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Protein

BTB/POZ domain-containing protein 6

Gene

Btbd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter protein for the CUL3 E3 ubiquitin-protein ligase complex. Involved in late neuronal development and muscle formation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-8951664. Neddylation.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein 6
Gene namesi
Name:Btbd6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:3026623. Btbd6.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001862141 – 488BTB/POZ domain-containing protein 6Add BLAST488

Proteomic databases

PaxDbiQ8K2J9.
PRIDEiQ8K2J9.

PTM databases

PhosphoSitePlusiQ8K2J9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002803.
CleanExiMM_BTBD6.
ExpressionAtlasiQ8K2J9. baseline and differential.
GenevisibleiQ8K2J9. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002880.

Structurei

3D structure databases

ProteinModelPortaliQ8K2J9.
SMRiQ8K2J9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 156BTBPROSITE-ProRule annotationAdd BLAST71

Phylogenomic databases

eggNOGiKOG2075. Eukaryota.
ENOG410XQ3X. LUCA.
GeneTreeiENSGT00550000074511.
HOGENOMiHOG000293364.
HOVERGENiHBG050743.
InParanoidiQ8K2J9.
KOiK10478.
PhylomeDBiQ8K2J9.

Family and domain databases

InterProiView protein in InterPro
IPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR012983. PHR.
IPR011333. SKP1/BTB/POZ.
PfamiView protein in Pfam
PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF08005. PHR. 1 hit.
SMARTiView protein in SMART
SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K2J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAELYPPAS PSAATATDIA NSNAAGAAES TKVGLCCPPC LAPAPLPPLP
60 70 80 90 100
APPLPDNNNP ESPNWQSFHP TLRERNALMF NNELMADVHF IVGALGAARR
110 120 130 140 150
VPAHKYVLAV GSSVFYAMFY GDLAEVKSEI HIPDVEPAAF LVLLKYMYSD
160 170 180 190 200
EIDLEADTVL ATLYAAKKYI VPALAKACVN FLETSLEAKN ACVLLSQSRL
210 220 230 240 250
FEEPELTQRC WEVIDAQAEM ALRSEGFCEI DRQTLEIIVT REALNTKEAV
260 270 280 290 300
VFEAVLNWAE AECKRQGLPV TPHNKRHVLG RALYLVRIPT MTLEEFANGA
310 320 330 340 350
AQSDILTLEE THNIFLWYTA AKKPLLDFPL TKRKGLAPQR CHRFQSSAYR
360 370 380 390 400
SNQWRYRGRC DSIQFAVDRR VFIAGLGLYG SSSGKAEYSV KIELKRLGMV
410 420 430 440 450
LAQNLTKFVS DGSSNTFPVW FEHPVQVEQD TFYTASAVLD GSELSYFGQE
460 470 480
GMTEVQCGKV AFQFQCSSDS TNGTGVQGGQ IPELIFYA
Length:488
Mass (Da):53,842
Last modified:July 28, 2009 - v2
Checksum:i8C4A24F6B5BDCD14
GO

Sequence cautioni

The sequence AAH31195 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146991 mRNA. Translation: BAE27593.1.
CH466549 Genomic DNA. Translation: EDL18570.1.
BC031195 mRNA. Translation: AAH31195.1. Different initiation.
CCDSiCCDS49194.1.
RefSeqiNP_001139372.1. NM_001145900.1.
NP_964008.2. NM_201646.2.
XP_006516119.1. XM_006516056.3.
UniGeneiMm.440140.

Genome annotation databases

EnsembliENSMUST00000165079; ENSMUSP00000127286; ENSMUSG00000002803.
GeneIDi399566.
KEGGimmu:399566.
UCSCiuc011yvh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146991 mRNA. Translation: BAE27593.1.
CH466549 Genomic DNA. Translation: EDL18570.1.
BC031195 mRNA. Translation: AAH31195.1. Different initiation.
CCDSiCCDS49194.1.
RefSeqiNP_001139372.1. NM_001145900.1.
NP_964008.2. NM_201646.2.
XP_006516119.1. XM_006516056.3.
UniGeneiMm.440140.

3D structure databases

ProteinModelPortaliQ8K2J9.
SMRiQ8K2J9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002880.

PTM databases

PhosphoSitePlusiQ8K2J9.

Proteomic databases

PaxDbiQ8K2J9.
PRIDEiQ8K2J9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165079; ENSMUSP00000127286; ENSMUSG00000002803.
GeneIDi399566.
KEGGimmu:399566.
UCSCiuc011yvh.1. mouse.

Organism-specific databases

CTDi90135.
MGIiMGI:3026623. Btbd6.

Phylogenomic databases

eggNOGiKOG2075. Eukaryota.
ENOG410XQ3X. LUCA.
GeneTreeiENSGT00550000074511.
HOGENOMiHOG000293364.
HOVERGENiHBG050743.
InParanoidiQ8K2J9.
KOiK10478.
PhylomeDBiQ8K2J9.

Enzyme and pathway databases

ReactomeiR-MMU-8951664. Neddylation.

Miscellaneous databases

PROiPR:Q8K2J9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002803.
CleanExiMM_BTBD6.
ExpressionAtlasiQ8K2J9. baseline and differential.
GenevisibleiQ8K2J9. MM.

Family and domain databases

InterProiView protein in InterPro
IPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR012983. PHR.
IPR011333. SKP1/BTB/POZ.
PfamiView protein in Pfam
PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF08005. PHR. 1 hit.
SMARTiView protein in SMART
SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBTBD6_MOUSE
AccessioniPrimary (citable) accession number: Q8K2J9
Secondary accession number(s): Q3UIB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: July 28, 2009
Last modified: June 7, 2017
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.