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Q8K2Q7 (BROX_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BRO1 domain-containing protein BROX
Alternative name(s):
BRO1 domain- and CAAX motif-containing protein
Gene names
Name:Brox
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Interacts with CHMP4B By similarity.

Subcellular location

Membrane; Lipid-anchor Potential.

Sequence similarities

Belongs to the BROX family.

Contains 1 BRO1 domain.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   PTMLipoprotein
Methylation
Prenylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentmembrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8K2Q7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8K2Q7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     102-103: SA → RF
     104-411: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 408408BRO1 domain-containing protein BROX
PRO_0000304613
Propeptide409 – 4113Removed in mature form By similarity
PRO_0000396737

Regions

Domain90 – 408319BRO1

Amino acid modifications

Modified residue4081Cysteine methyl ester By similarity
Lipidation4081S-farnesyl cysteine By similarity

Natural variations

Alternative sequence102 – 1032SA → RF in isoform 2.
VSP_028041
Alternative sequence104 – 411308Missing in isoform 2.
VSP_028042

Experimental info

Sequence conflict1631P → S in BAC34307. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 5079195FBA23DF87

FASTA41146,202
        10         20         30         40         50         60 
MTHWFHRNPL KATAPVSFNY YGMITGPPAS KICNDLRSAR TRLLELFTDL SCNPETMKNA 

        70         80         90        100        110        120 
ADLYFSLLQG FINSVGDSTQ ESKLRYIQNF KWTDTLQGHV PSAQQDAVFE LISMGFNVAL 

       130        140        150        160        170        180 
WYTKYASRLA GKENITEDEA KEVHRSLKIA AGIFKHLKES HIPKLLTPAE KGRDLEARLI 

       190        200        210        220        230        240 
DAYIIQCQAE AQEVTIARAI ELKHAPGLIA ALAYDTASFY QKADHTLSSL EPAHSAKWRK 

       250        260        270        280        290        300 
YLHLKMCFYT AYAYCYHGQT LLASDKCGEA IRSLQEAEKL YAEAEALCKE YGETKGPGPT 

       310        320        330        340        350        360 
AKPSGHLFFR KLGSLVKNTL DKCQRENGFI YFQKIPTEAP QLELKANYGL VEPVPFEFPP 

       370        380        390        400        410 
MSAHWTPEAL AAFDLTKRPK DDSVKPKPEE DVKPVKEPDI RPQKDTGCSV S

« Hide

Isoform 2 [UniParc].

Checksum: 8AD95D0E8FD5F7F5
Show »

FASTA10311,832

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Egg, Kidney and Pancreas.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK002489 mRNA. Translation: BAB22138.1.
AK050525 mRNA. Translation: BAC34307.1.
AK162247 mRNA. Translation: BAE36814.1.
BC030340 mRNA. Translation: AAH30340.1.
BC120692 mRNA. Translation: AAI20693.1.
BC125527 mRNA. Translation: AAI25528.1.
IPIIPI00453679.
IPI00857687.
RefSeqNP_082137.1. NM_027861.2.
UniGeneMm.392270.

3D structure databases

ProteinModelPortalQ8K2Q7.
SMRQ8K2Q7. Positions 2-374.
ModBaseSearch...

PTM databases

PhosphoSiteQ8K2Q7.

Proteomic databases

PRIDEQ8K2Q7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000057062; ENSMUSP00000061345; ENSMUSG00000046836.
GeneID71678.
KEGGmmu:71678.
UCSCuc008icq.1. mouse.

Organism-specific databases

CTD148362.
MGIMGI:1918928. Brox.

Phylogenomic databases

eggNOGroNOG08430.
GeneTreeENSGT00390000006681.
HOGENOMHBG279654.
HOVERGENHBG107541.
InParanoidQ8K2Q7.
OMADTLQGQV.
OrthoDBEOG4HDSTK.
PhylomeDBQ8K2Q7.

Gene expression databases

BgeeQ8K2Q7.
CleanExMM_0610010K06RIK.
GenevestigatorQ8K2Q7.

Family and domain databases

InterProIPR004328. BRO1_dom.
[Graphical view]
Gene3DG3DSA:1.25.40.280. BRO1. 1 hit.
PfamPF03097. BRO1. 1 hit.
[Graphical view]
SMARTSM01041. BRO1. 1 hit.
[Graphical view]
PROSITEPS51180. BRO1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio334207.
SOURCESearch...

Entry information

Entry nameBROX_MOUSE
AccessionPrimary (citable) accession number: Q8K2Q7
Secondary accession number(s): Q8BWM8, Q9DCT7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents