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Protein

Deoxycytidylate deaminase

Gene

Dctd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Supplies the nucleotide substrate for thymidylate synthetase.By similarity

Catalytic activityi

dCMP + H2O = dUMP + NH3.

Cofactori

Zn2+By similarity

Enzyme regulationi

Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84Zinc; catalyticBy similarity1
Active sitei86Proton donorBy similarity1
Metal bindingi110Zinc; catalyticBy similarity1
Metal bindingi113Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidylate deaminase (EC:3.5.4.12)
Alternative name(s):
dCMP deaminase
Gene namesi
Name:Dctd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2444529. Dctd.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001716921 – 178Deoxycytidylate deaminaseAdd BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K2D6.
MaxQBiQ8K2D6.
PaxDbiQ8K2D6.
PRIDEiQ8K2D6.

PTM databases

PhosphoSitePlusiQ8K2D6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031562.
CleanExiMM_DCTD.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033966.

Structurei

3D structure databases

ProteinModelPortaliQ8K2D6.
SMRiQ8K2D6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 145CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST132

Sequence similaritiesi

Contains 1 CMP/dCMP-type deaminase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3127. Eukaryota.
COG2131. LUCA.
HOGENOMiHOG000015715.
HOVERGENiHBG025823.
InParanoidiQ8K2D6.
KOiK01493.
PhylomeDBiQ8K2D6.

Family and domain databases

CDDicd01286. deoxycytidylate_deaminase. 1 hit.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 1 hit.
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K2D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDISCKKRD DYLEWPEYFM AVAFLSAQRS KDPSSQVGAC IVNTENKIVG
60 70 80 90 100
IGYNGMPNGC SDDLLPWRRT AENKLDTKYP YVCHAELNAI MNKNSADVKG
110 120 130 140 150
CSMYVALFPC NECAKLIIQA GIKEVIFMSD KYHDSEETTA ARLLFKLAGV
160 170
TFRKFTPKYS KIVIDFDSIN SRPSQKPQ
Length:178
Mass (Da):20,059
Last modified:October 1, 2002 - v1
Checksum:iA53ED5C676965029
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35S → F in BAC36937 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031645 mRNA. Translation: BAC27492.1.
AK039066 mRNA. Translation: BAC30229.1.
AK077663 mRNA. Translation: BAC36937.1.
BC031719 mRNA. Translation: AAH31719.1.
RefSeqiNP_001154987.1. NM_001161515.1.
NP_001154988.1. NM_001161516.1.
NP_848903.2. NM_178788.4.
UniGeneiMm.121549.

Genome annotation databases

GeneIDi320685.
KEGGimmu:320685.
UCSCiuc012gdt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031645 mRNA. Translation: BAC27492.1.
AK039066 mRNA. Translation: BAC30229.1.
AK077663 mRNA. Translation: BAC36937.1.
BC031719 mRNA. Translation: AAH31719.1.
RefSeqiNP_001154987.1. NM_001161515.1.
NP_001154988.1. NM_001161516.1.
NP_848903.2. NM_178788.4.
UniGeneiMm.121549.

3D structure databases

ProteinModelPortaliQ8K2D6.
SMRiQ8K2D6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033966.

PTM databases

PhosphoSitePlusiQ8K2D6.

Proteomic databases

EPDiQ8K2D6.
MaxQBiQ8K2D6.
PaxDbiQ8K2D6.
PRIDEiQ8K2D6.

Protocols and materials databases

DNASUi320685.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi320685.
KEGGimmu:320685.
UCSCiuc012gdt.1. mouse.

Organism-specific databases

CTDi1635.
MGIiMGI:2444529. Dctd.

Phylogenomic databases

eggNOGiKOG3127. Eukaryota.
COG2131. LUCA.
HOGENOMiHOG000015715.
HOVERGENiHBG025823.
InParanoidiQ8K2D6.
KOiK01493.
PhylomeDBiQ8K2D6.

Miscellaneous databases

ChiTaRSiDctd. mouse.
PROiQ8K2D6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031562.
CleanExiMM_DCTD.

Family and domain databases

CDDicd01286. deoxycytidylate_deaminase. 1 hit.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 1 hit.
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCTD_MOUSE
AccessioniPrimary (citable) accession number: Q8K2D6
Secondary accession number(s): Q8BP55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.