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Protein

Lipase member M

Gene

Lipm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei186 – 1861NucleophileBy similarity
Active sitei357 – 3571Charge relay systemPROSITE-ProRule annotation
Active sitei386 – 3861Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-192456. Digestion of dietary lipid.

Protein family/group databases

ESTHERimouse-LIPM. Acidic_Lipase.
MEROPSiS33.A58.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase member M (EC:3.1.1.-)
Alternative name(s):
Lipase-like abhydrolase domain-containing protein 3
Gene namesi
Name:Lipm
Synonyms:Lipl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1926003. Lipm.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 422389Lipase member MPRO_0000286830Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence analysis
Disulfide bondi260 ↔ 269By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8K2A6.
PRIDEiQ8K2A6.

PTM databases

iPTMnetiQ8K2A6.
PhosphoSiteiQ8K2A6.

Expressioni

Gene expression databases

BgeeiQ8K2A6.
CleanExiMM_LIPM.
GenevisibleiQ8K2A6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025685.

Structurei

3D structure databases

ProteinModelPortaliQ8K2A6.
SMRiQ8K2A6. Positions 42-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00550000074328.
HOGENOMiHOG000240694.
HOVERGENiHBG006265.
InParanoidiQ8K2A6.
KOiK19406.
OMAiMPREESK.
OrthoDBiEOG71RXJN.
PhylomeDBiQ8K2A6.
TreeFamiTF315485.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K2A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEILSRVWT VSHRVEIWLL ILVAYLLQRN VNSGHLPTKA ADPEAFMNVS
60 70 80 90 100
EIIKHKGYPS EEYEVATEDG YILSVNRIPR GQTRLKKEGS RPVVLLQHGL
110 120 130 140 150
LGDASNWISN LPNNSLGFIL ADAGFDVWMG NSRGNTWSRK HKTLSIDQDE
160 170 180 190 200
FWAFSYDEMA RFDLPAVINF ILQKTGQKKV YYVGYSQGTT MGFIAFSTMP
210 220 230 240 250
ELAHKIKMYF ALAPIATVKY ARSPGTKFLL LPDMMIKVLF GRQEFLYQTR
260 270 280 290 300
FFRQLFIYLC GQMILDQICS NIILLLGGFN TNNMNMSRAN VYVAHTPAGT
310 320 330 340 350
SVQNILHWSQ AVNSGELRAF DWGSETKNQE KCNQPTPIRY KVRDMMVPTA
360 370 380 390 400
MWTGGQDWLS NPDDVKTLLS EVTNLIYHKN IPEWAHVDFI WGLDAPQRVY
410 420
NEIIHLMKQE PNLPQGTCRV KL
Length:422
Mass (Da):48,254
Last modified:October 1, 2002 - v1
Checksum:iC6EFBC140963E051
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti72 – 721I → F in BAC29757 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037091 mRNA. Translation: BAC29699.1.
AK037214 mRNA. Translation: BAC29757.1.
AK085719 mRNA. Translation: BAC39517.1.
BC031933 mRNA. Translation: AAH31933.1.
CCDSiCCDS50419.1.
RefSeqiNP_076392.1. NM_023903.1.
XP_006527529.1. XM_006527466.2.
UniGeneiMm.195937.

Genome annotation databases

EnsembliENSMUST00000025685; ENSMUSP00000025685; ENSMUSG00000056078.
GeneIDi78753.
KEGGimmu:78753.
UCSCiuc008hga.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037091 mRNA. Translation: BAC29699.1.
AK037214 mRNA. Translation: BAC29757.1.
AK085719 mRNA. Translation: BAC39517.1.
BC031933 mRNA. Translation: AAH31933.1.
CCDSiCCDS50419.1.
RefSeqiNP_076392.1. NM_023903.1.
XP_006527529.1. XM_006527466.2.
UniGeneiMm.195937.

3D structure databases

ProteinModelPortaliQ8K2A6.
SMRiQ8K2A6. Positions 42-407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025685.

Protein family/group databases

ESTHERimouse-LIPM. Acidic_Lipase.
MEROPSiS33.A58.

PTM databases

iPTMnetiQ8K2A6.
PhosphoSiteiQ8K2A6.

Proteomic databases

PaxDbiQ8K2A6.
PRIDEiQ8K2A6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025685; ENSMUSP00000025685; ENSMUSG00000056078.
GeneIDi78753.
KEGGimmu:78753.
UCSCiuc008hga.2. mouse.

Organism-specific databases

CTDi340654.
MGIiMGI:1926003. Lipm.

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00550000074328.
HOGENOMiHOG000240694.
HOVERGENiHBG006265.
InParanoidiQ8K2A6.
KOiK19406.
OMAiMPREESK.
OrthoDBiEOG71RXJN.
PhylomeDBiQ8K2A6.
TreeFamiTF315485.

Enzyme and pathway databases

ReactomeiR-MMU-192456. Digestion of dietary lipid.

Miscellaneous databases

PROiQ8K2A6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K2A6.
CleanExiMM_LIPM.
GenevisibleiQ8K2A6. MM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland, Neonatal skin and Vagina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiLIPM_MOUSE
AccessioniPrimary (citable) accession number: Q8K2A6
Secondary accession number(s): Q8BJ28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.