UniProtKB - Q8K284 (TF3C1_MOUSE)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
General transcription factor 3C polypeptide 1
Gene
Gtf3c1
Organism
Mus musculus (Mouse)
Status
Functioni
Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element (By similarity).By similarity
GO - Molecular functioni
- RNA polymerase III type 1 promoter sequence-specific DNA binding Source: GO_Central
- RNA polymerase III type 2 promoter sequence-specific DNA binding Source: GO_Central
- transcription factor activity, RNA polymerase III transcription factor binding Source: GO_Central
GO - Biological processi
- 5S class rRNA transcription by RNA polymerase III Source: GO_Central
- transcription initiation from RNA polymerase III promoter Source: GO_Central
- tRNA transcription Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription |
Enzyme and pathway databases
Reactomei | R-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter. R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter. |
Names & Taxonomyi
Protein namesi | Recommended name: General transcription factor 3C polypeptide 1Alternative name(s): TF3C-alpha TFIIIC box B-binding subunit Transcription factor IIIC 220 kDa subunit Short name: TFIIIC 220 kDa subunit Short name: TFIIIC220 Transcription factor IIIC subunit alpha |
Gene namesi | Name:Gtf3c1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107887. Gtf3c1. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000209711 | 1 – 2101 | General transcription factor 3C polypeptide 1Add BLAST | 2101 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 534 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 667 | PhosphoserineBy similarity | 1 | |
Cross-linki | 770 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 833 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1063 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1196 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1854 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1890 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8K284. |
PaxDbi | Q8K284. |
PeptideAtlasi | Q8K284. |
PRIDEi | Q8K284. |
PTM databases
iPTMneti | Q8K284. |
PhosphoSitePlusi | Q8K284. |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032777. |
CleanExi | MM_GTF3C1. |
ExpressionAtlasi | Q8K284. baseline and differential. |
Genevisiblei | Q8K284. MM. |
Interactioni
Subunit structurei
Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with IGHMBP2.By similarity
Protein-protein interaction databases
BioGridi | 231457. 5 interactors. |
IntActi | Q8K284. 1 interactor. |
MINTi | Q8K284. |
STRINGi | 10090.ENSMUSP00000056719. |
Structurei
3D structure databases
ProteinModelPortali | Q8K284. |
SMRi | Q8K284. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 344 – 354 | Asp/Glu-rich (acidic)Add BLAST | 11 | |
Compositional biasi | 1199 – 1227 | Arg/Lys-rich (basic)Add BLAST | 29 | |
Compositional biasi | 1607 – 1617 | Asp/Glu-rich (acidic)Add BLAST | 11 |
Sequence similaritiesi
Belongs to the TFIIIC subunit 1 family.Curated
Phylogenomic databases
eggNOGi | KOG4560. Eukaryota. ENOG410XSJ5. LUCA. |
GeneTreei | ENSGT00390000008664. |
HOGENOMi | HOG000154556. |
HOVERGENi | HBG057283. |
InParanoidi | Q8K284. |
KOi | K15199. |
OMAi | VYPIHMI. |
OrthoDBi | EOG091G00PD. |
PhylomeDBi | Q8K284. |
TreeFami | TF351624. |
Family and domain databases
CDDi | cd16169. Tau138_eWH. 1 hit. |
InterProi | View protein in InterPro IPR035625. Tfc3_eWH. IPR007309. TFIIIC_Bblock-bd. |
Pfami | View protein in Pfam PF04182. B-block_TFIIIC. 1 hit. |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8K284-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MDALESLLDE VALEGLDGLC LPALWSRLES RSPAFPLPLE PYTQEFLWRA
60 70 80 90 100
LATHPGISFY EEPRERPDLQ LQDRYEEIDL ETGILESRRD PVTLEDVYPI
110 120 130 140 150
HMILENKDGI QGSCRYFKER KDITSSIRSK CLQPRCTMVE AFSRWGKKLI
160 170 180 190 200
IVASQDMRYR ALIGLEGDPD LKLPDFSYCI LERLGRSRWQ GELQRDLHTT
210 220 230 240 250
AFKVDAGKLH YHRKILNKNG LITMQSHVIR LPTGAQQHSI LLLLNRFHVD
260 270 280 290 300
RRSKYDILME KLSMMLSTRS NQIETLGKLR EELGLCERTF KRLYQYMLNA
310 320 330 340 350
GLAKVVSLPL QEIHPECGPC KTKKGTDVMV RCLKLLKEFK RKMEDDHDDD
360 370 380 390 400
DDEEVISKGV PPVDIVFERD MLTQTYELIE RRGTKGISQA EIRVAMNVGK
410 420 430 440 450
LEARMLCRLL QRFKVVKGFM EDEGRQRTTK YISCVFAEES DLSRQYAREK
460 470 480 490 500
ARGELLTTVS LASVQDESLM PEGEEAFLSD SESEEESSCS GGKRRGRGSR
510 520 530 540 550
GHARASGDAG SGSRPHHSTP AKGGWKVLNL HPLKKPKAAA EERSRRSSAC
560 570 580 590 600
RDGLDTSSSS ELNAPFDPHS MDSHSGDIAV IEEVRLDNPK EGGGSQKGGR
610 620 630 640 650
HGSSQDKPHK TYRLLKRRNL IIEAVTNLRL IESLFTIQKM IMDQEKQEGV
660 670 680 690 700
STKCCKKSII RLVRNLSEEG LLRLYRTTVI QDGIKKKVDL VVHPSMDQND
710 720 730 740 750
PLVRSAIEQV RFRISNSSTA NRVKVPPAPA PQEEAEEENQ EPEVPSRSAN
760 770 780 790 800
SDPNTSSKPE STRVKKTDEK MGITPLKNYK PVIVPGLGRS IGFLPKMPRL
810 820 830 840 850
KAMHLFLWYL VYGHPAGHTG EQPALHSERK TGKQESSRPG AQPSSGDDWD
860 870 880 890 900
TSEAKNNTES SSWESEMELS TEIVYVDEIS WMRYVPPIPI HRDFGFGWAL
910 920 930 940 950
VSDILLCLPL SIFVQLVQVS YKVDNLEDFL NDPLKKHTLI RFLPRHIRQQ
960 970 980 990 1000
LLYKRRYIFS VVENLQRLCY MGLLQFGPTE KFQDKDQVFV FLKKNAVIVD
1010 1020 1030 1040 1050
TTICDPHYNL AHSSRPFERR LYVLDSMQDV ECYWFDLQCI CLNTPLGVVR
1060 1070 1080 1090 1100
CPCAQKICPD PGSDPEGSLR KEQESAMDKH NLERKCAMLE YTTGSREVVD
1110 1120 1130 1140 1150
EGLVPGDGLG AAGLDSSFYA HLKRNWVWTS YIINKARKNN TSENGLTGRL
1160 1170 1180 1190 1200
QTFLSKRPMP LGSGGSGRLP LWSEGRADAE LCADKEEQFE LDREPTPGRN
1210 1220 1230 1240 1250
RKVRGGKSQK RKRLKKEPIR KTKRRRRGEH PEAKSKKLRY QDEADQNALR
1260 1270 1280 1290 1300
MMTRLRVSWS MQEDGLLMLC RIASNVLNTK VKGPFVTWQV VRDILHATFE
