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Protein

Protein farnesyltransferase subunit beta

Gene

Fntb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.1 Publication

Catalytic activityi

Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.1 Publication

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei102Important for selectivity against geranylgeranyl diphosphateBy similarity1
Metal bindingi297Zinc; catalyticBy similarity1
Metal bindingi299Zinc; catalyticBy similarity1
Metal bindingi362Zinc; via tele nitrogen; catalyticBy similarity1

GO - Molecular functioni

  • drug binding Source: Ensembl
  • farnesyltranstransferase activity Source: MGI
  • isoprenoid binding Source: Ensembl
  • peptide binding Source: Ensembl
  • protein farnesyltransferase activity Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • negative regulation of cell proliferation Source: MGI
  • positive regulation of cell cycle Source: Ensembl
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of fibroblast proliferation Source: MGI
  • positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  • protein farnesylation Source: UniProtKB
  • response to cytokine Source: Ensembl
  • response to inorganic substance Source: Ensembl
  • response to organic cyclic compound Source: Ensembl
  • wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein farnesyltransferase subunit beta (EC:2.5.1.58)
Short name:
FTase-beta
Alternative name(s):
CAAX farnesyltransferase subunit beta
Ras proteins prenyltransferase subunit beta
Gene namesi
Name:Fntb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1861305. Fntb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2096912.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197621 – 437Protein farnesyltransferase subunit betaAdd BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei432PhosphoserineCombined sources1
Modified residuei436PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K2I1.
MaxQBiQ8K2I1.
PaxDbiQ8K2I1.
PeptideAtlasiQ8K2I1.
PRIDEiQ8K2I1.

PTM databases

iPTMnetiQ8K2I1.
PhosphoSitePlusiQ8K2I1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033373.
CleanExiMM_FNTB.
ExpressionAtlasiQ8K2I1. baseline and differential.
GenevisibleiQ8K2I1. MM.

Interactioni

Subunit structurei

Heterodimer of FNTA and FNTB.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035498.

Chemistry databases

BindingDBiQ8K2I1.

Structurei

Secondary structure

1437
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 263
Helixi28 – 336
Helixi43 – 6523
Helixi75 – 8511
Helixi91 – 966
Helixi100 – 11314
Helixi120 – 13314
Beta strandi138 – 1436
Helixi150 – 16314
Helixi166 – 1716
Helixi174 – 18411
Beta strandi191 – 1944
Helixi201 – 21414
Turni219 – 2246
Helixi225 – 2328
Beta strandi237 – 2393
Helixi249 – 26214
Helixi265 – 2673
Helixi270 – 27910
Turni283 – 2853
Beta strandi286 – 2916
Helixi300 – 3034
Helixi305 – 3073
Helixi308 – 31710
Helixi332 – 34211
Helixi360 – 37415
Helixi390 – 3923
Turni399 – 4013
Helixi405 – 41612

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PZ4X-ray2.10B2-427[»]
ProteinModelPortaliQ8K2I1.
SMRiQ8K2I1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati123 – 164PFTB 1Add BLAST42
Repeati174 – 215PFTB 2Add BLAST42
Repeati222 – 263PFTB 3Add BLAST42
Repeati270 – 312PFTB 4Add BLAST43
Repeati332 – 374PFTB 5Add BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni248 – 251Farnesyl diphosphate bindingBy similarity4
Regioni291 – 294Farnesyl diphosphate bindingBy similarity4
Regioni300 – 303Farnesyl diphosphate bindingBy similarity4

Sequence similaritiesi

Contains 5 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0365. Eukaryota.
COG5029. LUCA.
GeneTreeiENSGT00550000075042.
HOGENOMiHOG000190594.
HOVERGENiHBG008173.
InParanoidiQ8K2I1.
KOiK05954.
OMAiFMLRMKD.
PhylomeDBiQ8K2I1.
TreeFamiTF353162.

