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Q8K2W3 (TXD11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thioredoxin domain-containing protein 11
Gene names
Name:Txndc11
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length948 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H2O2 generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H2O2 generation By similarity.

Subunit structure

Interacts with the cytoplasmic part of DUOX1 and DUOX2. Interacts with TPO and CYBA By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the protein disulfide isomerase family.

Contains 2 thioredoxin domains.

Sequence caution

The sequence AAH19564.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8K2W3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8K2W3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     230-236: PGVLGYF → KQQATQY
     237-948: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 948948Thioredoxin domain-containing protein 11
PRO_0000120174

Regions

Transmembrane61 – 8121Helical; Potential
Domain88 – 214127Thioredoxin 1
Domain618 – 768151Thioredoxin 2
Coiled coil793 – 87482 Potential

Amino acid modifications

Modified residue7981Phosphoserine By similarity
Disulfide bond438 ↔ 441Redox-active By similarity
Disulfide bond688 ↔ 691Redox-active By similarity

Natural variations

Alternative sequence230 – 2367PGVLGYF → KQQATQY in isoform 2.
VSP_014338
Alternative sequence237 – 948712Missing in isoform 2.
VSP_014339

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 23AAC6C544919DC1

FASTA948105,959
        10         20         30         40         50         60 
MSECGGRGGG GGNNSEDAED EGGGPKGSGS LSPAGAAASL EGRIRRGLRG ASLMARQRPE 

        70         80         90        100        110        120 
LLCGAVALGC ALLFALKFTC SRAKDVIIPA KPPVSFFSSR SPVLDLFQGQ LDYADHVRQD 

       130        140        150        160        170        180 
SEVVVLFFYA PWCGQSIAAR AEIEQAASRL SDQVLFVAIN CWWNQGKCRK QKHFFYFPVI 

       190        200        210        220        230        240 
HLYHRSFGPI EYKGPMSAVY IEKFVRRAMK PLLYIPSQSA LLDFLSSYEP GVLGYFEFSG 

       250        260        270        280        290        300 
SPQPPGYLTF FTSALHSLKK DYLGTVRFGV ITDKHLARLV SLVHSGSVYL HRHFNTSLVF 

       310        320        330        340        350        360 
PREVMNFTAE NIYKWASENQ ETLFRWLQPH GGKSLLLNNE LKKGPALFLF IPFDPLAERH 

       370        380        390        400        410        420 
PLLDEITEVA LEYNNCHGDQ VVERLLQHLR RVEAPVLQSL APELPASLPD TQLMAASPCC 

       430        440        450        460        470        480 
NTVVLPQGPA LSRTHNVCEL CVNQTVGGTR PSSVSVPQCS FFEMAAALDS FYLKEQTFYH 

       490        500        510        520        530        540 
VVSGSIECSN FLTSYSPFSY YTACCRTISR GMASFTGSEQ NVLTAPAIEF SSLEKSCEAT 

       550        560        570        580        590        600 
APSSIPHIEE NRYRFPQVGL TSTAFTGLSC RTNKTLNIYL LDSNLFWLYA ERLGAPSSAP 

       610        620        630        640        650        660 
VKEFATIVDV KEESHYILDP KQALMKFTLE SFIQNFSVLY SPLKRHLTGS DSAQFPTQHL 

       670        680        690        700        710        720 
ITEVTTDTFW EVTLRKQDVL LLYYTQWCGF CPSLNHIFIQ LARLLPEDTF TVARIDVSQN 

       730        740        750        760        770        780 
DLPWEFMVDR LPTVLFFPCN RKDLSVKYPG DLPITLPNLL RFILHHSDAA SAPQDPGISP 

       790        800        810        820        830        840 
PTQDCVQSKA VLQREHISHV ENAMQKLRSE MSSLRRTQEQ VEGRLLSARR DGHRLLRRQR 

       850        860        870        880        890        900 
TLEQQHRLLR RHSQKLQALY LKKARELQEL ARASGTPLPE HTWLKILVAT MERELEGQGG 

       910        920        930        940 
AKEPAPLGKA RPNHSKSMGT TQLPGDTPPP STTSSTLASE TKHENRTD 

« Hide

Isoform 2 [UniParc].

Checksum: 87B1A764E76E9319
Show »

FASTA23625,897

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Skin.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: Czech II.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK029166 mRNA. Translation: BAC26333.1.
BC019564 mRNA. Translation: AAH19564.1. Different initiation.
BC029643 mRNA. Translation: AAH29643.1.
RefSeqNP_083858.1. NM_029582.2.
NP_598866.1. NM_134105.2.
UniGeneMm.291015.

3D structure databases

ProteinModelPortalQ8K2W3.
SMRQ8K2W3. Positions 91-279, 565-782.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8K2W3.

Proteomic databases

PaxDbQ8K2W3.
PRIDEQ8K2W3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038424; ENSMUSP00000041113; ENSMUSG00000022498. [Q8K2W3-1]
GeneID106200.
KEGGmmu:106200.
UCSCuc007yet.1. mouse. [Q8K2W3-1]
uc007yew.1. mouse. [Q8K2W3-2]

Organism-specific databases

CTD51061.
MGIMGI:1923620. Txndc11.

Phylogenomic databases

eggNOGCOG0526.
GeneTreeENSGT00390000016020.
HOGENOMHOG000132983.
HOVERGENHBG082866.
InParanoidQ8K2W3.
OMANFSVLYS.
OrthoDBEOG7ZSHSG.
PhylomeDBQ8K2W3.
TreeFamTF323602.

Gene expression databases

ArrayExpressQ8K2W3.
BgeeQ8K2W3.
CleanExMM_TXNDC11.
GenevestigatorQ8K2W3.

Family and domain databases

Gene3D3.40.30.10. 2 hits.
InterProIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMSSF52833. SSF52833. 2 hits.
PROSITEPS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTXNDC11. mouse.
NextBio358090.
PROQ8K2W3.
SOURCESearch...

Entry information

Entry nameTXD11_MOUSE
AccessionPrimary (citable) accession number: Q8K2W3
Secondary accession number(s): Q8BMR8, Q8VCK9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot