Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Atp1a1 protein

Gene

Atp1a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • ADP binding Source: Ensembl
  • ATP binding Source: InterPro
  • chaperone binding Source: MGI
  • phosphatase activity Source: MGI
  • potassium ion binding Source: Ensembl
  • sodium:potassium-exchanging ATPase activity Source: MGI
  • sodium ion binding Source: Ensembl
  • steroid hormone binding Source: MGI

GO - Biological processi

  • cellular potassium ion homeostasis Source: MGI
  • cellular response to mechanical stimulus Source: Ensembl
  • cellular response to steroid hormone stimulus Source: MGI
  • cellular sodium ion homeostasis Source: MGI
  • dephosphorylation Source: GOC
  • membrane hyperpolarization Source: Ensembl
  • membrane repolarization Source: MGI
  • negative regulation of glucocorticoid biosynthetic process Source: MGI
  • negative regulation of heart contraction Source: MGI
  • positive regulation of heart contraction Source: MGI
  • positive regulation of striated muscle contraction Source: MGI
  • potassium ion import Source: MGI
  • regulation of blood pressure Source: MGI
  • regulation of cardiac muscle cell contraction Source: Ensembl
  • regulation of sodium ion transport Source: Ensembl
  • regulation of the force of heart contraction Source: MGI
  • response to drug Source: MGI
  • response to glycoside Source: Ensembl
  • sodium ion export from cell Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Atp1a1 proteinImported
Gene namesi
Name:Atp1a1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88105. Atp1a1.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • basolateral plasma membrane Source: MGI
  • caveola Source: Ensembl
  • endoplasmic reticulum Source: Ensembl
  • endosome Source: Ensembl
  • extracellular exosome Source: MGI
  • Golgi apparatus Source: Ensembl
  • membrane Source: MGI
  • neuronal postsynaptic density Source: MGI
  • plasma membrane Source: MGI
  • protein complex Source: MGI
  • sarcolemma Source: MGI
  • sodium:potassium-exchanging ATPase complex Source: MGI
  • vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ8K2R2.

Expressioni

Gene expression databases

BgeeiQ8K2R2.
ExpressionAtlasiQ8K2R2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039657.

Structurei

3D structure databases

ProteinModelPortaliQ8K2R2.
SMRiQ8K2R2. Positions 1-433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG004298.

Family and domain databases

Gene3Di1.20.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR023298. ATPase_P-typ_TM_dom.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K2R2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDPPRAAVP DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET
60 70 80 90 100
VEDIAARLNI PVNQVNPRDA KACVVHGSDL KDMTSEELDD ILRYHTEIVF
110 120 130 140 150
ARTSPQQKLI IVEGCQRQGA IVAVTGDGVN DSPALKKADI GVAMGIVGSD
160 170 180 190 200
VSKQAADMIL LDDNFASIVT GVEEGRLIFD NLKKSIAYTL TSNIPEITPF
210 220 230 240 250
LIFIIANIPL PLGTVTILCI DLGTDMVPAI SLAYEQAESD IMKRQPRNPK
260 270 280 290 300
TDKLVNERLI SMAYGQIGMI QALGGFFTYF VILAENGFLP FHLLGIRETW
310 320 330 340 350
DDRWVNDVED SYGQQWTYEQ RKIVEFTCHT AFFVSIVVVQ WADLVICKTR
360 370 380 390 400
RNSVFQQGMK NKILIFGLFE ETALAAFLSY CPGMGAALRM YPLKPTWWFC
410 420 430
AFPYSLLIFV YDEVRKLIIR RRPGGWVEKE TYY
Length:433
Mass (Da):48,140
Last modified:October 1, 2002 - v1
Checksum:iE025F674710FC0FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030326 mRNA. Translation: AAH30326.1.
UniGeneiMm.280103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030326 mRNA. Translation: AAH30326.1.
UniGeneiMm.280103.

3D structure databases

ProteinModelPortaliQ8K2R2.
SMRiQ8K2R2. Positions 1-433.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039657.

Proteomic databases

PRIDEiQ8K2R2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:88105. Atp1a1.

Phylogenomic databases

HOVERGENiHBG004298.

Miscellaneous databases

ChiTaRSiAtp1a1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K2R2.
ExpressionAtlasiQ8K2R2. baseline and differential.

Family and domain databases

Gene3Di1.20.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR023298. ATPase_P-typ_TM_dom.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3Imported.
    Tissue: Mammary tumor. MMTV-LTR/INT3 model. 5 month old mouse. Taken by biopsy.Imported.

Entry informationi

Entry nameiQ8K2R2_MOUSE
AccessioniPrimary (citable) accession number: Q8K2R2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.