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Protein

Anillin

Gene

Anln

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for cytokinesis (By similarity). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression (By similarity). May play a significant role in podocyte cell migration (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Anillin
Gene namesi
Name:Anln
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1920174. Anln.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasmcytoskeleton By similarity
  • Cytoplasmcell cortex By similarity

  • Note: Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area of the prospective contractile ring in anaphase. This pattern persists until telophase, when the protein becomes concentrated in the midbody.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002279661 – 1121AnillinAdd BLAST1121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei73PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1
Modified residuei192PhosphothreonineCombined sources1
Modified residuei223PhosphoserineBy similarity1
Modified residuei250PhosphoserineBy similarity1
Modified residuei259PhosphoserineCombined sources1
Modified residuei316PhosphothreonineBy similarity1
Modified residuei318PhosphoserineBy similarity1
Modified residuei334PhosphoserineBy similarity1
Modified residuei359PhosphothreonineBy similarity1
Modified residuei366N6-acetyllysineBy similarity1
Modified residuei392PhosphothreonineBy similarity1
Modified residuei396PhosphothreonineBy similarity1
Modified residuei414PhosphoserineBy similarity1
Modified residuei444PhosphoserineBy similarity1
Modified residuei513PhosphoserineBy similarity1
Modified residuei548PhosphoserineCombined sources1
Modified residuei556PhosphoserineBy similarity1
Modified residuei637PhosphoserineCombined sources1
Modified residuei653PhosphoserineCombined sources1
Modified residuei656PhosphoserineCombined sources1
Modified residuei659PhosphoserineCombined sources1
Modified residuei666PhosphotyrosineCombined sources1
Modified residuei673PhosphoserineBy similarity1
Modified residuei683PhosphoserineBy similarity1
Modified residuei787PhosphoserineBy similarity1
Modified residuei924PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated during mitosis.By similarity
Ubiquitinated, and this requires FZR1/CDH1.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8K298.
MaxQBiQ8K298.
PaxDbiQ8K298.
PeptideAtlasiQ8K298.
PRIDEiQ8K298.

PTM databases

iPTMnetiQ8K298.
PhosphoSitePlusiQ8K298.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036777.
GenevisibleiQ8K298. MM.

Interactioni

Subunit structurei

Interacts with F-actin. Interacts with CD2AP. May interact with RHOA. Interacts with FZR1/CDH1 during mitotic exit (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213029. 2 interactors.
IntActiQ8K298. 1 interactor.
STRINGi10090.ENSMUSP00000045873.

Structurei

3D structure databases

ProteinModelPortaliQ8K298.
SMRiQ8K298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini980 – 1104PHPROSITE-ProRule annotationAdd BLAST125

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 228Nuclear localizationBy similarityAdd BLAST228
Regioni1 – 154Interaction with CD2APBy similarityAdd BLAST154
Regioni1 – 45Required for ubiquitinationBy similarityAdd BLAST45
Regioni229 – 671Interaction with F-actinBy similarityAdd BLAST443
Regioni725 – 1121Localization to the cleavage furrowBy similarityAdd BLAST397

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili564 – 599Sequence analysisAdd BLAST36

