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Q8K2R2 (Q8K2R2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Atp1a1 MGI 88105
OrganismMus musculus (Mouse) EMBL AAH30326.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS006068
   Molecular functionHydrolase SAAS SAAS001757
Gene Ontology (GO)
   Biological_processATP biosynthetic process

Inferred from electronic annotation. Source: InterPro

cellular response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

dephosphorylation

Inferred from mutant phenotype PubMed 10360172. Source: GOC

membrane hyperpolarization

Inferred from electronic annotation. Source: Ensembl

negative regulation of glucocorticoid biosynthetic process

Inferred from mutant phenotype PubMed 17234593. Source: MGI

negative regulation of heart contraction

Inferred from mutant phenotype PubMed 15485817. Source: MGI

positive regulation of heart contraction

Inferred from mutant phenotype PubMed 10360172. Source: MGI

positive regulation of striated muscle contraction

Inferred from mutant phenotype PubMed 11507009. Source: MGI

potassium ion import

Inferred from electronic annotation. Source: Ensembl

regulation of blood pressure

Inferred from genetic interaction PubMed 16243970. Source: MGI

regulation of cardiac muscle cell contraction

Inferred from electronic annotation. Source: Ensembl

regulation of sodium ion transport

Inferred from electronic annotation. Source: Ensembl

regulation of the force of heart contraction

Inferred from mutant phenotype PubMed 10360172PubMed 15485817. Source: MGI

response to drug

Inferred from mutant phenotype PubMed 17234593. Source: MGI

sodium ion transmembrane transport

Inferred from mutant phenotype PubMed 10360172PubMed 15485817. Source: GOC

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

apical plasma membrane

Inferred from direct assay PubMed 21705333. Source: MGI

basolateral plasma membrane

Inferred from direct assay PubMed 8144700. Source: MGI

caveola

Inferred from electronic annotation. Source: Ensembl

endoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

endosome

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay PubMed 10468580PubMed 10837135. Source: MGI

sarcolemma

Inferred from direct assay PubMed 15485817. Source: MGI

sodium:potassium-exchanging ATPase complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionADP binding

Inferred from electronic annotation. Source: Ensembl

ATP binding

Inferred from electronic annotation. Source: Ensembl

phosphatase activity

Inferred from mutant phenotype PubMed 10360172. Source: MGI

potassium ion binding

Inferred from electronic annotation. Source: Ensembl

sodium ion binding

Inferred from electronic annotation. Source: Ensembl

sodium:potassium-exchanging ATPase activity

Inferred from mutant phenotype PubMed 10360172PubMed 15485817. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8K2R2 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: E025F674710FC0FA

FASTA43348,140
        10         20         30         40         50         60 
MIDPPRAAVP DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI 

        70         80         90        100        110        120 
PVNQVNPRDA KACVVHGSDL KDMTSEELDD ILRYHTEIVF ARTSPQQKLI IVEGCQRQGA 

       130        140        150        160        170        180 
IVAVTGDGVN DSPALKKADI GVAMGIVGSD VSKQAADMIL LDDNFASIVT GVEEGRLIFD 

       190        200        210        220        230        240 
NLKKSIAYTL TSNIPEITPF LIFIIANIPL PLGTVTILCI DLGTDMVPAI SLAYEQAESD 

       250        260        270        280        290        300 
IMKRQPRNPK TDKLVNERLI SMAYGQIGMI QALGGFFTYF VILAENGFLP FHLLGIRETW 

       310        320        330        340        350        360 
DDRWVNDVED SYGQQWTYEQ RKIVEFTCHT AFFVSIVVVQ WADLVICKTR RNSVFQQGMK 

       370        380        390        400        410        420 
NKILIFGLFE ETALAAFLSY CPGMGAALRM YPLKPTWWFC AFPYSLLIFV YDEVRKLIIR 

       430 
RRPGGWVEKE TYY 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N-3 EMBL AAH30326.1.
Tissue: Mammary tumor. MMTV-LTR/INT3 model. 5 month old mouse. Taken by biopsy. EMBL AAH30326.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC030326 mRNA. Translation: AAH30326.1.
UniGeneMm.280103.

3D structure databases

ProteinModelPortalQ8K2R2.
SMRQ8K2R2. Positions 1-433.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ8K2R2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:88105. Atp1a1.

Phylogenomic databases

HOVERGENHBG004298.
InParanoidQ8K2R2.

Gene expression databases

ArrayExpressQ8K2R2.
BgeeQ8K2R2.
GenevestigatorQ8K2R2.

Family and domain databases

Gene3D1.20.1110.10. 1 hit.
InterProIPR006068. ATPase_P-typ_cation-transptr_C.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR023298. ATPase_P-typ_TM_dom.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
ProtoNetSearch...

Other

ChiTaRSATP1A1. mouse.
SOURCESearch...

Entry information

Entry nameQ8K2R2_MOUSE
AccessionPrimary (citable) accession number: Q8K2R2
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)