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Protein

Sodium/potassium-transporting ATPase subunit alpha

Gene

Atp1a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processIon transport, Potassium transportUniRule annotation, Transport
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alphaUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:Atp1a1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88105. Atp1a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei200 – 220HelicalUniRule annotationAdd BLAST21
Transmembranei263 – 284HelicalUniRule annotationAdd BLAST22
Transmembranei323 – 342HelicalUniRule annotationAdd BLAST20
Transmembranei363 – 390HelicalUniRule annotationAdd BLAST28
Transmembranei396 – 414HelicalUniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ8K2R2.
PeptideAtlasiQ8K2R2.
PRIDEiQ8K2R2.

Structurei

3D structure databases

ProteinModelPortaliQ8K2R2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 418Cation_ATPase_CInterPro annotationAdd BLAST210

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
HOVERGENiHBG004298.

Family and domain databases

Gene3Di3.40.1110.10. 1 hit.
InterProiView protein in InterPro
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR023299. ATPase_P-typ_cyto_domN.
IPR023298. ATPase_P-typ_TM_dom.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00689. Cation_ATPase_C. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81665. SSF81665. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K2R2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDPPRAAVP DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET
60 70 80 90 100
VEDIAARLNI PVNQVNPRDA KACVVHGSDL KDMTSEELDD ILRYHTEIVF
110 120 130 140 150
ARTSPQQKLI IVEGCQRQGA IVAVTGDGVN DSPALKKADI GVAMGIVGSD
160 170 180 190 200
VSKQAADMIL LDDNFASIVT GVEEGRLIFD NLKKSIAYTL TSNIPEITPF
210 220 230 240 250
LIFIIANIPL PLGTVTILCI DLGTDMVPAI SLAYEQAESD IMKRQPRNPK
260 270 280 290 300
TDKLVNERLI SMAYGQIGMI QALGGFFTYF VILAENGFLP FHLLGIRETW
310 320 330 340 350
DDRWVNDVED SYGQQWTYEQ RKIVEFTCHT AFFVSIVVVQ WADLVICKTR
360 370 380 390 400
RNSVFQQGMK NKILIFGLFE ETALAAFLSY CPGMGAALRM YPLKPTWWFC
410 420 430
AFPYSLLIFV YDEVRKLIIR RRPGGWVEKE TYY
Length:433
Mass (Da):48,140
Last modified:October 1, 2002 - v1
Checksum:iE025F674710FC0FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030326 mRNA. Translation: AAH30326.1.
UniGeneiMm.193670.
Mm.280103.

Similar proteinsi

Entry informationi

Entry nameiQ8K2R2_MOUSE
AccessioniPrimary (citable) accession number: Q8K2R2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation