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Q8K2R2

- Q8K2R2_MOUSE

UniProt

Q8K2R2 - Q8K2R2_MOUSE

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Protein
Submitted name:

Atp1a1 protein

Gene

Atp1a1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ADP binding Source: Ensembl
  2. ATP binding Source: InterPro
  3. phosphatase activity Source: MGI
  4. potassium ion binding Source: Ensembl
  5. sodium:potassium-exchanging ATPase activity Source: MGI
  6. sodium ion binding Source: Ensembl

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
  2. cellular response to mechanical stimulus Source: Ensembl
  3. dephosphorylation Source: GOC
  4. membrane hyperpolarization Source: Ensembl
  5. negative regulation of glucocorticoid biosynthetic process Source: MGI
  6. negative regulation of heart contraction Source: MGI
  7. positive regulation of heart contraction Source: MGI
  8. positive regulation of striated muscle contraction Source: MGI
  9. potassium ion import Source: Ensembl
  10. regulation of blood pressure Source: MGI
  11. regulation of cardiac muscle cell contraction Source: Ensembl
  12. regulation of sodium ion transport Source: Ensembl
  13. regulation of the force of heart contraction Source: MGI
  14. response to drug Source: MGI
  15. sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Atp1a1 proteinImported
Gene namesi
Name:Atp1a1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88105. Atp1a1.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. basolateral plasma membrane Source: MGI
  3. caveola Source: Ensembl
  4. endoplasmic reticulum Source: Ensembl
  5. endosome Source: Ensembl
  6. extracellular vesicular exosome Source: Ensembl
  7. Golgi apparatus Source: Ensembl
  8. membrane Source: MGI
  9. plasma membrane Source: MGI
  10. protein complex Source: MGI
  11. sarcolemma Source: MGI
  12. sodium:potassium-exchanging ATPase complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ8K2R2.

Expressioni

Gene expression databases

BgeeiQ8K2R2.
ExpressionAtlasiQ8K2R2. baseline and differential.
GenevestigatoriQ8K2R2.

Structurei

3D structure databases

ProteinModelPortaliQ8K2R2.
SMRiQ8K2R2. Positions 1-433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG004298.

Family and domain databases

Gene3Di1.20.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR023298. ATPase_P-typ_TM_dom.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K2R2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIDPPRAAVP DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET
60 70 80 90 100
VEDIAARLNI PVNQVNPRDA KACVVHGSDL KDMTSEELDD ILRYHTEIVF
110 120 130 140 150
ARTSPQQKLI IVEGCQRQGA IVAVTGDGVN DSPALKKADI GVAMGIVGSD
160 170 180 190 200
VSKQAADMIL LDDNFASIVT GVEEGRLIFD NLKKSIAYTL TSNIPEITPF
210 220 230 240 250
LIFIIANIPL PLGTVTILCI DLGTDMVPAI SLAYEQAESD IMKRQPRNPK
260 270 280 290 300
TDKLVNERLI SMAYGQIGMI QALGGFFTYF VILAENGFLP FHLLGIRETW
310 320 330 340 350
DDRWVNDVED SYGQQWTYEQ RKIVEFTCHT AFFVSIVVVQ WADLVICKTR
360 370 380 390 400
RNSVFQQGMK NKILIFGLFE ETALAAFLSY CPGMGAALRM YPLKPTWWFC
410 420 430
AFPYSLLIFV YDEVRKLIIR RRPGGWVEKE TYY
Length:433
Mass (Da):48,140
Last modified:October 1, 2002 - v1
Checksum:iE025F674710FC0FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030326 mRNA. Translation: AAH30326.1.
UniGeneiMm.280103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030326 mRNA. Translation: AAH30326.1 .
UniGenei Mm.280103.

3D structure databases

ProteinModelPortali Q8K2R2.
SMRi Q8K2R2. Positions 1-433.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8K2R2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:88105. Atp1a1.

Phylogenomic databases

HOVERGENi HBG004298.

Miscellaneous databases

ChiTaRSi Atp1a1. mouse.
SOURCEi Search...

Gene expression databases

Bgeei Q8K2R2.
ExpressionAtlasi Q8K2R2. baseline and differential.
Genevestigatori Q8K2R2.

Family and domain databases

Gene3Di 1.20.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR023298. ATPase_P-typ_TM_dom.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3Imported.
    Tissue: Mammary tumor. MMTV-LTR/INT3 model. 5 month old mouse. Taken by biopsy.Imported.

Entry informationi

Entry nameiQ8K2R2_MOUSE
AccessioniPrimary (citable) accession number: Q8K2R2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)