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Protein

Importin-11

Gene

Ipo11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPL12, and of UBE2E3 (By similarity).By similarity1 Publication

GO - Molecular functioni

  • protein transporter activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-11
Short name:
Imp11
Alternative name(s):
Ran-binding protein 11
Short name:
RanBP11
Gene namesi
Name:Ipo11
Synonyms:Ranbp11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2442377. Ipo11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207571 – 975Importin-11Add BLAST975

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei343PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8K2V6.
PaxDbiQ8K2V6.
PeptideAtlasiQ8K2V6.
PRIDEiQ8K2V6.

PTM databases

iPTMnetiQ8K2V6.
PhosphoSitePlusiQ8K2V6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042590.
CleanExiMM_IPO11.
ExpressionAtlasiQ8K2V6. baseline and differential.
GenevisibleiQ8K2V6. MM.

Interactioni

Subunit structurei

Interacts with UBE2E3 and RPL12.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079667.

Structurei

3D structure databases

ProteinModelPortaliQ8K2V6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 100Importin N-terminalPROSITE-ProRule annotationAdd BLAST73
Repeati123 – 160HEAT 1Add BLAST38
Repeati283 – 317HEAT 2Add BLAST35
Repeati318 – 356HEAT 3Add BLAST39
Repeati422 – 459HEAT 4Add BLAST38
Repeati473 – 509HEAT 5Add BLAST37
Repeati511 – 548HEAT 6Add BLAST38
Repeati555 – 593HEAT 7Add BLAST39
Repeati600 – 636HEAT 8Add BLAST37
Repeati640 – 677HEAT 9Add BLAST38
Repeati683 – 720HEAT 10Add BLAST38
Repeati731 – 773HEAT 11Add BLAST43
Repeati819 – 849HEAT 12Add BLAST31
Repeati850 – 887HEAT 13Add BLAST38
Repeati957 – 974HEAT 14Add BLAST18

Sequence similaritiesi

Belongs to the importin beta family.Curated
Contains 14 HEAT repeats.Curated
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1993. Eukaryota.
COG5657. LUCA.
GeneTreeiENSGT00390000014071.
HOGENOMiHOG000008140.
HOVERGENiHBG061387.
InParanoidiQ8K2V6.
OMAiLLLIRAC.
OrthoDBiEOG091G01EL.
PhylomeDBiQ8K2V6.
TreeFamiTF324336.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K2V6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLNSASSVV LQVLTQATSQ DTAVLKPAEE QLKQWETQPG FYSVLLNIFT
60 70 80 90 100
NHTLDINVRW LAVLYFKHGI DRYWRRVAPH ALSEEEKSTL RAGLITNFNE
110 120 130 140 150
PINQIATQIA VLIAKVARLD CPRQWPELIP TLVESVKVQD DLRQHRALLT
160 170 180 190 200
FYHVTKTLAS KRLAADRKLF YDLASGIYNF ACSLWNHHTD TFLQHVSSGN
210 220 230 240 250
EAAVLSSLER TLLSLKVLRK LTVNGFVEPH KNMEVMGFLH GIFERLKQFL
260 270 280 290 300
ECSRSIGTDN VCRDRLEKTI ILFTKVLLDF LDQHPISFTP LIQRSLEFSV
310 320 330 340 350
SYVFTEVGEG VTFERFIVQC MNLIKMIVKN YAYKPSKNFE DSSPETLEAH
360 370 380 390 400
KIKMAFFTYP TLTEICRRLV SHYFLLTEEE LTMWEEDPEG FTVEETGGDS
410 420 430 440 450
WKYSLRPCTE VLFIDIFHEY NQTLTPVLLE MMQTLEGPTN VEDMNALLIK
460 470 480 490 500
DAVYNAVGLA AFELFDSVDF DQWFKTQLLP ELQVSHNRYK PLRRRVIWLI
510 520 530 540 550
GQWISVKFKS DLRPMLYEAI CNLLQDQDLV VRIETATTLK LTVDDFEFRT
560 570 580 590 600
DQFLPYLETM FTLLFQLLQQ VTECDTKMHV LHVLSCVIER VNVQIRPYVG
610 620 630 640 650
CLVQYLPLLW KQSEEHNMLR CAILTTLIHL VQGLGADSKN LYPFLLPVIQ
660 670 680 690 700
LSTDVSQPPH VYLLEDGLEL WLVTLENSPC VTPELLRIFQ NMSPLLELSS
710 720 730 740 750
ENLRTCFKII NGYIFLSSTE FLQTYAAGLC QSFYELLPEI TTEGQVQVLK
760 770 780 790 800
VVENALKVNP VLGPQMFQRI LPCVFRGVIE GERYPVVMSI YLAVMGRVLL
810 820 830 840 850
QNTSFFSSLL NEMGHEFNQE MDQLLGNVIE MWVDRMDNIT QPERKKLSAL
860 870 880 890 900
ALLSLLPSDN SVIQDKFCGI INISVEALHD VMTEDPETRT YKDCMLMSQH
910 920 930 940 950
EEPKVTEDEE PPTEQDKRKK MLALKDPVHT VSLQQFIYEK LKAQQEILGE
960 970
QGFQSLMETV DTEIVTQLQE FLQGF
Length:975
Mass (Da):112,416
Last modified:October 1, 2002 - v1
Checksum:i3DEA79E8028C483D
GO
Isoform 2 (identifier: Q8K2V6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     698-698: L → LPSSCLANEL

Show »
Length:984
Mass (Da):113,331
Checksum:iF5C9BCD9E209DF25
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti349A → V in BAC40005 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010935698L → LPSSCLANEL in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029746 mRNA. Translation: AAH29746.1.
BC031900 mRNA. Translation: AAH31900.1.
AK087793 mRNA. Translation: BAC40005.1.
CCDSiCCDS36776.1. [Q8K2V6-1]
RefSeqiNP_083941.2. NM_029665.3. [Q8K2V6-1]
XP_006517849.1. XM_006517786.3. [Q8K2V6-2]
UniGeneiMm.132208.
Mm.482687.

Genome annotation databases

EnsembliENSMUST00000080856; ENSMUSP00000079667; ENSMUSG00000042590. [Q8K2V6-1]
ENSMUST00000186033; ENSMUSP00000140046; ENSMUSG00000042590. [Q8K2V6-2]
GeneIDi76582.
KEGGimmu:76582.
UCSCiuc007rtx.1. mouse. [Q8K2V6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029746 mRNA. Translation: AAH29746.1.
BC031900 mRNA. Translation: AAH31900.1.
AK087793 mRNA. Translation: BAC40005.1.
CCDSiCCDS36776.1. [Q8K2V6-1]
RefSeqiNP_083941.2. NM_029665.3. [Q8K2V6-1]
XP_006517849.1. XM_006517786.3. [Q8K2V6-2]
UniGeneiMm.132208.
Mm.482687.

3D structure databases

ProteinModelPortaliQ8K2V6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079667.

PTM databases

iPTMnetiQ8K2V6.
PhosphoSitePlusiQ8K2V6.

Proteomic databases

EPDiQ8K2V6.
PaxDbiQ8K2V6.
PeptideAtlasiQ8K2V6.
PRIDEiQ8K2V6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080856; ENSMUSP00000079667; ENSMUSG00000042590. [Q8K2V6-1]
ENSMUST00000186033; ENSMUSP00000140046; ENSMUSG00000042590. [Q8K2V6-2]
GeneIDi76582.
KEGGimmu:76582.
UCSCiuc007rtx.1. mouse. [Q8K2V6-1]

Organism-specific databases

CTDi51194.
MGIiMGI:2442377. Ipo11.

Phylogenomic databases

eggNOGiKOG1993. Eukaryota.
COG5657. LUCA.
GeneTreeiENSGT00390000014071.
HOGENOMiHOG000008140.
HOVERGENiHBG061387.
InParanoidiQ8K2V6.
OMAiLLLIRAC.
OrthoDBiEOG091G01EL.
PhylomeDBiQ8K2V6.
TreeFamiTF324336.

Miscellaneous databases

PROiQ8K2V6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042590.
CleanExiMM_IPO11.
ExpressionAtlasiQ8K2V6. baseline and differential.
GenevisibleiQ8K2V6. MM.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPO11_MOUSE
AccessioniPrimary (citable) accession number: Q8K2V6
Secondary accession number(s): Q8BU45, Q8K0B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.