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Protein
Submitted name:

Cc2d1a protein

Gene

Cc2d1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: MGI
  3. signal transducer activity Source: MGI

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  2. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  3. signal transduction Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cc2d1a proteinImported
Gene namesi
Name:Cc2d1aImported
Synonyms:BC016188Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:2384831. Cc2d1a.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
  2. membrane Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8K2N4.

Expressioni

Gene expression databases

GenevestigatoriQ8K2N4.

Structurei

3D structure databases

ProteinModelPortaliQ8K2N4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000285993.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K2N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLFIVKGIN LPTPTGLSPS DLDAFVRFDF PYPNVEEAQK DKTSVIKNTD
60 70 80 90 100
SPEFKEQFKL CINRGHRGFR RAIQTKGIKF EVVHKGGLFK TDRVLGTAQL
110 120 130 140 150
KLGTLETACE VHEILEVLDG RRPTGGRLEV MVRIREPLTA QQLETTTERW
160 170 180 190 200
LVIDHIPAAM PTVTGPKAKA PLIPASSREA GNRSARPLHS LSVLAFDQER
210 220 230 240 250
LERKILALRQ ARRPVPPEVA QQYQDVVQRS QWQRAQLEQG GAALRREYAS
260 270 280 290
HLERQLHFYT EAARRLGYDG SRVSWTYVSV RYQVRGSGSS
Length:290
Mass (Da):32,780
Last modified:October 1, 2002 - v1
Checksum:iADEC6716807B9448
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030439 mRNA. Translation: AAH30439.1.
UniGeneiMm.41424.

Genome annotation databases

UCSCiuc009mmb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030439 mRNA. Translation: AAH30439.1.
UniGeneiMm.41424.

3D structure databases

ProteinModelPortaliQ8K2N4.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8K2N4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc009mmb.1. mouse.

Organism-specific databases

MGIiMGI:2384831. Cc2d1a.

Phylogenomic databases

HOGENOMiHOG000285993.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

GenevestigatoriQ8K2N4.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3Imported.
    Tissue: Mammary tumor. MMTV-LTR/INT3 model. 5 month old mouse. Taken by biopsy.Imported.

Entry informationi

Entry nameiQ8K2N4_MOUSE
AccessioniPrimary (citable) accession number: Q8K2N4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.