PWK. Tissue: Monocyte. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1079-1416 (ISOFORM 2). |
Cross-references
Sequence databases | |
|---|---|
| AJ441079 mRNA. Translation: CAD29578.1. BC029551 mRNA. Translation: AAH29551.1. Frameshift. | |
| IPI | IPI00170015. IPI00227819. |
| RefSeq | NP_700438.2. |
| UniGene | Mm.32775 Mm.441066 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUSG00000046808. Mus musculus. [Contig view] |
| GeneID | 231287. |
| KEGG | mmu:231287. |
Organism-specific databases | |
| MGI | MGI:2450125. Atp10d. |
Phylogenomic databases | |
| HOGENOM | Q8K2X1. |
| HOVERGEN | Q8K2X1. |
Enzyme and pathway databases | |
| BRENDA | 3.6.3.1. 244. |
Gene expression databases | |
| ArrayExpress | Q8K2X1. |
| Bgee | Q8K2X1. |
| CleanEx | MM_ATP10D. |
| GermOnline | ENSMUSG00000046808. Mus musculus. |
Family and domain databases | |
| InterPro | IPR008250. ATPase_P-typ_ATPase-assoc-reg. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_phosphor_site. IPR006539. ATPase_P-typ_Plipid-transl. [Graphical view] |
| PANTHER | PTHR11939. ATPase_P. 1 hit. |
| Pfam | PF00122. E1-E2_ATPase. 1 hit. [Graphical view] |
| PRINTS | PR00119. CATATPASE. |
| TIGRFAMs | TIGR01652. ATPase-Plipid. 1 hit. TIGR01494. ATPase_P-type. 3 hits. |
| PROSITE | PS00154. ATPASE_E1_E2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 380484. |
| SOURCE | Search... |
Entry information
| Entry name | AT10D_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8K2X1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


