Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8K2I1

- FNTB_MOUSE

UniProt

Q8K2I1 - FNTB_MOUSE

Protein

Protein farnesyltransferase subunit beta

Gene

Fntb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.1 Publication

    Catalytic activityi

    Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.1 Publication

    Cofactori

    Binds 1 zinc ion per subunit.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei102 – 1021Important for selectivity against geranylgeranyl diphosphateBy similarity
    Metal bindingi297 – 2971Zinc; catalyticBy similarity
    Metal bindingi299 – 2991Zinc; catalyticBy similarity
    Metal bindingi362 – 3621Zinc; via tele nitrogen; catalyticBy similarity

    GO - Molecular functioni

    1. farnesyltranstransferase activity Source: MGI
    2. protein farnesyltransferase activity Source: UniProtKB
    3. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of cell proliferation Source: MGI
    2. positive regulation of cell cycle Source: Ensembl
    3. positive regulation of cell proliferation Source: MGI
    4. positive regulation of fibroblast proliferation Source: MGI
    5. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
    6. protein farnesylation Source: UniProtKB
    7. response to cytokine Source: Ensembl
    8. response to inorganic substance Source: Ensembl
    9. response to organic cyclic compound Source: Ensembl
    10. wound healing Source: MGI

    Keywords - Molecular functioni

    Prenyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein farnesyltransferase subunit beta (EC:2.5.1.58)
    Short name:
    FTase-beta
    Alternative name(s):
    CAAX farnesyltransferase subunit beta
    Ras proteins prenyltransferase subunit beta
    Gene namesi
    Name:Fntb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1861305. Fntb.

    Subcellular locationi

    GO - Cellular componenti

    1. microtubule associated complex Source: Ensembl
    2. protein farnesyltransferase complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 437437Protein farnesyltransferase subunit betaPRO_0000119762Add
    BLAST

    Proteomic databases

    MaxQBiQ8K2I1.
    PRIDEiQ8K2I1.

    PTM databases

    PhosphoSiteiQ8K2I1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K2I1.
    BgeeiQ8K2I1.
    CleanExiMM_FNTB.
    GenevestigatoriQ8K2I1.

    Interactioni

    Subunit structurei

    Heterodimer of FNTA and FNTB.1 Publication

    Structurei

    Secondary structure

    1
    437
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi24 – 263
    Helixi28 – 336
    Helixi43 – 6523
    Helixi75 – 8511
    Helixi91 – 966
    Helixi100 – 11314
    Helixi120 – 13314
    Beta strandi138 – 1436
    Helixi150 – 16314
    Helixi166 – 1716
    Helixi174 – 18411
    Beta strandi191 – 1944
    Helixi201 – 21414
    Turni219 – 2246
    Helixi225 – 2328
    Beta strandi237 – 2393
    Helixi249 – 26214
    Helixi265 – 2673
    Helixi270 – 27910
    Turni283 – 2853
    Beta strandi286 – 2916
    Helixi300 – 3034
    Helixi305 – 3073
    Helixi308 – 31710
    Helixi332 – 34211
    Helixi360 – 37415
    Helixi390 – 3923
    Turni399 – 4013
    Helixi405 – 41612

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3PZ4X-ray2.10B2-427[»]
    ProteinModelPortaliQ8K2I1.
    SMRiQ8K2I1. Positions 17-423.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati123 – 16442PFTB 1Add
    BLAST
    Repeati174 – 21542PFTB 2Add
    BLAST
    Repeati222 – 26342PFTB 3Add
    BLAST
    Repeati270 – 31243PFTB 4Add
    BLAST
    Repeati332 – 37443PFTB 5Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni248 – 2514Farnesyl diphosphate bindingBy similarity
    Regioni291 – 2944Farnesyl diphosphate bindingBy similarity
    Regioni300 – 3034Farnesyl diphosphate bindingBy similarity

    Sequence similaritiesi

    Contains 5 PFTB repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    GeneTreeiENSGT00550000075042.
    HOGENOMiHOG000190594.
    HOVERGENiHBG008173.
    InParanoidiQ8K2I1.
    KOiK05954.
    OMAiKLLDFLW.
    PhylomeDBiQ8K2I1.
    TreeFamiTF353162.

