Reviewed,
UniProtKB/Swiss-Prot Q8K2I3 (FMO2_MOUSE)
Last modified
June 16, 2009.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dimethylaniline monooxygenase [N-oxide-forming] 2 EC=1.14.13.8 Alternative name(s): Pulmonary flavin-containing monooxygenase 2 Short name=FMO 2 Dimethylaniline oxidase 2 | ||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 535 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Shows catalytic activity towards methimazole, thiourea, trimethylamine, and the insecticide phorate. |
| Catalytic activity | N,N-dimethylaniline + NADPH + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. |
| Cofactor | FAD By similarity. Magnesium By similarity. |
| Subcellular location | Microsome membrane By similarity. Endoplasmic reticulum membrane By similarity. |
| Sequence similarities | Belongs to the FMO family. |
| biophysicochemical properties | pH dependence: Optimum pH is 10.5. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 535 | 534 | Dimethylaniline monooxygenase [N-oxide-forming] 2 | PRO_0000147648 | |||||
Regions | |||||||||
| Nucleotide binding | 9 – 14 | 6 | FAD Potential | ||||||
| Nucleotide binding | 191 – 196 | 6 | NADP Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylalanine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 169 | 1 | Q → R in AAD56413. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequencing, expression, and characterization of cDNA expressed flavin-containing monooxygenase 2 from mouse." Karoly E.D., Rose R.L. J. Biochem. Mol. Toxicol. 15:300-308(2001) [PubMed: 11835629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Strain: C57BL/6. Tissue: Kidney. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Czech II. Tissue: Mammary tumor. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF184981 mRNA. Translation: AAD56413.1. BC031415 mRNA. Translation: AAH31415.1. | |
| IPI | IPI00322245. |
| RefSeq | NP_061369.2. |
| UniGene | Mm.10929 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUSG00000040170. Mus musculus. [Contig view] |
| GeneID | 55990. |
| KEGG | mmu:55990. |
Organism-specific databases | |
| MGI | MGI:1916776. Fmo2. |
Phylogenomic databases | |
| HOGENOM | Q8K2I3. |
| HOVERGEN | Q8K2I3. |
| OMA | Q8K2I3. NYVDYLD. |
Enzyme and pathway databases | |
| BRENDA | 1.14.13.8. 244. |
Gene expression databases | |
| ArrayExpress | Q8K2I3. |
| Bgee | Q8K2I3. |
| CleanEx | MM_FMO2. |
| GermOnline | ENSMUSG00000040170. Mus musculus. |
Family and domain databases | |
| InterPro | IPR012143. dManiline_mOase. IPR000960. Flavin_mOase. IPR002254. Flavin_mOase_2. [Graphical view] |
| Pfam | PF00743. FMO-like. 1 hit. [Graphical view] |
| PIRSF | PIRSF000332. FMO. 1 hit. |
| PRINTS | PR00370. FMOXYGENASE. PR01122. FMOXYGENASE2. |
| ProDom | PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 311714. |
| SOURCE | Search... |
Entry information
| Entry name | FMO2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8K2I3 Secondary accession number(s): Q9QZF7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


