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Protein

General transcription factor 3C polypeptide 1

Gene

Gtf3c1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor 3C polypeptide 1
Alternative name(s):
TF3C-alpha
TFIIIC box B-binding subunit
Transcription factor IIIC 220 kDa subunit
Short name:
TFIIIC 220 kDa subunit
Short name:
TFIIIC220
Transcription factor IIIC subunit alpha
Gene namesi
Name:Gtf3c1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107887. Gtf3c1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21012101General transcription factor 3C polypeptide 1PRO_0000209711Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei667 – 6671PhosphoserineBy similarity
Cross-linki833 – 833Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1063 – 10631PhosphoserineBy similarity
Modified residuei1196 – 11961PhosphothreonineCombined sources
Modified residuei1854 – 18541PhosphoserineBy similarity
Modified residuei1890 – 18901PhosphoserineCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8K284.
MaxQBiQ8K284.
PaxDbiQ8K284.
PeptideAtlasiQ8K284.
PRIDEiQ8K284.

PTM databases

iPTMnetiQ8K284.
PhosphoSiteiQ8K284.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032777.
CleanExiMM_GTF3C1.
GenevisibleiQ8K284. MM.

Interactioni

Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with IGHMBP2.By similarity

Protein-protein interaction databases

BioGridi231457. 5 interactions.
IntActiQ8K284. 1 interaction.
MINTiMINT-4137479.
STRINGi10090.ENSMUSP00000056719.

Structurei

3D structure databases

ProteinModelPortaliQ8K284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi344 – 35411Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi1199 – 122729Arg/Lys-rich (basic)Add
BLAST
Compositional biasi1607 – 161711Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the TFIIIC subunit 1 family.Curated

Phylogenomic databases

eggNOGiKOG4560. Eukaryota.
ENOG410XSJ5. LUCA.
GeneTreeiENSGT00390000008664.
HOGENOMiHOG000154556.
HOVERGENiHBG057283.
InParanoidiQ8K284.
KOiK15199.
OMAiVYPIHMI.
OrthoDBiEOG091G00PD.
PhylomeDBiQ8K284.
TreeFamiTF351624.

