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Q8K2D6

- DCTD_MOUSE

UniProt

Q8K2D6 - DCTD_MOUSE

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Protein
Deoxycytidylate deaminase
Gene
Dctd
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Supplies the nucleotide substrate for thymidylate synthetase By similarity.

Catalytic activityi

dCMP + H2O = dUMP + NH3.

Cofactori

Zinc By similarity.

Enzyme regulationi

Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841Zinc; catalytic By similarity
Active sitei86 – 861Proton donor By similarity
Metal bindingi110 – 1101Zinc; catalytic By similarity
Metal bindingi113 – 1131Zinc; catalytic By similarity

GO - Molecular functioni

  1. dCMP deaminase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. nucleotide biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidylate deaminase (EC:3.5.4.12)
Alternative name(s):
dCMP deaminase
Gene namesi
Name:Dctd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2444529. Dctd.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178Deoxycytidylate deaminase
PRO_0000171692Add
BLAST

Proteomic databases

PRIDEiQ8K2D6.

PTM databases

PhosphoSiteiQ8K2D6.

Expressioni

Gene expression databases

ArrayExpressiQ8K2D6.
BgeeiQ8K2D6.
CleanExiMM_DCTD.
GenevestigatoriQ8K2D6.

Interactioni

Subunit structurei

Homohexamer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8K2D6.
SMRiQ8K2D6. Positions 12-173.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2131.
HOGENOMiHOG000015715.
HOVERGENiHBG025823.
InParanoidiQ8K2D6.
KOiK01493.
PhylomeDBiQ8K2D6.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
IPR015517. dCMP_deaminase-rel.
[Graphical view]
PANTHERiPTHR11086. PTHR11086. 1 hit.
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
PIRSFiPIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K2D6-1 [UniParc]FASTAAdd to Basket

« Hide

MSDISCKKRD DYLEWPEYFM AVAFLSAQRS KDPSSQVGAC IVNTENKIVG    50
IGYNGMPNGC SDDLLPWRRT AENKLDTKYP YVCHAELNAI MNKNSADVKG 100
CSMYVALFPC NECAKLIIQA GIKEVIFMSD KYHDSEETTA ARLLFKLAGV 150
TFRKFTPKYS KIVIDFDSIN SRPSQKPQ 178
Length:178
Mass (Da):20,059
Last modified:October 1, 2002 - v1
Checksum:iA53ED5C676965029
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351S → F in BAC36937. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK031645 mRNA. Translation: BAC27492.1.
AK039066 mRNA. Translation: BAC30229.1.
AK077663 mRNA. Translation: BAC36937.1.
BC031719 mRNA. Translation: AAH31719.1.
RefSeqiNP_001154987.1. NM_001161515.1.
NP_001154988.1. NM_001161516.1.
NP_848903.2. NM_178788.4.
UniGeneiMm.121549.

Genome annotation databases

GeneIDi320685.
KEGGimmu:320685.
UCSCiuc012gdt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK031645 mRNA. Translation: BAC27492.1 .
AK039066 mRNA. Translation: BAC30229.1 .
AK077663 mRNA. Translation: BAC36937.1 .
BC031719 mRNA. Translation: AAH31719.1 .
RefSeqi NP_001154987.1. NM_001161515.1.
NP_001154988.1. NM_001161516.1.
NP_848903.2. NM_178788.4.
UniGenei Mm.121549.

3D structure databases

ProteinModelPortali Q8K2D6.
SMRi Q8K2D6. Positions 12-173.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8K2D6.

Proteomic databases

PRIDEi Q8K2D6.

Protocols and materials databases

DNASUi 320685.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 320685.
KEGGi mmu:320685.
UCSCi uc012gdt.1. mouse.

Organism-specific databases

CTDi 1635.
MGIi MGI:2444529. Dctd.

Phylogenomic databases

eggNOGi COG2131.
HOGENOMi HOG000015715.
HOVERGENi HBG025823.
InParanoidi Q8K2D6.
KOi K01493.
PhylomeDBi Q8K2D6.

Miscellaneous databases

ChiTaRSi DCTD. mouse.
NextBioi 397213.
PROi Q8K2D6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8K2D6.
Bgeei Q8K2D6.
CleanExi MM_DCTD.
Genevestigatori Q8K2D6.

Family and domain databases

InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
IPR015517. dCMP_deaminase-rel.
[Graphical view ]
PANTHERi PTHR11086. PTHR11086. 1 hit.
Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMi SSF53927. SSF53927. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hypothalamus and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiDCTD_MOUSE
AccessioniPrimary (citable) accession number: Q8K2D6
Secondary accession number(s): Q8BP55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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