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UniProtKB - Q8K284 (TF3C1_MOUSE)

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Protein

General transcription factor 3C polypeptide 1

Gene

Gtf3c1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionDNA-binding
Biological processTranscription

Enzyme and pathway databases

ReactomeiR-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor 3C polypeptide 1
Alternative name(s):
TF3C-alpha
TFIIIC box B-binding subunit
Transcription factor IIIC 220 kDa subunit
Short name:
TFIIIC 220 kDa subunit
Short name:
TFIIIC220
Transcription factor IIIC subunit alpha
Gene namesi
Name:Gtf3c1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107887. Gtf3c1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097111 – 2101General transcription factor 3C polypeptide 1Add BLAST2101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei667PhosphoserineBy similarity1
Cross-linki833Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1063PhosphoserineBy similarity1
Modified residuei1196PhosphothreonineCombined sources1
Modified residuei1854PhosphoserineBy similarity1
Modified residuei1890PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8K284.
PaxDbiQ8K284.
PeptideAtlasiQ8K284.
PRIDEiQ8K284.

PTM databases

iPTMnetiQ8K284.
PhosphoSitePlusiQ8K284.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032777.
CleanExiMM_GTF3C1.
ExpressionAtlasiQ8K284. baseline and differential.
GenevisibleiQ8K284. MM.

Interactioni

Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with IGHMBP2.By similarity

Protein-protein interaction databases

BioGridi231457. 5 interactors.
IntActiQ8K284. 1 interactor.
MINTiMINT-4137479.
STRINGi10090.ENSMUSP00000056719.

Structurei

3D structure databases

ProteinModelPortaliQ8K284.
SMRiQ8K284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi344 – 354Asp/Glu-rich (acidic)Add BLAST11
Compositional biasi1199 – 1227Arg/Lys-rich (basic)Add BLAST29
Compositional biasi1607 – 1617Asp/Glu-rich (acidic)Add BLAST11

Sequence similaritiesi

Belongs to the TFIIIC subunit 1 family.Curated

Phylogenomic databases

eggNOGiKOG4560. Eukaryota.
ENOG410XSJ5. LUCA.
GeneTreeiENSGT00390000008664.
HOGENOMiHOG000154556.
HOVERGENiHBG057283.
InParanoidiQ8K284.
KOiK15199.
OMAiVYPIHMI.
OrthoDBiEOG091G00PD.
PhylomeDBiQ8K284.
TreeFamiTF351624.

