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Q8K2J0

- PLCD3_MOUSE

UniProt

Q8K2J0 - PLCD3_MOUSE

Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

Gene

Plcd3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.1 Publication

    Catalytic activityi

    1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

    Cofactori

    Binds 3 calcium ions per subunit. Two of the calcium ions are bound to the C2 domain By similarity.By similarity

    Enzyme regulationi

    Strongly activated by phosphatidic acid. Inhibited by phosphatidylethanolamine (PtdEtn), phosphatidylcholine (PtdCho), sphingomyelin and phosphatidylserine (PtdSer) By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei348 – 3481PROSITE-ProRule annotation
    Metal bindingi349 – 3491Calcium 1; catalyticBy similarity
    Metal bindingi378 – 3781Calcium 1; catalyticBy similarity
    Metal bindingi380 – 3801Calcium 1; catalyticBy similarity
    Active sitei393 – 3931PROSITE-ProRule annotation
    Metal bindingi427 – 4271Calcium 1; catalyticBy similarity
    Binding sitei476 – 4761SubstrateBy similarity
    Binding sitei478 – 4781SubstrateBy similarity
    Binding sitei553 – 5531SubstrateBy similarity
    Binding sitei580 – 5801SubstrateBy similarity
    Metal bindingi679 – 6791Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi681 – 6811Calcium 2By similarity
    Metal bindingi705 – 7051Calcium 2By similarity
    Metal bindingi734 – 7341Calcium 3By similarity
    Metal bindingi735 – 7351Calcium 3; via carbonyl oxygenBy similarity
    Metal bindingi736 – 7361Calcium 3By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi191 – 202121Sequence AnalysisAdd
    BLAST
    Calcium bindingi227 – 238122Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
    3. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. angiogenesis Source: MGI
    2. intracellular signal transduction Source: InterPro
    3. labyrinthine layer blood vessel development Source: MGI
    4. lipid catabolic process Source: UniProtKB-KW
    5. regulation of cell proliferation Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Transducer

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196473. Synthesis of IP3 and IP4 in the cytosol.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC:3.1.4.11)
    Alternative name(s):
    Phosphoinositide phospholipase C-delta-3
    Phospholipase C-delta-3
    Short name:
    PLC-delta-3
    Gene namesi
    Name:Plcd3
    Synonyms:Kiaa1964
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:107451. Plcd3.

    Subcellular locationi

    Membrane By similarity; Peripheral membrane protein By similarity. Cytoplasm By similarity. Cleavage furrow
    Note: Localizes at the cleavage furrow during cytokinesis.

    GO - Cellular componenti

    1. cleavage furrow Source: UniProtKB-SubCell
    2. cytosol Source: Ensembl
    3. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice lacking Plcd1 and Plcd3 die between 11.5 and 13.5 dpc. They exhibit severe disruption of the normal labyrinth architecture in the placenta and decreased placental vascularization, as well as abnormal proliferation and apoptosis of trophoblasts in the labyrinth area. Furthermore, Plcd1 and Plcd3 double knockout embryos supplied with a normal placenta by the tetraploid aggregation method survive beyond 14.5 dpc, indicating that the embryonic lethality is caused by a defect in trophoblasts.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7857851-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3PRO_0000306822Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei101 – 1011PhosphoserineBy similarity
    Modified residuei492 – 4921Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8K2J0.
    PRIDEiQ8K2J0.

    PTM databases

    PhosphoSiteiQ8K2J0.

    Expressioni

    Gene expression databases

    BgeeiQ8K2J0.
    CleanExiMM_PLCD3.
    GenevestigatoriQ8K2J0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K2J0.
    SMRiQ8K2J0. Positions 51-784.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini65 – 168104PHAdd
    BLAST
    Domaini178 – 21336EF-hand 1Add
    BLAST
    Domaini214 – 24936EF-hand 2Add
    BLAST
    Domaini246 – 28136EF-hand 3Add
    BLAST
    Domaini333 – 478146PI-PLC X-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini524 – 640117PI-PLC Y-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini643 – 748106C2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni69 – 9729Substrate bindingBy similarityAdd
    BLAST

    Domaini

    The C2 domain is a Ca2+-dependent membrane-targeting module.By similarity
    The PH domain mediates interaction with the surface membrane by binding to PIP2.By similarity

    Sequence similaritiesi

    Contains 1 C2 domain.PROSITE-ProRule annotation
    Contains 3 EF-hand domains.Curated
    Contains 1 PH domain.Curated
    Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
    Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG149692.
    GeneTreeiENSGT00740000114979.
    HOGENOMiHOG000006871.
    HOVERGENiHBG053610.
    InParanoidiQ8K2J0.
    KOiK05857.
    OMAiHWGQTLQ.
    OrthoDBiEOG7V49XT.
    PhylomeDBiQ8K2J0.
    TreeFamiTF313216.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001192. PI-PLC_fam.
    IPR028406. PLC-delta3.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view]
    PANTHERiPTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF33. PTHR10336:SF33. 1 hit.
    PfamiPF00168. C2. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view]
    PRINTSiPR00390. PHPHLIPASEC.
    SMARTiSM00239. C2. 1 hit.
    SM00233. PH. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 1 hit.
    PROSITEiPS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K2J0-1 [UniParc]FASTAAdd to Basket

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    MLCGGWKRSR RSPEESRVSA QVAAPLAFPP SPASSDSSTK RPGLRALKKM    50
    GLTEDEDVQA MLRGSRLLKI RSRTWHKERL YRLQEDGLSV WFQRRIPRAA 100
    SKHIFFVQHI EAVREGHQSE GLRRFGGAFA PACCLTIAFK GRRKNLDLAA 150
    PTAEEAQRWV RGLAKLRARL DAMSQRERLD HWIHSYLHRA DSDQDSKMSF 200
    KEIKSLLRMV NVDMNDMYAY RLFKECDHSN NERLEGAEIE AFLRRLLKRP 250
    ELEEIFRRYS GEDRVLSASE LLEFLEDQGE DGATLACAQQ LIQTYELNET 300
    AKQHELMTLD GFMMYLLSPE GAALNVAHTC VFQDMGQPLA HYFISSSHNT 350
    YLTDSQIGGT SSTEAYIRAF AQGCRCVELD CWEGPGGEPV IYHGHTLTSK 400
    ILFRDVIQAV RDHAFTSSPY PVILSLENHC GLEQQAVMAR HLRSILGDML 450
    VTQALDSQNP EELPSPEQLK GRILVKGKKL PAARSEDGRI LSDREEEEEE 500
    EEEAEEALEA AEQRSRAKQI SPELSALAVY CCATRLRTLD PSPGPPQSCT 550
    VGSLSERKAR KFTREAGTSF VRHNTQQLTR VYPLGLRMNS ANYNPQEMWN 600
    SGCQLVALNF QTPGYEMDLN TGRFLINGQC GYVLKPAYLR QLNTTFDPEC 650
    PGPPRTTLAI QVLTAQQLPK LNAEKPSSIV DPLVRVEIHG VPEDCAQKET 700
    DYVLNNGFNP CWEQTLQFRL RAPELVLVRF VVEDYDTTSP NDFVGQSTLP 750
    LSSLKQGYRH IHLLSKDGAS LAPATLFVHI RIQNS 785
    Length:785
    Mass (Da):88,607
    Last modified:October 2, 2007 - v2
    Checksum:i8B3DE84FB7A52238
    GO