    Family and domain databases

    Gene3Di1.50.10.20. 1 hit.
    InterProiIPR026872. FTB.
    IPR001330. Prenyltrans.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PANTHERiPTHR11774:SF6. PTHR11774:SF6. 1 hit.
    PfamiPF00432. Prenyltrans. 2 hits.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8K2I1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSSSFTYY CPPSSSPVWS EPLYSLRPEH VRERLQDDSV ETVTSIEQAK    50
    VEEKIQEVFS SYKFNHLVPR LILQREKHFH YLKRGLRQLT DAYECLDASR 100
    PWLCYWILHS LELLDEPIPQ IVATDVCQFL ELCQSPDGGF GGGPGQYPHL 150
    APTYAAVNAL CIIGTEEAYN VINREKLLQY LYSLKQPDGS FLMHVGGEVD 200
    VRSAYCAASV ASLTNIITPD LFEGTAEWIA RCQNWEGGIG GVPGMEAHGG 250
    YTFCGLAALV ILKKERSLNL KSLLQWVTSR QMRFEGGFQG RCNKLVDGCY 300
    SFWQAGLLPL LHRALHAQGD PALSMSHWMF HQQALQEYIL MCCQCPAGGL 350
    LDKPGKSRDF YHTCYCLSGL SIAQHFGSGA MLHDMVMGVP ENVLQPTHPV 400
    YNIGPEKVIQ ATTHFLQKPV PGFEECEDEV TSDPATD 437
    Length:437
    Mass (Da):48,820
    Last modified:October 1, 2002 - v1
    Checksum:i42B780B356136950
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC031417 mRNA. Translation: AAH31417.1.
    CCDSiCCDS25998.1.
    RefSeqiNP_666039.1. NM_145927.2.
    UniGeneiMm.151174.

    Genome annotation databases

    EnsembliENSMUST00000041008; ENSMUSP00000035498; ENSMUSG00000033373.
    GeneIDi110606.
    KEGGimmu:110606.
    UCSCiuc007nyu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC031417 mRNA. Translation: AAH31417.1 .
    CCDSi CCDS25998.1.
    RefSeqi NP_666039.1. NM_145927.2.
    UniGenei Mm.151174.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3PZ4 X-ray 2.10 B 2-427 [» ]
    ProteinModelPortali Q8K2I1.
    SMRi Q8K2I1. Positions 17-423.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q8K2I1.
    ChEMBLi CHEMBL2096912.

    PTM databases

    PhosphoSitei Q8K2I1.

    Proteomic databases

    MaxQBi Q8K2I1.
    PRIDEi Q8K2I1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041008 ; ENSMUSP00000035498 ; ENSMUSG00000033373 .
    GeneIDi 110606.
    KEGGi mmu:110606.
    UCSCi uc007nyu.1. mouse.

    Organism-specific databases

    CTDi 2342.
    MGIi MGI:1861305. Fntb.

    Phylogenomic databases

    GeneTreei ENSGT00550000075042.
    HOGENOMi HOG000190594.
    HOVERGENi HBG008173.
    InParanoidi Q8K2I1.
    KOi K05954.
    OMAi KLLDFLW.
    PhylomeDBi Q8K2I1.
    TreeFami TF353162.

    Enzyme and pathway databases

    Reactomei REACT_188266. Inactivation, recovery and regulation of the phototransduction cascade.

    Miscellaneous databases

    ChiTaRSi FNTB. mouse.
    NextBioi 364317.
    PROi Q8K2I1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K2I1.
    Bgeei Q8K2I1.
    CleanExi MM_FNTB.
    Genevestigatori Q8K2I1.

    Family and domain databases

    Gene3Di 1.50.10.20. 1 hit.
    InterProi IPR026872. FTB.
    IPR001330. Prenyltrans.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    PANTHERi PTHR11774:SF6. PTHR11774:SF6. 1 hit.
    Pfami PF00432. Prenyltrans. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129.
      Tissue: Mammary tumor.
    2. Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 2-427 IN COMPLEX WITH FNTA AND ZINC IONS, SUBUNIT, CATALYTIC ACTIVITY, FUNCTION, COFACTOR.

    Entry informationi

    Entry nameiFNTB_MOUSE
    AccessioniPrimary (citable) accession number: Q8K2I1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3