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Protein

Procollagen galactosyltransferase 1

Gene

Colgalt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen. By acting on collagen glycosylation, facilitates the formation of collagen triple helix.By similarity

Catalytic activityi

UDP-alpha-D-galactose + [procollagen]-(2S,5R)-5-hydroxy-L-lysine = UDP + [procollagen]-(2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-1650814 Collagen biosynthesis and modifying enzymes

Protein family/group databases

CAZyiGT25 Glycosyltransferase Family 25

Names & Taxonomyi

Protein namesi
Recommended name:
Procollagen galactosyltransferase 1 (EC:2.4.1.50By similarity)
Alternative name(s):
Collagen beta(1-O)galactosyltransferase 1
Glycosyltransferase 25 family member 1
Hydroxylysine galactosyltransferase 1
Gene namesi
Name:Colgalt1
Synonyms:Glt25d1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1924348 Colgalt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000030953732 – 617Procollagen galactosyltransferase 1Add BLAST586

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi376N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8K297
MaxQBiQ8K297
PaxDbiQ8K297
PeptideAtlasiQ8K297
PRIDEiQ8K297

PTM databases

iPTMnetiQ8K297
PhosphoSitePlusiQ8K297

Expressioni

Gene expression databases

BgeeiENSMUSG00000034807
CleanExiMM_GLT25D1
GenevisibleiQ8K297 MM

Interactioni

Protein-protein interaction databases

BioGridi231529, 2 interactors
IntActiQ8K297, 2 interactors
MINTiQ8K297
STRINGi10090.ENSMUSP00000047923

Structurei

3D structure databases

ProteinModelPortaliQ8K297
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi614 – 617Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the glycosyltransferase 25 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4179 Eukaryota
ENOG410XQQN LUCA
GeneTreeiENSGT00550000074427
HOGENOMiHOG000007198
HOVERGENiHBG058097
InParanoidiQ8K297
KOiK11703
OMAiMWADYIL
OrthoDBiEOG091G0SKW
PhylomeDBiQ8K297
TreeFamiTF313826

Family and domain databases

CDDicd06532 Glyco_transf_25, 1 hit
Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR002654 Glyco_trans_25
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF01755 Glyco_transf_25, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALPRGSRG LPLLPLLLLL PPLGGPRGAD GYFPEERWSP ESPLQAPRVL
60 70 80 90 100
IALLARNAAP ALPATLGALE QLRHPRERTA LWVATDHNTD NTSAILREWL
110 120 130 140 150
VAVKGLYHSV EWRPAEEPSS YPDEEGPKHW SDSRYEHVMK LRQAALKSAR
160 170 180 190 200
DMWADYILFM DIDNLITNPD TLSLLIAENK TVVAPMLDSR AAYSNFWCGM
210 220 230 240 250
TSQGYYKRTP AYIPIRKRDR RGCFAVPMVH STFLIDLRKA ASRNLAFYPT
260 270 280 290 300
HPDYTWSFDD IIVFAFSCKQ AEVQMYVCNK EVYGFLPVPL RAHSSLQDEA
310 320 330 340 350
ESFMHVQLEV MVKHPPVQLS RFISAPRKTS DKMGFDEVFM INLKRRRDRR
360 370 380 390 400
ERMLRALHEQ EIDCQLVEAV DGKAMNTSQV EAMGIQMLPG YRDPYHGRPL
410 420 430 440 450
TKGELGCFLS HYNIWKEVVD RGLQKSLVFE DDLRFEIFFK RRLMNLMRDV
460 470 480 490 500
EREGLDWDLI YVGRKRMQVE HPEKAVPHVR NLVEADYSYW TLAYVISLQG
510 520 530 540 550
AQKLLAAKPL AKMLPVDEFL PVMFDKHPMS EYKSHFSPRN LRAFSVEPLL
560 570 580 590 600
IYPTHYTGDD GYVSDTETSV VWNNEQVKTD WDRAKSQKMR EQQALSREAK
610
NSDVLQSPLD STARDEL
Length:617
Mass (Da):71,061
Last modified:November 13, 2007 - v2
Checksum:i828D28E3300D9CC6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8S → L in BAE43293 (PubMed:16141072).Curated1
Sequence conflicti30D → A in BAE43293 (PubMed:16141072).Curated1
Sequence conflicti250T → P in AAH32165 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035788 mRNA Translation: BAE43293.1
BC032165 mRNA Translation: AAH32165.1
BC056951 mRNA Translation: AAH56951.1
CCDSiCCDS22401.1
RefSeqiNP_666323.2, NM_146211.3
UniGeneiMm.240885
Mm.273836
Mm.334606

Genome annotation databases

EnsembliENSMUST00000047903; ENSMUSP00000047923; ENSMUSG00000034807
GeneIDi234407
KEGGimmu:234407
UCSCiuc009mee.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGT251_MOUSE
AccessioniPrimary (citable) accession number: Q8K297
Secondary accession number(s): Q3V3R5, Q6PGL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health