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Protein

Deubiquitinase OTUD6B

Gene

Otud6b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (By similarity). May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (By similarity). May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (By similarity). May also play a role in proteasome assembly and function (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei156By similarity1
Active sitei159NucleophileBy similarity1
Active sitei278By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Deubiquitinase OTUD6BCurated
Alternative name(s):
OTU domain-containing protein 6BImported (EC:3.4.19.12By similarity)
Gene namesi
Name:Otud6bImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1919451 Otud6b

Pathology & Biotechi

Disruption phenotypei

Mice are sub-viable and die between embryonic day 18.5 and shortly after birth. They show intrauterine growth retardation and a high percentage of ventricular septal cardiac defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000762801 – 294Deubiquitinase OTUD6BAdd BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8K2H2
MaxQBiQ8K2H2
PaxDbiQ8K2H2
PeptideAtlasiQ8K2H2
PRIDEiQ8K2H2

PTM databases

iPTMnetiQ8K2H2
PhosphoSitePlusiQ8K2H2

Expressioni

Tissue specificityi

Ubiquitously expressed. Expression is observed in several organ systems including the cardiovascular, digestive, central and peripheral nervous and musculoskeletal systems.2 Publications

Inductioni

Up-regulated by cytokines but followed by a rapid decline in B lymphocytes.1 Publication

Gene expression databases

CleanExiMM_OTUD6B

Interactioni

Subunit structurei

Interacts with the eukaryotic translation initiation factor 4F complex.By similarity

Protein-protein interaction databases

IntActiQ8K2H2, 1 interactor
MINTiQ8K2H2
STRINGi10090.ENSMUSP00000113553

Structurei

3D structure databases

ProteinModelPortaliQ8K2H2
SMRiQ8K2H2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini148 – 285OTUPROSITE-ProRule annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 159Cys-loopBy similarity7
Regioni220 – 230Variable-loopBy similarityAdd BLAST11
Regioni268 – 278His-loopBy similarityAdd BLAST11

Phylogenomic databases

eggNOGiKOG2606 Eukaryota
COG5539 LUCA
HOGENOMiHOG000192906
HOVERGENiHBG080227
InParanoidiQ8K2H2
KOiK18342
TreeFamiTF315010

Family and domain databases

InterProiView protein in InterPro
IPR003323 OTU_dom
PfamiView protein in Pfam
PF02338 OTU, 1 hit
PROSITEiView protein in PROSITE
PS50802 OTU, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K2H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEVVAEELD DEEQLVRRHR KEKKELQAKI QGMKNAVPKN DKKRRKQLTE
60 70 80 90 100
DVAKLEREME QKHREELEQL KQLTFKDSKI DSVAVNISNL VLENQPPRIS
110 120 130 140 150
KAQKRREKKA ALEKEREERI AEAEIENLSG ARHLESEKLA QILAARELEI
160 170 180 190 200
KQIPSDGHCM YGALEDQLRE QDCALTVASL RRQTAEYMQT HSDDFLPFLT
210 220 230 240 250
NPSTGDMYTP EEFGKYCDDI VNTAAWGGQL ELRALSHILQ TPIEILQADA
260 270 280 290
PPIIVGEEYP RNPLVLVYMR HAYGLGEHYN SVTRLVNSAT ENCS
Length:294
Mass (Da):33,758
Last modified:October 1, 2002 - v1
Checksum:i024FB22EF139F517
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53A → T in BAE33424 (PubMed:16141072).Curated1
Sequence conflicti190T → S in BAE42955 (PubMed:16141072).Curated1
Sequence conflicti190T → S in BAE42895 (PubMed:16141072).Curated1
Sequence conflicti190T → S in BAE38781 (PubMed:16141072).Curated1
Sequence conflicti190T → S in EDL05608 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155761 mRNA Translation: BAE33424.1
AK169134 mRNA Translation: BAE40913.1
AK166445 mRNA Translation: BAE38781.1
AK172229 mRNA Translation: BAE42895.1
AK172338 mRNA Translation: BAE42955.1
AL831792 Genomic DNA No translation available.
CH466538 Genomic DNA Translation: EDL05608.1
BC031474 mRNA Translation: AAH31474.1
BC087552 mRNA Translation: AAH87552.1
RefSeqiNP_690025.2, NM_152812.3
UniGeneiMm.387724

Genome annotation databases

GeneIDi72201
KEGGimmu:72201

Similar proteinsi

Entry informationi

Entry nameiOTU6B_MOUSE
AccessioniPrimary (citable) accession number: Q8K2H2
Secondary accession number(s): A2AP24, Q3T9X5, Q3U1R9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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