Gtf3c1

Functionⁱ

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element (By similarity).By similarity

GO - Molecular functionⁱ

RNA polymerase III type 1 promoter sequence-specific DNA binding Source: GO_Central
RNA polymerase III type 2 promoter sequence-specific DNA binding Source: GO_Central
transcription factor activity, RNA polymerase III transcription factor binding Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

5S class rRNA transcription from RNA polymerase III type 1 promoter Source: GO_Central
transcription initiation from RNA polymerase III promoter Source: GO_Central
tRNA transcription Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription

Enzyme and pathway databases

Reactomeⁱ	R-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter. R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Reactomeⁱ

R-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: General transcription factor 3C polypeptide 1 Alternative name(s): TF3C-alpha TFIIIC box B-binding subunit Transcription factor IIIC 220 kDa subunit Short name: TFIIIC 220 kDa subunit Short name: TFIIIC220 Transcription factor IIIC subunit alpha
Gene namesⁱ	Name:Gtf3c1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:107887. Gtf3c1.

Subcellular locationⁱ

Nucleus By similarity

GO - Cellular componentⁱ

intracellular ribonucleoprotein complex
Source: MGI
Inferred from direct assayⁱ
- 19299493
membrane Source: MGI
nucleolus Source: MGI
nucleus Source: MGI
transcription factor TFIIIC complex Source: MGI

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000209711	1 – 2101	General transcription factor 3C polypeptide 1Add BLAST		2101

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	534	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	667	PhosphoserineBy similarity	1
Cross-linkⁱ	770	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	833	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	1063	PhosphoserineBy similarity	1
Modified residueⁱ	1196	PhosphothreonineCombined sources	1
Modified residueⁱ	1854	PhosphoserineBy similarity	1
Modified residueⁱ	1890	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8K284.
PaxDbⁱ	Q8K284.
PeptideAtlas More...PeptideAtlasⁱ	Q8K284.
PRIDEⁱ	Q8K284.

PTM databases

iPTMnetⁱ	Q8K284.
PhosphoSitePlusⁱ	Q8K284.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000032777.
CleanExⁱ	MM_GTF3C1.
ExpressionAtlasⁱ	Q8K284. baseline and differential.
Genevisibleⁱ	Q8K284. MM.

Interactionⁱ

Subunit structureⁱ

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with IGHMBP2.By similarity

Protein-protein interaction databases

BioGridⁱ	231457. 5 interactors.
IntActⁱ	Q8K284. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-4137479.
STRINGⁱ	10090.ENSMUSP00000056719.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8K284.
SMRⁱ	Q8K284.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	344 – 354	Asp/Glu-rich (acidic)Add BLAST	11
Compositional biasⁱ	1199 – 1227	Arg/Lys-rich (basic)Add BLAST	29
Compositional biasⁱ	1607 – 1617	Asp/Glu-rich (acidic)Add BLAST	11

Sequence similaritiesⁱ

Belongs to the TFIIIC subunit 1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4560. Eukaryota. ENOG410XSJ5. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008664.
HOGENOMⁱ	HOG000154556.
HOVERGENⁱ	HBG057283.
InParanoidⁱ	Q8K284.
KEGG Orthology (KO) More...KOⁱ	K15199.
OMAⁱ	VYPIHMI.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00PD.
PhylomeDBⁱ	Q8K284.
TreeFamⁱ	TF351624.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd16169. Tau138_eWH. 1 hit.
InterProⁱ	View protein in InterPro IPR035625. Tfc3_eWH. IPR007309. TFIIIC_Bblock-bd.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04182. B-block_TFIIIC. 1 hit.

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8K284-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDALESLLDE VALEGLDGLC LPALWSRLES RSPAFPLPLE PYTQEFLWRA 
        60         70         80         90        100
LATHPGISFY EEPRERPDLQ LQDRYEEIDL ETGILESRRD PVTLEDVYPI 
       110        120        130        140        150
HMILENKDGI QGSCRYFKER KDITSSIRSK CLQPRCTMVE AFSRWGKKLI 
       160        170        180        190        200
IVASQDMRYR ALIGLEGDPD LKLPDFSYCI LERLGRSRWQ GELQRDLHTT 
       210        220        230        240        250
AFKVDAGKLH YHRKILNKNG LITMQSHVIR LPTGAQQHSI LLLLNRFHVD 
       260        270        280        290        300
RRSKYDILME KLSMMLSTRS NQIETLGKLR EELGLCERTF KRLYQYMLNA 
       310        320        330        340        350
GLAKVVSLPL QEIHPECGPC KTKKGTDVMV RCLKLLKEFK RKMEDDHDDD 
       360        370        380        390        400
DDEEVISKGV PPVDIVFERD MLTQTYELIE RRGTKGISQA EIRVAMNVGK 
       410        420        430        440        450
LEARMLCRLL QRFKVVKGFM EDEGRQRTTK YISCVFAEES DLSRQYAREK 
       460        470        480        490        500
ARGELLTTVS LASVQDESLM PEGEEAFLSD SESEEESSCS GGKRRGRGSR 
       510        520        530        540        550
GHARASGDAG SGSRPHHSTP AKGGWKVLNL HPLKKPKAAA EERSRRSSAC 
       560        570        580        590        600
RDGLDTSSSS ELNAPFDPHS MDSHSGDIAV IEEVRLDNPK EGGGSQKGGR 
       610        620        630        640        650
HGSSQDKPHK TYRLLKRRNL IIEAVTNLRL IESLFTIQKM IMDQEKQEGV 
       660        670        680        690        700
STKCCKKSII RLVRNLSEEG LLRLYRTTVI QDGIKKKVDL VVHPSMDQND 
       710        720        730        740        750
PLVRSAIEQV RFRISNSSTA NRVKVPPAPA PQEEAEEENQ EPEVPSRSAN 
       760        770        780        790        800
SDPNTSSKPE STRVKKTDEK MGITPLKNYK PVIVPGLGRS IGFLPKMPRL 
       810        820        830        840        850
KAMHLFLWYL VYGHPAGHTG EQPALHSERK TGKQESSRPG AQPSSGDDWD 
       860        870        880        890        900
TSEAKNNTES SSWESEMELS TEIVYVDEIS WMRYVPPIPI HRDFGFGWAL 
       910        920        930        940        950
VSDILLCLPL SIFVQLVQVS YKVDNLEDFL NDPLKKHTLI RFLPRHIRQQ 
       960        970        980        990       1000
LLYKRRYIFS VVENLQRLCY MGLLQFGPTE KFQDKDQVFV FLKKNAVIVD 
      1010       1020       1030       1040       1050
TTICDPHYNL AHSSRPFERR LYVLDSMQDV ECYWFDLQCI CLNTPLGVVR 
