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Q8K2D3

- EDC3_MOUSE

UniProt

Q8K2D3 - EDC3_MOUSE

Protein

Enhancer of mRNA-decapping protein 3

Gene

Edc3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Binds single-stranded RNA. In the process of mRNA degradation, may play a role in mRNA decapping By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Enhancer of mRNA-decapping protein 3
    Alternative name(s):
    YjeF domain-containing protein 1
    Gene namesi
    Name:Edc3
    Synonyms:Yjdc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2142951. Edc3.

    Subcellular locationi

    CytoplasmP-body By similarity
    Note: Processing bodies (PB).By similarity

    GO - Cellular componenti

    1. cytoplasmic mRNA processing body Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508Enhancer of mRNA-decapping protein 3PRO_0000119056Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei131 – 1311Phosphoserine1 Publication
    Modified residuei138 – 1381PhosphoserineBy similarity
    Modified residuei140 – 1401PhosphoserineBy similarity
    Modified residuei161 – 1611PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8K2D3.
    PaxDbiQ8K2D3.
    PRIDEiQ8K2D3.

    PTM databases

    PhosphoSiteiQ8K2D3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K2D3.
    BgeeiQ8K2D3.
    GenevestigatoriQ8K2D3.

    Interactioni

    Subunit structurei

    Homodimer (via YjeF N-terminal domain). Forms a complex with DCP1A, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with DCP1A and DDX6. Interacts with ZFP36 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi237268. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K2D3.
    SMRiQ8K2D3. Positions 4-74, 197-226, 258-507.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini192 – 22837DFDFPROSITE-ProRule annotationAdd
    BLAST
    Domaini283 – 487205YjeF N-terminalPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 7979Required for P-body targeting and interaction with DCP1ABy similarityAdd
    BLAST
    Regioni191 – 296106Required for interaction with DDX6By similarityAdd
    BLAST

    Domaini

    The DFDF domain is unstructured by itself. It assumes a helical fold upon interaction with DDX6 By similarity.By similarity

    Sequence similaritiesi

    Belongs to the EDC3 family.Curated
    Contains 1 DFDF domain.PROSITE-ProRule annotation
    Contains 1 YjeF N-terminal domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG271303.
    GeneTreeiENSGT00390000016435.
    HOGENOMiHOG000231481.
    HOVERGENiHBG079428.
    InParanoidiQ8K2D3.
    KOiK12615.
    OMAiPEVTFRA.
    OrthoDBiEOG7H793B.
    PhylomeDBiQ8K2D3.
    TreeFamiTF324695.

    Family and domain databases

    Gene3Di3.40.50.10260. 1 hit.
    InterProiIPR025762. DFDF.
    IPR019050. FDF_dom.
    IPR025609. Lsm14_N.
    IPR004443. YjeF_N_dom.
    [Graphical view]
    PfamiPF09532. FDF. 1 hit.
    PF12701. LSM14. 1 hit.
    PF03853. YjeF_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF64153. SSF64153. 1 hit.
    PROSITEiPS51512. DFDF. 1 hit.
    PS51385. YJEF_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K2D3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMDWLGSIV SINCGDSLGV YQGRVSAVDQ VSQTISLTRP FHNGVKCLVP    50
    EVTFRAGDIT ELKILEIPGP GDNQQVGDLH QTELGPSGVG YQMSISQNGT 100
    GKVVKKPASS SSAPQSIPKR TDVKSQDVAI SPQQQQCSKS YVDRHMESLS 150
    QSKSFRRRHN SWSSSSRHPN QATPKKSGLK NGQMKNKDDE CFGDDIEELP 200
    DTDFDFEGNL ALFDKAAVFE EIDTYERRSG SRSRGVPNER PARYRHDENI 250
    LESEPIVYRR ITVPHSVSKE FCTDSGLVVP SVSYELHKKL LSVAEKHGLT 300
    LERRLEMTGV CASQMALTLL GGPNRLNPKN VHQRPTVALL CGPHVKGAQG 350
    ISCGRHLANH DVQVILFLPN FVKMLESITN ELSLFSKTQG QQVSSLRDLP 400
    ASPVDLVINC LDCPENAFLR DQPWYKAAVA WANQNRAPVL SIDPPVHEVE 450
    QGIDAKWSLA LGLPLPLGEH AGRVYLCDIG IPQQVFQEVG INYHSPFGCK 500
    FVIPLHSA 508
    Length:508
    Mass (Da):55,957
    Last modified:October 1, 2002 - v1
    Checksum:iDD1F449BEF1341C8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti237 – 2371P → T in BAE40089. (PubMed:16141072)Curated
    Sequence conflicti333 – 3331Q → R in BAE40089. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK146804 mRNA. Translation: BAE27445.1.
    AK166286 mRNA. Translation: BAE38683.1.
    AK168118 mRNA. Translation: BAE40089.1.
    BC031725 mRNA. Translation: AAH31725.1.
    BC033484 mRNA. Translation: AAH33484.1.
    CCDSiCCDS23231.1.
    RefSeqiNP_722494.1. NM_153799.3.
    UniGeneiMm.268104.