1310 1320 1330 1340 1350
ESLDKTSHSV GRRARYIVKN PQAFMNYKVC LAEVYQDKAL VGDFMSRKGN
1360 1370 1380 1390 1400
YEDPKVCAKE FKEFVEKLKE KFSSGLRNPN LEIPNTLQEL FAKYRVLAIG
1410 1420 1430 1440 1450
DEKDRVRKED ELNSVEDIHF LVLQNLIQST LSLSNSQSNS CQSFQIFRLY
1460 1470 1480 1490 1500
REFREPVLVR AFMECQKRSL VNRRRVSHSQ GPKKNRAVPF VPMSYQLSQS
1510 1520 1530 1540 1550
YYKLFTWRFP TTICTESFQF YDRLRTNGML DQPDHFSFKD LDSSDPSNDL
1560 1570 1580 1590 1600
VAFSLDSPGG HCVTALALFS LGLLSVDVRI PEQIVVVDSS MVESEVMKSL
1610 1620 1630 1640 1650
GKDGGLDDDE EEEDLDEGSG TKRQGVEVKA HQASHTKYLL MRGYYTVPGM
1660 1670 1680 1690 1700
VSTRNLNPND SIVVNSCQVK FRLRNTPAST QLGPTGFTAT PLEELQAGLS
1710 1720 1730 1740 1750
CLPASFTSLV DPQLRTHCPE EFAHQMAQSG YSPEDVAASL EILQAVAAAD
1760 1770 1780 1790 1800
CFGIDKEKLS RQFSALEKIA DRRTRTFLDY IQDLLEQEQV MEVGGNTVRL
1810 1820 1830 1840 1850
VTMASAQPWL LHSMRLRDME VDTKASGDDS QSRLPEGPSI EDHTSEGAAV
1860 1870 1880 1890 1900
PPVSSHSTKK RPHCPETDAE EATRLPAKKP TLQDVRVAAS PRPGAEEQAE
1910 1920 1930 1940 1950
AQAPAQLAAP EDADAGGPRQ ENQENVGVSG LEQLGCEFQL PEGSEDPRGL
1960 1970 1980 1990 2000
TESNMAQAAW ESGCERVCFV GRPWRGVDGH LNMPVCKGML EAVLYHIMSR
2010 2020 2030 2040 2050
PGVPESCLLQ YYQGVLQPVA VLELLRGLES LGCIQKRTLR KPASVSLFSR
2060 2070 2080 2090 2100
PVVEGLGQAS EAEALSCHES TVTFYEPTLD CTIRLGRVFP HDINWNKWIH
L
Sequence cautioni
The sequence AAH32208 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1599 | S → N in AAH32208 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010573 | 1 – 156 | Missing in isoform 3. 1 PublicationAdd BLAST | 156 | |
Alternative sequenceiVSP_010574 | 326 – 375 | TDVMV…MLTQT → KSRTLWPTGSPCCHFLWSHS ALKCEDYTSFSSLLLSAFYL KRIREVCPEF in isoform 3. 1 PublicationAdd BLAST | 50 | |
Alternative sequenceiVSP_010575 | 376 – 2101 | Missing in isoform 3. 1 PublicationAdd BLAST | 1726 | |
Alternative sequenceiVSP_010576 | 1503 – 1598 | Missing in isoform 2. 1 PublicationAdd BLAST | 96 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK038537 mRNA. Translation: BAC30032.1. BC032208 mRNA. Translation: AAH32208.1. Different initiation. BC067041 mRNA. Translation: AAH67041.1. |
CCDSi | CCDS40122.1. [Q8K284-1] |
RefSeqi | NP_997122.1. NM_207239.1. [Q8K284-1] |
UniGenei | Mm.294173. |
Genome annotation databases
Ensembli | ENSMUST00000055506; ENSMUSP00000056719; ENSMUSG00000032777. [Q8K284-1] |
GeneIDi | 233863. |
KEGGi | mmu:233863. |
UCSCi | uc009jqh.1. mouse. [Q8K284-1] uc009jql.1. mouse. [Q8K284-3] uc012fto.1. mouse. [Q8K284-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | TF3C1_MOUSE | |
Accessioni | Q8K284Primary (citable) accession number: Q8K284 Secondary accession number(s): Q8CAL9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2004 |
Last sequence update: | June 7, 2004 | |
Last modified: | March 28, 2018 | |
This is version 117 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |