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Q8K2W3

- TXD11_MOUSE

UniProt

Q8K2W3 - TXD11_MOUSE

Protein

Thioredoxin domain-containing protein 11

Gene

Txndc11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H2O2 generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H2O2 generation By similarity.By similarity

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: RefGenome

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. protein folding Source: RefGenome
    3. response to endoplasmic reticulum stress Source: RefGenome

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thioredoxin domain-containing protein 11
    Gene namesi
    Name:Txndc11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1923620. Txndc11.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RefGenome
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 948948Thioredoxin domain-containing protein 11PRO_0000120174Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi438 ↔ 441Redox-activePROSITE-ProRule annotation
    Disulfide bondi688 ↔ 691Redox-activePROSITE-ProRule annotation
    Modified residuei798 – 7981PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    PaxDbiQ8K2W3.
    PRIDEiQ8K2W3.

    PTM databases

    PhosphoSiteiQ8K2W3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K2W3.
    BgeeiQ8K2W3.
    CleanExiMM_TXNDC11.
    GenevestigatoriQ8K2W3.

    Interactioni

    Subunit structurei

    Interacts with the cytoplasmic part of DUOX1 and DUOX2. Interacts with TPO and CYBA By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K2W3.
    SMRiQ8K2W3. Positions 128-262, 565-782.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei61 – 8121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini88 – 214127Thioredoxin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini618 – 768151Thioredoxin 2PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili793 – 87482Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 2 thioredoxin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Redox-active center, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0526.
    GeneTreeiENSGT00390000016020.
    HOGENOMiHOG000132983.
    HOVERGENiHBG082866.
    InParanoidiQ8K2W3.
    OMAiNFSVLYS.
    OrthoDBiEOG7ZSHSG.
    PhylomeDBiQ8K2W3.
    TreeFamiTF323602.

    Family and domain databases

    Gene3Di3.40.30.10. 2 hits.
    InterProiIPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 2 hits.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 2 hits.
    PROSITEiPS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8K2W3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSECGGRGGG GGNNSEDAED EGGGPKGSGS LSPAGAAASL EGRIRRGLRG    50
    ASLMARQRPE LLCGAVALGC ALLFALKFTC SRAKDVIIPA KPPVSFFSSR 100
    SPVLDLFQGQ LDYADHVRQD SEVVVLFFYA PWCGQSIAAR AEIEQAASRL 150
    SDQVLFVAIN CWWNQGKCRK QKHFFYFPVI HLYHRSFGPI EYKGPMSAVY 200
    IEKFVRRAMK PLLYIPSQSA LLDFLSSYEP GVLGYFEFSG SPQPPGYLTF 250
    FTSALHSLKK DYLGTVRFGV ITDKHLARLV SLVHSGSVYL HRHFNTSLVF 300
    PREVMNFTAE NIYKWASENQ ETLFRWLQPH GGKSLLLNNE LKKGPALFLF 350
    IPFDPLAERH PLLDEITEVA LEYNNCHGDQ VVERLLQHLR RVEAPVLQSL 400
    APELPASLPD TQLMAASPCC NTVVLPQGPA LSRTHNVCEL CVNQTVGGTR 450
    PSSVSVPQCS FFEMAAALDS FYLKEQTFYH VVSGSIECSN FLTSYSPFSY 500
    YTACCRTISR GMASFTGSEQ NVLTAPAIEF SSLEKSCEAT APSSIPHIEE 550
    NRYRFPQVGL TSTAFTGLSC RTNKTLNIYL LDSNLFWLYA ERLGAPSSAP 600
    VKEFATIVDV KEESHYILDP KQALMKFTLE SFIQNFSVLY SPLKRHLTGS 650
    DSAQFPTQHL ITEVTTDTFW EVTLRKQDVL LLYYTQWCGF CPSLNHIFIQ 700
    LARLLPEDTF TVARIDVSQN DLPWEFMVDR LPTVLFFPCN RKDLSVKYPG 750
    DLPITLPNLL RFILHHSDAA SAPQDPGISP PTQDCVQSKA VLQREHISHV 800
    ENAMQKLRSE MSSLRRTQEQ VEGRLLSARR DGHRLLRRQR TLEQQHRLLR 850
    RHSQKLQALY LKKARELQEL ARASGTPLPE HTWLKILVAT MERELEGQGG 900
    AKEPAPLGKA RPNHSKSMGT TQLPGDTPPP STTSSTLASE TKHENRTD 948
    Length:948
    Mass (Da):105,959
    Last modified:October 1, 2002 - v1
    Checksum:i23AAC6C544919DC1
    GO
    Isoform 2 (identifier: Q8K2W3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         230-236: PGVLGYF → KQQATQY
         237-948: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:236
    Mass (Da):25,897
    Checksum:i87B1A764E76E9319
    GO

