Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myotubularin-related protein 3

Gene

Mtmr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotationBy similarity
1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.By similarity
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei413Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei459SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1117 – 1177FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processLipid metabolism
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 3 (EC:3.1.3.48)
Alternative name(s):
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.95By similarity)
Phosphatidylinositol-3-phosphate phosphatase (EC:3.1.3.64By similarity)
Gene namesi
Name:Mtmr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1921552. Mtmr3.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000949371 – 1196Myotubularin-related protein 3Add BLAST1196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineCombined sources1
Modified residuei613PhosphoserineCombined sources1
Modified residuei633PhosphoserineBy similarity1
Modified residuei647PhosphoserineBy similarity1
Modified residuei651PhosphoserineBy similarity1
Modified residuei907PhosphoserineBy similarity1
Modified residuei1062PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K296.
PaxDbiQ8K296.
PRIDEiQ8K296.

PTM databases

iPTMnetiQ8K296.
PhosphoSitePlusiQ8K296.

Expressioni

Gene expression databases

CleanExiMM_MTMR3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049079.

Structurei

3D structure databases

ProteinModelPortaliQ8K296.
SMRiQ8K296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 576Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST422

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni326 – 329Substrate bindingBy similarity4
Regioni351 – 352Substrate bindingBy similarity2
Regioni413 – 419Substrate bindingBy similarity7

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1027 – 1060Sequence analysisAdd BLAST34

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1117 – 1177FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG4471. Eukaryota.
ENOG410XPTU. LUCA.
HOGENOMiHOG000004861.
HOVERGENiHBG052526.
InParanoidiQ8K296.
PhylomeDBiQ8K296.
TreeFamiTF315197.

Family and domain databases

CDDicd13341. PH-GRAM_MTMR3. 1 hit.
Gene3Di2.30.29.30. 1 hit.
3.30.40.10. 1 hit.
3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR035888. MTMR3_PH-GRAM.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH-like_dom_sf.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
PANTHERiPTHR10807. PTHR10807. 1 hit.
PfamiView protein in Pfam
PF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
SMARTiView protein in SMART
SM00064. FYVE. 1 hit.
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiView protein in PROSITE
PS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50178. ZF_FYVE. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K296-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEEMRHSLE CIQANQIFPR KQLIREDENL QVPFLELHGE STEYVGRAEE
60 70 80 90 100
AIIALSNYRL HIKFKESLVN VPLQLIESVE CRDIFQLHLT CKDCKVIRCQ
110 120 130 140 150
FPTFEQCQDW LKRLNNAIRP PGKIEDLFSF AYHAWCMEVY ASEKEQHGDL
160 170 180 190 200
CRPGEHVTSR FKNEVERMGF DMNNAWRISN INEKYKLCGS YPQELIVPAW
210 220 230 240 250
ITDKELESVA GFRSWKRIPA VIYRHQSNGA VIARCGQPEV SWWGWRNADD
260 270 280 290 300
EHLVQSVARA CASDSQSSIS KVSTRNSCRD FPNAGDLSDV EFDSSLSNTS
310 320 330 340 350
GAESLALQPQ KLLILDARSY AAAVANRAKG GGCECPEYYP NCEVVFMGMA
360 370 380 390 400
NIHSIRRSFQ SLRLLCTQMP DPGNWLSALE STKWLHHLSV LLKSALLVVH
410 420 430 440 450
AVDRDQRPVL VHCSDGWDRT PQIVALAKLL LDPYYRTIEG FQVLVEMEWL
460 470 480 490 500
DFGHKFADRC GHGEDSDDLN ERCPVFLQWL DCVHQLQRQF PCSFEFNEAF
510 520 530 540 550
LVKLVQHTYS CLFGTFLCNN AKERGEKQTQ ERTCSVWSLL RAGNKAFKNL
560 570 580 590 600
LYSSQSEAVL YPVCHVRNLM LWSAVYLPCP SPSTPTDDSC APYPVPGTSP
610 620 630 640 650
DEPPLSRLPK TRSFDNLTTT CENMVPLASR RSSDPSLNEK WQEHGRSLEL
660 670 680 690 700
SSFASAGEEV PAMDSLRKPS RLLGGAELSV AAGVAEGQME NILQEATKEE
710 720 730 740 750
SGVEEPTHRG HTEVPEVKEE APLAKESSMA AEGPVVLYQE PQLDDATLRS
760 770 780 790 800
HQGPSLSLFS QGIPEHQDGH NVLSSSLQAP LRGEDSQEVP VEQPQVENIA
810 820 830 840 850
EDRENVAPAV PVDAKVGLGI SQSSSLLPSQ VPFETRGPHI NNSVHMLLED
860 870 880 890 900
KVKSESGPQL HHRPCPASSG RFSGKDMLPV APEPRSAERP QWDSVLHRTS
910 920 930 940 950
SPGNTLSLLQ APCALPLDKC RQGIVCNGAL ETENKASEQP AGFDTLQKYP
960 970 980 990 1000
TPNGHCANWE AGRSKDSLSH QLSATSCSSA HLYSRNLHHK WLNSHSGRPS
1010 1020 1030 1040 1050
TTSSPDQPSR SHLDDDGMPV YTDTIQQRLR QIESGHQQEV ETLKKQVQEL
1060 1070 1080 1090 1100
KSRLESQYLT SSLRFNGDFG DEVTSIPDSE SNLDQNCVSR CSTEIFSEAS
1110 1120 1130 1140 1150
WEQVDKQDTE MTRWLPDHLA AHCYACDSAF WLASRKHHCR NCGNVFCSSC
1160 1170 1180 1190
CNQKVPVPSQ QLFEPSRVCK SCYSSLHPTS SSIDLELDKP IAATSN
Length:1,196
Mass (Da):133,840
Last modified:May 29, 2007 - v2
Checksum:i409D23ABBEABAC7D
GO
Isoform 2 (identifier: Q8K296-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1076-1196: Missing.

Show »
Length:1,075
Mass (Da):120,297
Checksum:i8BDF16BAC02132E8
GO

Sequence cautioni

The sequence CAI35184 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti782R → S in AAH32166 (PubMed:15489334).Curated1
Sequence conflicti1074T → V in AAH32166 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0260271076 – 1196Missing in isoform 2. 1 PublicationAdd BLAST121

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645910 Genomic DNA. Translation: CAI35184.1. Sequence problems.
BC032166 mRNA. Translation: AAH32166.1.
RefSeqiXP_006514910.1. XM_006514847.3. [Q8K296-1]
UniGeneiMm.425669.

Genome annotation databases

GeneIDi74302.
UCSCiuc007huy.1. mouse. [Q8K296-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMTMR3_MOUSE
AccessioniPrimary (citable) accession number: Q8K296
Secondary accession number(s): Q5NCA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 29, 2007
Last modified: November 22, 2017
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families