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Q8K2H2 (OTU6B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
OTU domain-containing protein 6B

EC=3.4.19.12
Gene names
Name:Otud6b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Contains 1 OTU domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Molecular functionHydrolase
Protease
Thiol protease
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294OTU domain-containing protein 6B
PRO_0000076280

Regions

Domain148 – 285138OTU
Region153 – 1597Cys-loop By similarity
Region220 – 23011Variable-loop By similarity
Region268 – 27811His-loop By similarity

Sites

Active site1561 By similarity
Active site1591Nucleophile By similarity
Active site2781 By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Experimental info

Sequence conflict531A → T in BAE33424. Ref.1
Sequence conflict1901T → S in BAE42955. Ref.1
Sequence conflict1901T → S in BAE42895. Ref.1
Sequence conflict1901T → S in BAE38781. Ref.1
Sequence conflict1901T → S in EDL05608. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8K2H2 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 024FB22EF139F517

FASTA29433,758
        10         20         30         40         50         60 
MEEVVAEELD DEEQLVRRHR KEKKELQAKI QGMKNAVPKN DKKRRKQLTE DVAKLEREME 

        70         80         90        100        110        120 
QKHREELEQL KQLTFKDSKI DSVAVNISNL VLENQPPRIS KAQKRREKKA ALEKEREERI 

       130        140        150        160        170        180 
AEAEIENLSG ARHLESEKLA QILAARELEI KQIPSDGHCM YGALEDQLRE QDCALTVASL 

       190        200        210        220        230        240 
RRQTAEYMQT HSDDFLPFLT NPSTGDMYTP EEFGKYCDDI VNTAAWGGQL ELRALSHILQ 

       250        260        270        280        290 
TPIEILQADA PPIIVGEEYP RNPLVLVYMR HAYGLGEHYN SVTRLVNSAT ENCS 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Liver, Mammary gland and Spleen.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Embryo and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK155761 mRNA. Translation: BAE33424.1.
AK169134 mRNA. Translation: BAE40913.1.
AK166445 mRNA. Translation: BAE38781.1.
AK172229 mRNA. Translation: BAE42895.1.
AK172338 mRNA. Translation: BAE42955.1.
AL831792 Genomic DNA. No translation available.
CH466538 Genomic DNA. Translation: EDL05608.1.
BC031474 mRNA. Translation: AAH31474.1.
BC087552 mRNA. Translation: AAH87552.1.
RefSeqNP_690025.2. NM_152812.3.
UniGeneMm.387724.

3D structure databases

ProteinModelPortalQ8K2H2.
SMRQ8K2H2. Positions 139-285.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8K2H2. 1 interaction.
MINTMINT-4117344.
STRING10090.ENSMUSP00000113553.

PTM databases

PhosphoSiteQ8K2H2.

Proteomic databases

MaxQBQ8K2H2.
PaxDbQ8K2H2.
PRIDEQ8K2H2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID72201.
KEGGmmu:72201.

Organism-specific databases

CTD51633.
MGIMGI:1919451. Otud6b.

Phylogenomic databases

eggNOGCOG5539.
HOGENOMHOG000192906.
HOVERGENHBG080227.
InParanoidQ8K2H2.
OrthoDBEOG7WT42W.
TreeFamTF315010.

Gene expression databases

ArrayExpressQ8K2H2.
BgeeQ8K2H2.
CleanExMM_OTUD6B.
GenevestigatorQ8K2H2.

Family and domain databases

InterProIPR003323. OTU.
[Graphical view]
PfamPF02338. OTU. 1 hit.
[Graphical view]
PROSITEPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio335685.
PROQ8K2H2.
SOURCESearch...

Entry information

Entry nameOTU6B_MOUSE
AccessionPrimary (citable) accession number: Q8K2H2
Secondary accession number(s): A2AP24, Q3T9X5, Q3U1R9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot