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Protein

Anillin

Gene

Anln

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Anillin
Gene namesi
Name:Anln
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1920174 Anln

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002279661 – 1121AnillinAdd BLAST1121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei73PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Modified residuei192PhosphothreonineCombined sources1
Modified residuei223PhosphoserineBy similarity1
Modified residuei250PhosphoserineBy similarity1
Modified residuei259PhosphoserineCombined sources1
Modified residuei316PhosphothreonineBy similarity1
Modified residuei318PhosphoserineBy similarity1
Modified residuei334PhosphoserineBy similarity1
Modified residuei359PhosphothreonineBy similarity1
Modified residuei366N6-acetyllysineBy similarity1
Modified residuei392PhosphothreonineBy similarity1
Modified residuei396PhosphothreonineBy similarity1
Modified residuei414PhosphoserineBy similarity1
Modified residuei444PhosphoserineBy similarity1
Modified residuei513PhosphoserineBy similarity1
Modified residuei548PhosphoserineCombined sources1
Modified residuei556PhosphoserineBy similarity1
Modified residuei637PhosphoserineCombined sources1
Modified residuei653PhosphoserineCombined sources1
Modified residuei656PhosphoserineCombined sources1
Modified residuei659PhosphoserineCombined sources1
Modified residuei666PhosphotyrosineCombined sources1
Modified residuei673PhosphoserineBy similarity1
Modified residuei683PhosphoserineBy similarity1
Modified residuei787PhosphoserineBy similarity1
Modified residuei924PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated during mitosis.By similarity
Ubiquitinated, and this requires FZR1/CDH1.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8K298
MaxQBiQ8K298
PaxDbiQ8K298
PeptideAtlasiQ8K298
PRIDEiQ8K298

PTM databases

iPTMnetiQ8K298
PhosphoSitePlusiQ8K298

Expressioni

Gene expression databases

BgeeiENSMUSG00000036777
ExpressionAtlasiQ8K298 baseline and differential
GenevisibleiQ8K298 MM

Interactioni

Subunit structurei

Interacts with F-actin. Interacts with CD2AP. May interact with RHOA. Interacts with FZR1/CDH1 during mitotic exit.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213029, 2 interactors
IntActiQ8K298, 1 interactor
STRINGi10090.ENSMUSP00000045873

Structurei

3D structure databases

ProteinModelPortaliQ8K298
SMRiQ8K298
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini980 – 1104PHPROSITE-ProRule annotationAdd BLAST125

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 228Nuclear localizationBy similarityAdd BLAST228
Regioni1 – 154Interaction with CD2APBy similarityAdd BLAST154
Regioni1 – 45Required for ubiquitinationBy similarityAdd BLAST45
Regioni229 – 671Interaction with F-actinBy similarityAdd BLAST443
Regioni725 – 1121Localization to the cleavage furrowBy similarityAdd BLAST397

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili564 – 599Sequence analysisAdd BLAST36

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3640 Eukaryota
ENOG4110J5Z LUCA
GeneTreeiENSGT00390000008749
HOGENOMiHOG000033950
HOVERGENiHBG059477
InParanoidiQ8K298
KOiK18621
OMAiGEEKSCT
OrthoDBiEOG091G01HH
PhylomeDBiQ8K298
TreeFamiTF106494

Family and domain databases

CDDicd01263 PH_anillin, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR012966 AHD
IPR031970 Anillin_N
IPR011993 PH-like_dom_sf
IPR037840 PH_Anillin
IPR001849 PH_domain
PfamiView protein in Pfam
PF08174 Anillin, 1 hit
PF16018 Anillin_N, 2 hits
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPFTEKLLE RTRARRENLQ RKMAERPTAV ARSAPHAKRG REPLSEASNQ
60 70 80 90 100
QQPLPGGEEK SCTKPSPSKK RCSDKIEVGA PDLENTEPID VAKPCSPMPA
110 120 130 140 150
PRQAKPPAPA AISESVAAPA ALLSADRGLN SGSEASATSS VKTRMQRLAE
160 170 180 190 200
QRRHWDSDLT DDVSESSYFA PVPTEDKAAS PSKPPISNAS ATPVGRRGRL
210 220 230 240 250
ANLAATICSW EDDVSHSSAK QNSVQEQPGT ACLSKSSSAS GASASINSSS
260 270 280 290 300
VQQEATCCSP RDGNASVRKD PSSNAAHGPL LSASVSSSVK ASSPVTAATF
310 320 330 340 350
ITENREAQNP ELLHKTASPL KTEARKPCEK PTLSQGAQPK EEANREVCLQ
360 370 380 390 400
SQSKDKLATP GGRGIKPFLE RFGERCQEHS KESPSYRASH KTPNITPNTK
410 420 430 440 450
AIQERLFKQN TCSSTTHLAQ QLKQEREKEL ACLRGRLDKG NLWSAEKNEK
460 470 480 490 500
SRSKHLETKQ EVHCQNTPLK KHQTVASTPL TSVTDKVAEN EPAVKLSSTE
510 520 530 540 550
PAGSTESEMT KSSPLKITLF LEEEKSLKVA SDLEVEQNTE AVREVEMSVD
560 570 580 590 600
DEDINSSRVI NDIFSDVLEE GELDVEKSQE EMDQVGAENS EEQEDALNIS
610 620 630 640 650
SMSLLAPLAQ TVGVVSLENV ISSPPSELRD SNLSAASPKP GKFQRTRVPR
660 670 680 690 700
AESADSLGSE DRDLLYSIDA YRSQRFKETE RPSIKQVIVR KEDVTSKLGE
710 720 730 740 750
KKNVFSGQVN IKQKMQELNN DINLQQTVIY QASQALNCCV DEEHGKGSLE
760 770 780 790 800
EAEAERLLLI ATEKRALLID ELNKLKSEGP QRRNKTSVIS QSEFAPSKGS
810 820 830 840 850
VTLSEICLPL KADFVCSTAQ KTDASNYYYL IMLKAGAEQM VATPLASTAN
860 870 880 890 900
SLSGDALTFP TTFTLHDVSN DFEINIEVYS LVQKKDSLGP DKKKKASKSK
910 920 930 940 950
AITPKRLLTS ITSKSSLHSS VMASPGGLGA VRTSNFTLVG SHTLSLSSVG
960 970 980 990 1000
DTKFALDKVP FLSPLEGHIC LKISCQVNSA VEEKGFLTIF EDVSGFGAWH
1010 1020 1030 1040 1050
RRWCVLSGNC ISYWTYPDDE RRKNPIGRIN LANCISHQIE PANREFCARR
1060 1070 1080 1090 1100
NTLELITVRP QREDDRETLV SQCRDTLCVT KNWLSADTKE ERDLWMQKLN
1110 1120
QVIVDIRLWQ PDACYKPVGK P
Length:1,121
Mass (Da):122,794
Last modified:March 21, 2006 - v2
Checksum:i0D23488D3264E525
GO

Sequence cautioni

The sequence AAH30489 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC32605 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti366K → N in AAH32164 (PubMed:15489334).Curated1
Sequence conflicti613G → S in BAC32464 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030489 mRNA Translation: AAH30489.1 Different initiation.
BC032164 mRNA Translation: AAH32164.1
AK013624 mRNA Translation: BAB28931.3
AK045703 mRNA Translation: BAC32464.1
AK046102 mRNA Translation: BAC32605.1 Different initiation.
CCDSiCCDS22927.1
RefSeqiNP_082666.2, NM_028390.3
UniGeneiMm.282751
Mm.453238

Genome annotation databases

EnsembliENSMUST00000040912; ENSMUSP00000045873; ENSMUSG00000036777
GeneIDi68743
KEGGimmu:68743
UCSCiuc009ook.2 mouse

Similar proteinsi

Entry informationi

Entry nameiANLN_MOUSE
AccessioniPrimary (citable) accession number: Q8K298
Secondary accession number(s): Q8BL79
, Q8BLB3, Q8K2N0, Q9CUY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: March 28, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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