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Protein

Enhancer of mRNA-decapping protein 3

Gene

Edc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-430039. mRNA decay by 5' to 3' exoribonuclease.

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of mRNA-decapping protein 3
Alternative name(s):
YjeF domain-containing protein 1
Gene namesi
Name:Edc3
Synonyms:Yjdc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2142951. Edc3.

Subcellular locationi

  • CytoplasmP-body By similarity

  • Note: Processing bodies (PB).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190561 – 508Enhancer of mRNA-decapping protein 3Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131PhosphoserineCombined sources1
Modified residuei138PhosphoserineBy similarity1
Modified residuei140PhosphoserineBy similarity1
Modified residuei161PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K2D3.
MaxQBiQ8K2D3.
PaxDbiQ8K2D3.
PRIDEiQ8K2D3.

PTM databases

iPTMnetiQ8K2D3.
PhosphoSitePlusiQ8K2D3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038957.
ExpressionAtlasiQ8K2D3. baseline and differential.
GenevisibleiQ8K2D3. MM.

Interactioni

Subunit structurei

Homodimer (via YjeF N-terminal domain). Forms a complex with DCP1A, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with DCP1A and DDX6. Interacts with ZFP36 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi237268. 1 interactor.
STRINGi10090.ENSMUSP00000049146.

Structurei

3D structure databases

ProteinModelPortaliQ8K2D3.
SMRiQ8K2D3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 228DFDFPROSITE-ProRule annotationAdd BLAST37
Domaini283 – 487YjeF N-terminalPROSITE-ProRule annotationAdd BLAST205

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 79Required for P-body targeting and interaction with DCP1ABy similarityAdd BLAST79
Regioni191 – 296Required for interaction with DDX6By similarityAdd BLAST106

Domaini

The DFDF domain is unstructured by itself. It assumes a helical fold upon interaction with DDX6 (By similarity).By similarity

Sequence similaritiesi

Belongs to the EDC3 family.Curated
Contains 1 DFDF domain.PROSITE-ProRule annotation
Contains 1 YjeF N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2585. Eukaryota.
COG0062. LUCA.
GeneTreeiENSGT00390000016435.
HOGENOMiHOG000231481.
HOVERGENiHBG079428.
InParanoidiQ8K2D3.
KOiK12615.
OMAiNQHFGDL.
OrthoDBiEOG091G09C2.
PhylomeDBiQ8K2D3.
TreeFamiTF324695.

Family and domain databases

Gene3Di3.40.50.10260. 1 hit.
InterProiIPR025762. DFDF.
IPR019050. FDF_dom.
IPR025609. Lsm14_N.
IPR004443. YjeF_N_dom.
[Graphical view]
PfamiPF09532. FDF. 1 hit.
PF12701. LSM14. 1 hit.
PF03853. YjeF_N. 1 hit.
[Graphical view]
SMARTiSM01199. FDF. 1 hit.
SM01271. LSM14. 1 hit.
[Graphical view]
SUPFAMiSSF64153. SSF64153. 1 hit.
PROSITEiPS51512. DFDF. 1 hit.
PS51385. YJEF_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K2D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMDWLGSIV SINCGDSLGV YQGRVSAVDQ VSQTISLTRP FHNGVKCLVP
60 70 80 90 100
EVTFRAGDIT ELKILEIPGP GDNQQVGDLH QTELGPSGVG YQMSISQNGT
110 120 130 140 150
GKVVKKPASS SSAPQSIPKR TDVKSQDVAI SPQQQQCSKS YVDRHMESLS
160 170 180 190 200
QSKSFRRRHN SWSSSSRHPN QATPKKSGLK NGQMKNKDDE CFGDDIEELP
210 220 230 240 250
DTDFDFEGNL ALFDKAAVFE EIDTYERRSG SRSRGVPNER PARYRHDENI
260 270 280 290 300
LESEPIVYRR ITVPHSVSKE FCTDSGLVVP SVSYELHKKL LSVAEKHGLT
310 320 330 340 350
LERRLEMTGV CASQMALTLL GGPNRLNPKN VHQRPTVALL CGPHVKGAQG
360 370 380 390 400
ISCGRHLANH DVQVILFLPN FVKMLESITN ELSLFSKTQG QQVSSLRDLP
410 420 430 440 450
ASPVDLVINC LDCPENAFLR DQPWYKAAVA WANQNRAPVL SIDPPVHEVE
460 470 480 490 500
QGIDAKWSLA LGLPLPLGEH AGRVYLCDIG IPQQVFQEVG INYHSPFGCK

