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Q8K2R2

- Q8K2R2_MOUSE

UniProt

Q8K2R2 - Q8K2R2_MOUSE

Protein
Submitted name:

Atp1a1 protein

Gene

Atp1a1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ADP binding Source: Ensembl
    2. ATP binding Source: Ensembl
    3. phosphatase activity Source: MGI
    4. potassium ion binding Source: Ensembl
    5. protein binding Source: MGI
    6. sodium:potassium-exchanging ATPase activity Source: MGI
    7. sodium ion binding Source: Ensembl

    GO - Biological processi

    1. ATP biosynthetic process Source: InterPro
    2. cellular response to mechanical stimulus Source: Ensembl
    3. dephosphorylation Source: GOC
    4. membrane hyperpolarization Source: Ensembl
    5. negative regulation of glucocorticoid biosynthetic process Source: MGI
    6. negative regulation of heart contraction Source: MGI
    7. positive regulation of heart contraction Source: MGI
    8. positive regulation of striated muscle contraction Source: MGI
    9. potassium ion import Source: Ensembl
    10. regulation of blood pressure Source: MGI
    11. regulation of cardiac muscle cell contraction Source: Ensembl
    12. regulation of sodium ion transport Source: Ensembl
    13. regulation of the force of heart contraction Source: MGI
    14. response to drug Source: MGI
    15. sodium ion transmembrane transport Source: GOC

    Keywords - Molecular functioni

    HydrolaseSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Atp1a1 proteinImported
    Gene namesi
    Name:Atp1a1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:88105. Atp1a1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. basolateral plasma membrane Source: MGI
    3. caveola Source: Ensembl
    4. endoplasmic reticulum Source: Ensembl
    5. endosome Source: Ensembl
    6. Golgi apparatus Source: Ensembl
    7. plasma membrane Source: MGI
    8. protein complex Source: MGI
    9. sarcolemma Source: MGI
    10. sodium:potassium-exchanging ATPase complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PRIDEiQ8K2R2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K2R2.
    BgeeiQ8K2R2.
    GenevestigatoriQ8K2R2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K2R2.
    SMRiQ8K2R2. Positions 1-433.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG004298.
    InParanoidiQ8K2R2.

    Family and domain databases

    Gene3Di1.20.1110.10. 1 hit.
    InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8K2R2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIDPPRAAVP DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET    50
    VEDIAARLNI PVNQVNPRDA KACVVHGSDL KDMTSEELDD ILRYHTEIVF 100
    ARTSPQQKLI IVEGCQRQGA IVAVTGDGVN DSPALKKADI GVAMGIVGSD 150
    VSKQAADMIL LDDNFASIVT GVEEGRLIFD NLKKSIAYTL TSNIPEITPF 200
    LIFIIANIPL PLGTVTILCI DLGTDMVPAI SLAYEQAESD IMKRQPRNPK 250
    TDKLVNERLI SMAYGQIGMI QALGGFFTYF VILAENGFLP FHLLGIRETW 300
    DDRWVNDVED SYGQQWTYEQ RKIVEFTCHT AFFVSIVVVQ WADLVICKTR 350
    RNSVFQQGMK NKILIFGLFE ETALAAFLSY CPGMGAALRM YPLKPTWWFC 400
    AFPYSLLIFV YDEVRKLIIR RRPGGWVEKE TYY 433
    Length:433
    Mass (Da):48,140
    Last modified:October 1, 2002 - v1
    Checksum:iE025F674710FC0FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC030326 mRNA. Translation: AAH30326.1.
    UniGeneiMm.280103.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC030326 mRNA. Translation: AAH30326.1 .
    UniGenei Mm.280103.

    3D structure databases

    ProteinModelPortali Q8K2R2.
    SMRi Q8K2R2. Positions 1-433.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8K2R2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:88105. Atp1a1.

    Phylogenomic databases

    HOVERGENi HBG004298.
    InParanoidi Q8K2R2.

    Miscellaneous databases

    ChiTaRSi ATP1A1. mouse.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K2R2.
    Bgeei Q8K2R2.
    Genevestigatori Q8K2R2.

    Family and domain databases

    Gene3Di 1.20.1110.10. 1 hit.
    InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N-3Imported.
      Tissue: Mammary tumor. MMTV-LTR/INT3 model. 5 month old mouse. Taken by biopsy.Imported.

    Entry informationi

    Entry nameiQ8K2R2_MOUSE
    AccessioniPrimary (citable) accession number: Q8K2R2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)