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Protein

Protein farnesyltransferase subunit beta

Gene

Fntb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.1 Publication

Catalytic activityi

Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.1 Publication

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei102 – 1021Important for selectivity against geranylgeranyl diphosphateBy similarity
Metal bindingi297 – 2971Zinc; catalyticBy similarity
Metal bindingi299 – 2991Zinc; catalyticBy similarity
Metal bindingi362 – 3621Zinc; via tele nitrogen; catalyticBy similarity

GO - Molecular functioni

  • drug binding Source: Ensembl
  • farnesyltranstransferase activity Source: MGI
  • isoprenoid binding Source: Ensembl
  • peptide binding Source: Ensembl
  • protein farnesyltransferase activity Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • negative regulation of cell proliferation Source: MGI
  • positive regulation of cell cycle Source: Ensembl
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of fibroblast proliferation Source: MGI
  • positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  • protein farnesylation Source: UniProtKB
  • response to cytokine Source: Ensembl
  • response to inorganic substance Source: Ensembl
  • response to organic cyclic compound Source: Ensembl
  • wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_311545. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein farnesyltransferase subunit beta (EC:2.5.1.58)
Short name:
FTase-beta
Alternative name(s):
CAAX farnesyltransferase subunit beta
Ras proteins prenyltransferase subunit beta
Gene namesi
Name:Fntb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1861305. Fntb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Protein farnesyltransferase subunit betaPRO_0000119762Add
BLAST

Proteomic databases

MaxQBiQ8K2I1.
PRIDEiQ8K2I1.

PTM databases

PhosphoSiteiQ8K2I1.

Expressioni

Gene expression databases

BgeeiQ8K2I1.
CleanExiMM_FNTB.
ExpressionAtlasiQ8K2I1. baseline and differential.
GenevisibleiQ8K2I1. MM.

Interactioni

Subunit structurei

Heterodimer of FNTA and FNTB.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035498.

Structurei

Secondary structure

1
437
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi24 – 263
Helixi28 – 336
Helixi43 – 6523
Helixi75 – 8511
Helixi91 – 966
Helixi100 – 11314
Helixi120 – 13314
Beta strandi138 – 1436
Helixi150 – 16314
Helixi166 – 1716
Helixi174 – 18411
Beta strandi191 – 1944
Helixi201 – 21414
Turni219 – 2246
Helixi225 – 2328
Beta strandi237 – 2393
Helixi249 – 26214
Helixi265 – 2673
Helixi270 – 27910
Turni283 – 2853
Beta strandi286 – 2916
Helixi300 – 3034
Helixi305 – 3073
Helixi308 – 31710
Helixi332 – 34211
Helixi360 – 37415
Helixi390 – 3923
Turni399 – 4013
Helixi405 – 41612

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PZ4X-ray2.10B2-427[»]
ProteinModelPortaliQ8K2I1.
SMRiQ8K2I1. Positions 17-423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati123 – 16442PFTB 1Add
BLAST
Repeati174 – 21542PFTB 2Add
BLAST
Repeati222 – 26342PFTB 3Add
BLAST
Repeati270 – 31243PFTB 4Add
BLAST
Repeati332 – 37443PFTB 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni248 – 2514Farnesyl diphosphate bindingBy similarity
Regioni291 – 2944Farnesyl diphosphate bindingBy similarity
Regioni300 – 3034Farnesyl diphosphate bindingBy similarity

Sequence similaritiesi

Contains 5 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00550000075042.
HOGENOMiHOG000190594.
HOVERGENiHBG008173.
InParanoidiQ8K2I1.
KOiK05954.
OMAiPIHPLYN.
PhylomeDBiQ8K2I1.
TreeFamiTF353162.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR026872. FTB.
IPR001330. Prenyltrans.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF6. PTHR11774:SF6. 1 hit.
PfamiPF00432. Prenyltrans. 2 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K2I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSSFTYY CPPSSSPVWS EPLYSLRPEH VRERLQDDSV ETVTSIEQAK
60 70 80 90 100
VEEKIQEVFS SYKFNHLVPR LILQREKHFH YLKRGLRQLT DAYECLDASR
110 120 130 140 150
PWLCYWILHS LELLDEPIPQ IVATDVCQFL ELCQSPDGGF GGGPGQYPHL
160 170 180 190 200
APTYAAVNAL CIIGTEEAYN VINREKLLQY LYSLKQPDGS FLMHVGGEVD
210 220 230 240 250
VRSAYCAASV ASLTNIITPD LFEGTAEWIA RCQNWEGGIG GVPGMEAHGG
260 270 280 290 300
YTFCGLAALV ILKKERSLNL KSLLQWVTSR QMRFEGGFQG RCNKLVDGCY
310 320 330 340 350
SFWQAGLLPL LHRALHAQGD PALSMSHWMF HQQALQEYIL MCCQCPAGGL
360 370 380 390 400
LDKPGKSRDF YHTCYCLSGL SIAQHFGSGA MLHDMVMGVP ENVLQPTHPV
410 420 430
YNIGPEKVIQ ATTHFLQKPV PGFEECEDEV TSDPATD
Length:437
Mass (Da):48,820
Last modified:October 1, 2002 - v1
Checksum:i42B780B356136950
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031417 mRNA. Translation: AAH31417.1.
CCDSiCCDS25998.1.
RefSeqiNP_666039.1. NM_145927.2.
UniGeneiMm.151174.

Genome annotation databases

EnsembliENSMUST00000041008; ENSMUSP00000035498; ENSMUSG00000033373.
GeneIDi110606.
KEGGimmu:110606.
UCSCiuc007nyu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031417 mRNA. Translation: AAH31417.1.
CCDSiCCDS25998.1.
RefSeqiNP_666039.1. NM_145927.2.
UniGeneiMm.151174.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PZ4X-ray2.10B2-427[»]
ProteinModelPortaliQ8K2I1.
SMRiQ8K2I1. Positions 17-423.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035498.

Chemistry

BindingDBiQ8K2I1.
ChEMBLiCHEMBL2096912.

PTM databases

PhosphoSiteiQ8K2I1.

Proteomic databases

MaxQBiQ8K2I1.
PRIDEiQ8K2I1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041008; ENSMUSP00000035498; ENSMUSG00000033373.
GeneIDi110606.
KEGGimmu:110606.
UCSCiuc007nyu.1. mouse.

Organism-specific databases

CTDi2342.
MGIiMGI:1861305. Fntb.

Phylogenomic databases

GeneTreeiENSGT00550000075042.
HOGENOMiHOG000190594.
HOVERGENiHBG008173.
InParanoidiQ8K2I1.
KOiK05954.
OMAiPIHPLYN.
PhylomeDBiQ8K2I1.
TreeFamiTF353162.

Enzyme and pathway databases

ReactomeiREACT_311545. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

ChiTaRSiFntb. mouse.
NextBioi364317.
PROiQ8K2I1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K2I1.
CleanExiMM_FNTB.
ExpressionAtlasiQ8K2I1. baseline and differential.
GenevisibleiQ8K2I1. MM.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR026872. FTB.
IPR001330. Prenyltrans.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF6. PTHR11774:SF6. 1 hit.
PfamiPF00432. Prenyltrans. 2 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary tumor.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 2-427 IN COMPLEX WITH FNTA AND ZINC IONS, SUBUNIT, CATALYTIC ACTIVITY, FUNCTION, COFACTOR.

Entry informationi

Entry nameiFNTB_MOUSE
AccessioniPrimary (citable) accession number: Q8K2I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.