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Protein

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6

Gene

Alkbh6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron.By similarity

Cofactori

Fe2+PROSITE-ProRule annotationNote: Binds 1 Fe2+ ion per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi114Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi116Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi182Iron; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 (EC:1.14.11.-)
Alternative name(s):
Alkylated DNA repair protein alkB homolog 6
Gene namesi
Name:Alkbh6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2142037. Alkbh6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003237171 – 238Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6Add BLAST238

Proteomic databases

EPDiQ8K2U2.
MaxQBiQ8K2U2.
PaxDbiQ8K2U2.
PRIDEiQ8K2U2.

PTM databases

iPTMnetiQ8K2U2.
PhosphoSitePlusiQ8K2U2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042831.
CleanExiMM_ALKBH6.
ExpressionAtlasiQ8K2U2. baseline and differential.
GenevisibleiQ8K2U2. MM.

Interactioni

Subunit structurei

Interacts with VCPKMT.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051515.

Structurei

3D structure databases

ProteinModelPortaliQ8K2U2.
SMRiQ8K2U2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 227Fe2OG dioxygenasePROSITE-ProRule annotationAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni103 – 105Alpha-ketoglutarate bindingBy similarity3
Regioni218 – 224Alpha-ketoglutarate bindingBy similarity7

Sequence similaritiesi

Belongs to the alkB family.Curated
Contains 1 Fe2OG dioxygenase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3200. Eukaryota.
ENOG410XR69. LUCA.
GeneTreeiENSGT00510000048626.
HOGENOMiHOG000210721.
HOVERGENiHBG056765.
InParanoidiQ8K2U2.
KOiK10768.
OMAiEVRKCPP.
OrthoDBiEOG091G0R50.
TreeFamiTF314467.

Family and domain databases

Gene3Di2.60.120.590. 1 hit.
InterProiIPR027450. AlkB-like.
IPR032862. ALKBH6.
IPR005123. Oxoglu/Fe-dep_dioxygenase.
[Graphical view]
PANTHERiPTHR13069:SF11. PTHR13069:SF11. 1 hit.
PfamiPF13532. 2OG-FeII_Oxy_2. 1 hit.
[Graphical view]
PROSITEiPS51471. FE2OG_OXY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K2U2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEQDARVPA LEPFRVEQAP PLIYYVPDFI SKEEEEYLLR QVFNAPKPKW
60 70 80 90 100
TQLSGRKLQN WGGLPHPRGM VPERLPPWLQ RYVDKVSDLS LFGGLPANHV
110 120 130 140 150
LVNQYLPGEG IMPHEDGPLY YPTVSTISLG SHTVLDFYEP RQPDDDVPME
160 170 180 190 200
QPRPPQRPIT SLLVEPRSLL VLRGTAYTRL LHGISATRVD ELDATSLPPN
210 220 230
ATACKSALPG AHLVRGTRVS LTIRRVPRVL RASLLLSK
Length:238
Mass (Da):26,776
Last modified:September 18, 2013 - v3
Checksum:iE67EA27846A9121D
GO

Sequence cautioni

The sequence AAH29805 differs from that shown. Reason: Frameshift at positions 7, 210, 221, 227 and 231.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC149067 Genomic DNA. No translation available.
CH466593 Genomic DNA. Translation: EDL24033.1.
BC029805 mRNA. Translation: AAH29805.1. Frameshift.
CCDSiCCDS21085.1.
RefSeqiNP_932144.2. NM_198027.2.
UniGeneiMm.276277.

Genome annotation databases

EnsembliENSMUST00000060834; ENSMUSP00000051515; ENSMUSG00000042831.
GeneIDi233065.
KEGGimmu:233065.
UCSCiuc009geb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC149067 Genomic DNA. No translation available.
CH466593 Genomic DNA. Translation: EDL24033.1.
BC029805 mRNA. Translation: AAH29805.1. Frameshift.
CCDSiCCDS21085.1.
RefSeqiNP_932144.2. NM_198027.2.
UniGeneiMm.276277.

3D structure databases

ProteinModelPortaliQ8K2U2.
SMRiQ8K2U2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051515.

PTM databases

iPTMnetiQ8K2U2.
PhosphoSitePlusiQ8K2U2.

Proteomic databases

EPDiQ8K2U2.
MaxQBiQ8K2U2.
PaxDbiQ8K2U2.
PRIDEiQ8K2U2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060834; ENSMUSP00000051515; ENSMUSG00000042831.
GeneIDi233065.
KEGGimmu:233065.
UCSCiuc009geb.1. mouse.

Organism-specific databases

CTDi84964.
MGIiMGI:2142037. Alkbh6.

Phylogenomic databases

eggNOGiKOG3200. Eukaryota.
ENOG410XR69. LUCA.
GeneTreeiENSGT00510000048626.
HOGENOMiHOG000210721.
HOVERGENiHBG056765.
InParanoidiQ8K2U2.
KOiK10768.
OMAiEVRKCPP.
OrthoDBiEOG091G0R50.
TreeFamiTF314467.

Miscellaneous databases

ChiTaRSiAlkbh6. mouse.
PROiQ8K2U2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042831.
CleanExiMM_ALKBH6.
ExpressionAtlasiQ8K2U2. baseline and differential.
GenevisibleiQ8K2U2. MM.

Family and domain databases

Gene3Di2.60.120.590. 1 hit.
InterProiIPR027450. AlkB-like.
IPR032862. ALKBH6.
IPR005123. Oxoglu/Fe-dep_dioxygenase.
[Graphical view]
PANTHERiPTHR13069:SF11. PTHR13069:SF11. 1 hit.
PfamiPF13532. 2OG-FeII_Oxy_2. 1 hit.
[Graphical view]
PROSITEiPS51471. FE2OG_OXY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALKB6_MOUSE
AccessioniPrimary (citable) accession number: Q8K2U2
Secondary accession number(s): G3X994
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: September 18, 2013
Last modified: November 2, 2016
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.