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Q8K2W3

- TXD11_MOUSE

UniProt

Q8K2W3 - TXD11_MOUSE

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Protein

Thioredoxin domain-containing protein 11

Gene

Txndc11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H2O2 generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H2O2 generation (By similarity).By similarity

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: RefGenome

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. protein folding Source: RefGenome
  3. response to endoplasmic reticulum stress Source: RefGenome
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 11
Gene namesi
Name:Txndc11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1923620. Txndc11.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: RefGenome
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 948948Thioredoxin domain-containing protein 11PRO_0000120174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi438 ↔ 441Redox-activePROSITE-ProRule annotation
Disulfide bondi688 ↔ 691Redox-activePROSITE-ProRule annotation
Modified residuei798 – 7981PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ8K2W3.
PaxDbiQ8K2W3.
PRIDEiQ8K2W3.

PTM databases

PhosphoSiteiQ8K2W3.

Expressioni

Gene expression databases

BgeeiQ8K2W3.
CleanExiMM_TXNDC11.
ExpressionAtlasiQ8K2W3. baseline and differential.
GenevestigatoriQ8K2W3.

Interactioni

Subunit structurei

Interacts with the cytoplasmic part of DUOX1 and DUOX2. Interacts with TPO and CYBA (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8K2W3.
SMRiQ8K2W3. Positions 128-262, 565-782.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei61 – 8121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 214127Thioredoxin 1PROSITE-ProRule annotationAdd
BLAST
Domaini618 – 768151Thioredoxin 2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili793 – 87482Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated
Contains 2 thioredoxin domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Redox-active center, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0526.
GeneTreeiENSGT00390000016020.
HOGENOMiHOG000132983.
HOVERGENiHBG082866.
InParanoidiQ8K2W3.
OMAiNFSVLYS.
OrthoDBiEOG7ZSHSG.
PhylomeDBiQ8K2W3.
TreeFamiTF323602.

Family and domain databases

Gene3Di3.40.30.10. 2 hits.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 2 hits.
PROSITEiPS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8K2W3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSECGGRGGG GGNNSEDAED EGGGPKGSGS LSPAGAAASL EGRIRRGLRG
60 70 80 90 100
ASLMARQRPE LLCGAVALGC ALLFALKFTC SRAKDVIIPA KPPVSFFSSR
110 120 130 140 150
SPVLDLFQGQ LDYADHVRQD SEVVVLFFYA PWCGQSIAAR AEIEQAASRL
160 170 180 190 200
SDQVLFVAIN CWWNQGKCRK QKHFFYFPVI HLYHRSFGPI EYKGPMSAVY
210 220 230 240 250
IEKFVRRAMK PLLYIPSQSA LLDFLSSYEP GVLGYFEFSG SPQPPGYLTF
260 270 280 290 300
FTSALHSLKK DYLGTVRFGV ITDKHLARLV SLVHSGSVYL HRHFNTSLVF
310 320 330 340 350
PREVMNFTAE NIYKWASENQ ETLFRWLQPH GGKSLLLNNE LKKGPALFLF
360 370 380 390 400
IPFDPLAERH PLLDEITEVA LEYNNCHGDQ VVERLLQHLR RVEAPVLQSL
410 420 430 440 450
APELPASLPD TQLMAASPCC NTVVLPQGPA LSRTHNVCEL CVNQTVGGTR
460 470 480 490 500
PSSVSVPQCS FFEMAAALDS FYLKEQTFYH VVSGSIECSN FLTSYSPFSY
510 520 530 540 550
YTACCRTISR GMASFTGSEQ NVLTAPAIEF SSLEKSCEAT APSSIPHIEE
560 570 580 590 600
NRYRFPQVGL TSTAFTGLSC RTNKTLNIYL LDSNLFWLYA ERLGAPSSAP
610 620 630 640 650
VKEFATIVDV KEESHYILDP KQALMKFTLE SFIQNFSVLY SPLKRHLTGS
660 670 680 690 700
DSAQFPTQHL ITEVTTDTFW EVTLRKQDVL LLYYTQWCGF CPSLNHIFIQ
710 720 730 740 750
LARLLPEDTF TVARIDVSQN DLPWEFMVDR LPTVLFFPCN RKDLSVKYPG
760 770 780 790 800
DLPITLPNLL RFILHHSDAA SAPQDPGISP PTQDCVQSKA VLQREHISHV
810 820 830 840 850
ENAMQKLRSE MSSLRRTQEQ VEGRLLSARR DGHRLLRRQR TLEQQHRLLR
860 870 880 890 900
RHSQKLQALY LKKARELQEL ARASGTPLPE HTWLKILVAT MERELEGQGG
910 920 930 940
AKEPAPLGKA RPNHSKSMGT TQLPGDTPPP STTSSTLASE TKHENRTD
Length:948
Mass (Da):105,959
Last modified:October 1, 2002 - v1
Checksum:i23AAC6C544919DC1
GO
Isoform 2 (identifier: Q8K2W3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-236: PGVLGYF → KQQATQY
     237-948: Missing.