    Sequence cautioni

    The sequence BAD32589.1 differs from that shown. Reason: Intron retention.
    The sequence BAC32829.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAM22088.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti199 – 1991S → N in BAE26150. (PubMed:16141072)Curated
    Sequence conflicti301 – 3022AK → GE in BAD32589. (PubMed:15368895)Curated
    Sequence conflicti378 – 3781E → K in BAE26150. (PubMed:16141072)Curated
    Sequence conflicti540 – 5401D → E in AAH31392. (PubMed:15489334)Curated
    Sequence conflicti659 – 6591A → T in BAE26150. (PubMed:16141072)Curated
    Sequence conflicti660 – 6601I → V in BAE26150. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK173311 Transcribed RNA. Translation: BAD32589.1. Sequence problems.
    AK046669 mRNA. Translation: BAC32829.1. Different initiation.
    AK144950 mRNA. Translation: BAE26150.1.
    AL731805 Genomic DNA. Translation: CAM22088.1. Sequence problems.
    AL731805 Genomic DNA. Translation: CAM22089.1.
    BC031392 mRNA. Translation: AAH31392.1.
    CCDSiCCDS25512.1.
    RefSeqiNP_690026.2. NM_152813.3.
    UniGeneiMm.264743.

    Genome annotation databases

    EnsembliENSMUST00000103077; ENSMUSP00000099366; ENSMUSG00000020937.
    GeneIDi72469.
    KEGGimmu:72469.
    UCSCiuc007ltf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK173311 Transcribed RNA. Translation: BAD32589.1 . Sequence problems.
    AK046669 mRNA. Translation: BAC32829.1 . Different initiation.
    AK144950 mRNA. Translation: BAE26150.1 .
    AL731805 Genomic DNA. Translation: CAM22088.1 . Sequence problems.
    AL731805 Genomic DNA. Translation: CAM22089.1 .
    BC031392 mRNA. Translation: AAH31392.1 .
    CCDSi CCDS25512.1.
    RefSeqi NP_690026.2. NM_152813.3.
    UniGenei Mm.264743.

    3D structure databases

    ProteinModelPortali Q8K2J0.
    SMRi Q8K2J0. Positions 51-784.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8K2J0.

    Proteomic databases

    PaxDbi Q8K2J0.
    PRIDEi Q8K2J0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000103077 ; ENSMUSP00000099366 ; ENSMUSG00000020937 .
    GeneIDi 72469.
    KEGGi mmu:72469.
    UCSCi uc007ltf.2. mouse.

    Organism-specific databases

    CTDi 113026.
    MGIi MGI:107451. Plcd3.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG149692.
    GeneTreei ENSGT00740000114979.
    HOGENOMi HOG000006871.
    HOVERGENi HBG053610.
    InParanoidi Q8K2J0.
    KOi K05857.
    OMAi HWGQTLQ.
    OrthoDBi EOG7V49XT.
    PhylomeDBi Q8K2J0.
    TreeFami TF313216.

    Enzyme and pathway databases

    Reactomei REACT_196473. Synthesis of IP3 and IP4 in the cytosol.

    Miscellaneous databases

    NextBioi 336294.
    PROi Q8K2J0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K2J0.
    CleanExi MM_PLCD3.
    Genevestigatori Q8K2J0.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    2.30.29.30. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001192. PI-PLC_fam.
    IPR028406. PLC-delta3.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view ]
    PANTHERi PTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF33. PTHR10336:SF33. 1 hit.
    Pfami PF00168. C2. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view ]
    PRINTSi PR00390. PHPHLIPASEC.
    SMARTi SM00239. C2. 1 hit.
    SM00233. PH. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 1 hit.
    PROSITEi PS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryonic intestine.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Adipose tissue and Mammary gland.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    5. "Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development."
      Nakamura Y., Hamada Y., Fujiwara T., Enomoto H., Hiroe T., Tanaka S., Nose M., Nakahara M., Yoshida N., Takenawa T., Fukami K.
      Mol. Cell. Biol. 25:10979-10988(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-492, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPLCD3_MOUSE
    AccessioniPrimary (citable) accession number: Q8K2J0
    Secondary accession number(s): A2AHR0
    , A2AHR1, Q3UME8, Q69Z55, Q8BL19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3