Reviewed, UniProtKB/Swiss-Prot Q8K2I1 (FNTB_MOUSE)

Names and origin

Protein names

Recommended name:
    Protein farnesyltransferase subunit beta
      Short name=FTase-beta
    EC=2.5.1.58
Alternative name(s):
    CAAX farnesyltransferase subunit beta
    Ras proteins prenyltransferase subunit beta

Gene names

Name:

Fntb

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding By similarity.
Catalytic activity	Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Heterodimer of an alpha and a beta subunit By similarity.
Sequence similarities	Belongs to the protein prenyltransferase subunit beta family. Contains 5 PFTB repeats.

Ontologies

Keywords
Domain	Repeat
Ligand	Metal-binding Zinc
Molecular function	Prenyltransferase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	negative regulation of cell proliferation Inferred from mutant phenotype. Source: MGI positive regulation of fibroblast proliferation Inferred from mutant phenotype. Source: MGI wound healing Inferred from mutant phenotype. Source: MGI
Molecular function	farnesyltranstransferase activity Inferred from mutant phenotype. Source: MGI protein farnesyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	Protein farnesyltransferase subunit beta		PRO_0000119762
Regions
	Repeat	123 – 164	42	PFTB 1
	Repeat	174 – 215	42	PFTB 2
	Repeat	222 – 263	42	PFTB 3
	Repeat	270 – 312	43	PFTB 4
	Repeat	332 – 374	43	PFTB 5
Sites
	Metal binding	297	1	Zinc By similarity
	Metal binding	299	1	Zinc By similarity
	Metal binding	362	1	Zinc By similarity
Amino acid modifications
	Modified residue	300	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8K2I1-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 42B780B356136950	FASTA	437	48,820
	10 20 30 40 50 60 MASSSSFTYY CPPSSSPVWS EPLYSLRPEH VRERLQDDSV ETVTSIEQAK VEEKIQEVFS 70 80 90 100 110 120 SYKFNHLVPR LILQREKHFH YLKRGLRQLT DAYECLDASR PWLCYWILHS LELLDEPIPQ 130 140 150 160 170 180 IVATDVCQFL ELCQSPDGGF GGGPGQYPHL APTYAAVNAL CIIGTEEAYN VINREKLLQY 190 200 210 220 230 240 LYSLKQPDGS FLMHVGGEVD VRSAYCAASV ASLTNIITPD LFEGTAEWIA RCQNWEGGIG 250 260 270 280 290 300 GVPGMEAHGG YTFCGLAALV ILKKERSLNL KSLLQWVTSR QMRFEGGFQG RCNKLVDGCY 310 320 330 340 350 360 SFWQAGLLPL LHRALHAQGD PALSMSHWMF HQQALQEYIL MCCQCPAGGL LDKPGKSRDF 370 380 390 400 410 420 YHTCYCLSGL SIAQHFGSGA MLHDMVMGVP ENVLQPTHPV YNIGPEKVIQ ATTHFLQKPV 430 PGFEECEDEV TSDPATD

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: 129. Tissue: Mammary tumor.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC031417 mRNA. Translation: AAH31417.1.
IPI	IPI00169914.
RefSeq	NP_666039.1.
UniGene	Mm.151174
3D structure databases
HSSP	HSSP built from PDB template 1FT1 based on UniProtKB Q02293.
SMR	Q8K2I1. Positions 15-424.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8K2I1.
PTM databases
PhosphoSite	Q8K2I1.
Proteomic databases
PRIDE	Q8K2I1.
Genome annotation databases
Ensembl	ENSMUST00000041008; ENSMUSP00000035498; ENSMUSG00000033373; Mus musculus. [Genome view]
GeneID	110606.
KEGG	mmu:110606.
UCSC	uc007nyu.1. mouse.
Organism-specific databases
CTD	110606.
MGI	MGI:1861305. Fntb.
Phylogenomic databases
HOGENOM	Q8K2I1.
HOVERGEN	Q8K2I1.
OMA	AHLAPTY.
Enzyme and pathway databases
BRENDA	2.5.1.58. 244.
Gene expression databases
ArrayExpress	Q8K2I1.
Bgee	Q8K2I1.
CleanEx	MM_FNTB.
Genevestigator	Q8K2I1.
GermOnline	ENSMUSG00000033373. Mus musculus.
Family and domain databases
InterPro	IPR001330. Prenyltrans. [Graphical view]
Pfam	PF00432. Prenyltrans. 5 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	364317.
SOURCE	Search...

Entry information

Entry name

FNTB_MOUSE

Accession

Primary (citable) accession number: Q8K2I1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	October 1, 2002
Last modified:	November 3, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)