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Q8K296 (MTMR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myotubularin-related protein 3

EC=3.1.3.48
Gene names
Name:Mtmr3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1196 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Contains 1 FYVE-type zinc finger.

Contains 1 myotubularin phosphatase domain.

Sequence caution

The sequence CAI35184.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8K296-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8K296-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1076-1196: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11961196Myotubularin-related protein 3
PRO_0000094937

Regions

Domain155 – 576422Myotubularin phosphatase
Zinc finger1117 – 117761FYVE-type
Region326 – 3294Substrate binding By similarity
Region351 – 3522Substrate binding By similarity
Region413 – 4197Substrate binding By similarity
Coiled coil1027 – 106034 Potential

Sites

Active site4131Phosphocysteine intermediate By similarity
Binding site4591Substrate By similarity

Amino acid modifications

Modified residue6331Phosphoserine By similarity
Modified residue6471Phosphoserine By similarity

Natural variations

Alternative sequence1076 – 1196121Missing in isoform 2.
VSP_026027

Experimental info

Sequence conflict7821R → S in AAH32166. Ref.2
Sequence conflict10741T → V in AAH32166. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 29, 2007. Version 2.
Checksum: 409D23ABBEABAC7D

FASTA1,196133,840
        10         20         30         40         50         60 
MDEEMRHSLE CIQANQIFPR KQLIREDENL QVPFLELHGE STEYVGRAEE AIIALSNYRL 

        70         80         90        100        110        120 
HIKFKESLVN VPLQLIESVE CRDIFQLHLT CKDCKVIRCQ FPTFEQCQDW LKRLNNAIRP 

       130        140        150        160        170        180 
PGKIEDLFSF AYHAWCMEVY ASEKEQHGDL CRPGEHVTSR FKNEVERMGF DMNNAWRISN 

       190        200        210        220        230        240 
INEKYKLCGS YPQELIVPAW ITDKELESVA GFRSWKRIPA VIYRHQSNGA VIARCGQPEV 

       250        260        270        280        290        300 
SWWGWRNADD EHLVQSVARA CASDSQSSIS KVSTRNSCRD FPNAGDLSDV EFDSSLSNTS 

       310        320        330        340        350        360 
GAESLALQPQ KLLILDARSY AAAVANRAKG GGCECPEYYP NCEVVFMGMA NIHSIRRSFQ 

       370        380        390        400        410        420 
SLRLLCTQMP DPGNWLSALE STKWLHHLSV LLKSALLVVH AVDRDQRPVL VHCSDGWDRT 

       430        440        450        460        470        480 
PQIVALAKLL LDPYYRTIEG FQVLVEMEWL DFGHKFADRC GHGEDSDDLN ERCPVFLQWL 

       490        500        510        520        530        540 
DCVHQLQRQF PCSFEFNEAF LVKLVQHTYS CLFGTFLCNN AKERGEKQTQ ERTCSVWSLL 

       550        560        570        580        590        600 
RAGNKAFKNL LYSSQSEAVL YPVCHVRNLM LWSAVYLPCP SPSTPTDDSC APYPVPGTSP 

       610        620        630        640        650        660 
DEPPLSRLPK TRSFDNLTTT CENMVPLASR RSSDPSLNEK WQEHGRSLEL SSFASAGEEV 

       670        680        690        700        710        720 
PAMDSLRKPS RLLGGAELSV AAGVAEGQME NILQEATKEE SGVEEPTHRG HTEVPEVKEE 

       730        740        750        760        770        780 
APLAKESSMA AEGPVVLYQE PQLDDATLRS HQGPSLSLFS QGIPEHQDGH NVLSSSLQAP 

       790        800        810        820        830        840 
LRGEDSQEVP VEQPQVENIA EDRENVAPAV PVDAKVGLGI SQSSSLLPSQ VPFETRGPHI 

       850        860        870        880        890        900 
NNSVHMLLED KVKSESGPQL HHRPCPASSG RFSGKDMLPV APEPRSAERP QWDSVLHRTS 

       910        920        930        940        950        960 
SPGNTLSLLQ APCALPLDKC RQGIVCNGAL ETENKASEQP AGFDTLQKYP TPNGHCANWE 

       970        980        990       1000       1010       1020 
AGRSKDSLSH QLSATSCSSA HLYSRNLHHK WLNSHSGRPS TTSSPDQPSR SHLDDDGMPV 

      1030       1040       1050       1060       1070       1080 
YTDTIQQRLR QIESGHQQEV ETLKKQVQEL KSRLESQYLT SSLRFNGDFG DEVTSIPDSE 

      1090       1100       1110       1120       1130       1140 
SNLDQNCVSR CSTEIFSEAS WEQVDKQDTE MTRWLPDHLA AHCYACDSAF WLASRKHHCR 

      1150       1160       1170       1180       1190 
NCGNVFCSSC CNQKVPVPSQ QLFEPSRVCK SCYSSLHPTS SSIDLELDKP IAATSN 

« Hide

Isoform 2 [UniParc].

Checksum: 8BDF16BAC02132E8
Show »

FASTA1,075120,297

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL645910 Genomic DNA. Translation: CAI35184.1. Sequence problems.
BC032166 mRNA. Translation: AAH32166.1.
RefSeqXP_006514910.1. XM_006514847.1.
UniGeneMm.425669.

3D structure databases

ProteinModelPortalQ8K296.
SMRQ8K296. Positions 48-577, 1059-1177.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8K296.

Proteomic databases

PaxDbQ8K296.
PRIDEQ8K296.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID74302.
UCSCuc007huy.1. mouse. [Q8K296-1]

Organism-specific databases

MGIMGI:1921552. Mtmr3.

Phylogenomic databases

eggNOGNOG322789.
HOGENOMHOG000004861.
HOVERGENHBG052526.
InParanoidQ8K296.
PhylomeDBQ8K296.
TreeFamTF315197.

Gene expression databases

ArrayExpressQ8K296.
BgeeQ8K296.
CleanExMM_MTMR3.
GenevestigatorQ8K296.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR010569. Myotubularin-like_Pase_dom.
IPR016130. Tyr_Pase_AS.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMSSF57903. SSF57903. 1 hit.
PROSITEPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ8K296.
SOURCESearch...

Entry information

Entry nameMTMR3_MOUSE
AccessionPrimary (citable) accession number: Q8K296
Secondary accession number(s): Q5NCA4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 29, 2007
Last modified: April 16, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot