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Q8K2I1 (FNTB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein farnesyltransferase subunit beta
Short name=FTase-beta
EC=2.5.1.58
Alternative name(s):
CAAX farnesyltransferase subunit beta
Ras proteins prenyltransferase subunit beta
Gene names
Name:Fntb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding By similarity.

Catalytic activity

Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Heterodimer of an alpha and a beta subunit By similarity.

Sequence similarities

Belongs to the protein prenyltransferase subunit beta family.

Contains 5 PFTB repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 437437Protein farnesyltransferase subunit beta
PRO_0000119762

Regions

Repeat123 – 16442PFTB 1
Repeat174 – 21542PFTB 2
Repeat222 – 26342PFTB 3
Repeat270 – 31243PFTB 4
Repeat332 – 37443PFTB 5

Sites

Metal binding2971Zinc By similarity
Metal binding2991Zinc By similarity
Metal binding3621Zinc By similarity

Secondary structure

1 ........................................................ 437
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8K2I1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 42B780B356136950

FASTA43748,820
        10         20         30         40         50         60 
MASSSSFTYY CPPSSSPVWS EPLYSLRPEH VRERLQDDSV ETVTSIEQAK VEEKIQEVFS 

        70         80         90        100        110        120 
SYKFNHLVPR LILQREKHFH YLKRGLRQLT DAYECLDASR PWLCYWILHS LELLDEPIPQ 

       130        140        150        160        170        180 
IVATDVCQFL ELCQSPDGGF GGGPGQYPHL APTYAAVNAL CIIGTEEAYN VINREKLLQY 

       190        200        210        220        230        240 
LYSLKQPDGS FLMHVGGEVD VRSAYCAASV ASLTNIITPD LFEGTAEWIA RCQNWEGGIG 

       250        260        270        280        290        300 
GVPGMEAHGG YTFCGLAALV ILKKERSLNL KSLLQWVTSR QMRFEGGFQG RCNKLVDGCY 

       310        320        330        340        350        360 
SFWQAGLLPL LHRALHAQGD PALSMSHWMF HQQALQEYIL MCCQCPAGGL LDKPGKSRDF 

       370        380        390        400        410        420 
YHTCYCLSGL SIAQHFGSGA MLHDMVMGVP ENVLQPTHPV YNIGPEKVIQ ATTHFLQKPV 

       430 
PGFEECEDEV TSDPATD

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: 129.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC031417 mRNA. Translation: AAH31417.1.
IPIIPI00169914.
RefSeqNP_666039.1. NM_145927.2.
UniGeneMm.151174.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3PZ4X-ray2.10B2-427[»]
ProteinModelPortalQ8K2I1.
SMRQ8K2I1. Positions 17-423.
ModBaseSearch...

PTM databases

PhosphoSiteQ8K2I1.

Proteomic databases

PRIDEQ8K2I1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000041008; ENSMUSP00000035498; ENSMUSG00000033373.
GeneID110606.
KEGGmmu:110606.
UCSCuc007nyu.1. mouse.

Organism-specific databases

CTD2342.
MGIMGI:1861305. Fntb.

Phylogenomic databases

GeneTreeENSGT00550000075042.
HOGENOMHOG000190594.
HOVERGENHBG008173.
InParanoidQ8K2I1.
KOK05954.
OMAHPVYNIC.
OrthoDBEOG4KKZ33.

Gene expression databases

ArrayExpressQ8K2I1.
BgeeQ8K2I1.
CleanExMM_FNTB.
GenevestigatorQ8K2I1.
GermOnlineENSMUSG00000033373. Mus musculus.

Family and domain databases

InterProIPR026872. FTB.
IPR001330. Prenyltrans.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERPTHR11774:SF6. PTHR11774:SF6. 1 hit.
PfamPF00432. Prenyltrans. 2 hits.
[Graphical view]
SUPFAMSSF48239. Terp_cyc_toroid. 1 hit.
ProtoNetSearch...

Other

BindingDBQ8K2I1.
ChEMBLCHEMBL2631.
ChiTaRSFNTB. mouse.
NextBio364317.
SOURCESearch...

Entry information

Entry nameFNTB_MOUSE
AccessionPrimary (citable) accession number: Q8K2I1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 1, 2002
Last modified: April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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