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Q8K2H2

- OTU6B_MOUSE

UniProt

Q8K2H2 - OTU6B_MOUSE

Protein

OTU domain-containing protein 6B

Gene

Otud6b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei156 – 1561By similarity
    Active sitei159 – 1591NucleophileBy similarity
    Active sitei278 – 2781By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OTU domain-containing protein 6B (EC:3.4.19.12)
    Gene namesi
    Name:Otud6b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1919451. Otud6b.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294OTU domain-containing protein 6BPRO_0000076280Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8K2H2.
    PaxDbiQ8K2H2.
    PRIDEiQ8K2H2.

    PTM databases

    PhosphoSiteiQ8K2H2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K2H2.
    BgeeiQ8K2H2.
    CleanExiMM_OTUD6B.
    GenevestigatoriQ8K2H2.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8K2H2. 1 interaction.
    MINTiMINT-4117344.
    STRINGi10090.ENSMUSP00000113553.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K2H2.
    SMRiQ8K2H2. Positions 139-285.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini148 – 285138OTUPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni153 – 1597Cys-loopBy similarity
    Regioni220 – 23011Variable-loopBy similarityAdd
    BLAST
    Regioni268 – 27811His-loopBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 OTU domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5539.
    HOGENOMiHOG000192906.
    HOVERGENiHBG080227.
    InParanoidiQ8K2H2.
    KOiK18342.
    OrthoDBiEOG7WT42W.
    TreeFamiTF315010.

    Family and domain databases

    InterProiIPR003323. OTU.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K2H2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEVVAEELD DEEQLVRRHR KEKKELQAKI QGMKNAVPKN DKKRRKQLTE    50
    DVAKLEREME QKHREELEQL KQLTFKDSKI DSVAVNISNL VLENQPPRIS 100
    KAQKRREKKA ALEKEREERI AEAEIENLSG ARHLESEKLA QILAARELEI 150
    KQIPSDGHCM YGALEDQLRE QDCALTVASL RRQTAEYMQT HSDDFLPFLT 200
    NPSTGDMYTP EEFGKYCDDI VNTAAWGGQL ELRALSHILQ TPIEILQADA 250
    PPIIVGEEYP RNPLVLVYMR HAYGLGEHYN SVTRLVNSAT ENCS 294
    Length:294
    Mass (Da):33,758
    Last modified:October 1, 2002 - v1
    Checksum:i024FB22EF139F517
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 531A → T in BAE33424. (PubMed:16141072)Curated
    Sequence conflicti190 – 1901T → S in BAE42955. (PubMed:16141072)Curated
    Sequence conflicti190 – 1901T → S in BAE42895. (PubMed:16141072)Curated
    Sequence conflicti190 – 1901T → S in BAE38781. (PubMed:16141072)Curated
    Sequence conflicti190 – 1901T → S in EDL05608. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK155761 mRNA. Translation: BAE33424.1.
    AK169134 mRNA. Translation: BAE40913.1.
    AK166445 mRNA. Translation: BAE38781.1.
    AK172229 mRNA. Translation: BAE42895.1.
    AK172338 mRNA. Translation: BAE42955.1.
    AL831792 Genomic DNA. No translation available.
    CH466538 Genomic DNA. Translation: EDL05608.1.
    BC031474 mRNA. Translation: AAH31474.1.
    BC087552 mRNA. Translation: AAH87552.1.
    RefSeqiNP_690025.2. NM_152812.3.
    UniGeneiMm.387724.

    Genome annotation databases

    GeneIDi72201.
    KEGGimmu:72201.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK155761 mRNA. Translation: BAE33424.1 .
    AK169134 mRNA. Translation: BAE40913.1 .
    AK166445 mRNA. Translation: BAE38781.1 .
    AK172229 mRNA. Translation: BAE42895.1 .
    AK172338 mRNA. Translation: BAE42955.1 .
    AL831792 Genomic DNA. No translation available.
    CH466538 Genomic DNA. Translation: EDL05608.1 .
    BC031474 mRNA. Translation: AAH31474.1 .
    BC087552 mRNA. Translation: AAH87552.1 .
    RefSeqi NP_690025.2. NM_152812.3.
    UniGenei Mm.387724.

    3D structure databases

    ProteinModelPortali Q8K2H2.
    SMRi Q8K2H2. Positions 139-285.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8K2H2. 1 interaction.
    MINTi MINT-4117344.
    STRINGi 10090.ENSMUSP00000113553.

    PTM databases

    PhosphoSitei Q8K2H2.

    Proteomic databases

    MaxQBi Q8K2H2.
    PaxDbi Q8K2H2.
    PRIDEi Q8K2H2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 72201.
    KEGGi mmu:72201.

    Organism-specific databases

    CTDi 51633.
    MGIi MGI:1919451. Otud6b.

    Phylogenomic databases

    eggNOGi COG5539.
    HOGENOMi HOG000192906.
    HOVERGENi HBG080227.
    InParanoidi Q8K2H2.
    KOi K18342.
    OrthoDBi EOG7WT42W.
    TreeFami TF315010.

    Miscellaneous databases

    NextBioi 335685.
    PROi Q8K2H2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K2H2.
    Bgeei Q8K2H2.
    CleanExi MM_OTUD6B.
    Genevestigatori Q8K2H2.

    Family and domain databases

    InterProi IPR003323. OTU.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Liver, Mammary gland and Spleen.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Embryo and Mammary tumor.

    Entry informationi

    Entry nameiOTU6B_MOUSE
    AccessioniPrimary (citable) accession number: Q8K2H2
    Secondary accession number(s): A2AP24, Q3T9X5, Q3U1R9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3