      1060       1070       1080       1090       1100
CPCAQKICPD PGSDPEGSLR KEQESAMDKH NLERKCAMLE YTTGSREVVD 
      1110       1120       1130       1140       1150
EGLVPGDGLG AAGLDSSFYA HLKRNWVWTS YIINKARKNN TSENGLTGRL 
      1160       1170       1180       1190       1200
QTFLSKRPMP LGSGGSGRLP LWSEGRADAE LCADKEEQFE LDREPTPGRN 
      1210       1220       1230       1240       1250
RKVRGGKSQK RKRLKKEPIR KTKRRRRGEH PEAKSKKLRY QDEADQNALR 
      1260       1270       1280       1290       1300
MMTRLRVSWS MQEDGLLMLC RIASNVLNTK VKGPFVTWQV VRDILHATFE 
      1310       1320       1330       1340       1350
ESLDKTSHSV GRRARYIVKN PQAFMNYKVC LAEVYQDKAL VGDFMSRKGN 
      1360       1370       1380       1390       1400
YEDPKVCAKE FKEFVEKLKE KFSSGLRNPN LEIPNTLQEL FAKYRVLAIG 
      1410       1420       1430       1440       1450
DEKDRVRKED ELNSVEDIHF LVLQNLIQST LSLSNSQSNS CQSFQIFRLY 
      1460       1470       1480       1490       1500
REFREPVLVR AFMECQKRSL VNRRRVSHSQ GPKKNRAVPF VPMSYQLSQS 
      1510       1520       1530       1540       1550
YYKLFTWRFP TTICTESFQF YDRLRTNGML DQPDHFSFKD LDSSDPSNDL 
      1560       1570       1580       1590       1600
VAFSLDSPGG HCVTALALFS LGLLSVDVRI PEQIVVVDSS MVESEVMKSL 
      1610       1620       1630       1640       1650
GKDGGLDDDE EEEDLDEGSG TKRQGVEVKA HQASHTKYLL MRGYYTVPGM 
      1660       1670       1680       1690       1700
VSTRNLNPND SIVVNSCQVK FRLRNTPAST QLGPTGFTAT PLEELQAGLS 
      1710       1720       1730       1740       1750
CLPASFTSLV DPQLRTHCPE EFAHQMAQSG YSPEDVAASL EILQAVAAAD 
      1760       1770       1780       1790       1800
CFGIDKEKLS RQFSALEKIA DRRTRTFLDY IQDLLEQEQV MEVGGNTVRL 
      1810       1820       1830       1840       1850
VTMASAQPWL LHSMRLRDME VDTKASGDDS QSRLPEGPSI EDHTSEGAAV 
      1860       1870       1880       1890       1900
PPVSSHSTKK RPHCPETDAE EATRLPAKKP TLQDVRVAAS PRPGAEEQAE 
      1910       1920       1930       1940       1950
AQAPAQLAAP EDADAGGPRQ ENQENVGVSG LEQLGCEFQL PEGSEDPRGL 
      1960       1970       1980       1990       2000
TESNMAQAAW ESGCERVCFV GRPWRGVDGH LNMPVCKGML EAVLYHIMSR 
      2010       2020       2030       2040       2050
PGVPESCLLQ YYQGVLQPVA VLELLRGLES LGCIQKRTLR KPASVSLFSR 
      2060       2070       2080       2090       2100
PVVEGLGQAS EAEALSCHES TVTFYEPTLD CTIRLGRVFP HDINWNKWIH 