Note: No experimental confirmation available.

Show »
Length:236
Mass (Da):25,897
Checksum:i87B1A764E76E9319
GO

Sequence cautioni

The sequence AAH19564.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei230 – 2367PGVLGYF → KQQATQY in isoform 2. 1 PublicationVSP_014338
Alternative sequencei237 – 948712Missing in isoform 2. 1 PublicationVSP_014339Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK029166 mRNA. Translation: BAC26333.1.
BC019564 mRNA. Translation: AAH19564.1. Different initiation.
BC029643 mRNA. Translation: AAH29643.1.
CCDSiCCDS27960.1. [Q8K2W3-1]
RefSeqiNP_083858.1. NM_029582.2. [Q8K2W3-1]
NP_598866.1. NM_134105.2.
UniGeneiMm.291015.

Genome annotation databases

EnsembliENSMUST00000038424; ENSMUSP00000041113; ENSMUSG00000022498. [Q8K2W3-1]
GeneIDi106200.
KEGGimmu:106200.
UCSCiuc007yet.1. mouse. [Q8K2W3-1]
uc007yew.1. mouse. [Q8K2W3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK029166 mRNA. Translation: BAC26333.1 .
BC019564 mRNA. Translation: AAH19564.1 . Different initiation.
BC029643 mRNA. Translation: AAH29643.1 .
CCDSi CCDS27960.1. [Q8K2W3-1 ]
RefSeqi NP_083858.1. NM_029582.2. [Q8K2W3-1 ]
NP_598866.1. NM_134105.2.
UniGenei Mm.291015.

3D structure databases

ProteinModelPortali Q8K2W3.
SMRi Q8K2W3. Positions 128-262, 565-782.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8K2W3.

Proteomic databases

MaxQBi Q8K2W3.
PaxDbi Q8K2W3.
PRIDEi Q8K2W3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038424 ; ENSMUSP00000041113 ; ENSMUSG00000022498 . [Q8K2W3-1 ]
GeneIDi 106200.
KEGGi mmu:106200.
UCSCi uc007yet.1. mouse. [Q8K2W3-1 ]
uc007yew.1. mouse. [Q8K2W3-2 ]

Organism-specific databases

CTDi 51061.
MGIi MGI:1923620. Txndc11.

Phylogenomic databases

eggNOGi COG0526.
GeneTreei ENSGT00390000016020.
HOGENOMi HOG000132983.
HOVERGENi HBG082866.
InParanoidi Q8K2W3.
OMAi NFSVLYS.
OrthoDBi EOG7ZSHSG.
PhylomeDBi Q8K2W3.
TreeFami TF323602.

Miscellaneous databases

ChiTaRSi TXNDC11. mouse.
NextBioi 358090.
PROi Q8K2W3.
SOURCEi Search...

Gene expression databases

Bgeei Q8K2W3.
CleanExi MM_TXNDC11.
ExpressionAtlasi Q8K2W3. baseline and differential.
Genevestigatori Q8K2W3.

Family and domain databases

Gene3Di 3.40.30.10. 2 hits.
InterProi IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 2 hits.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 2 hits.
PROSITEi PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiTXD11_MOUSE
AccessioniPrimary (citable) accession number: Q8K2W3
Secondary accession number(s): Q8BMR8, Q8VCK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3