Family and domain databases

InterProiView protein in InterPro
IPR007309. TFIIIC_Bblock-bd.
PfamiView protein in Pfam
PF04182. B-block_TFIIIC. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K284-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDALESLLDE VALEGLDGLC LPALWSRLES RSPAFPLPLE PYTQEFLWRA 
        60         70         80         90        100
LATHPGISFY EEPRERPDLQ LQDRYEEIDL ETGILESRRD PVTLEDVYPI 
       110        120        130        140        150
HMILENKDGI QGSCRYFKER KDITSSIRSK CLQPRCTMVE AFSRWGKKLI 
       160        170        180        190        200
IVASQDMRYR ALIGLEGDPD LKLPDFSYCI LERLGRSRWQ GELQRDLHTT 
       210        220        230        240        250
AFKVDAGKLH YHRKILNKNG LITMQSHVIR LPTGAQQHSI LLLLNRFHVD 
       260        270        280        290        300
RRSKYDILME KLSMMLSTRS NQIETLGKLR EELGLCERTF KRLYQYMLNA 
       310        320        330        340        350
GLAKVVSLPL QEIHPECGPC KTKKGTDVMV RCLKLLKEFK RKMEDDHDDD 
       360        370        380        390        400
DDEEVISKGV PPVDIVFERD MLTQTYELIE RRGTKGISQA EIRVAMNVGK 
       410        420        430        440        450
LEARMLCRLL QRFKVVKGFM EDEGRQRTTK YISCVFAEES DLSRQYAREK 
       460        470        480        490        500
ARGELLTTVS LASVQDESLM PEGEEAFLSD SESEEESSCS GGKRRGRGSR 
       510        520        530        540        550
GHARASGDAG SGSRPHHSTP AKGGWKVLNL HPLKKPKAAA EERSRRSSAC 
       560        570        580        590        600
RDGLDTSSSS ELNAPFDPHS MDSHSGDIAV IEEVRLDNPK EGGGSQKGGR 
       610        620        630        640        650
HGSSQDKPHK TYRLLKRRNL IIEAVTNLRL IESLFTIQKM IMDQEKQEGV 
       660        670        680        690        700
STKCCKKSII RLVRNLSEEG LLRLYRTTVI QDGIKKKVDL VVHPSMDQND 
       710        720        730        740        750
PLVRSAIEQV RFRISNSSTA NRVKVPPAPA PQEEAEEENQ EPEVPSRSAN 
       760        770        780        790        800
SDPNTSSKPE STRVKKTDEK MGITPLKNYK PVIVPGLGRS IGFLPKMPRL 
       810        820        830        840        850
KAMHLFLWYL VYGHPAGHTG EQPALHSERK TGKQESSRPG AQPSSGDDWD 
       860        870        880        890        900
TSEAKNNTES SSWESEMELS TEIVYVDEIS WMRYVPPIPI HRDFGFGWAL 
       910        920        930        940        950
VSDILLCLPL SIFVQLVQVS YKVDNLEDFL NDPLKKHTLI RFLPRHIRQQ 
       960        970        980        990       1000
LLYKRRYIFS VVENLQRLCY MGLLQFGPTE KFQDKDQVFV FLKKNAVIVD 
      1010       1020       1030       1040       1050
TTICDPHYNL AHSSRPFERR LYVLDSMQDV ECYWFDLQCI CLNTPLGVVR 
      1060       1070       1080       1090       1100
CPCAQKICPD PGSDPEGSLR KEQESAMDKH NLERKCAMLE YTTGSREVVD 
      1110       1120       1130       1140       1150
EGLVPGDGLG AAGLDSSFYA HLKRNWVWTS YIINKARKNN TSENGLTGRL 
      1160       1170       1180       1190       1200
QTFLSKRPMP LGSGGSGRLP LWSEGRADAE LCADKEEQFE LDREPTPGRN 
      1210       1220       1230       1240       1250
RKVRGGKSQK RKRLKKEPIR KTKRRRRGEH PEAKSKKLRY QDEADQNALR 
      1260       1270       1280       1290       1300
MMTRLRVSWS MQEDGLLMLC RIASNVLNTK VKGPFVTWQV VRDILHATFE 
      1310       1320       1330       1340       1350
ESLDKTSHSV GRRARYIVKN PQAFMNYKVC LAEVYQDKAL VGDFMSRKGN 
      1360       1370       1380       1390       1400
YEDPKVCAKE FKEFVEKLKE KFSSGLRNPN LEIPNTLQEL FAKYRVLAIG 
      1410       1420       1430       1440       1450
DEKDRVRKED ELNSVEDIHF LVLQNLIQST LSLSNSQSNS CQSFQIFRLY 
      1460       1470       1480       1490       1500
REFREPVLVR AFMECQKRSL VNRRRVSHSQ GPKKNRAVPF VPMSYQLSQS 
      1510       1520       1530       1540       1550
YYKLFTWRFP TTICTESFQF YDRLRTNGML DQPDHFSFKD LDSSDPSNDL 
      1560       1570       1580       1590       1600
VAFSLDSPGG HCVTALALFS LGLLSVDVRI PEQIVVVDSS MVESEVMKSL 
      1610       1620       1630       1640       1650
GKDGGLDDDE EEEDLDEGSG TKRQGVEVKA HQASHTKYLL MRGYYTVPGM 
      1660       1670       1680       1690       1700
VSTRNLNPND SIVVNSCQVK FRLRNTPAST QLGPTGFTAT PLEELQAGLS 
      1710       1720       1730       1740       1750
CLPASFTSLV DPQLRTHCPE EFAHQMAQSG YSPEDVAASL EILQAVAAAD 
      1760       1770       1780       1790       1800
CFGIDKEKLS RQFSALEKIA DRRTRTFLDY IQDLLEQEQV MEVGGNTVRL 
      1810       1820       1830       1840       1850
VTMASAQPWL LHSMRLRDME VDTKASGDDS QSRLPEGPSI EDHTSEGAAV 
      1860       1870       1880       1890       1900
PPVSSHSTKK RPHCPETDAE EATRLPAKKP TLQDVRVAAS PRPGAEEQAE 
      1910       1920       1930       1940       1950
AQAPAQLAAP EDADAGGPRQ ENQENVGVSG LEQLGCEFQL PEGSEDPRGL 
      1960       1970       1980       1990       2000
TESNMAQAAW ESGCERVCFV GRPWRGVDGH LNMPVCKGML EAVLYHIMSR 
      2010       2020       2030       2040       2050
PGVPESCLLQ YYQGVLQPVA VLELLRGLES LGCIQKRTLR KPASVSLFSR 
      2060       2070       2080       2090       2100
PVVEGLGQAS EAEALSCHES TVTFYEPTLD CTIRLGRVFP HDINWNKWIH 

L
Length:2,101
Mass (Da):237,476
Last modified:June 7, 2004 - v2
Checksum:i182C2EFFD9599AD6
GO
Isoform 2 (identifier: Q8K284-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1503-1598: Missing.

Note: Incomplete sequence.
Show »
Length:2,005
Mass (Da):226,731
Checksum:i056891D09CC78140
GO
Isoform 3 (identifier: Q8K284-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: Missing.
     326-375: TDVMVRCLKL...VFERDMLTQT → KSRTLWPTGS...KRIREVCPEF
     376-2101: Missing.

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):25,427
Checksum:iA16FC3AA7DE188F1
GO

Sequence cautioni

The sequence AAH32208 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1599S → N in AAH32208 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0105731 – 156Missing in isoform 3. 1 PublicationAdd BLAST156
Alternative sequenceiVSP_010574326 – 375TDVMV…MLTQT → KSRTLWPTGSPCCHFLWSHS ALKCEDYTSFSSLLLSAFYL KRIREVCPEF in isoform 3. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_010575376 – 2101Missing in isoform 3. 1 PublicationAdd BLAST1726
Alternative sequenceiVSP_0105761503 – 1598Missing in isoform 2. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038537 mRNA. Translation: BAC30032.1.
BC032208 mRNA. Translation: AAH32208.1. Different initiation.
BC067041 mRNA. Translation: AAH67041.1.
CCDSiCCDS40122.1. [Q8K284-1]
RefSeqiNP_997122.1. NM_207239.1. [Q8K284-1]
UniGeneiMm.294173.

Genome annotation databases

EnsembliENSMUST00000055506; ENSMUSP00000056719; ENSMUSG00000032777. [Q8K284-1]
GeneIDi233863.
KEGGimmu:233863.
UCSCiuc009jqh.1. mouse. [Q8K284-1]
uc009jql.1. mouse. [Q8K284-3]
uc012fto.1. mouse. [Q8K284-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTF3C1_MOUSE
AccessioniPrimary (citable) accession number: Q8K284
Secondary accession number(s): Q8CAL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: May 10, 2017
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families