L

Length:2,101

Mass (Da):237,476

Last modified:June 7, 2004 - v2

Checksum:ⁱ182C2EFFD9599AD6

GO

Isoform 2 (identifier: Q8K284-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1503-1598: Missing.

« Hide

        10         20         30         40         50
MDALESLLDE VALEGLDGLC LPALWSRLES RSPAFPLPLE PYTQEFLWRA 
        60         70         80         90        100
LATHPGISFY EEPRERPDLQ LQDRYEEIDL ETGILESRRD PVTLEDVYPI 
       110        120        130        140        150
HMILENKDGI QGSCRYFKER KDITSSIRSK CLQPRCTMVE AFSRWGKKLI 
       160        170        180        190        200
IVASQDMRYR ALIGLEGDPD LKLPDFSYCI LERLGRSRWQ GELQRDLHTT 
       210        220        230        240        250
AFKVDAGKLH YHRKILNKNG LITMQSHVIR LPTGAQQHSI LLLLNRFHVD 
       260        270        280        290        300
RRSKYDILME KLSMMLSTRS NQIETLGKLR EELGLCERTF KRLYQYMLNA 
       310        320        330        340        350
GLAKVVSLPL QEIHPECGPC KTKKGTDVMV RCLKLLKEFK RKMEDDHDDD 
       360        370        380        390        400
DDEEVISKGV PPVDIVFERD MLTQTYELIE RRGTKGISQA EIRVAMNVGK 
       410        420        430        440        450
LEARMLCRLL QRFKVVKGFM EDEGRQRTTK YISCVFAEES DLSRQYAREK 
       460        470        480        490        500
ARGELLTTVS LASVQDESLM PEGEEAFLSD SESEEESSCS GGKRRGRGSR 
       510        520        530        540        550
GHARASGDAG SGSRPHHSTP AKGGWKVLNL HPLKKPKAAA EERSRRSSAC 
       560        570        580        590        600
RDGLDTSSSS ELNAPFDPHS MDSHSGDIAV IEEVRLDNPK EGGGSQKGGR 
       610        620        630        640        650
HGSSQDKPHK TYRLLKRRNL IIEAVTNLRL IESLFTIQKM IMDQEKQEGV 
       660        670        680        690        700
STKCCKKSII RLVRNLSEEG LLRLYRTTVI QDGIKKKVDL VVHPSMDQND 
       710        720        730        740        750
PLVRSAIEQV RFRISNSSTA NRVKVPPAPA PQEEAEEENQ EPEVPSRSAN 
       760        770        780        790        800
SDPNTSSKPE STRVKKTDEK MGITPLKNYK PVIVPGLGRS IGFLPKMPRL 
       810        820        830        840        850
KAMHLFLWYL VYGHPAGHTG EQPALHSERK TGKQESSRPG AQPSSGDDWD 
       860        870        880        890        900
TSEAKNNTES SSWESEMELS TEIVYVDEIS WMRYVPPIPI HRDFGFGWAL 
       910        920        930        940        950
VSDILLCLPL SIFVQLVQVS YKVDNLEDFL NDPLKKHTLI RFLPRHIRQQ 
       960        970        980        990       1000
LLYKRRYIFS VVENLQRLCY MGLLQFGPTE KFQDKDQVFV FLKKNAVIVD 
      1010       1020       1030       1040       1050
TTICDPHYNL AHSSRPFERR LYVLDSMQDV ECYWFDLQCI CLNTPLGVVR 
      1060       1070       1080       1090       1100
CPCAQKICPD PGSDPEGSLR KEQESAMDKH NLERKCAMLE YTTGSREVVD 
      1110       1120       1130       1140       1150
EGLVPGDGLG AAGLDSSFYA HLKRNWVWTS YIINKARKNN TSENGLTGRL 
      1160       1170       1180       1190       1200
QTFLSKRPMP LGSGGSGRLP LWSEGRADAE LCADKEEQFE LDREPTPGRN 
      1210       1220       1230       1240       1250
RKVRGGKSQK RKRLKKEPIR KTKRRRRGEH PEAKSKKLRY QDEADQNALR 
      1260       1270       1280       1290       1300
MMTRLRVSWS MQEDGLLMLC RIASNVLNTK VKGPFVTWQV VRDILHATFE 
      1310       1320       1330       1340       1350
ESLDKTSHSV GRRARYIVKN PQAFMNYKVC LAEVYQDKAL VGDFMSRKGN 
      1360       1370       1380       1390       1400
YEDPKVCAKE FKEFVEKLKE KFSSGLRNPN LEIPNTLQEL FAKYRVLAIG 
      1410       1420       1430       1440       1450
DEKDRVRKED ELNSVEDIHF LVLQNLIQST LSLSNSQSNS CQSFQIFRLY 
      1460       1470       1480       1490       1500
REFREPVLVR AFMECQKRSL VNRRRVSHSQ GPKKNRAVPF VPMSYQLSQS 
      1510       1520       1530       1540       1550
YYSLGKDGGL DDDEEEEDLD EGSGTKRQGV EVKAHQASHT KYLLMRGYYT 
      1560       1570       1580       1590       1600
VPGMVSTRNL NPNDSIVVNS CQVKFRLRNT PASTQLGPTG FTATPLEELQ 
      1610       1620       1630       1640       1650
AGLSCLPASF TSLVDPQLRT HCPEEFAHQM AQSGYSPEDV AASLEILQAV 
      1660       1670       1680       1690       1700
AAADCFGIDK EKLSRQFSAL EKIADRRTRT FLDYIQDLLE QEQVMEVGGN 
      1710       1720       1730       1740       1750
TVRLVTMASA QPWLLHSMRL RDMEVDTKAS GDDSQSRLPE GPSIEDHTSE 
      1760       1770       1780       1790       1800
GAAVPPVSSH STKKRPHCPE TDAEEATRLP AKKPTLQDVR VAASPRPGAE 
      1810       1820       1830       1840       1850
EQAEAQAPAQ LAAPEDADAG GPRQENQENV GVSGLEQLGC EFQLPEGSED 
      1860       1870       1880       1890       1900
PRGLTESNMA QAAWESGCER VCFVGRPWRG VDGHLNMPVC KGMLEAVLYH 
      1910       1920       1930       1940       1950
IMSRPGVPES CLLQYYQGVL QPVAVLELLR GLESLGCIQK RTLRKPASVS 
      1960       1970       1980       1990       2000
LFSRPVVEGL GQASEAEALS CHESTVTFYE PTLDCTIRLG RVFPHDINWN 

KWIHL

Note: Incomplete sequence.

