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Protein

Protein farnesyltransferase subunit beta

Gene

Fntb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.1 Publication

Catalytic activityi

Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.1 Publication

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei102Important for selectivity against geranylgeranyl diphosphateBy similarity1
Metal bindingi297Zinc; catalyticBy similarity1
Metal bindingi299Zinc; catalyticBy similarity1
Metal bindingi362Zinc; via tele nitrogen; catalyticBy similarity1

GO - Molecular functioni

  • drug binding Source: Ensembl
  • farnesyltranstransferase activity Source: MGI
  • isoprenoid binding Source: Ensembl
  • peptide binding Source: Ensembl
  • protein farnesyltransferase activity Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • negative regulation of cell proliferation Source: MGI
  • positive regulation of cell cycle Source: Ensembl
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of fibroblast proliferation Source: MGI
  • positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  • protein farnesylation Source: UniProtKB
  • response to cytokine Source: Ensembl
  • response to inorganic substance Source: Ensembl
  • response to organic cyclic compound Source: Ensembl
  • wound healing Source: MGI

Keywordsi

Molecular functionPrenyltransferase, Transferase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-2514859 Inactivation, recovery and regulation of the phototransduction cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Protein farnesyltransferase subunit beta (EC:2.5.1.58)
Short name:
FTase-beta
Alternative name(s):
CAAX farnesyltransferase subunit beta
Ras proteins prenyltransferase subunit beta
Gene namesi
Name:Fntb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1861305 Fntb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2096912

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197621 – 437Protein farnesyltransferase subunit betaAdd BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei432PhosphoserineCombined sources1
Modified residuei436PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K2I1
MaxQBiQ8K2I1
PaxDbiQ8K2I1
PeptideAtlasiQ8K2I1
PRIDEiQ8K2I1

PTM databases

iPTMnetiQ8K2I1
PhosphoSitePlusiQ8K2I1

Expressioni

Gene expression databases

BgeeiENSMUSG00000033373
CleanExiMM_FNTB
ExpressionAtlasiQ8K2I1 baseline and differential
GenevisibleiQ8K2I1 MM

Interactioni

Subunit structurei

Heterodimer of FNTA and FNTB.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035498

Chemistry databases

BindingDBiQ8K2I1

Structurei

Secondary structure

1437
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 263
Helixi28 – 336
Helixi43 – 6523
Helixi75 – 8511
Helixi91 – 966
Helixi100 – 11314
Helixi120 – 13314
Beta strandi138 – 1436
Helixi150 – 16314
Helixi166 – 1716
Helixi174 – 18411
Beta strandi191 – 1944
Helixi201 – 21414
Turni219 – 2246
Helixi225 – 2328
Beta strandi237 – 2393
Helixi249 – 26214
Helixi265 – 2673
Helixi270 – 27910
Turni283 – 2853
Beta strandi286 – 2916
Helixi300 – 3034
Helixi305 – 3073
Helixi308 – 31710
Helixi332 – 34211
Helixi360 – 37415
Helixi390 – 3923
Turni399 – 4013
Helixi405 – 41612

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PZ4X-ray2.10B2-427[»]
ProteinModelPortaliQ8K2I1
SMRiQ8K2I1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati123 – 164PFTB 1Add BLAST42
Repeati174 – 215PFTB 2Add BLAST42
Repeati222 – 263PFTB 3Add BLAST42
Repeati270 – 312PFTB 4Add BLAST43
Repeati332 – 374PFTB 5Add BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni248 – 251Farnesyl diphosphate bindingBy similarity4
Regioni291 – 294Farnesyl diphosphate bindingBy similarity4
Regioni300 – 303Farnesyl diphosphate bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0365 Eukaryota
COG5029 LUCA
GeneTreeiENSGT00550000075042
HOGENOMiHOG000190594
HOVERGENiHBG008173
InParanoidiQ8K2I1
KOiK05954
OMAiLYHTCYT
PhylomeDBiQ8K2I1
TreeFamiTF353162

Family and domain databases

CDDicd02893 FTase, 1 hit
InterProiView protein in InterPro
IPR026872 FTB
IPR001330 PFTB_repeat
IPR008930 Terpenoid_cyclase/PrenylTrfase
PANTHERiPTHR11774:SF6 PTHR11774:SF6, 1 hit
PfamiView protein in Pfam
PF00432 Prenyltrans, 5 hits
SUPFAMiSSF48239 SSF48239, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K2I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSSFTYY CPPSSSPVWS EPLYSLRPEH VRERLQDDSV ETVTSIEQAK
60 70 80 90 100
VEEKIQEVFS SYKFNHLVPR LILQREKHFH YLKRGLRQLT DAYECLDASR
110 120 130 140 150
PWLCYWILHS LELLDEPIPQ IVATDVCQFL ELCQSPDGGF GGGPGQYPHL
160 170 180 190 200
APTYAAVNAL CIIGTEEAYN VINREKLLQY LYSLKQPDGS FLMHVGGEVD
210 220 230 240 250
VRSAYCAASV ASLTNIITPD LFEGTAEWIA RCQNWEGGIG GVPGMEAHGG
260 270 280 290 300
YTFCGLAALV ILKKERSLNL KSLLQWVTSR QMRFEGGFQG RCNKLVDGCY
310 320 330 340 350
SFWQAGLLPL LHRALHAQGD PALSMSHWMF HQQALQEYIL MCCQCPAGGL
360 370 380 390 400
LDKPGKSRDF YHTCYCLSGL SIAQHFGSGA MLHDMVMGVP ENVLQPTHPV
410 420 430
YNIGPEKVIQ ATTHFLQKPV PGFEECEDEV TSDPATD
Length:437
Mass (Da):48,820
Last modified:October 1, 2002 - v1
Checksum:i42B780B356136950
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031417 mRNA Translation: AAH31417.1
CCDSiCCDS25998.1
RefSeqiNP_666039.1, NM_145927.2
UniGeneiMm.151174

Genome annotation databases

EnsembliENSMUST00000041008; ENSMUSP00000035498; ENSMUSG00000033373
GeneIDi110606
KEGGimmu:110606
UCSCiuc007nyu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFNTB_MOUSE
AccessioniPrimary (citable) accession number: Q8K2I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health