    Genome annotation databases

    EnsembliENSMUST00000043990; ENSMUSP00000049146; ENSMUSG00000038957.
    GeneIDi353190.
    KEGGimmu:353190.
    UCSCiuc009pvp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK146804 mRNA. Translation: BAE27445.1 .
    AK166286 mRNA. Translation: BAE38683.1 .
    AK168118 mRNA. Translation: BAE40089.1 .
    BC031725 mRNA. Translation: AAH31725.1 .
    BC033484 mRNA. Translation: AAH33484.1 .
    CCDSi CCDS23231.1.
    RefSeqi NP_722494.1. NM_153799.3.
    UniGenei Mm.268104.

    3D structure databases

    ProteinModelPortali Q8K2D3.
    SMRi Q8K2D3. Positions 4-74, 197-226, 258-507.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 237268. 1 interaction.

    PTM databases

    PhosphoSitei Q8K2D3.

    Proteomic databases

    MaxQBi Q8K2D3.
    PaxDbi Q8K2D3.
    PRIDEi Q8K2D3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043990 ; ENSMUSP00000049146 ; ENSMUSG00000038957 .
    GeneIDi 353190.
    KEGGi mmu:353190.
    UCSCi uc009pvp.1. mouse.

    Organism-specific databases

    CTDi 80153.
    MGIi MGI:2142951. Edc3.

    Phylogenomic databases

    eggNOGi NOG271303.
    GeneTreei ENSGT00390000016435.
    HOGENOMi HOG000231481.
    HOVERGENi HBG079428.
    InParanoidi Q8K2D3.
    KOi K12615.
    OMAi PEVTFRA.
    OrthoDBi EOG7H793B.
    PhylomeDBi Q8K2D3.
    TreeFami TF324695.

    Miscellaneous databases

    ChiTaRSi EDC3. mouse.
    NextBioi 400339.
    PROi Q8K2D3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K2D3.
    Bgeei Q8K2D3.
    Genevestigatori Q8K2D3.

    Family and domain databases

    Gene3Di 3.40.50.10260. 1 hit.
    InterProi IPR025762. DFDF.
    IPR019050. FDF_dom.
    IPR025609. Lsm14_N.
    IPR004443. YjeF_N_dom.
    [Graphical view ]
    Pfami PF09532. FDF. 1 hit.
    PF12701. LSM14. 1 hit.
    PF03853. YjeF_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64153. SSF64153. 1 hit.
    PROSITEi PS51512. DFDF. 1 hit.
    PS51385. YJEF_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and DBA/2.
      Tissue: Mammary gland and Stomach.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II and FVB/N.
      Tissue: Mammary tumor.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiEDC3_MOUSE
    AccessioniPrimary (citable) accession number: Q8K2D3
    Secondary accession number(s): Q3THV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3