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Q8K2H2

- OTU6B_MOUSE

UniProt

Q8K2H2 - OTU6B_MOUSE

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Protein

OTU domain-containing protein 6B

Gene

Otud6b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei156 – 1561By similarity
Active sitei159 – 1591NucleophileBy similarity
Active sitei278 – 2781By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 6B (EC:3.4.19.12)
Gene namesi
Name:Otud6b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1919451. Otud6b.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294OTU domain-containing protein 6BPRO_0000076280Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8K2H2.
PaxDbiQ8K2H2.
PRIDEiQ8K2H2.

PTM databases

PhosphoSiteiQ8K2H2.

Expressioni

Gene expression databases

BgeeiQ8K2H2.
CleanExiMM_OTUD6B.
GenevestigatoriQ8K2H2.

Interactioni

Protein-protein interaction databases

IntActiQ8K2H2. 1 interaction.
MINTiMINT-4117344.
STRINGi10090.ENSMUSP00000113553.

Structurei

3D structure databases

ProteinModelPortaliQ8K2H2.
SMRiQ8K2H2. Positions 139-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini148 – 285138OTUPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni153 – 1597Cys-loopBy similarity
Regioni220 – 23011Variable-loopBy similarityAdd
BLAST
Regioni268 – 27811His-loopBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 OTU domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5539.
HOGENOMiHOG000192906.
HOVERGENiHBG080227.
InParanoidiQ8K2H2.
KOiK18342.
OrthoDBiEOG7WT42W.
TreeFamiTF315010.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K2H2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEVVAEELD DEEQLVRRHR KEKKELQAKI QGMKNAVPKN DKKRRKQLTE
60 70 80 90 100
DVAKLEREME QKHREELEQL KQLTFKDSKI DSVAVNISNL VLENQPPRIS
110 120 130 140 150
KAQKRREKKA ALEKEREERI AEAEIENLSG ARHLESEKLA QILAARELEI
160 170 180 190 200
KQIPSDGHCM YGALEDQLRE QDCALTVASL RRQTAEYMQT HSDDFLPFLT
210 220 230 240 250
NPSTGDMYTP EEFGKYCDDI VNTAAWGGQL ELRALSHILQ TPIEILQADA
260 270 280 290
PPIIVGEEYP RNPLVLVYMR HAYGLGEHYN SVTRLVNSAT ENCS
Length:294
Mass (Da):33,758
Last modified:October 1, 2002 - v1
Checksum:i024FB22EF139F517
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531A → T in BAE33424. (PubMed:16141072)Curated
Sequence conflicti190 – 1901T → S in BAE42955. (PubMed:16141072)Curated
Sequence conflicti190 – 1901T → S in BAE42895. (PubMed:16141072)Curated
Sequence conflicti190 – 1901T → S in BAE38781. (PubMed:16141072)Curated
Sequence conflicti190 – 1901T → S in EDL05608. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155761 mRNA. Translation: BAE33424.1.
AK169134 mRNA. Translation: BAE40913.1.
AK166445 mRNA. Translation: BAE38781.1.
AK172229 mRNA. Translation: BAE42895.1.
AK172338 mRNA. Translation: BAE42955.1.
AL831792 Genomic DNA. No translation available.
CH466538 Genomic DNA. Translation: EDL05608.1.
BC031474 mRNA. Translation: AAH31474.1.
BC087552 mRNA. Translation: AAH87552.1.
RefSeqiNP_690025.2. NM_152812.3.
UniGeneiMm.387724.

Genome annotation databases

GeneIDi72201.
KEGGimmu:72201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155761 mRNA. Translation: BAE33424.1 .
AK169134 mRNA. Translation: BAE40913.1 .
AK166445 mRNA. Translation: BAE38781.1 .
AK172229 mRNA. Translation: BAE42895.1 .
AK172338 mRNA. Translation: BAE42955.1 .
AL831792 Genomic DNA. No translation available.
CH466538 Genomic DNA. Translation: EDL05608.1 .
BC031474 mRNA. Translation: AAH31474.1 .
BC087552 mRNA. Translation: AAH87552.1 .
RefSeqi NP_690025.2. NM_152812.3.
UniGenei Mm.387724.

3D structure databases

ProteinModelPortali Q8K2H2.
SMRi Q8K2H2. Positions 139-285.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8K2H2. 1 interaction.
MINTi MINT-4117344.
STRINGi 10090.ENSMUSP00000113553.

PTM databases

PhosphoSitei Q8K2H2.

Proteomic databases

MaxQBi Q8K2H2.
PaxDbi Q8K2H2.
PRIDEi Q8K2H2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 72201.
KEGGi mmu:72201.

Organism-specific databases

CTDi 51633.
MGIi MGI:1919451. Otud6b.

Phylogenomic databases

eggNOGi COG5539.
HOGENOMi HOG000192906.
HOVERGENi HBG080227.
InParanoidi Q8K2H2.
KOi K18342.
OrthoDBi EOG7WT42W.
TreeFami TF315010.

Miscellaneous databases

NextBioi 335685.
PROi Q8K2H2.
SOURCEi Search...

Gene expression databases

Bgeei Q8K2H2.
CleanExi MM_OTUD6B.
Genevestigatori Q8K2H2.

Family and domain databases

InterProi IPR003323. OTU.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Liver, Mammary gland and Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Embryo and Mammary tumor.

Entry informationi

Entry nameiOTU6B_MOUSE
AccessioniPrimary (citable) accession number: Q8K2H2
Secondary accession number(s): A2AP24, Q3T9X5, Q3U1R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3