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Q8K2I2

- CCHCR_MOUSE

UniProt

Q8K2I2 - CCHCR_MOUSE

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Protein
Coiled-coil alpha-helical rod protein 1
Gene
Cchcr1, Hcr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be a regulator of keratinocyte proliferation or differentiation By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. protein export from nucleus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil alpha-helical rod protein 1
Alternative name(s):
Alpha-helical coiled-coil rod protein
Gene namesi
Name:Cchcr1
Synonyms:Hcr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:2385321. Cchcr1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. centriole Source: UniProtKB
  2. cytoplasm Source: MGI
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 770770Coiled-coil alpha-helical rod protein 1
PRO_0000089417Add
BLAST

Proteomic databases

PRIDEiQ8K2I2.

PTM databases

PhosphoSiteiQ8K2I2.

Expressioni

Gene expression databases

ArrayExpressiQ8K2I2.
CleanExiMM_CCHCR1.
GenevestigatoriQ8K2I2.

Structurei

3D structure databases

ProteinModelPortaliQ8K2I2.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili56 – 289234 Reviewed prediction
Add
BLAST
Coiled coili334 – 42087 Reviewed prediction
Add
BLAST
Coiled coili476 – 669194 Reviewed prediction
Add
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG130491.
GeneTreeiENSGT00710000106841.
HOGENOMiHOG000231221.
HOVERGENiHBG048718.
InParanoidiQ8K2I2.
KOiK16760.
OrthoDBiEOG75F4F8.
TreeFamiTF336947.

Family and domain databases

InterProiIPR009800. HCR.
[Graphical view]
PANTHERiPTHR23161:SF4. PTHR23161:SF4. 1 hit.
PfamiPF07111. HCR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K2I2-1 [UniParc]FASTAAdd to Basket

« Hide

MLPPSGFAGL VPPSHFQARP LPTLPRMAPT WASDVPLVQS PASQDVLERR    50
LDAQRSTVTT WGQDFCGDGQ GLGRRGRSLE LGFSSALSQQ AELISRQLQE 100
LRRLEEEVRS LRETSLQQKM RLETQAVELD ALAVAEKAGQ AEAEGLRTAL 150
AGAEMVRKNL EEAKHKELEE IQSLHQEQLS SLTQAHQKAL DSLASKAEGL 200
EKSLNSLETK RAGEAKQLAM AQKEADMLRN QLSKTQEELE AQVTLVESLR 250
KYVGEQVLPE FPSQEWELER KELLDTLKHL KEDRADLQAT VELLQVRVQS 300
LTHMLALQEE ELTRKIQPLD PLEPEFPKKC RSLLRNWREK VFALMVQLKA 350
QDLQHRDSTS QLRIQVAELQ EQVTSQSQEQ AILQRALQDK TAQVEVERMS 400
TKSLQMELDQ AQEARRRQEQ QIASAEEQLK FVVGAMNSTQ AKLQSTMTRM 450
DQAVARIPSL SNRLSYAVRK VHTIKGLMAR KVALAQLRVE SSPPSEAAPP 500
LDTDLSVELE QLREERNRLD AELQLSAHLI QQEVGRAREQ GEVERRRLIE 550
VAQQLEQELQ RAQESLASVG QQLEAARRGQ QESTEEAASL RQELTQQQEI 600
YGQALQEKVA EVETRLREQL SDTKRRLNEA RREQAKAVVS LRQIQHKATQ 650
EKERNQELRR LQDEARKEEG QRLTRRVQEL ERDKNLMLQR LLAVLPSGVN 700
KKCSPRSVES SSSESPAAAS CKESVKGSLT VLLDNLQGLS EAISRDEDIC 750
VEDNQNTKKT KNPPSDPLLS 770
Length:770
Mass (Da):87,105
Last modified:October 3, 2012 - v3
Checksum:iCAC0D3143E0660C7
GO

Sequence cautioni

The sequence AAH31416.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti720 – 7201S → L in AAH31416. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR974473 Genomic DNA. No translation available.
CH466559 Genomic DNA. Translation: EDL23219.1.
BC031416 mRNA. Translation: AAH31416.1. Different initiation.
CCDSiCCDS50090.1.
RefSeqiNP_666360.2. NM_146248.2.
UniGeneiMm.49544.

Genome annotation databases

EnsembliENSMUST00000045956; ENSMUSP00000046612; ENSMUSG00000040312.
ENSMUST00000164242; ENSMUSP00000132028; ENSMUSG00000040312.
GeneIDi240084.
KEGGimmu:240084.
UCSCiuc008chx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR974473 Genomic DNA. No translation available.
CH466559 Genomic DNA. Translation: EDL23219.1 .
BC031416 mRNA. Translation: AAH31416.1 . Different initiation.
CCDSi CCDS50090.1.
RefSeqi NP_666360.2. NM_146248.2.
UniGenei Mm.49544.

3D structure databases

ProteinModelPortali Q8K2I2.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8K2I2.

Proteomic databases

PRIDEi Q8K2I2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000045956 ; ENSMUSP00000046612 ; ENSMUSG00000040312 .
ENSMUST00000164242 ; ENSMUSP00000132028 ; ENSMUSG00000040312 .
GeneIDi 240084.
KEGGi mmu:240084.
UCSCi uc008chx.2. mouse.

Organism-specific databases

CTDi 54535.
MGIi MGI:2385321. Cchcr1.

Phylogenomic databases

eggNOGi NOG130491.
GeneTreei ENSGT00710000106841.
HOGENOMi HOG000231221.
HOVERGENi HBG048718.
InParanoidi Q8K2I2.
KOi K16760.
OrthoDBi EOG75F4F8.
TreeFami TF336947.

Miscellaneous databases

ChiTaRSi CCHCR1. mouse.
NextBioi 384437.
PROi Q8K2I2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8K2I2.
CleanExi MM_CCHCR1.
Genevestigatori Q8K2I2.

Family and domain databases

InterProi IPR009800. HCR.
[Graphical view ]
PANTHERi PTHR23161:SF4. PTHR23161:SF4. 1 hit.
Pfami PF07111. HCR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCCHCR_MOUSE
AccessioniPrimary (citable) accession number: Q8K2I2
Secondary accession number(s): G3UWG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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