Reviewed,
UniProtKB/Swiss-Prot Q8K2I1 (FNTB_MOUSE)
Last modified
November 3, 2009.
Version 53.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein farnesyltransferase subunit beta Short name=FTase-beta EC=2.5.1.58 Alternative name(s): CAAX farnesyltransferase subunit beta Ras proteins prenyltransferase subunit beta | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 437 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding By similarity. |
| Catalytic activity | Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Subunit structure | Heterodimer of an alpha and a beta subunit By similarity. |
| Sequence similarities | Belongs to the protein prenyltransferase subunit beta family. Contains 5 PFTB repeats. |
Ontologies
| Keywords | |
|---|---|
| Domain | Repeat |
| Ligand | Metal-binding Zinc |
| Molecular function | Prenyltransferase Transferase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | negative regulation of cell proliferation Inferred from mutant phenotype. Source: MGI positive regulation of fibroblast proliferationInferred from mutant phenotype. Source: MGI wound healingInferred from mutant phenotype. Source: MGI |
| Molecular function | farnesyltranstransferase activity Inferred from mutant phenotype. Source: MGI protein farnesyltransferase activityInferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 437 | 437 | Protein farnesyltransferase subunit beta | PRO_0000119762 | |||||
Regions | |||||||||
| Repeat | 123 – 164 | 42 | PFTB 1 | ||||||
| Repeat | 174 – 215 | 42 | PFTB 2 | ||||||
| Repeat | 222 – 263 | 42 | PFTB 3 | ||||||
| Repeat | 270 – 312 | 43 | PFTB 4 | ||||||
| Repeat | 332 – 374 | 43 | PFTB 5 | ||||||
Sites | |||||||||
| Metal binding | 297 | 1 | Zinc By similarity | ||||||
| Metal binding | 299 | 1 | Zinc By similarity | ||||||
| Metal binding | 362 | 1 | Zinc By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 300 | 1 | Phosphotyrosine By similarity | ||||||
Sequences
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References
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: 129. Tissue: Mammary tumor. |
Cross-references
Sequence databases | |
|---|---|
| BC031417 mRNA. Translation: AAH31417.1. | |
| IPI | IPI00169914. |
| RefSeq | NP_666039.1. |
| UniGene | Mm.151174 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FT1 based on UniProtKB Q02293. |
| SMR | Q8K2I1. Positions 15-424. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8K2I1. |
PTM databases | |
| PhosphoSite | Q8K2I1. |
Proteomic databases | |
| PRIDE | Q8K2I1. |
Genome annotation databases | |
| Ensembl | ENSMUST00000041008; ENSMUSP00000035498; ENSMUSG00000033373; Mus musculus. [Genome view] |
| GeneID | 110606. |
| KEGG | mmu:110606. |
| UCSC | uc007nyu.1. mouse. |
Organism-specific databases | |
| CTD | 110606. |
| MGI | MGI:1861305. Fntb. |
Phylogenomic databases | |
| HOGENOM | Q8K2I1. |
| HOVERGEN | Q8K2I1. |
| OMA | AHLAPTY. |
Enzyme and pathway databases | |
| BRENDA | 2.5.1.58. 244. |
Gene expression databases | |
| ArrayExpress | Q8K2I1. |
| Bgee | Q8K2I1. |
| CleanEx | MM_FNTB. |
| Genevestigator | Q8K2I1. |
| GermOnline | ENSMUSG00000033373. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001330. Prenyltrans. [Graphical view] |
| Pfam | PF00432. Prenyltrans. 5 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 364317. |
| SOURCE | Search... |
Entry information
| Entry name | FNTB_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8K2I1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