Family and domain databases

CDDicd02893. FTase. 1 hit.
Gene3Di1.50.10.20. 1 hit.
InterProiIPR026872. FTB.
IPR001330. PFTB_repeat.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF6. PTHR11774:SF6. 1 hit.
PfamiPF00432. Prenyltrans. 5 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K2I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSSFTYY CPPSSSPVWS EPLYSLRPEH VRERLQDDSV ETVTSIEQAK
60 70 80 90 100
VEEKIQEVFS SYKFNHLVPR LILQREKHFH YLKRGLRQLT DAYECLDASR
110 120 130 140 150
PWLCYWILHS LELLDEPIPQ IVATDVCQFL ELCQSPDGGF GGGPGQYPHL
160 170 180 190 200
APTYAAVNAL CIIGTEEAYN VINREKLLQY LYSLKQPDGS FLMHVGGEVD
210 220 230 240 250
VRSAYCAASV ASLTNIITPD LFEGTAEWIA RCQNWEGGIG GVPGMEAHGG
260 270 280 290 300
YTFCGLAALV ILKKERSLNL KSLLQWVTSR QMRFEGGFQG RCNKLVDGCY
310 320 330 340 350
SFWQAGLLPL LHRALHAQGD PALSMSHWMF HQQALQEYIL MCCQCPAGGL
360 370 380 390 400
LDKPGKSRDF YHTCYCLSGL SIAQHFGSGA MLHDMVMGVP ENVLQPTHPV
410 420 430
YNIGPEKVIQ ATTHFLQKPV PGFEECEDEV TSDPATD
Length:437
Mass (Da):48,820
Last modified:October 1, 2002 - v1
Checksum:i42B780B356136950
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031417 mRNA. Translation: AAH31417.1.
CCDSiCCDS25998.1.
RefSeqiNP_666039.1. NM_145927.2.
UniGeneiMm.151174.

Genome annotation databases

EnsembliENSMUST00000041008; ENSMUSP00000035498; ENSMUSG00000033373.
GeneIDi110606.
KEGGimmu:110606.
UCSCiuc007nyu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031417 mRNA. Translation: AAH31417.1.
CCDSiCCDS25998.1.
RefSeqiNP_666039.1. NM_145927.2.
UniGeneiMm.151174.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PZ4X-ray2.10B2-427[»]
ProteinModelPortaliQ8K2I1.
SMRiQ8K2I1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035498.

Chemistry databases

BindingDBiQ8K2I1.
ChEMBLiCHEMBL2096912.

PTM databases

iPTMnetiQ8K2I1.
PhosphoSitePlusiQ8K2I1.

Proteomic databases

EPDiQ8K2I1.
MaxQBiQ8K2I1.
PaxDbiQ8K2I1.
PeptideAtlasiQ8K2I1.
PRIDEiQ8K2I1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041008; ENSMUSP00000035498; ENSMUSG00000033373.
GeneIDi110606.
KEGGimmu:110606.
UCSCiuc007nyu.1. mouse.

Organism-specific databases

CTDi2342.
MGIiMGI:1861305. Fntb.

Phylogenomic databases

eggNOGiKOG0365. Eukaryota.
COG5029. LUCA.
GeneTreeiENSGT00550000075042.
HOGENOMiHOG000190594.
HOVERGENiHBG008173.
InParanoidiQ8K2I1.
KOiK05954.
OMAiFMLRMKD.
PhylomeDBiQ8K2I1.
TreeFamiTF353162.

Enzyme and pathway databases

ReactomeiR-MMU-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

ChiTaRSiFntb. mouse.
PROiQ8K2I1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033373.
CleanExiMM_FNTB.
ExpressionAtlasiQ8K2I1. baseline and differential.
GenevisibleiQ8K2I1. MM.

Family and domain databases

CDDicd02893. FTase. 1 hit.
Gene3Di1.50.10.20. 1 hit.
InterProiIPR026872. FTB.
IPR001330. PFTB_repeat.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF6. PTHR11774:SF6. 1 hit.
PfamiPF00432. Prenyltrans. 5 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFNTB_MOUSE
AccessioniPrimary (citable) accession number: Q8K2I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.