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Q8K2Q2

- GSTO2_MOUSE

UniProt

Q8K2Q2 - GSTO2_MOUSE

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Protein

Glutathione S-transferase omega-2

Gene
Gsto2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) By similarity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei32 – 321Nucleophile By similarity
Binding sitei59 – 591Glutathione By similarity
Binding sitei72 – 721Glutathione; via amide nitrogen and carbonyl oxygen By similarity

GO - Molecular functioni

  1. glutathione dehydrogenase (ascorbate) activity Source: UniProtKB
  2. glutathione transferase activity Source: UniProtKB-EC
  3. methylarsonate reductase activity Source: UniProtKB-EC
  4. oxidoreductase activity Source: UniProtKB

GO - Biological processi

  1. cellular response to arsenic-containing substance Source: UniProtKB
  2. L-ascorbic acid metabolic process Source: UniProtKB
  3. oxidation-reduction process Source: UniProtKB
  4. xenobiotic metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Transferase

Enzyme and pathway databases

ReactomeiREACT_215258. Vitamin C (ascorbate) metabolism.
REACT_215316. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase omega-2 (EC:2.5.1.18)
Short name:
GSTO-2
Alternative name(s):
Glutathione S-transferase omega 2-2
Short name:
GSTO 2-2
Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1)
Monomethylarsonic acid reductase (EC:1.20.4.2)
Short name:
MMA(V) reductase
Gene namesi
Name:Gsto2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1915464. Gsto2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Glutathione S-transferase omega-2PRO_0000239141Add
BLAST

Proteomic databases

PaxDbiQ8K2Q2.
PRIDEiQ8K2Q2.

PTM databases

PhosphoSiteiQ8K2Q2.

Expressioni

Gene expression databases

BgeeiQ8K2Q2.
CleanExiMM_GSTO2.
GenevestigatoriQ8K2Q2.

Structurei

3D structure databases

ProteinModelPortaliQ8K2Q2.
SMRiQ8K2Q2. Positions 7-239.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 10180GST N-terminalAdd
BLAST
Domaini106 – 231126GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni85 – 862Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Omega family.

Phylogenomic databases

eggNOGiCOG0625.
GeneTreeiENSGT00390000005479.
HOGENOMiHOG000006560.
HOVERGENiHBG051853.
InParanoidiQ8K2Q2.
KOiK00799.
OMAiFCNLEEI.
OrthoDBiEOG71CFNG.
PhylomeDBiQ8K2Q2.
TreeFamiTF105325.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01625. GSTRNSFRASEO.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K2Q2-1 [UniParc]FASTAAdd to Basket

« Hide

MSGDLSRCLG KGSCPPGPVP EGVIRIYSMR FCPYSHRARL VLKAKGIRHE    50
VININLKSKP DWYYTKHPFG QIPVLENSQC QLVYESVIAC EYLDDVYPGR 100
KLFPYDPYER ARQKMLLELF CKVPPLSKEC LIALRCGRDC TDLKVALRQE 150
LCNMEEILEY QNTTFFGGDC ISMIDYLVWP WFERLDVYGL ADCVNHTPML 200
RLWIASMKQD PAVCALHTDK SVFLGFLNLY FQNNPCAFDF GLCNPIIR 248
Length:248
Mass (Da):28,599
Last modified:October 1, 2002 - v1
Checksum:iADB9FCFCA9F0FE48
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK077086 mRNA. Translation: BAC36604.1.
BC030371 mRNA. Translation: AAH30371.1.
CCDSiCCDS29894.1.
RefSeqiNP_080895.2. NM_026619.2.
NP_084327.1. NM_030051.1.
UniGeneiMm.63791.

Genome annotation databases

EnsembliENSMUST00000056159; ENSMUSP00000052592; ENSMUSG00000025069.
ENSMUST00000120645; ENSMUSP00000113409; ENSMUSG00000025069.
GeneIDi68214.
KEGGimmu:68214.
UCSCiuc008hvs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK077086 mRNA. Translation: BAC36604.1 .
BC030371 mRNA. Translation: AAH30371.1 .
CCDSi CCDS29894.1.
RefSeqi NP_080895.2. NM_026619.2.
NP_084327.1. NM_030051.1.
UniGenei Mm.63791.

3D structure databases

ProteinModelPortali Q8K2Q2.
SMRi Q8K2Q2. Positions 7-239.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8K2Q2.

Proteomic databases

PaxDbi Q8K2Q2.
PRIDEi Q8K2Q2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000056159 ; ENSMUSP00000052592 ; ENSMUSG00000025069 .
ENSMUST00000120645 ; ENSMUSP00000113409 ; ENSMUSG00000025069 .
GeneIDi 68214.
KEGGi mmu:68214.
UCSCi uc008hvs.1. mouse.

Organism-specific databases

CTDi 119391.
MGIi MGI:1915464. Gsto2.

Phylogenomic databases

eggNOGi COG0625.
GeneTreei ENSGT00390000005479.
HOGENOMi HOG000006560.
HOVERGENi HBG051853.
InParanoidi Q8K2Q2.
KOi K00799.
OMAi FCNLEEI.
OrthoDBi EOG71CFNG.
PhylomeDBi Q8K2Q2.
TreeFami TF105325.

Enzyme and pathway databases

Reactomei REACT_215258. Vitamin C (ascorbate) metabolism.
REACT_215316. Glutathione conjugation.

Miscellaneous databases

NextBioi 326722.
PROi Q8K2Q2.
SOURCEi Search...

Gene expression databases

Bgeei Q8K2Q2.
CleanExi MM_GSTO2.
Genevestigatori Q8K2Q2.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF13417. GST_N_3. 1 hit.
[Graphical view ]
PRINTSi PR01625. GSTRNSFRASEO.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiGSTO2_MOUSE
AccessioniPrimary (citable) accession number: Q8K2Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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