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Protein

Serine/threonine-protein phosphatase 4 regulatory subunit 1

Gene

Ppp4r1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 regulatory subunit 1
Gene namesi
Name:Ppp4r1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1917601. Ppp4r1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 951951Serine/threonine-protein phosphatase 4 regulatory subunit 1PRO_0000071528Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei936 – 9361PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K2V1.
MaxQBiQ8K2V1.
PaxDbiQ8K2V1.
PeptideAtlasiQ8K2V1.
PRIDEiQ8K2V1.

PTM databases

iPTMnetiQ8K2V1.
PhosphoSiteiQ8K2V1.

Expressioni

Gene expression databases

CleanExiMM_PPP4R1.

Interactioni

Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R1. Interacts with HDAC3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072848.

Structurei

3D structure databases

ProteinModelPortaliQ8K2V1.
SMRiQ8K2V1. Positions 50-113, 169-323, 664-930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 6338HEAT 1Add
BLAST
Repeati65 – 8117HEAT 2Add
BLAST
Repeati82 – 11938HEAT 3Add
BLAST
Repeati127 – 16438HEAT 4Add
BLAST
Repeati168 – 20639HEAT 5Add
BLAST
Repeati208 – 24639HEAT 6Add
BLAST
Repeati248 – 28538HEAT 7Add
BLAST
Repeati287 – 32438HEAT 8Add
BLAST
Repeati506 – 54338HEAT 9Add
BLAST
Repeati699 – 73537HEAT 10Add
BLAST
Repeati800 – 83839HEAT 11Add
BLAST
Repeati862 – 89938HEAT 12Add
BLAST

Sequence similaritiesi

Contains 12 HEAT repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IUDJ. Eukaryota.
ENOG410XQII. LUCA.
HOGENOMiHOG000115650.
HOVERGENiHBG053649.
InParanoidiQ8K2V1.
KOiK15424.
PhylomeDBiQ8K2V1.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR021133. HEAT_type_2.
IPR031087. PP4R1.
[Graphical view]
PANTHERiPTHR10648:SF8. PTHR10648:SF8. 2 hits.
PfamiPF02985. HEAT. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50077. HEAT_REPEAT. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K2V1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADLSLLQED LPEDADGLDV DDYSSESDVI IIPSALDFVS QDEMLTPLGR
60 70 80 90 100
LDKYAASENV FNRQMVARSL LDTLREVCDD ERDCIAVLER ISRLADDSEP
110 120 130 140 150
TVRAELMEQV PHIALFCQEN RPSIPYAFSK YLLPIVVRYL ADQNNQVRKT
160 170 180 190 200
SQAALLALLE QELIERFDVE TKVCPVLIDL TAPDSNDDVK TEAVAIMCKM
210 220 230 240 250
APMVGKDITE RLILPRFCEM CCDCRMFHVR KVCAANFGDI CSVVGQQATE
260 270 280 290 300
EMLLPRFFQL CSDNVWGVRK ACAECFMAVS CATCQEIRRT KLSALFINLI
310 320 330 340 350
SDPSRWVRQA AFQSLGPFIS TFANPSSSGQ CFKDESKSSE DSSAEDKDRM
360 370 380 390 400
RDNDVVEEEH RRPEDAPSDL SAPHSSARLE SLEGCAAKTP GHSAGDVPAP
410 420 430 440 450
VDSSLLCTLS SESPQEAASN DENGRKPDTN SKSASRPDAG TSSPEATPLD
460 470 480 490 500
QDMFNSFHFW RTPLPKIDLD KELQQDPEER LSPERTGDVP AAPLPGPPNI
510 520 530 540 550
TMATRKELEE MIENLEPHMD DPDVKAQVDV LSAALRASSL DAHEETGGVE
560 570 580 590 600
QRSELQDEVC VSELPDCNIS HDTCVPLISA AEENAEATPD YVHGGADVSP
610 620 630 640 650
GDGFSPDEDR RPKVQDVVPQ ALLDQYLSMT DPSRAQTVDT EIAKHCAYSL
660 670 680 690 700
PGVALTLGRQ NWHCLRETYE TLASDMQWKV RRTLAFSIHE LAVILGDQLT
710 720 730 740 750
AADLVPIFNG FLKDLDEVRI GVLKHLHDFL KLLHIDKRRE YLYQLQEFLV
760 770 780 790 800
TDNSRNWRFR AELAEQLILL LELYSPRDVY DYLRPIALNL CADKVSSVRW
810 820 830 840 850
ISYKLVSEMV KKLHTATPPT FGVDLINELV ENFGRCPKWS GRQAFVFVCQ
860 870 880 890 900
TVIEDDCLPM DQFAVHLMPH LLTLANDRVP NVRVLLAKTL RQTLLEKEYF
910 920 930 940 950
LASASCHQEA VEQTIMALQM DRDSDVKYFA SIHPSSTKLS EDAMSTASST

Y
Length:951
Mass (Da):106,298
Last modified:March 1, 2004 - v2
Checksum:iEE79740F81DE67C0
GO
Isoform 2 (identifier: Q8K2V1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-349: Missing.

Note: No experimental confirmation available.
Show »
Length:602
Mass (Da):67,180
Checksum:i37FCF5B4E0FA6876
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti353 – 3531N → S in AAH29761 (PubMed:15489334).Curated
Sequence conflicti375 – 3751S → P in AAH29761 (PubMed:15489334).Curated
Sequence conflicti529 – 5291D → E in AAH29761 (PubMed:15489334).Curated
Sequence conflicti585 – 5851A → V in AAH29761 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 349349Missing in isoform 2. 1 PublicationVSP_009470Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026489 mRNA. Translation: AAH26489.1.
BC029761 mRNA. Translation: AAH29761.1.
CCDSiCCDS28941.2. [Q8K2V1-1]
RefSeqiNP_001107603.1. NM_001114131.1.
NP_666193.2. NM_146081.2.
XP_006524957.1. XM_006524894.2. [Q8K2V1-2]
XP_006524958.1. XM_006524895.2. [Q8K2V1-2]
UniGeneiMm.48686.

Genome annotation databases

GeneIDi70351.
KEGGimmu:70351.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026489 mRNA. Translation: AAH26489.1.
BC029761 mRNA. Translation: AAH29761.1.
CCDSiCCDS28941.2. [Q8K2V1-1]
RefSeqiNP_001107603.1. NM_001114131.1.
NP_666193.2. NM_146081.2.
XP_006524957.1. XM_006524894.2. [Q8K2V1-2]
XP_006524958.1. XM_006524895.2. [Q8K2V1-2]
UniGeneiMm.48686.

3D structure databases

ProteinModelPortaliQ8K2V1.
SMRiQ8K2V1. Positions 50-113, 169-323, 664-930.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072848.

PTM databases

iPTMnetiQ8K2V1.
PhosphoSiteiQ8K2V1.

Proteomic databases

EPDiQ8K2V1.
MaxQBiQ8K2V1.
PaxDbiQ8K2V1.
PeptideAtlasiQ8K2V1.
PRIDEiQ8K2V1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi70351.
KEGGimmu:70351.

Organism-specific databases

CTDi9989.
MGIiMGI:1917601. Ppp4r1.

Phylogenomic databases

eggNOGiENOG410IUDJ. Eukaryota.
ENOG410XQII. LUCA.
HOGENOMiHOG000115650.
HOVERGENiHBG053649.
InParanoidiQ8K2V1.
KOiK15424.
PhylomeDBiQ8K2V1.

Miscellaneous databases

ChiTaRSiPpp4r1. mouse.
PROiQ8K2V1.
SOURCEiSearch...

Gene expression databases

CleanExiMM_PPP4R1.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR021133. HEAT_type_2.
IPR031087. PP4R1.
[Graphical view]
PANTHERiPTHR10648:SF8. PTHR10648:SF8. 2 hits.
PfamiPF02985. HEAT. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50077. HEAT_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiPP4R1_MOUSE
AccessioniPrimary (citable) accession number: Q8K2V1
Secondary accession number(s): Q8R0R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: July 6, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.