Show »

Length:2,005

Mass (Da):226,731

Checksum:ⁱ056891D09CC78140

GO

Isoform 3 (identifier: Q8K284-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: Missing.
     326-375: TDVMVRCLKL...VFERDMLTQT → KSRTLWPTGS...KRIREVCPEF
     376-2101: Missing.

« Hide

        10         20         30         40         50
MRYRALIGLE GDPDLKLPDF SYCILERLGR SRWQGELQRD LHTTAFKVDA 
        60         70         80         90        100
GKLHYHRKIL NKNGLITMQS HVIRLPTGAQ QHSILLLLNR FHVDRRSKYD 
       110        120        130        140        150
ILMEKLSMML STRSNQIETL GKLREELGLC ERTFKRLYQY MLNAGLAKVV 
       160        170        180        190        200
SLPLQEIHPE CGPCKTKKGK SRTLWPTGSP CCHFLWSHSA LKCEDYTSFS 
       210 
SLLLSAFYLK RIREVCPEF

Note: No experimental confirmation available.

Show »

Length:219

Mass (Da):25,427

Checksum:ⁱA16FC3AA7DE188F1

GO

Sequence cautionⁱ

The sequence AAH32208 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	1599	S → N in AAH32208 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_010573	1 – 156	Missing in isoform 3. 1 PublicationAdd BLAST	156
Alternative sequenceⁱVSP_010574	326 – 375	TDVMV…MLTQT → KSRTLWPTGSPCCHFLWSHS ALKCEDYTSFSSLLLSAFYL KRIREVCPEF in isoform 3. 1 PublicationAdd BLAST	50
Alternative sequenceⁱVSP_010575	376 – 2101	Missing in isoform 3. 1 PublicationAdd BLAST	1726
Alternative sequenceⁱVSP_010576	1503 – 1598	Missing in isoform 2. 1 PublicationAdd BLAST	96

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK038537 mRNA. Translation: BAC30032.1. BC032208 mRNA. Translation: AAH32208.1. Different initiation. BC067041 mRNA. Translation: AAH67041.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS40122.1. [Q8K284-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_997122.1. NM_207239.1. [Q8K284-1]
UniGeneⁱ	Mm.294173.

Genome annotation databases

Ensemblⁱ	ENSMUST00000055506; ENSMUSP00000056719; ENSMUSG00000032777. [Q8K284-1]
GeneIDⁱ	233863.
KEGGⁱ	mmu:233863.
UCSC genome browser More...UCSCⁱ	uc009jqh.1. mouse. [Q8K284-1] uc009jql.1. mouse. [Q8K284-3] uc012fto.1. mouse. [Q8K284-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q8K284	Q3UPZ9 Q3UQ70 Q3UY03 A0JLN7	Mus musculus (Mouse)	2,101	UniRef100_Q8K284	Cluster: General transcription factor 3C polypeptide 1	5

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q8K284	Q3UPZ9 Q3UQ70 Q3UY03 A0JLN7 UPI000819D7D5 UPI00042AD372 A0A1U7Q307 UPI00038C5D02 UPI000A3198CD UPI000A323ACC +3	Mus musculus (Mouse) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Peromyscus maniculatus bairdii (prairie deer mouse) Mesocricetus auratus (Golden hamster) Microtus ochrogaster (Prairie vole) Mus caroli (Ryukyu mouse) (Ricefield mouse) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)	2,101	UniRef90_Q8K284	Cluster: General transcription factor 3C polypeptide 1	14
Q8K284-2	A0A0U1RPD8	Mus musculus (Mouse)	2,005	UniRef90_Q8K284-2	Cluster: Isoform 2 of General transcription factor 3C polypeptide 1	2

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q8K284	Q3UPZ9 Q3UQ70 Q3UY03 A0JLN7 UPI000819D7D5 UPI00042AD372 A0A1U7Q307 UPI000A323ACC UPI00038C5D02 UPI000A3198CD +175	Mus musculus (Mouse) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Peromyscus maniculatus bairdii (prairie deer mouse) Mesocricetus auratus (Golden hamster) Microtus ochrogaster (Prairie vole) Mus caroli (Ryukyu mouse) (Ricefield mouse) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Heterocephalus glaber (Naked mole rat) Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis) And more	2,101	UniRef50_Q8K284	Cluster: General transcription factor 3C polypeptide 1	186
Q8K284-2	Q12789 UPI0005334581 Q6AWA4 Q7Z7H4 I3L1Z3 UPI0005F4AE6F I2CY52 A0A096NHJ3 F7HDU1 UPI0005F3EF4D +86	Homo sapiens (Human) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Macaca nemestrina (Pig-tailed macaque) Macaca mulatta (Rhesus macaque) Papio anubis (Olive baboon) Colobus angolensis palliatus (Peters' Angolan colobus) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Mandrillus leucophaeus (Drill) (Papio leucophaeus) And more	2,109	UniRef50_Q12789	Cluster: General transcription factor 3C polypeptide 1	97

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK038537 mRNA. Translation: BAC30032.1. BC032208 mRNA. Translation: AAH32208.1. Different initiation. BC067041 mRNA. Translation: AAH67041.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS40122.1. [Q8K284-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_997122.1. NM_207239.1. [Q8K284-1]
UniGeneⁱ	Mm.294173.

3D structure databases

ProteinModelPortalⁱ	Q8K284.
SMRⁱ	Q8K284.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	231457. 5 interactors.
IntActⁱ	Q8K284. 1 interactor.
Molecular INTeraction database More...MINTⁱ	MINT-4137479.
STRINGⁱ	10090.ENSMUSP00000056719.

PTM databases

iPTMnetⁱ	Q8K284.
PhosphoSitePlusⁱ	Q8K284.

Proteomic databases

EPDⁱ	Q8K284.
PaxDbⁱ	Q8K284.
PeptideAtlas More...PeptideAtlasⁱ	Q8K284.
PRIDEⁱ	Q8K284.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

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Genome annotation databases

Ensemblⁱ	ENSMUST00000055506; ENSMUSP00000056719; ENSMUSG00000032777. [Q8K284-1]
GeneIDⁱ	233863.
KEGGⁱ	mmu:233863.
UCSC genome browser More...UCSCⁱ	uc009jqh.1. mouse. [Q8K284-1] uc009jql.1. mouse. [Q8K284-3] uc012fto.1. mouse. [Q8K284-2]

Organism-specific databases

CTDⁱ	2975.
MGIⁱ	MGI:107887. Gtf3c1.

Phylogenomic databases

eggNOGⁱ	KOG4560. Eukaryota. ENOG410XSJ5. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008664.
HOGENOMⁱ	HOG000154556.
HOVERGENⁱ	HBG057283.
InParanoidⁱ	Q8K284.
KEGG Orthology (KO) More...KOⁱ	K15199.
OMAⁱ	VYPIHMI.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00PD.
PhylomeDBⁱ	Q8K284.
TreeFamⁱ	TF351624.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter. R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Reactomeⁱ

R-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Miscellaneous databases

ChiTaRSⁱ	Gtf3c1. mouse.
Protein Ontology More...PROⁱ	PR:Q8K284.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000032777.
CleanExⁱ	MM_GTF3C1.
ExpressionAtlasⁱ	Q8K284. baseline and differential.
Genevisibleⁱ	Q8K284. MM.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd16169. Tau138_eWH. 1 hit.
InterProⁱ	View protein in InterPro IPR035625. Tfc3_eWH. IPR007309. TFIIIC_Bblock-bd.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04182. B-block_TFIIIC. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TF3C1_MOUSE
Accessionⁱ	Q8K284Primary (citable) accession number: Q8K284 Secondary accession number(s): Q8CAL9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
	Last sequence update:	June 7, 2004
	Last modified:	August 30, 2017
	This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q8K284 (TF3C1_MOUSE)

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General transcription factor 3C polypeptide 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (3)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