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Protein

Zinc finger protein 668

Gene

Znf668

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 44C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri84 – 106C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri112 – 134C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 668
Gene namesi
Name:Znf668
Synonyms:Zfp668
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2442943 Zfp668

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002514801 – 619Zinc finger protein 668Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei10PhosphoserineBy similarity1
Cross-linki59Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei387PhosphoserineBy similarity1
Cross-linki512Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8K2R5
MaxQBiQ8K2R5
PaxDbiQ8K2R5
PeptideAtlasiQ8K2R5
PRIDEiQ8K2R5

PTM databases

iPTMnetiQ8K2R5
PhosphoSitePlusiQ8K2R5

Expressioni

Gene expression databases

BgeeiENSMUSG00000049728
CleanExiMM_ZFP668
ExpressionAtlasiQ8K2R5 baseline and differential
GenevisibleiQ8K2R5 MM

Interactioni

Protein-protein interaction databases

IntActiQ8K2R5, 1 interactor
STRINGi10090.ENSMUSP00000056105

Structurei

3D structure databases

ProteinModelPortaliQ8K2R5
SMRiQ8K2R5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 44C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri84 – 106C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri112 – 134C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144207
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8K2R5
OMAiCTKTFPN
OrthoDBiEOG091G02KC
PhylomeDBiQ8K2R5
TreeFamiTF331849

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

Sequencei

Sequence statusi: Complete.

Q8K2R5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVEATEARS PGPCYKRSGR RYKCLFCTKT FPNAPRAARH AATHTPTDCT
60 70 80 90 100
EEVREAQPKV DTEPKAEEAS GDKVSASVAK PRPYACPLCP KAYKTAPELR
110 120 130 140 150
SHGRSHTGEK PFPCPECGRR FMQPVCLRVH LASHAGELPF RCTHCPKAYG
160 170 180 190 200
TLSKLKIHQR GHTGERPYAC PDCGKSFADP SVFRKHRRTH AGLRPYSCER
210 220 230 240 250
CGKAYAELKD LRNHERSHTG ERPFLCSECG KSFSRSSSLT CHQRIHAAQK
260 270 280 290 300
PYRCPACGKG FTQLSSYQSH ERTHSGEKPF LCPRCGRMFS DPSSFRRHQR
310 320 330 340 350
AHEGVKPYRC EKCGKDFRQP ADLAMHRRVH TGDRPFKCLQ CDKTFVASWD
360 370 380 390 400
LKRHALVHSG QRPFRCEECG RAFAERASLT KHSRMHSGER PFHCNACGKS
410 420 430 440 450
FVVLSSLRKH ERTHRSNETT GAAPQQELVL GLALPVGVVG EGSAAPVAGA
460 470 480 490 500
GVGDAPAGLL GLPPESGGVV ATQWQVVGMT VEHVECQDAG VGEAPSTLGD
510 520 530 540 550
AGEVGGEETD EKPPQFVCRE CKETFSTLTL LRRHERSHPE LRPFPCTQCG
560 570 580 590 600
KSFSDRAGLR KHSRTHSSVR PYSCSQCPKA FLSASDLRKH ERTHPVPIGT
610
PIPLEPLVAL LGMPEEGSA
Length:619
Mass (Da):68,347
Last modified:October 1, 2002 - v1
Checksum:iA50C008267E810B5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86C → Y in BAE41226 (PubMed:16141072).Curated1
Sequence conflicti94K → R in BAE41226 (PubMed:16141072).Curated1
Sequence conflicti95T → I in BAC33091 (PubMed:16141072).Curated1
Sequence conflicti233F → L in BAE31234 (PubMed:16141072).Curated1
Sequence conflicti296R → G in BAC33091 (PubMed:16141072).Curated1
Sequence conflicti407L → I in BAC33091 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047593 mRNA Translation: BAC33091.1
AK053438 mRNA Translation: BAC35386.1
AK152456 mRNA Translation: BAE31234.1
AK169556 mRNA Translation: BAE41226.1
BC030314 mRNA Translation: AAH30314.1
CCDSiCCDS21881.1
RefSeqiNP_666371.1, NM_146259.3
XP_006507911.1, XM_006507848.2
XP_006507912.1, XM_006507849.1
XP_006507913.1, XM_006507850.2
XP_006507914.1, XM_006507851.3
XP_017177743.1, XM_017322254.1
XP_017177744.1, XM_017322255.1
XP_017177745.1, XM_017322256.1
UniGeneiMm.207872
Mm.277874
Mm.488249
Mm.491243

Genome annotation databases

EnsembliENSMUST00000054415; ENSMUSP00000056105; ENSMUSG00000049728
ENSMUST00000106261; ENSMUSP00000101868; ENSMUSG00000049728
ENSMUST00000106262; ENSMUSP00000101869; ENSMUSG00000049728
ENSMUST00000106263; ENSMUSP00000101870; ENSMUSG00000049728
GeneIDi244219
KEGGimmu:244219
UCSCiuc009jxa.1 mouse

Similar proteinsi

Entry informationi

Entry nameiZN668_MOUSE
AccessioniPrimary (citable) accession number: Q8K2R5
Secondary accession number(s): Q3TEM2, Q3U7Y5, Q8C8B7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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