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Protein

Lipase member M

Gene

Lipm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei186NucleophileBy similarity1
Active sitei357Charge relay systemPROSITE-ProRule annotation1
Active sitei386Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-6809371 Formation of the cornified envelope

Protein family/group databases

ESTHERimouse-LIPM Acidic_Lipase
MEROPSiS33.A58

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase member M (EC:3.1.1.-)
Alternative name(s):
Lipase-like abhydrolase domain-containing protein 3
Gene namesi
Name:Lipm
Synonyms:Lipl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1926003 Lipm

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000028683034 – 422Lipase member MAdd BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi260 ↔ 269By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8K2A6
PRIDEiQ8K2A6

PTM databases

iPTMnetiQ8K2A6
PhosphoSitePlusiQ8K2A6

Expressioni

Gene expression databases

BgeeiENSMUSG00000056078
CleanExiMM_LIPM
GenevisibleiQ8K2A6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025685

Structurei

3D structure databases

ProteinModelPortaliQ8K2A6
SMRiQ8K2A6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 392AB hydrolase-1Sequence analysisAdd BLAST301

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2624 Eukaryota
COG0596 LUCA
GeneTreeiENSGT00550000074328
HOGENOMiHOG000240694
HOVERGENiHBG006265
InParanoidiQ8K2A6
KOiK19406
OMAiPEWAHVD
OrthoDBiEOG091G09AX
PhylomeDBiQ8K2A6
TreeFamiTF315485

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR025483 Lipase_euk
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PIRSFiPIRSF000862 Steryl_ester_lip, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K2A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEILSRVWT VSHRVEIWLL ILVAYLLQRN VNSGHLPTKA ADPEAFMNVS
60 70 80 90 100
EIIKHKGYPS EEYEVATEDG YILSVNRIPR GQTRLKKEGS RPVVLLQHGL
110 120 130 140 150
LGDASNWISN LPNNSLGFIL ADAGFDVWMG NSRGNTWSRK HKTLSIDQDE
160 170 180 190 200
FWAFSYDEMA RFDLPAVINF ILQKTGQKKV YYVGYSQGTT MGFIAFSTMP
210 220 230 240 250
ELAHKIKMYF ALAPIATVKY ARSPGTKFLL LPDMMIKVLF GRQEFLYQTR
260 270 280 290 300
FFRQLFIYLC GQMILDQICS NIILLLGGFN TNNMNMSRAN VYVAHTPAGT
310 320 330 340 350
SVQNILHWSQ AVNSGELRAF DWGSETKNQE KCNQPTPIRY KVRDMMVPTA
360 370 380 390 400
MWTGGQDWLS NPDDVKTLLS EVTNLIYHKN IPEWAHVDFI WGLDAPQRVY
410 420
NEIIHLMKQE PNLPQGTCRV KL
Length:422
Mass (Da):48,254
Last modified:October 1, 2002 - v1
Checksum:iC6EFBC140963E051
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72I → F in BAC29757 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037091 mRNA Translation: BAC29699.1
AK037214 mRNA Translation: BAC29757.1
AK085719 mRNA Translation: BAC39517.1
BC031933 mRNA Translation: AAH31933.1
CCDSiCCDS50419.1
RefSeqiNP_076392.1, NM_023903.1
XP_006527529.1, XM_006527466.3
UniGeneiMm.195937

Genome annotation databases

EnsembliENSMUST00000025685; ENSMUSP00000025685; ENSMUSG00000056078
GeneIDi78753
KEGGimmu:78753
UCSCiuc008hga.2 mouse

Similar proteinsi

Entry informationi

Entry nameiLIPM_MOUSE
AccessioniPrimary (citable) accession number: Q8K2A6
Secondary accession number(s): Q8BJ28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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