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Protein

Zinc finger protein 668

Gene

Znf668

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri22 – 4423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri84 – 10623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri112 – 13423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri140 – 16223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri168 – 19023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri196 – 21823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri516 – 53823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri544 – 56623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri572 – 59423C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 668
Gene namesi
Name:Znf668
Synonyms:Zfp668
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2442943. Zfp668.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Zinc finger protein 668PRO_0000251480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei387 – 3871PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8K2R5.
MaxQBiQ8K2R5.
PaxDbiQ8K2R5.
PRIDEiQ8K2R5.

PTM databases

iPTMnetiQ8K2R5.
PhosphoSiteiQ8K2R5.

Expressioni

Gene expression databases

BgeeiQ8K2R5.
CleanExiMM_ZFP668.
ExpressionAtlasiQ8K2R5. baseline and differential.
GenevisibleiQ8K2R5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056105.

Structurei

3D structure databases

ProteinModelPortaliQ8K2R5.
SMRiQ8K2R5. Positions 22-414, 509-594.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri22 – 4423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri84 – 10623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri112 – 13423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri140 – 16223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri168 – 19023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri196 – 21823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri516 – 53823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri544 – 56623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri572 – 59423C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00810000125521.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8K2R5.
OMAiVCRECKE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8K2R5.
TreeFamiTF331849.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 16 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K2R5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVEATEARS PGPCYKRSGR RYKCLFCTKT FPNAPRAARH AATHTPTDCT
60 70 80 90 100
EEVREAQPKV DTEPKAEEAS GDKVSASVAK PRPYACPLCP KAYKTAPELR
110 120 130 140 150
SHGRSHTGEK PFPCPECGRR FMQPVCLRVH LASHAGELPF RCTHCPKAYG
160 170 180 190 200
TLSKLKIHQR GHTGERPYAC PDCGKSFADP SVFRKHRRTH AGLRPYSCER
210 220 230 240 250
CGKAYAELKD LRNHERSHTG ERPFLCSECG KSFSRSSSLT CHQRIHAAQK
260 270 280 290 300
PYRCPACGKG FTQLSSYQSH ERTHSGEKPF LCPRCGRMFS DPSSFRRHQR
310 320 330 340 350
AHEGVKPYRC EKCGKDFRQP ADLAMHRRVH TGDRPFKCLQ CDKTFVASWD
360 370 380 390 400
LKRHALVHSG QRPFRCEECG RAFAERASLT KHSRMHSGER PFHCNACGKS
410 420 430 440 450
FVVLSSLRKH ERTHRSNETT GAAPQQELVL GLALPVGVVG EGSAAPVAGA
460 470 480 490 500
GVGDAPAGLL GLPPESGGVV ATQWQVVGMT VEHVECQDAG VGEAPSTLGD
510 520 530 540 550
AGEVGGEETD EKPPQFVCRE CKETFSTLTL LRRHERSHPE LRPFPCTQCG
560 570 580 590 600
KSFSDRAGLR KHSRTHSSVR PYSCSQCPKA FLSASDLRKH ERTHPVPIGT
610
PIPLEPLVAL LGMPEEGSA
Length:619
Mass (Da):68,347
Last modified:October 1, 2002 - v1
Checksum:iA50C008267E810B5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti86 – 861C → Y in BAE41226 (PubMed:16141072).Curated
Sequence conflicti94 – 941K → R in BAE41226 (PubMed:16141072).Curated
Sequence conflicti95 – 951T → I in BAC33091 (PubMed:16141072).Curated
Sequence conflicti233 – 2331F → L in BAE31234 (PubMed:16141072).Curated
Sequence conflicti296 – 2961R → G in BAC33091 (PubMed:16141072).Curated
Sequence conflicti407 – 4071L → I in BAC33091 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047593 mRNA. Translation: BAC33091.1.
AK053438 mRNA. Translation: BAC35386.1.
AK152456 mRNA. Translation: BAE31234.1.
AK169556 mRNA. Translation: BAE41226.1.
BC030314 mRNA. Translation: AAH30314.1.
CCDSiCCDS21881.1.
RefSeqiNP_666371.1. NM_146259.3.
XP_006507911.1. XM_006507848.1.
XP_006507912.1. XM_006507849.1.
XP_006507913.1. XM_006507850.1.
XP_006507914.1. XM_006507851.2.
XP_006507915.1. XM_006507852.2.
XP_011240102.1. XM_011241800.1.
UniGeneiMm.207872.
Mm.488249.
Mm.491243.

Genome annotation databases

EnsembliENSMUST00000054415; ENSMUSP00000056105; ENSMUSG00000049728.
ENSMUST00000106261; ENSMUSP00000101868; ENSMUSG00000049728.
ENSMUST00000106262; ENSMUSP00000101869; ENSMUSG00000049728.
ENSMUST00000106263; ENSMUSP00000101870; ENSMUSG00000049728.
GeneIDi244219.
KEGGimmu:244219.
UCSCiuc009jxa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047593 mRNA. Translation: BAC33091.1.
AK053438 mRNA. Translation: BAC35386.1.
AK152456 mRNA. Translation: BAE31234.1.
AK169556 mRNA. Translation: BAE41226.1.
BC030314 mRNA. Translation: AAH30314.1.
CCDSiCCDS21881.1.
RefSeqiNP_666371.1. NM_146259.3.
XP_006507911.1. XM_006507848.1.
XP_006507912.1. XM_006507849.1.
XP_006507913.1. XM_006507850.1.
XP_006507914.1. XM_006507851.2.
XP_006507915.1. XM_006507852.2.
XP_011240102.1. XM_011241800.1.
UniGeneiMm.207872.
Mm.488249.
Mm.491243.

3D structure databases

ProteinModelPortaliQ8K2R5.
SMRiQ8K2R5. Positions 22-414, 509-594.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056105.

PTM databases

iPTMnetiQ8K2R5.
PhosphoSiteiQ8K2R5.

Proteomic databases

EPDiQ8K2R5.
MaxQBiQ8K2R5.
PaxDbiQ8K2R5.
PRIDEiQ8K2R5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054415; ENSMUSP00000056105; ENSMUSG00000049728.
ENSMUST00000106261; ENSMUSP00000101868; ENSMUSG00000049728.
ENSMUST00000106262; ENSMUSP00000101869; ENSMUSG00000049728.
ENSMUST00000106263; ENSMUSP00000101870; ENSMUSG00000049728.
GeneIDi244219.
KEGGimmu:244219.
UCSCiuc009jxa.1. mouse.

Organism-specific databases

CTDi244219.
MGIiMGI:2442943. Zfp668.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00810000125521.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8K2R5.
OMAiVCRECKE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8K2R5.
TreeFamiTF331849.

Miscellaneous databases

PROiQ8K2R5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K2R5.
CleanExiMM_ZFP668.
ExpressionAtlasiQ8K2R5. baseline and differential.
GenevisibleiQ8K2R5. MM.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 16 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Cerebellum, Eye and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiZN668_MOUSE
AccessioniPrimary (citable) accession number: Q8K2R5
Secondary accession number(s): Q3TEM2, Q3U7Y5, Q8C8B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.