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Q8K2I2

- CCHCR_MOUSE

UniProt

Q8K2I2 - CCHCR_MOUSE

Protein

Coiled-coil alpha-helical rod protein 1

Gene

Cchcr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 3 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    May be a regulator of keratinocyte proliferation or differentiation.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. protein export from nucleus Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil alpha-helical rod protein 1
    Alternative name(s):
    Alpha-helical coiled-coil rod protein
    Gene namesi
    Name:Cchcr1
    Synonyms:Hcr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:2385321. Cchcr1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. centriole Source: UniProtKB
    2. cytoplasm Source: MGI
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 770770Coiled-coil alpha-helical rod protein 1PRO_0000089417Add
    BLAST

    Proteomic databases

    PRIDEiQ8K2I2.

    PTM databases

    PhosphoSiteiQ8K2I2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K2I2.
    CleanExiMM_CCHCR1.
    GenevestigatoriQ8K2I2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K2I2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili56 – 289234Sequence AnalysisAdd
    BLAST
    Coiled coili334 – 42087Sequence AnalysisAdd
    BLAST
    Coiled coili476 – 669194Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG130491.
    GeneTreeiENSGT00710000106841.
    HOGENOMiHOG000231221.
    HOVERGENiHBG048718.
    InParanoidiQ8K2I2.
    KOiK16760.
    OrthoDBiEOG75F4F8.
    TreeFamiTF336947.

    Family and domain databases

    InterProiIPR009800. HCR.
    [Graphical view]
    PANTHERiPTHR23161:SF4. PTHR23161:SF4. 1 hit.
    PfamiPF07111. HCR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K2I2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPPSGFAGL VPPSHFQARP LPTLPRMAPT WASDVPLVQS PASQDVLERR    50
    LDAQRSTVTT WGQDFCGDGQ GLGRRGRSLE LGFSSALSQQ AELISRQLQE 100
    LRRLEEEVRS LRETSLQQKM RLETQAVELD ALAVAEKAGQ AEAEGLRTAL 150
    AGAEMVRKNL EEAKHKELEE IQSLHQEQLS SLTQAHQKAL DSLASKAEGL 200
    EKSLNSLETK RAGEAKQLAM AQKEADMLRN QLSKTQEELE AQVTLVESLR 250
    KYVGEQVLPE FPSQEWELER KELLDTLKHL KEDRADLQAT VELLQVRVQS 300
    LTHMLALQEE ELTRKIQPLD PLEPEFPKKC RSLLRNWREK VFALMVQLKA 350
    QDLQHRDSTS QLRIQVAELQ EQVTSQSQEQ AILQRALQDK TAQVEVERMS 400
    TKSLQMELDQ AQEARRRQEQ QIASAEEQLK FVVGAMNSTQ AKLQSTMTRM 450
    DQAVARIPSL SNRLSYAVRK VHTIKGLMAR KVALAQLRVE SSPPSEAAPP 500
    LDTDLSVELE QLREERNRLD AELQLSAHLI QQEVGRAREQ GEVERRRLIE 550
    VAQQLEQELQ RAQESLASVG QQLEAARRGQ QESTEEAASL RQELTQQQEI 600
    YGQALQEKVA EVETRLREQL SDTKRRLNEA RREQAKAVVS LRQIQHKATQ 650
    EKERNQELRR LQDEARKEEG QRLTRRVQEL ERDKNLMLQR LLAVLPSGVN 700
    KKCSPRSVES SSSESPAAAS CKESVKGSLT VLLDNLQGLS EAISRDEDIC 750
    VEDNQNTKKT KNPPSDPLLS 770
    Length:770
    Mass (Da):87,105
    Last modified:October 3, 2012 - v3
    Checksum:iCAC0D3143E0660C7
    GO

    Sequence cautioni

    The sequence AAH31416.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti720 – 7201S → L in AAH31416. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR974473 Genomic DNA. No translation available.
    CH466559 Genomic DNA. Translation: EDL23219.1.
    BC031416 mRNA. Translation: AAH31416.1. Different initiation.
    CCDSiCCDS50090.1.
    RefSeqiNP_666360.2. NM_146248.2.
    UniGeneiMm.49544.

    Genome annotation databases

    EnsembliENSMUST00000045956; ENSMUSP00000046612; ENSMUSG00000040312.
    ENSMUST00000164242; ENSMUSP00000132028; ENSMUSG00000040312.
    GeneIDi240084.
    KEGGimmu:240084.
    UCSCiuc008chx.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR974473 Genomic DNA. No translation available.
    CH466559 Genomic DNA. Translation: EDL23219.1 .
    BC031416 mRNA. Translation: AAH31416.1 . Different initiation.
    CCDSi CCDS50090.1.
    RefSeqi NP_666360.2. NM_146248.2.
    UniGenei Mm.49544.

    3D structure databases

    ProteinModelPortali Q8K2I2.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8K2I2.

    Proteomic databases

    PRIDEi Q8K2I2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045956 ; ENSMUSP00000046612 ; ENSMUSG00000040312 .
    ENSMUST00000164242 ; ENSMUSP00000132028 ; ENSMUSG00000040312 .
    GeneIDi 240084.
    KEGGi mmu:240084.
    UCSCi uc008chx.2. mouse.

    Organism-specific databases

    CTDi 54535.
    MGIi MGI:2385321. Cchcr1.

    Phylogenomic databases

    eggNOGi NOG130491.
    GeneTreei ENSGT00710000106841.
    HOGENOMi HOG000231221.
    HOVERGENi HBG048718.
    InParanoidi Q8K2I2.
    KOi K16760.
    OrthoDBi EOG75F4F8.
    TreeFami TF336947.

    Miscellaneous databases

    ChiTaRSi CCHCR1. mouse.
    NextBioi 384437.
    PROi Q8K2I2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K2I2.
    CleanExi MM_CCHCR1.
    Genevestigatori Q8K2I2.

    Family and domain databases

    InterProi IPR009800. HCR.
    [Graphical view ]
    PANTHERi PTHR23161:SF4. PTHR23161:SF4. 1 hit.
    Pfami PF07111. HCR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCCHCR_MOUSE
    AccessioniPrimary (citable) accession number: Q8K2I2
    Secondary accession number(s): G3UWG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 76 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3