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Q8K2D3

- EDC3_MOUSE

UniProt

Q8K2D3 - EDC3_MOUSE

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Protein
Enhancer of mRNA-decapping protein 3
Gene
Edc3, Yjdc
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Binds single-stranded RNA. In the process of mRNA degradation, may play a role in mRNA decapping By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of mRNA-decapping protein 3
Alternative name(s):
YjeF domain-containing protein 1
Gene namesi
Name:Edc3
Synonyms:Yjdc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2142951. Edc3.

Subcellular locationi

CytoplasmP-body By similarity
Note: Processing bodies (PB) By similarity.

GO - Cellular componenti

  1. cytoplasmic mRNA processing body Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Enhancer of mRNA-decapping protein 3
PRO_0000119056Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei131 – 1311Phosphoserine1 Publication
Modified residuei138 – 1381Phosphoserine By similarity
Modified residuei140 – 1401Phosphoserine By similarity
Modified residuei161 – 1611Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8K2D3.
PaxDbiQ8K2D3.
PRIDEiQ8K2D3.

PTM databases

PhosphoSiteiQ8K2D3.

Expressioni

Gene expression databases

ArrayExpressiQ8K2D3.
BgeeiQ8K2D3.
GenevestigatoriQ8K2D3.

Interactioni

Subunit structurei

Homodimer (via YjeF N-terminal domain). Forms a complex with DCP1A, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with DCP1A and DDX6. Interacts with ZFP36 By similarity.

Protein-protein interaction databases

BioGridi237268. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8K2D3.
SMRiQ8K2D3. Positions 4-74, 197-226, 258-507.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini192 – 22837DFDF
Add
BLAST
Domaini283 – 487205YjeF N-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7979Required for P-body targeting and interaction with DCP1A By similarity
Add
BLAST
Regioni191 – 296106Required for interaction with DDX6 By similarity
Add
BLAST

Domaini

The DFDF domain is unstructured by itself. It assumes a helical fold upon interaction with DDX6 By similarity.

Sequence similaritiesi

Belongs to the EDC3 family.
Contains 1 DFDF domain.

Phylogenomic databases

eggNOGiNOG271303.
GeneTreeiENSGT00390000016435.
HOGENOMiHOG000231481.
HOVERGENiHBG079428.
InParanoidiQ8K2D3.
KOiK12615.
OMAiPEVTFRA.
OrthoDBiEOG7H793B.
PhylomeDBiQ8K2D3.
TreeFamiTF324695.

Family and domain databases

Gene3Di3.40.50.10260. 1 hit.
InterProiIPR025762. DFDF.
IPR019050. FDF_dom.
IPR025609. Lsm14_N.
IPR004443. YjeF_N_dom.
[Graphical view]
PfamiPF09532. FDF. 1 hit.
PF12701. LSM14. 1 hit.
PF03853. YjeF_N. 1 hit.
[Graphical view]
SUPFAMiSSF64153. SSF64153. 1 hit.
PROSITEiPS51512. DFDF. 1 hit.
PS51385. YJEF_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K2D3-1 [UniParc]FASTAAdd to Basket

« Hide

MAMDWLGSIV SINCGDSLGV YQGRVSAVDQ VSQTISLTRP FHNGVKCLVP    50
EVTFRAGDIT ELKILEIPGP GDNQQVGDLH QTELGPSGVG YQMSISQNGT 100
GKVVKKPASS SSAPQSIPKR TDVKSQDVAI SPQQQQCSKS YVDRHMESLS 150
QSKSFRRRHN SWSSSSRHPN QATPKKSGLK NGQMKNKDDE CFGDDIEELP 200
DTDFDFEGNL ALFDKAAVFE EIDTYERRSG SRSRGVPNER PARYRHDENI 250
LESEPIVYRR ITVPHSVSKE FCTDSGLVVP SVSYELHKKL LSVAEKHGLT 300
LERRLEMTGV CASQMALTLL GGPNRLNPKN VHQRPTVALL CGPHVKGAQG 350
ISCGRHLANH DVQVILFLPN FVKMLESITN ELSLFSKTQG QQVSSLRDLP 400
ASPVDLVINC LDCPENAFLR DQPWYKAAVA WANQNRAPVL SIDPPVHEVE 450
QGIDAKWSLA LGLPLPLGEH AGRVYLCDIG IPQQVFQEVG INYHSPFGCK 500
FVIPLHSA 508
Length:508
Mass (Da):55,957
Last modified:October 1, 2002 - v1
Checksum:iDD1F449BEF1341C8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti237 – 2371P → T in BAE40089. 1 Publication
Sequence conflicti333 – 3331Q → R in BAE40089. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK146804 mRNA. Translation: BAE27445.1.
AK166286 mRNA. Translation: BAE38683.1.
AK168118 mRNA. Translation: BAE40089.1.
BC031725 mRNA. Translation: AAH31725.1.
BC033484 mRNA. Translation: AAH33484.1.
CCDSiCCDS23231.1.
RefSeqiNP_722494.1. NM_153799.3.
UniGeneiMm.268104.

Genome annotation databases

EnsembliENSMUST00000043990; ENSMUSP00000049146; ENSMUSG00000038957.
GeneIDi353190.
KEGGimmu:353190.
UCSCiuc009pvp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK146804 mRNA. Translation: BAE27445.1 .
AK166286 mRNA. Translation: BAE38683.1 .
AK168118 mRNA. Translation: BAE40089.1 .
BC031725 mRNA. Translation: AAH31725.1 .
BC033484 mRNA. Translation: AAH33484.1 .
CCDSi CCDS23231.1.
RefSeqi NP_722494.1. NM_153799.3.
UniGenei Mm.268104.

3D structure databases

ProteinModelPortali Q8K2D3.
SMRi Q8K2D3. Positions 4-74, 197-226, 258-507.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 237268. 1 interaction.

PTM databases

PhosphoSitei Q8K2D3.

Proteomic databases

MaxQBi Q8K2D3.
PaxDbi Q8K2D3.
PRIDEi Q8K2D3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043990 ; ENSMUSP00000049146 ; ENSMUSG00000038957 .
GeneIDi 353190.
KEGGi mmu:353190.
UCSCi uc009pvp.1. mouse.

Organism-specific databases

CTDi 80153.
MGIi MGI:2142951. Edc3.

Phylogenomic databases

eggNOGi NOG271303.
GeneTreei ENSGT00390000016435.
HOGENOMi HOG000231481.
HOVERGENi HBG079428.
InParanoidi Q8K2D3.
KOi K12615.
OMAi PEVTFRA.
OrthoDBi EOG7H793B.
PhylomeDBi Q8K2D3.
TreeFami TF324695.

Miscellaneous databases

ChiTaRSi EDC3. mouse.
NextBioi 400339.
PROi Q8K2D3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8K2D3.
Bgeei Q8K2D3.
Genevestigatori Q8K2D3.

Family and domain databases

Gene3Di 3.40.50.10260. 1 hit.
InterProi IPR025762. DFDF.
IPR019050. FDF_dom.
IPR025609. Lsm14_N.
IPR004443. YjeF_N_dom.
[Graphical view ]
Pfami PF09532. FDF. 1 hit.
PF12701. LSM14. 1 hit.
PF03853. YjeF_N. 1 hit.
[Graphical view ]
SUPFAMi SSF64153. SSF64153. 1 hit.
PROSITEi PS51512. DFDF. 1 hit.
PS51385. YJEF_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and DBA/2.
    Tissue: Mammary gland and Stomach.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiEDC3_MOUSE
AccessioniPrimary (citable) accession number: Q8K2D3
Secondary accession number(s): Q3THV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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