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Q8K296

- MTMR3_MOUSE

UniProt

Q8K296 - MTMR3_MOUSE

Protein

Myotubularin-related protein 3

Gene

Mtmr3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (29 May 2007)
      Previous versions | rss
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    Functioni

    Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei413 – 4131Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei459 – 4591SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1117 – 117761FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphatidylinositol-3-phosphatase activity Source: UniProtKB
    3. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. phosphatidylinositol dephosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198973. Synthesis of PIPs at the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myotubularin-related protein 3 (EC:3.1.3.48)
    Gene namesi
    Name:Mtmr3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1921552. Mtmr3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11961196Myotubularin-related protein 3PRO_0000094937Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei633 – 6331PhosphoserineBy similarity
    Modified residuei647 – 6471PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8K296.
    PRIDEiQ8K296.

    PTM databases

    PhosphoSiteiQ8K296.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K296.
    BgeeiQ8K296.
    CleanExiMM_MTMR3.
    GenevestigatoriQ8K296.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K296.
    SMRiQ8K296. Positions 48-577, 1059-1177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini155 – 576422Myotubularin phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni326 – 3294Substrate bindingBy similarity
    Regioni351 – 3522Substrate bindingBy similarity
    Regioni413 – 4197Substrate bindingBy similarity

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1027 – 106034Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
    Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1117 – 117761FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG322789.
    HOGENOMiHOG000004861.
    HOVERGENiHBG052526.
    InParanoidiQ8K296.
    KOiK18082.
    PhylomeDBiQ8K296.
    TreeFamiTF315197.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR010569. Myotubularin-like_Pase_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR016130. Tyr_Pase_AS.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01363. FYVE. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view]
    SMARTiSM00064. FYVE. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 2 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8K296-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDEEMRHSLE CIQANQIFPR KQLIREDENL QVPFLELHGE STEYVGRAEE     50
    AIIALSNYRL HIKFKESLVN VPLQLIESVE CRDIFQLHLT CKDCKVIRCQ 100
    FPTFEQCQDW LKRLNNAIRP PGKIEDLFSF AYHAWCMEVY ASEKEQHGDL 150
    CRPGEHVTSR FKNEVERMGF DMNNAWRISN INEKYKLCGS YPQELIVPAW 200
    ITDKELESVA GFRSWKRIPA VIYRHQSNGA VIARCGQPEV SWWGWRNADD 250
    EHLVQSVARA CASDSQSSIS KVSTRNSCRD FPNAGDLSDV EFDSSLSNTS 300
    GAESLALQPQ KLLILDARSY AAAVANRAKG GGCECPEYYP NCEVVFMGMA 350
    NIHSIRRSFQ SLRLLCTQMP DPGNWLSALE STKWLHHLSV LLKSALLVVH 400
    AVDRDQRPVL VHCSDGWDRT PQIVALAKLL LDPYYRTIEG FQVLVEMEWL 450
    DFGHKFADRC GHGEDSDDLN ERCPVFLQWL DCVHQLQRQF PCSFEFNEAF 500
    LVKLVQHTYS CLFGTFLCNN AKERGEKQTQ ERTCSVWSLL RAGNKAFKNL 550
    LYSSQSEAVL YPVCHVRNLM LWSAVYLPCP SPSTPTDDSC APYPVPGTSP 600
    DEPPLSRLPK TRSFDNLTTT CENMVPLASR RSSDPSLNEK WQEHGRSLEL 650
    SSFASAGEEV PAMDSLRKPS RLLGGAELSV AAGVAEGQME NILQEATKEE 700
    SGVEEPTHRG HTEVPEVKEE APLAKESSMA AEGPVVLYQE PQLDDATLRS 750
    HQGPSLSLFS QGIPEHQDGH NVLSSSLQAP LRGEDSQEVP VEQPQVENIA 800
    EDRENVAPAV PVDAKVGLGI SQSSSLLPSQ VPFETRGPHI NNSVHMLLED 850
    KVKSESGPQL HHRPCPASSG RFSGKDMLPV APEPRSAERP QWDSVLHRTS 900
    SPGNTLSLLQ APCALPLDKC RQGIVCNGAL ETENKASEQP AGFDTLQKYP 950
    TPNGHCANWE AGRSKDSLSH QLSATSCSSA HLYSRNLHHK WLNSHSGRPS 1000
    TTSSPDQPSR SHLDDDGMPV YTDTIQQRLR QIESGHQQEV ETLKKQVQEL 1050
    KSRLESQYLT SSLRFNGDFG DEVTSIPDSE SNLDQNCVSR CSTEIFSEAS 1100
    WEQVDKQDTE MTRWLPDHLA AHCYACDSAF WLASRKHHCR NCGNVFCSSC 1150
    CNQKVPVPSQ QLFEPSRVCK SCYSSLHPTS SSIDLELDKP IAATSN 1196
    Length:1,196
    Mass (Da):133,840
    Last modified:May 29, 2007 - v2
    Checksum:i409D23ABBEABAC7D
    GO
    Isoform 2 (identifier: Q8K296-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1076-1196: Missing.

    Show »
    Length:1,075
    Mass (Da):120,297
    Checksum:i8BDF16BAC02132E8
    GO

    Sequence cautioni

    The sequence CAI35184.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti782 – 7821R → S in AAH32166. (PubMed:15489334)Curated
    Sequence conflicti1074 – 10741T → V in AAH32166. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1076 – 1196121Missing in isoform 2. 1 PublicationVSP_026027Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL645910 Genomic DNA. Translation: CAI35184.1. Sequence problems.
    BC032166 mRNA. Translation: AAH32166.1.
    RefSeqiXP_006514910.1. XM_006514847.1. [Q8K296-1]
    UniGeneiMm.425669.

    Genome annotation databases

    GeneIDi74302.
    KEGGimmu:74302.
    UCSCiuc007huy.1. mouse. [Q8K296-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL645910 Genomic DNA. Translation: CAI35184.1 . Sequence problems.
    BC032166 mRNA. Translation: AAH32166.1 .
    RefSeqi XP_006514910.1. XM_006514847.1. [Q8K296-1 ]
    UniGenei Mm.425669.

    3D structure databases

    ProteinModelPortali Q8K296.
    SMRi Q8K296. Positions 48-577, 1059-1177.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8K296.

    Proteomic databases

    PaxDbi Q8K296.
    PRIDEi Q8K296.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 74302.
    KEGGi mmu:74302.
    UCSCi uc007huy.1. mouse. [Q8K296-1 ]

    Organism-specific databases

    CTDi 8897.
    MGIi MGI:1921552. Mtmr3.

    Phylogenomic databases

    eggNOGi NOG322789.
    HOGENOMi HOG000004861.
    HOVERGENi HBG052526.
    InParanoidi Q8K296.
    KOi K18082.
    PhylomeDBi Q8K296.
    TreeFami TF315197.

    Enzyme and pathway databases

    Reactomei REACT_198973. Synthesis of PIPs at the plasma membrane.

    Miscellaneous databases

    PROi Q8K296.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K296.
    Bgeei Q8K296.
    CleanExi MM_MTMR3.
    Genevestigatori Q8K296.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR010569. Myotubularin-like_Pase_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR016130. Tyr_Pase_AS.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01363. FYVE. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view ]
    SMARTi SM00064. FYVE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 2 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiMTMR3_MOUSE
    AccessioniPrimary (citable) accession number: Q8K296
    Secondary accession number(s): Q5NCA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3