Q8K296 (MTMR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 85.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Myotubularin-related protein 3 EC=3.1.3.48 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) [Reference proteome] | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 1196 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues By similarity. |
| Catalytic activity | Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| Sequence similarities | Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. Contains 1 FYVE-type zinc finger. Contains 1 myotubularin phosphatase domain. |
| Sequence caution | The sequence CAI35184.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Domain | Coiled coil Zinc-finger |
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase Protein phosphatase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC phosphatidylinositol dephosphorylationInferred from sequence or structural similarity. Source: UniProtKB |
| Molecular_function | metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphatidylinositol-3-phosphatase activityInferred from sequence or structural similarity. Source: UniProtKB protein tyrosine phosphatase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8K296-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8K296-2) The sequence of this isoform differs from the canonical sequence as follows: 1076-1196: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1196 | 1196 | Myotubularin-related protein 3 | PRO_0000094937 | |||||
Regions | |||||||||
| Domain | 155 – 576 | 422 | Myotubularin phosphatase | ||||||
| Zinc finger | 1117 – 1177 | 61 | FYVE-type | ||||||
| Region | 326 – 329 | 4 | Substrate binding By similarity | ||||||
| Region | 351 – 352 | 2 | Substrate binding By similarity | ||||||
| Region | 413 – 419 | 7 | Substrate binding By similarity | ||||||
| Coiled coil | 1027 – 1060 | 34 | Potential | ||||||
Sites | |||||||||
| Active site | 413 | 1 | Phosphocysteine intermediate By similarity | ||||||
| Binding site | 459 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 613 | 1 | Phosphoserine Ref.3 | ||||||
| Modified residue | 633 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 647 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 1179 | 1 | Phosphothreonine Ref.3 | ||||||
Natural variations | |||||||||
| Alternative sequence | 1076 – 1196 | 121 | Missing in isoform 2. | VSP_026027 | |||||
Experimental info | |||||||||
| Sequence conflict | 782 | 1 | R → S in AAH32166. Ref.2 | ||||||
| Sequence conflict | 1074 | 1 | T → V in AAH32166. Ref.2 | ||||||
Sequences
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References
| [1] | "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.  Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). |
| [3] | "Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613 AND THR-1179, MASS SPECTROMETRY. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL645910 Genomic DNA. Translation: CAI35184.1. Sequence problems. BC032166 mRNA. Translation: AAH32166.1. |
| IPI | IPI00551495. IPI00649536. |
| UniGene | Mm.425669. |
3D structure databases | |
| ProteinModelPortal | Q8K296. |
| SMR | Q8K296. Positions 48-577, 1059-1177. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q8K296. |
Proteomic databases | |
| PaxDb | Q8K296. |
| PRIDE | Q8K296. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000123506; ENSMUSP00000122422; ENSMUSG00000034354. |
| UCSC | uc007huy.1. mouse. |
Organism-specific databases | |
| MGI | MGI:1921552. Mtmr3. |
Phylogenomic databases | |
| eggNOG | NOG322789. |
| GeneTree | ENSGT00670000097670. |
| HOGENOM | HOG000004861. |
| HOVERGEN | HBG052526. |
| InParanoid | Q8K296. |
Gene expression databases | |
| ArrayExpress | Q8K296. |
| Bgee | Q8K296. |
| CleanEx | MM_MTMR3. |
| Genevestigator | Q8K296. |
| GermOnline | ENSMUSG00000034354. Mus musculus. |
Family and domain databases | |
| Gene3D | 3.30.40.10. 1 hit. |
| InterPro | IPR010569. Myotub-related. IPR017906. Myotubularin_phosphatase_dom. IPR016130. Tyr_Pase_AS. IPR000306. Znf_FYVE. IPR017455. Znf_FYVE-rel. IPR011011. Znf_FYVE_PHD. IPR013083. Znf_RING/FYVE/PHD. [Graphical view] |
| Pfam | PF01363. FYVE. 1 hit. PF06602. Myotub-related. 1 hit. [Graphical view] |
| SMART | SM00064. FYVE. 1 hit. [Graphical view] |
| SUPFAM | SSF57903. FYVE_PHD_ZnF. 1 hit. |
| PROSITE | PS51339. PPASE_MYOTUBULARIN. 1 hit. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. False negative. PS50178. ZF_FYVE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| SOURCE | Search... |
Entry information
| Entry name | MTMR3_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8K296 Secondary accession number(s): Q5NCA4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |