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Protein

39S ribosomal protein L38, mitochondrial

Gene

Mrpl38

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L38, mitochondrial
Short name:
L38mt
Short name:
MRP-L38
Gene namesi
Name:Mrpl38
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1926269. Mrpl38.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

  • mitochondrial ribosome Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionSequence analysisAdd BLAST26
ChainiPRO_000026165327 – 38039S ribosomal protein L38, mitochondrialAdd BLAST354

Proteomic databases

EPDiQ8K2M0.
PaxDbiQ8K2M0.
PeptideAtlasiQ8K2M0.
PRIDEiQ8K2M0.

PTM databases

PhosphoSitePlusiQ8K2M0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020775.
CleanExiMM_MRPL38.
GenevisibleiQ8K2M0. MM.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.By similarity

Protein-protein interaction databases

BioGridi208564. 1 interactor.
STRINGi10090.ENSMUSP00000102047.

Structurei

3D structure databases

ProteinModelPortaliQ8K2M0.
SMRiQ8K2M0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili100 – 123Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiKOG3346. Eukaryota.
COG1881. LUCA.
GeneTreeiENSGT00840000129951.
HOGENOMiHOG000231107.
HOVERGENiHBG054933.
InParanoidiQ8K2M0.
KOiK17419.
OMAiWDESLTQ.
OrthoDBiEOG091G09D8.
PhylomeDBiQ8K2M0.
TreeFamiTF315074.

Family and domain databases

Gene3Di3.90.280.10. 1 hit.
InterProiIPR008914. PEBP.
[Graphical view]
PfamiPF01161. PBP. 1 hit.
[Graphical view]
SUPFAMiSSF49777. SSF49777. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K2M0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPWWRAAF FGIGRCRGFS TSAFLSRRTP PLGPMPNEDI DVSNLERLEK
60 70 80 90 100
YRSFERYRRR AEQEARAPHW WRTYREHFVK ETDPKDKIDI GLPPPRVSRT
110 120 130 140 150
QKLLERKHFL RELRANVEEE RAARLRTASI PLEAVRAEWE RTCGPYHKQR
160 170 180 190 200
LAEYYGLYRD LFHGATFVPW VPLHVAYAVG EEDLIPVYHG NEVTPTEASR
210 220 230 240 250
APEVTYEADK DSLWTLLFIN LDGHLLEPDA EYVHWLLTNI PSNRVAEGQE
260 270 280 290 300
TCPYLPPFPA RGSGFHRFAF LLFKQDKPIN FSEDTRPSPC YQLAQRTFRT
310 320 330 340 350
FDFYKRHQEA MTPAGLAFFQ CRWDDSVTHT FHQLLDMREP VFEFVRPPPY
360 370 380
HPKQKRFPHE QPLRYLDRYR DSHEPTYGIY
Length:380
Mass (Da):45,030
Last modified:November 28, 2006 - v2
Checksum:i7CA22E40672E9BF3
GO
Isoform 2 (identifier: Q8K2M0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-35: Missing.

Note: No experimental confirmation available.
Show »
Length:346
Mass (Da):41,279
Checksum:iA27EDC7D23C2D395
GO

Sequence cautioni

The sequence AAH30739 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE30538 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE34778 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16C → S in BAE30538 (PubMed:16141072).Curated1
Sequence conflicti54F → Y in BAE34778 (PubMed:16141072).Curated1
Sequence conflicti86D → N in BAE34778 (PubMed:16141072).Curated1
Sequence conflicti189H → N in AAH30739 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0217482 – 35Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088343 mRNA. Translation: BAC40295.1. Sequence problems.
AK159033 mRNA. Translation: BAE34778.1. Different initiation.
AK151598 mRNA. Translation: BAE30538.1. Different initiation.
AL607108 Genomic DNA. Translation: CAM24056.1.
BC002319 mRNA. Translation: AAH02319.1.
BC030739 mRNA. Translation: AAH30739.1. Different initiation.
CCDSiCCDS25658.2. [Q8K2M0-1]
RefSeqiNP_077139.2. NM_024177.3. [Q8K2M0-1]
UniGeneiMm.29974.

Genome annotation databases

EnsembliENSMUST00000106439; ENSMUSP00000102047; ENSMUSG00000020775. [Q8K2M0-1]
GeneIDi60441.
KEGGimmu:60441.
UCSCiuc007mkc.1. mouse. [Q8K2M0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088343 mRNA. Translation: BAC40295.1. Sequence problems.
AK159033 mRNA. Translation: BAE34778.1. Different initiation.
AK151598 mRNA. Translation: BAE30538.1. Different initiation.
AL607108 Genomic DNA. Translation: CAM24056.1.
BC002319 mRNA. Translation: AAH02319.1.
BC030739 mRNA. Translation: AAH30739.1. Different initiation.
CCDSiCCDS25658.2. [Q8K2M0-1]
RefSeqiNP_077139.2. NM_024177.3. [Q8K2M0-1]
UniGeneiMm.29974.

3D structure databases

ProteinModelPortaliQ8K2M0.
SMRiQ8K2M0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208564. 1 interactor.
STRINGi10090.ENSMUSP00000102047.

PTM databases

PhosphoSitePlusiQ8K2M0.

Proteomic databases

EPDiQ8K2M0.
PaxDbiQ8K2M0.
PeptideAtlasiQ8K2M0.
PRIDEiQ8K2M0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106439; ENSMUSP00000102047; ENSMUSG00000020775. [Q8K2M0-1]
GeneIDi60441.
KEGGimmu:60441.
UCSCiuc007mkc.1. mouse. [Q8K2M0-1]

Organism-specific databases

CTDi64978.
MGIiMGI:1926269. Mrpl38.

Phylogenomic databases

eggNOGiKOG3346. Eukaryota.
COG1881. LUCA.
GeneTreeiENSGT00840000129951.
HOGENOMiHOG000231107.
HOVERGENiHBG054933.
InParanoidiQ8K2M0.
KOiK17419.
OMAiWDESLTQ.
OrthoDBiEOG091G09D8.
PhylomeDBiQ8K2M0.
TreeFamiTF315074.

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMrpl38. mouse.
PROiQ8K2M0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020775.
CleanExiMM_MRPL38.
GenevisibleiQ8K2M0. MM.

Family and domain databases

Gene3Di3.90.280.10. 1 hit.
InterProiIPR008914. PEBP.
[Graphical view]
PfamiPF01161. PBP. 1 hit.
[Graphical view]
SUPFAMiSSF49777. SSF49777. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRM38_MOUSE
AccessioniPrimary (citable) accession number: Q8K2M0
Secondary accession number(s): A2A869
, Q3TXY6, Q8BTZ1, Q99LM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: November 30, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.