FVIPLHSA
Length:508
Mass (Da):55,957
Last modified:October 1, 2002 - v1
Checksum:iDD1F449BEF1341C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti237P → T in BAE40089 (PubMed:16141072).Curated1
Sequence conflicti333Q → R in BAE40089 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146804 mRNA. Translation: BAE27445.1.
AK166286 mRNA. Translation: BAE38683.1.
AK168118 mRNA. Translation: BAE40089.1.
BC031725 mRNA. Translation: AAH31725.1.
BC033484 mRNA. Translation: AAH33484.1.
CCDSiCCDS23231.1.
RefSeqiNP_722494.1. NM_153799.3.
XP_011241062.1. XM_011242760.2.
UniGeneiMm.268104.

Genome annotation databases

EnsembliENSMUST00000043990; ENSMUSP00000049146; ENSMUSG00000038957.
GeneIDi353190.
KEGGimmu:353190.
UCSCiuc009pvp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146804 mRNA. Translation: BAE27445.1.
AK166286 mRNA. Translation: BAE38683.1.
AK168118 mRNA. Translation: BAE40089.1.
BC031725 mRNA. Translation: AAH31725.1.
BC033484 mRNA. Translation: AAH33484.1.
CCDSiCCDS23231.1.
RefSeqiNP_722494.1. NM_153799.3.
XP_011241062.1. XM_011242760.2.
UniGeneiMm.268104.

3D structure databases

ProteinModelPortaliQ8K2D3.
SMRiQ8K2D3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi237268. 1 interactor.
STRINGi10090.ENSMUSP00000049146.

PTM databases

iPTMnetiQ8K2D3.
PhosphoSitePlusiQ8K2D3.

Proteomic databases

EPDiQ8K2D3.
MaxQBiQ8K2D3.
PaxDbiQ8K2D3.
PRIDEiQ8K2D3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043990; ENSMUSP00000049146; ENSMUSG00000038957.
GeneIDi353190.
KEGGimmu:353190.
UCSCiuc009pvp.1. mouse.

Organism-specific databases

CTDi80153.
MGIiMGI:2142951. Edc3.

Phylogenomic databases

eggNOGiKOG2585. Eukaryota.
COG0062. LUCA.
GeneTreeiENSGT00390000016435.
HOGENOMiHOG000231481.
HOVERGENiHBG079428.
InParanoidiQ8K2D3.
KOiK12615.
OMAiNQHFGDL.
OrthoDBiEOG091G09C2.
PhylomeDBiQ8K2D3.
TreeFamiTF324695.

Enzyme and pathway databases

ReactomeiR-MMU-430039. mRNA decay by 5' to 3' exoribonuclease.

Miscellaneous databases

ChiTaRSiEdc3. mouse.
PROiQ8K2D3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038957.
ExpressionAtlasiQ8K2D3. baseline and differential.
GenevisibleiQ8K2D3. MM.

Family and domain databases

Gene3Di3.40.50.10260. 1 hit.
InterProiIPR025762. DFDF.
IPR019050. FDF_dom.
IPR025609. Lsm14_N.
IPR004443. YjeF_N_dom.
[Graphical view]
PfamiPF09532. FDF. 1 hit.
PF12701. LSM14. 1 hit.
PF03853. YjeF_N. 1 hit.
[Graphical view]
SMARTiSM01199. FDF. 1 hit.
SM01271. LSM14. 1 hit.
[Graphical view]
SUPFAMiSSF64153. SSF64153. 1 hit.
PROSITEiPS51512. DFDF. 1 hit.
PS51385. YJEF_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEDC3_MOUSE
AccessioniPrimary (citable) accession number: Q8K2D3
Secondary accession number(s): Q3THV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.