Family and domain databases

InterProiIPR007309. TFIIIC_Bblock-bd.
[Graphical view]
PfamiPF04182. B-block_TFIIIC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K284-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDALESLLDE VALEGLDGLC LPALWSRLES RSPAFPLPLE PYTQEFLWRA
60 70 80 90 100
LATHPGISFY EEPRERPDLQ LQDRYEEIDL ETGILESRRD PVTLEDVYPI
110 120 130 140 150
HMILENKDGI QGSCRYFKER KDITSSIRSK CLQPRCTMVE AFSRWGKKLI
160 170 180 190 200
IVASQDMRYR ALIGLEGDPD LKLPDFSYCI LERLGRSRWQ GELQRDLHTT
210 220 230 240 250
AFKVDAGKLH YHRKILNKNG LITMQSHVIR LPTGAQQHSI LLLLNRFHVD
260 270 280 290 300
RRSKYDILME KLSMMLSTRS NQIETLGKLR EELGLCERTF KRLYQYMLNA
310 320 330 340 350
GLAKVVSLPL QEIHPECGPC KTKKGTDVMV RCLKLLKEFK RKMEDDHDDD
360 370 380 390 400
DDEEVISKGV PPVDIVFERD MLTQTYELIE RRGTKGISQA EIRVAMNVGK
410 420 430 440 450
LEARMLCRLL QRFKVVKGFM EDEGRQRTTK YISCVFAEES DLSRQYAREK
460 470 480 490 500
ARGELLTTVS LASVQDESLM PEGEEAFLSD SESEEESSCS GGKRRGRGSR
510 520 530 540 550
GHARASGDAG SGSRPHHSTP AKGGWKVLNL HPLKKPKAAA EERSRRSSAC
560 570 580 590 600
RDGLDTSSSS ELNAPFDPHS MDSHSGDIAV IEEVRLDNPK EGGGSQKGGR
610 620 630 640 650
HGSSQDKPHK TYRLLKRRNL IIEAVTNLRL IESLFTIQKM IMDQEKQEGV
660 670 680 690 700
STKCCKKSII RLVRNLSEEG LLRLYRTTVI QDGIKKKVDL VVHPSMDQND
710 720 730 740 750
PLVRSAIEQV RFRISNSSTA NRVKVPPAPA PQEEAEEENQ EPEVPSRSAN
760 770 780 790 800
SDPNTSSKPE STRVKKTDEK MGITPLKNYK PVIVPGLGRS IGFLPKMPRL
810 820 830 840 850
KAMHLFLWYL VYGHPAGHTG EQPALHSERK TGKQESSRPG AQPSSGDDWD
860 870 880 890 900
TSEAKNNTES SSWESEMELS TEIVYVDEIS WMRYVPPIPI HRDFGFGWAL
910 920 930 940 950
VSDILLCLPL SIFVQLVQVS YKVDNLEDFL NDPLKKHTLI RFLPRHIRQQ
960 970 980 990 1000
LLYKRRYIFS VVENLQRLCY MGLLQFGPTE KFQDKDQVFV FLKKNAVIVD
1010 1020 1030 1040 1050
TTICDPHYNL AHSSRPFERR LYVLDSMQDV ECYWFDLQCI CLNTPLGVVR
1060 1070 1080 1090 1100
CPCAQKICPD PGSDPEGSLR KEQESAMDKH NLERKCAMLE YTTGSREVVD
1110 1120 1130 1140 1150
EGLVPGDGLG AAGLDSSFYA HLKRNWVWTS YIINKARKNN TSENGLTGRL
1160 1170 1180 1190 1200
QTFLSKRPMP LGSGGSGRLP LWSEGRADAE LCADKEEQFE LDREPTPGRN
1210 1220 1230 1240 1250
RKVRGGKSQK RKRLKKEPIR KTKRRRRGEH PEAKSKKLRY QDEADQNALR
1260 1270 1280 1290 1300
MMTRLRVSWS MQEDGLLMLC RIASNVLNTK VKGPFVTWQV VRDILHATFE
1310 1320 1330 1340 1350
ESLDKTSHSV GRRARYIVKN PQAFMNYKVC LAEVYQDKAL VGDFMSRKGN
1360 1370 1380 1390 1400
YEDPKVCAKE FKEFVEKLKE KFSSGLRNPN LEIPNTLQEL FAKYRVLAIG
1410 1420 1430 1440 1450
DEKDRVRKED ELNSVEDIHF LVLQNLIQST LSLSNSQSNS CQSFQIFRLY
1460 1470 1480 1490 1500
REFREPVLVR AFMECQKRSL VNRRRVSHSQ GPKKNRAVPF VPMSYQLSQS
1510 1520 1530 1540 1550
YYKLFTWRFP TTICTESFQF YDRLRTNGML DQPDHFSFKD LDSSDPSNDL
1560 1570 1580 1590 1600
VAFSLDSPGG HCVTALALFS LGLLSVDVRI PEQIVVVDSS MVESEVMKSL
1610 1620 1630 1640 1650
GKDGGLDDDE EEEDLDEGSG TKRQGVEVKA HQASHTKYLL MRGYYTVPGM
1660 1670 1680 1690 1700
VSTRNLNPND SIVVNSCQVK FRLRNTPAST QLGPTGFTAT PLEELQAGLS
1710 1720 1730 1740 1750
CLPASFTSLV DPQLRTHCPE EFAHQMAQSG YSPEDVAASL EILQAVAAAD
1760 1770 1780 1790 1800
CFGIDKEKLS RQFSALEKIA DRRTRTFLDY IQDLLEQEQV MEVGGNTVRL
1810 1820 1830 1840 1850
VTMASAQPWL LHSMRLRDME VDTKASGDDS QSRLPEGPSI EDHTSEGAAV
1860 1870 1880 1890 1900
PPVSSHSTKK RPHCPETDAE EATRLPAKKP TLQDVRVAAS PRPGAEEQAE
1910 1920 1930 1940 1950
AQAPAQLAAP EDADAGGPRQ ENQENVGVSG LEQLGCEFQL PEGSEDPRGL
1960 1970 1980 1990 2000
TESNMAQAAW ESGCERVCFV GRPWRGVDGH LNMPVCKGML EAVLYHIMSR
2010 2020 2030 2040 2050
PGVPESCLLQ YYQGVLQPVA VLELLRGLES LGCIQKRTLR KPASVSLFSR
2060 2070 2080 2090 2100
PVVEGLGQAS EAEALSCHES TVTFYEPTLD CTIRLGRVFP HDINWNKWIH

L
Length:2,101
Mass (Da):237,476
Last modified:June 7, 2004 - v2
Checksum:i182C2EFFD9599AD6
GO
Isoform 2 (identifier: Q8K284-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1503-1598: Missing.

Note: Incomplete sequence.
Show »
Length:2,005
Mass (Da):226,731
Checksum:i056891D09CC78140
GO
Isoform 3 (identifier: Q8K284-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: Missing.
     326-375: TDVMVRCLKL...VFERDMLTQT → KSRTLWPTGS...KRIREVCPEF
     376-2101: Missing.

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):25,427
Checksum:iA16FC3AA7DE188F1
GO

Sequence cautioni

The sequence AAH32208 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1599 – 15991S → N in AAH32208 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 156156Missing in isoform 3. 1 PublicationVSP_010573Add
BLAST
Alternative sequencei326 – 37550TDVMV…MLTQT → KSRTLWPTGSPCCHFLWSHS ALKCEDYTSFSSLLLSAFYL KRIREVCPEF in isoform 3. 1 PublicationVSP_010574Add
BLAST
Alternative sequencei376 – 21011726Missing in isoform 3. 1 PublicationVSP_010575Add
BLAST
Alternative sequencei1503 – 159896Missing in isoform 2. 1 PublicationVSP_010576Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038537 mRNA. Translation: BAC30032.1.
BC032208 mRNA. Translation: AAH32208.1. Different initiation.
BC067041 mRNA. Translation: AAH67041.1.
CCDSiCCDS40122.1. [Q8K284-1]
RefSeqiNP_997122.1. NM_207239.1. [Q8K284-1]
UniGeneiMm.294173.

Genome annotation databases

EnsembliENSMUST00000055506; ENSMUSP00000056719; ENSMUSG00000032777. [Q8K284-1]
GeneIDi233863.
KEGGimmu:233863.
UCSCiuc009jqh.1. mouse. [Q8K284-1]
uc009jql.1. mouse. [Q8K284-3]
uc012fto.1. mouse. [Q8K284-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038537 mRNA. Translation: BAC30032.1.
BC032208 mRNA. Translation: AAH32208.1. Different initiation.
BC067041 mRNA. Translation: AAH67041.1.
CCDSiCCDS40122.1. [Q8K284-1]
RefSeqiNP_997122.1. NM_207239.1. [Q8K284-1]
UniGeneiMm.294173.

3D structure databases

ProteinModelPortaliQ8K284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231457. 5 interactions.
IntActiQ8K284. 1 interaction.
MINTiMINT-4137479.
STRINGi10090.ENSMUSP00000056719.

PTM databases

iPTMnetiQ8K284.
PhosphoSiteiQ8K284.

Proteomic databases

EPDiQ8K284.
MaxQBiQ8K284.
PaxDbiQ8K284.
PeptideAtlasiQ8K284.
PRIDEiQ8K284.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055506; ENSMUSP00000056719; ENSMUSG00000032777. [Q8K284-1]
GeneIDi233863.
KEGGimmu:233863.
UCSCiuc009jqh.1. mouse. [Q8K284-1]
uc009jql.1. mouse. [Q8K284-3]
uc012fto.1. mouse. [Q8K284-2]

Organism-specific databases

CTDi2975.
MGIiMGI:107887. Gtf3c1.

Phylogenomic databases

eggNOGiKOG4560. Eukaryota.
ENOG410XSJ5. LUCA.
GeneTreeiENSGT00390000008664.
HOGENOMiHOG000154556.
HOVERGENiHBG057283.
InParanoidiQ8K284.
KOiK15199.
OMAiVYPIHMI.
OrthoDBiEOG091G00PD.
PhylomeDBiQ8K284.
TreeFamiTF351624.

Enzyme and pathway databases

ReactomeiR-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Miscellaneous databases

ChiTaRSiGtf3c1. mouse.
PROiQ8K284.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032777.
CleanExiMM_GTF3C1.
GenevisibleiQ8K284. MM.

Family and domain databases

InterProiIPR007309. TFIIIC_Bblock-bd.
[Graphical view]
PfamiPF04182. B-block_TFIIIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTF3C1_MOUSE
AccessioniPrimary (citable) accession number: Q8K284
Secondary accession number(s): Q8CAL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: September 7, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.