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Protein

Coiled-coil alpha-helical rod protein 1

Gene

Cchcr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a regulator of keratinocyte proliferation or differentiation.By similarity

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. protein export from nucleus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil alpha-helical rod protein 1
Alternative name(s):
Alpha-helical coiled-coil rod protein
Gene namesi
Name:Cchcr1
Synonyms:Hcr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2385321. Cchcr1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. centriole Source: UniProtKB
  2. cytoplasm Source: MGI
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 770770Coiled-coil alpha-helical rod protein 1PRO_0000089417Add
BLAST

Proteomic databases

PRIDEiQ8K2I2.

PTM databases

PhosphoSiteiQ8K2I2.

Expressioni

Gene expression databases

CleanExiMM_CCHCR1.
ExpressionAtlasiQ8K2I2. baseline and differential.
GenevestigatoriQ8K2I2.

Structurei

3D structure databases

ProteinModelPortaliQ8K2I2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili56 – 289234Sequence AnalysisAdd
BLAST
Coiled coili334 – 42087Sequence AnalysisAdd
BLAST
Coiled coili476 – 669194Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG130491.
GeneTreeiENSGT00710000106841.
HOGENOMiHOG000231221.
HOVERGENiHBG048718.
InParanoidiQ8K2I2.
KOiK16760.
OrthoDBiEOG75F4F8.
TreeFamiTF336947.

Family and domain databases

InterProiIPR009800. HCR.
[Graphical view]
PANTHERiPTHR23161:SF4. PTHR23161:SF4. 1 hit.
PfamiPF07111. HCR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K2I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPSGFAGL VPPSHFQARP LPTLPRMAPT WASDVPLVQS PASQDVLERR
60 70 80 90 100
LDAQRSTVTT WGQDFCGDGQ GLGRRGRSLE LGFSSALSQQ AELISRQLQE
110 120 130 140 150
LRRLEEEVRS LRETSLQQKM RLETQAVELD ALAVAEKAGQ AEAEGLRTAL
160 170 180 190 200
AGAEMVRKNL EEAKHKELEE IQSLHQEQLS SLTQAHQKAL DSLASKAEGL
210 220 230 240 250
EKSLNSLETK RAGEAKQLAM AQKEADMLRN QLSKTQEELE AQVTLVESLR
260 270 280 290 300
KYVGEQVLPE FPSQEWELER KELLDTLKHL KEDRADLQAT VELLQVRVQS
310 320 330 340 350
LTHMLALQEE ELTRKIQPLD PLEPEFPKKC RSLLRNWREK VFALMVQLKA
360 370 380 390 400
QDLQHRDSTS QLRIQVAELQ EQVTSQSQEQ AILQRALQDK TAQVEVERMS
410 420 430 440 450
TKSLQMELDQ AQEARRRQEQ QIASAEEQLK FVVGAMNSTQ AKLQSTMTRM
460 470 480 490 500
DQAVARIPSL SNRLSYAVRK VHTIKGLMAR KVALAQLRVE SSPPSEAAPP
510 520 530 540 550
LDTDLSVELE QLREERNRLD AELQLSAHLI QQEVGRAREQ GEVERRRLIE
560 570 580 590 600
VAQQLEQELQ RAQESLASVG QQLEAARRGQ QESTEEAASL RQELTQQQEI
610 620 630 640 650
YGQALQEKVA EVETRLREQL SDTKRRLNEA RREQAKAVVS LRQIQHKATQ
660 670 680 690 700
EKERNQELRR LQDEARKEEG QRLTRRVQEL ERDKNLMLQR LLAVLPSGVN
710 720 730 740 750
KKCSPRSVES SSSESPAAAS CKESVKGSLT VLLDNLQGLS EAISRDEDIC
760 770
VEDNQNTKKT KNPPSDPLLS
Length:770
Mass (Da):87,105
Last modified:October 2, 2012 - v3
Checksum:iCAC0D3143E0660C7
GO

Sequence cautioni

The sequence AAH31416.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti720 – 7201S → L in AAH31416 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974473 Genomic DNA. No translation available.
CH466559 Genomic DNA. Translation: EDL23219.1.
BC031416 mRNA. Translation: AAH31416.1. Different initiation.
CCDSiCCDS50090.1.
RefSeqiNP_666360.2. NM_146248.2.
UniGeneiMm.49544.

Genome annotation databases

EnsembliENSMUST00000045956; ENSMUSP00000046612; ENSMUSG00000040312.
ENSMUST00000164242; ENSMUSP00000132028; ENSMUSG00000040312.
GeneIDi240084.
KEGGimmu:240084.
UCSCiuc008chx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974473 Genomic DNA. No translation available.
CH466559 Genomic DNA. Translation: EDL23219.1.
BC031416 mRNA. Translation: AAH31416.1. Different initiation.
CCDSiCCDS50090.1.
RefSeqiNP_666360.2. NM_146248.2.
UniGeneiMm.49544.

3D structure databases

ProteinModelPortaliQ8K2I2.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8K2I2.

Proteomic databases

PRIDEiQ8K2I2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045956; ENSMUSP00000046612; ENSMUSG00000040312.
ENSMUST00000164242; ENSMUSP00000132028; ENSMUSG00000040312.
GeneIDi240084.
KEGGimmu:240084.
UCSCiuc008chx.2. mouse.

Organism-specific databases

CTDi54535.
MGIiMGI:2385321. Cchcr1.

Phylogenomic databases

eggNOGiNOG130491.
GeneTreeiENSGT00710000106841.
HOGENOMiHOG000231221.
HOVERGENiHBG048718.
InParanoidiQ8K2I2.
KOiK16760.
OrthoDBiEOG75F4F8.
TreeFamiTF336947.

Miscellaneous databases

NextBioi384437.
PROiQ8K2I2.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CCHCR1.
ExpressionAtlasiQ8K2I2. baseline and differential.
GenevestigatoriQ8K2I2.

Family and domain databases

InterProiIPR009800. HCR.
[Graphical view]
PANTHERiPTHR23161:SF4. PTHR23161:SF4. 1 hit.
PfamiPF07111. HCR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCCHCR_MOUSE
AccessioniPrimary (citable) accession number: Q8K2I2
Secondary accession number(s): G3UWG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2004
Last sequence update: October 2, 2012
Last modified: January 6, 2015
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.