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Protein

Deoxycytidylate deaminase

Gene

Dctd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Supplies the nucleotide substrate for thymidylate synthetase.By similarity

Catalytic activityi

dCMP + H2O = dUMP + NH3.

Cofactori

Zn2+By similarity

Enzyme regulationi

Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84Zinc; catalyticBy similarity1
Active sitei86Proton donorBy similarity1
Metal bindingi110Zinc; catalyticBy similarity1
Metal bindingi113Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Hydrolase
Biological processNucleotide biosynthesis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidylate deaminase (EC:3.5.4.12)
Alternative name(s):
dCMP deaminase
Gene namesi
Name:Dctd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2444529 Dctd

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001716921 – 178Deoxycytidylate deaminaseAdd BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K2D6
MaxQBiQ8K2D6
PaxDbiQ8K2D6
PRIDEiQ8K2D6

PTM databases

PhosphoSitePlusiQ8K2D6

Expressioni

Gene expression databases

CleanExiMM_DCTD

Interactioni

Subunit structurei

Homohexamer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033966

Structurei

3D structure databases

ProteinModelPortaliQ8K2D6
SMRiQ8K2D6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 145CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST132

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3127 Eukaryota
COG2131 LUCA
HOGENOMiHOG000015715
HOVERGENiHBG025823
InParanoidiQ8K2D6
KOiK01493
PhylomeDBiQ8K2D6

Family and domain databases

CDDicd01286 deoxycytidylate_deaminase, 1 hit
InterProiView protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like
IPR016473 dCMP_deaminase
IPR015517 dCMP_deaminase-rel
IPR035105 Deoxycytidylate_deaminase_dom
PANTHERiPTHR11086 PTHR11086, 1 hit
PfamiView protein in Pfam
PF00383 dCMP_cyt_deam_1, 1 hit
PIRSFiPIRSF006019 dCMP_deaminase, 1 hit
SUPFAMiSSF53927 SSF53927, 1 hit
PROSITEiView protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 1 hit
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K2D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDISCKKRD DYLEWPEYFM AVAFLSAQRS KDPSSQVGAC IVNTENKIVG
60 70 80 90 100
IGYNGMPNGC SDDLLPWRRT AENKLDTKYP YVCHAELNAI MNKNSADVKG
110 120 130 140 150
CSMYVALFPC NECAKLIIQA GIKEVIFMSD KYHDSEETTA ARLLFKLAGV
160 170
TFRKFTPKYS KIVIDFDSIN SRPSQKPQ
Length:178
Mass (Da):20,059
Last modified:October 1, 2002 - v1
Checksum:iA53ED5C676965029
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35S → F in BAC36937 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031645 mRNA Translation: BAC27492.1
AK039066 mRNA Translation: BAC30229.1
AK077663 mRNA Translation: BAC36937.1
BC031719 mRNA Translation: AAH31719.1
RefSeqiNP_001154987.1, NM_001161515.1
NP_001154988.1, NM_001161516.1
NP_848903.2, NM_178788.4
UniGeneiMm.121549

Genome annotation databases

GeneIDi320685
KEGGimmu:320685
UCSCiuc012gdt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDCTD_MOUSE
AccessioniPrimary (citable) accession number: Q8K2D6
Secondary accession number(s): Q8BP55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome