Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

OTU domain-containing protein 6B

Gene

Otud6b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei156By similarity1
Active sitei159NucleophileBy similarity1
Active sitei278By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 6B (EC:3.4.19.12)
Gene namesi
Name:Otud6b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1919451. Otud6b.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000762801 – 294OTU domain-containing protein 6BAdd BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8K2H2.
MaxQBiQ8K2H2.
PaxDbiQ8K2H2.
PeptideAtlasiQ8K2H2.
PRIDEiQ8K2H2.

PTM databases

iPTMnetiQ8K2H2.
PhosphoSitePlusiQ8K2H2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040550.
CleanExiMM_OTUD6B.

Interactioni

Protein-protein interaction databases

IntActiQ8K2H2. 1 interactor.
MINTiMINT-4117344.
STRINGi10090.ENSMUSP00000113553.

Structurei

3D structure databases

ProteinModelPortaliQ8K2H2.
SMRiQ8K2H2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini148 – 285OTUPROSITE-ProRule annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 159Cys-loopBy similarity7
Regioni220 – 230Variable-loopBy similarityAdd BLAST11
Regioni268 – 278His-loopBy similarityAdd BLAST11

Sequence similaritiesi

Contains 1 OTU domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2606. Eukaryota.
COG5539. LUCA.
HOGENOMiHOG000192906.
HOVERGENiHBG080227.
InParanoidiQ8K2H2.
KOiK18342.
TreeFamiTF315010.

Family and domain databases

InterProiIPR003323. OTU_dom.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K2H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEVVAEELD DEEQLVRRHR KEKKELQAKI QGMKNAVPKN DKKRRKQLTE
60 70 80 90 100
DVAKLEREME QKHREELEQL KQLTFKDSKI DSVAVNISNL VLENQPPRIS
110 120 130 140 150
KAQKRREKKA ALEKEREERI AEAEIENLSG ARHLESEKLA QILAARELEI
160 170 180 190 200
KQIPSDGHCM YGALEDQLRE QDCALTVASL RRQTAEYMQT HSDDFLPFLT
210 220 230 240 250
NPSTGDMYTP EEFGKYCDDI VNTAAWGGQL ELRALSHILQ TPIEILQADA
260 270 280 290
PPIIVGEEYP RNPLVLVYMR HAYGLGEHYN SVTRLVNSAT ENCS
Length:294
Mass (Da):33,758
Last modified:October 1, 2002 - v1
Checksum:i024FB22EF139F517
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53A → T in BAE33424 (PubMed:16141072).Curated1
Sequence conflicti190T → S in BAE42955 (PubMed:16141072).Curated1
Sequence conflicti190T → S in BAE42895 (PubMed:16141072).Curated1
Sequence conflicti190T → S in BAE38781 (PubMed:16141072).Curated1
Sequence conflicti190T → S in EDL05608 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155761 mRNA. Translation: BAE33424.1.
AK169134 mRNA. Translation: BAE40913.1.
AK166445 mRNA. Translation: BAE38781.1.
AK172229 mRNA. Translation: BAE42895.1.
AK172338 mRNA. Translation: BAE42955.1.
AL831792 Genomic DNA. No translation available.
CH466538 Genomic DNA. Translation: EDL05608.1.
BC031474 mRNA. Translation: AAH31474.1.
BC087552 mRNA. Translation: AAH87552.1.
RefSeqiNP_690025.2. NM_152812.3.
UniGeneiMm.387724.

Genome annotation databases

GeneIDi72201.
KEGGimmu:72201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155761 mRNA. Translation: BAE33424.1.
AK169134 mRNA. Translation: BAE40913.1.
AK166445 mRNA. Translation: BAE38781.1.
AK172229 mRNA. Translation: BAE42895.1.
AK172338 mRNA. Translation: BAE42955.1.
AL831792 Genomic DNA. No translation available.
CH466538 Genomic DNA. Translation: EDL05608.1.
BC031474 mRNA. Translation: AAH31474.1.
BC087552 mRNA. Translation: AAH87552.1.
RefSeqiNP_690025.2. NM_152812.3.
UniGeneiMm.387724.

3D structure databases

ProteinModelPortaliQ8K2H2.
SMRiQ8K2H2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K2H2. 1 interactor.
MINTiMINT-4117344.
STRINGi10090.ENSMUSP00000113553.

PTM databases

iPTMnetiQ8K2H2.
PhosphoSitePlusiQ8K2H2.

Proteomic databases

EPDiQ8K2H2.
MaxQBiQ8K2H2.
PaxDbiQ8K2H2.
PeptideAtlasiQ8K2H2.
PRIDEiQ8K2H2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi72201.
KEGGimmu:72201.

Organism-specific databases

CTDi51633.
MGIiMGI:1919451. Otud6b.

Phylogenomic databases

eggNOGiKOG2606. Eukaryota.
COG5539. LUCA.
HOGENOMiHOG000192906.
HOVERGENiHBG080227.
InParanoidiQ8K2H2.
KOiK18342.
TreeFamiTF315010.

Miscellaneous databases

PROiQ8K2H2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040550.
CleanExiMM_OTUD6B.

Family and domain databases

InterProiIPR003323. OTU_dom.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOTU6B_MOUSE
AccessioniPrimary (citable) accession number: Q8K2H2
Secondary accession number(s): A2AP24, Q3T9X5, Q3U1R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.