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3640. Eukaryota.
ENOG4110J5Z. LUCA.
GeneTreeiENSGT00390000008749.
HOGENOMiHOG000033950.
HOVERGENiHBG059477.
InParanoidiQ8K298.
KOiK18621.
OMAiHSKESPA.
OrthoDBiEOG091G01HH.
PhylomeDBiQ8K298.
TreeFamiTF106494.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR012966. AHD.
IPR031970. Anillin_N.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF08174. Anillin. 1 hit.
PF16018. Anillin_N. 2 hits.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPFTEKLLE RTRARRENLQ RKMAERPTAV ARSAPHAKRG REPLSEASNQ
60 70 80 90 100
QQPLPGGEEK SCTKPSPSKK RCSDKIEVGA PDLENTEPID VAKPCSPMPA
110 120 130 140 150
PRQAKPPAPA AISESVAAPA ALLSADRGLN SGSEASATSS VKTRMQRLAE
160 170 180 190 200
QRRHWDSDLT DDVSESSYFA PVPTEDKAAS PSKPPISNAS ATPVGRRGRL
210 220 230 240 250
ANLAATICSW EDDVSHSSAK QNSVQEQPGT ACLSKSSSAS GASASINSSS
260 270 280 290 300
VQQEATCCSP RDGNASVRKD PSSNAAHGPL LSASVSSSVK ASSPVTAATF
310 320 330 340 350
ITENREAQNP ELLHKTASPL KTEARKPCEK PTLSQGAQPK EEANREVCLQ
360 370 380 390 400
SQSKDKLATP GGRGIKPFLE RFGERCQEHS KESPSYRASH KTPNITPNTK
410 420 430 440 450
AIQERLFKQN TCSSTTHLAQ QLKQEREKEL ACLRGRLDKG NLWSAEKNEK
460 470 480 490 500
SRSKHLETKQ EVHCQNTPLK KHQTVASTPL TSVTDKVAEN EPAVKLSSTE
510 520 530 540 550
PAGSTESEMT KSSPLKITLF LEEEKSLKVA SDLEVEQNTE AVREVEMSVD
560 570 580 590 600
DEDINSSRVI NDIFSDVLEE GELDVEKSQE EMDQVGAENS EEQEDALNIS
610 620 630 640 650
SMSLLAPLAQ TVGVVSLENV ISSPPSELRD SNLSAASPKP GKFQRTRVPR
660 670 680 690 700
AESADSLGSE DRDLLYSIDA YRSQRFKETE RPSIKQVIVR KEDVTSKLGE
710 720 730 740 750
KKNVFSGQVN IKQKMQELNN DINLQQTVIY QASQALNCCV DEEHGKGSLE
760 770 780 790 800
EAEAERLLLI ATEKRALLID ELNKLKSEGP QRRNKTSVIS QSEFAPSKGS
810 820 830 840 850
VTLSEICLPL KADFVCSTAQ KTDASNYYYL IMLKAGAEQM VATPLASTAN
860 870 880 890 900
SLSGDALTFP TTFTLHDVSN DFEINIEVYS LVQKKDSLGP DKKKKASKSK
910 920 930 940 950
AITPKRLLTS ITSKSSLHSS VMASPGGLGA VRTSNFTLVG SHTLSLSSVG
960 970 980 990 1000
DTKFALDKVP FLSPLEGHIC LKISCQVNSA VEEKGFLTIF EDVSGFGAWH
1010 1020 1030 1040 1050
RRWCVLSGNC ISYWTYPDDE RRKNPIGRIN LANCISHQIE PANREFCARR
1060 1070 1080 1090 1100
NTLELITVRP QREDDRETLV SQCRDTLCVT KNWLSADTKE ERDLWMQKLN
1110 1120
QVIVDIRLWQ PDACYKPVGK P
Length:1,121
Mass (Da):122,794
Last modified:March 21, 2006 - v2
Checksum:i0D23488D3264E525
GO

Sequence cautioni

The sequence AAH30489 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC32605 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti366K → N in AAH32164 (PubMed:15489334).Curated1
Sequence conflicti613G → S in BAC32464 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030489 mRNA. Translation: AAH30489.1. Different initiation.
BC032164 mRNA. Translation: AAH32164.1.
AK013624 mRNA. Translation: BAB28931.3.
AK045703 mRNA. Translation: BAC32464.1.
AK046102 mRNA. Translation: BAC32605.1. Different initiation.
CCDSiCCDS22927.1.
RefSeqiNP_082666.2. NM_028390.3.
UniGeneiMm.282751.
Mm.453238.

Genome annotation databases

EnsembliENSMUST00000040912; ENSMUSP00000045873; ENSMUSG00000036777.
GeneIDi68743.
KEGGimmu:68743.
UCSCiuc009ook.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030489 mRNA. Translation: AAH30489.1. Different initiation.
BC032164 mRNA. Translation: AAH32164.1.
AK013624 mRNA. Translation: BAB28931.3.
AK045703 mRNA. Translation: BAC32464.1.
AK046102 mRNA. Translation: BAC32605.1. Different initiation.
CCDSiCCDS22927.1.
RefSeqiNP_082666.2. NM_028390.3.
UniGeneiMm.282751.
Mm.453238.

3D structure databases

ProteinModelPortaliQ8K298.
SMRiQ8K298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213029. 2 interactors.
IntActiQ8K298. 1 interactor.
STRINGi10090.ENSMUSP00000045873.

PTM databases

iPTMnetiQ8K298.
PhosphoSitePlusiQ8K298.

Proteomic databases

EPDiQ8K298.
MaxQBiQ8K298.
PaxDbiQ8K298.
PeptideAtlasiQ8K298.
PRIDEiQ8K298.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040912; ENSMUSP00000045873; ENSMUSG00000036777.
GeneIDi68743.
KEGGimmu:68743.
UCSCiuc009ook.2. mouse.

Organism-specific databases

CTDi54443.
MGIiMGI:1920174. Anln.

Phylogenomic databases

eggNOGiKOG3640. Eukaryota.
ENOG4110J5Z. LUCA.
GeneTreeiENSGT00390000008749.
HOGENOMiHOG000033950.
HOVERGENiHBG059477.
InParanoidiQ8K298.
KOiK18621.
OMAiHSKESPA.
OrthoDBiEOG091G01HH.
PhylomeDBiQ8K298.
TreeFamiTF106494.

Miscellaneous databases

PROiQ8K298.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036777.
GenevisibleiQ8K298. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR012966. AHD.
IPR031970. Anillin_N.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF08174. Anillin. 1 hit.
PF16018. Anillin_N. 2 hits.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANLN_MOUSE
AccessioniPrimary (citable) accession number: Q8K298
Secondary accession number(s): Q8BL79
, Q8BLB3, Q8K2N0, Q9CUY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.