Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Anaphase-promoting complex subunit 10

Gene

Anapc10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-MMU-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-MMU-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-MMU-174154. APC/C:Cdc20 mediated degradation of Securin.
R-MMU-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-MMU-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-MMU-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-MMU-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-MMU-176409. APC/C:Cdc20 mediated degradation of mitotic proteins.
R-MMU-176412. Phosphorylation of the APC/C.
R-MMU-179409. APC-Cdc20 mediated degradation of Nek2A.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 10
Short name:
APC10
Alternative name(s):
Cyclosome subunit 10
Gene namesi
Name:Anapc10
Synonyms:Apc10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1916249. Anapc10.

Subcellular locationi

GO - Cellular componenti

  • anaphase-promoting complex Source: UniProtKB
  • cytoplasm Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 185184Anaphase-promoting complex subunit 10PRO_0000174012Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity
Modified residuei169 – 1691N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8K2H6.
MaxQBiQ8K2H6.
PaxDbiQ8K2H6.
PRIDEiQ8K2H6.

PTM databases

PhosphoSiteiQ8K2H6.

Expressioni

Gene expression databases

BgeeiQ8K2H6.
CleanExiMM_ANAPC10.
GenevisibleiQ8K2H6. MM.

Interactioni

Subunit structurei

The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. The C-terminus of APC10 binds to CDC27/APC3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi213166. 1 interaction.
IntActiQ8K2H6. 1 interaction.
STRINGi10090.ENSMUSP00000048244.

Structurei

3D structure databases

ProteinModelPortaliQ8K2H6.
SMRiQ8K2H6. Positions 3-162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 185184DOCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the APC10 family.Curated
Contains 1 DOC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3437. Eukaryota.
COG5156. LUCA.
GeneTreeiENSGT00390000013722.
HOGENOMiHOG000241616.
HOVERGENiHBG050528.
InParanoidiQ8K2H6.
KOiK03357.
OMAiIRQIKVY.
OrthoDBiEOG7BW0KR.
PhylomeDBiQ8K2H6.
TreeFamiTF105446.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR016901. APC10.
IPR004939. APC_su10/DOC_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF03256. ANAPC10. 1 hit.
[Graphical view]
PIRSFiPIRSF028841. APC10_sub. 1 hit.
SMARTiSM01337. APC10. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiPS51284. DOC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K2H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTPNKTPPG ADPKQLERTA TVREIGSQAV WSLSSCKPGF GVDQLRDDNL
60 70 80 90 100
ETYWQSDGSQ PHLVNIQFRR KTTVKTLCIY ADYKSDESYT PSKISVRVGN
110 120 130 140 150
NFHNLQEIRQ LELVEPSGWI HVPLTDNHKK PTRTFMIQIA VLANHQNGRD
160 170 180
THMRQIKIYT PVEESSIGKF PRCTTIDFMM YRSIR
Length:185
Mass (Da):21,266
Last modified:October 1, 2002 - v1
Checksum:i9C198C42541A7C31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005303 mRNA. Translation: BAB23942.1.
AK041373 mRNA. Translation: BAC30921.1.
BC031460 mRNA. Translation: AAH31460.1.
CCDSiCCDS22439.1.
RefSeqiNP_081180.1. NM_026904.2.
XP_006531402.1. XM_006531339.2.
XP_006531403.1. XM_006531340.2.
XP_006531406.1. XM_006531343.2.
UniGeneiMm.257445.

Genome annotation databases

EnsembliENSMUST00000048147; ENSMUSP00000048244; ENSMUSG00000036977.
GeneIDi68999.
KEGGimmu:68999.
UCSCiuc009miv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005303 mRNA. Translation: BAB23942.1.
AK041373 mRNA. Translation: BAC30921.1.
BC031460 mRNA. Translation: AAH31460.1.
CCDSiCCDS22439.1.
RefSeqiNP_081180.1. NM_026904.2.
XP_006531402.1. XM_006531339.2.
XP_006531403.1. XM_006531340.2.
XP_006531406.1. XM_006531343.2.
UniGeneiMm.257445.

3D structure databases

ProteinModelPortaliQ8K2H6.
SMRiQ8K2H6. Positions 3-162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213166. 1 interaction.
IntActiQ8K2H6. 1 interaction.
STRINGi10090.ENSMUSP00000048244.

PTM databases

PhosphoSiteiQ8K2H6.

Proteomic databases

EPDiQ8K2H6.
MaxQBiQ8K2H6.
PaxDbiQ8K2H6.
PRIDEiQ8K2H6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048147; ENSMUSP00000048244; ENSMUSG00000036977.
GeneIDi68999.
KEGGimmu:68999.
UCSCiuc009miv.1. mouse.

Organism-specific databases

CTDi10393.
MGIiMGI:1916249. Anapc10.

Phylogenomic databases

eggNOGiKOG3437. Eukaryota.
COG5156. LUCA.
GeneTreeiENSGT00390000013722.
HOGENOMiHOG000241616.
HOVERGENiHBG050528.
InParanoidiQ8K2H6.
KOiK03357.
OMAiIRQIKVY.
OrthoDBiEOG7BW0KR.
PhylomeDBiQ8K2H6.
TreeFamiTF105446.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-MMU-141430. Inactivation of APC/C via direct inhibition of the APC/C complex.
R-MMU-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-MMU-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-MMU-174154. APC/C:Cdc20 mediated degradation of Securin.
R-MMU-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-MMU-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-MMU-176407. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
R-MMU-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-MMU-176409. APC/C:Cdc20 mediated degradation of mitotic proteins.
R-MMU-176412. Phosphorylation of the APC/C.
R-MMU-179409. APC-Cdc20 mediated degradation of Nek2A.
R-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

NextBioi328377.
PROiQ8K2H6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K2H6.
CleanExiMM_ANAPC10.
GenevisibleiQ8K2H6. MM.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR016901. APC10.
IPR004939. APC_su10/DOC_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF03256. ANAPC10. 1 hit.
[Graphical view]
PIRSFiPIRSF028841. APC10_sub. 1 hit.
SMARTiSM01337. APC10. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiPS51284. DOC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-169, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiAPC10_MOUSE
AccessioniPrimary (citable) accession number: Q8K2H6
Secondary accession number(s): Q9CW24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.