    Sequence cautioni

    The sequence AAH19564.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei230 – 2367PGVLGYF → KQQATQY in isoform 2. 1 PublicationVSP_014338
    Alternative sequencei237 – 948712Missing in isoform 2. 1 PublicationVSP_014339Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK029166 mRNA. Translation: BAC26333.1.
    BC019564 mRNA. Translation: AAH19564.1. Different initiation.
    BC029643 mRNA. Translation: AAH29643.1.
    CCDSiCCDS27960.1. [Q8K2W3-1]
    RefSeqiNP_083858.1. NM_029582.2. [Q8K2W3-1]
    NP_598866.1. NM_134105.2.
    UniGeneiMm.291015.

    Genome annotation databases

    EnsembliENSMUST00000038424; ENSMUSP00000041113; ENSMUSG00000022498. [Q8K2W3-1]
    GeneIDi106200.
    KEGGimmu:106200.
    UCSCiuc007yet.1. mouse. [Q8K2W3-1]
    uc007yew.1. mouse. [Q8K2W3-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK029166 mRNA. Translation: BAC26333.1 .
    BC019564 mRNA. Translation: AAH19564.1 . Different initiation.
    BC029643 mRNA. Translation: AAH29643.1 .
    CCDSi CCDS27960.1. [Q8K2W3-1 ]
    RefSeqi NP_083858.1. NM_029582.2. [Q8K2W3-1 ]
    NP_598866.1. NM_134105.2.
    UniGenei Mm.291015.

    3D structure databases

    ProteinModelPortali Q8K2W3.
    SMRi Q8K2W3. Positions 128-262, 565-782.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8K2W3.

    Proteomic databases

    PaxDbi Q8K2W3.
    PRIDEi Q8K2W3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038424 ; ENSMUSP00000041113 ; ENSMUSG00000022498 . [Q8K2W3-1 ]
    GeneIDi 106200.
    KEGGi mmu:106200.
    UCSCi uc007yet.1. mouse. [Q8K2W3-1 ]
    uc007yew.1. mouse. [Q8K2W3-2 ]

    Organism-specific databases

    CTDi 51061.
    MGIi MGI:1923620. Txndc11.

    Phylogenomic databases

    eggNOGi COG0526.
    GeneTreei ENSGT00390000016020.
    HOGENOMi HOG000132983.
    HOVERGENi HBG082866.
    InParanoidi Q8K2W3.
    OMAi NFSVLYS.
    OrthoDBi EOG7ZSHSG.
    PhylomeDBi Q8K2W3.
    TreeFami TF323602.

    Miscellaneous databases

    ChiTaRSi TXNDC11. mouse.
    NextBioi 358090.
    PROi Q8K2W3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K2W3.
    Bgeei Q8K2W3.
    CleanExi MM_TXNDC11.
    Genevestigatori Q8K2W3.

    Family and domain databases

    Gene3Di 3.40.30.10. 2 hits.
    InterProi IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 2 hits.
    PROSITEi PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Skin.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: Czech II.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiTXD11_MOUSE
    AccessioniPrimary (citable) accession number: Q8K2W3
    Secondary accession number(s): Q8BMR8, Q8VCK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3