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Protein

Ketosamine-3-kinase

Gene

Fn3krp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Enzyme and pathway databases

BRENDAi2.7.1.171. 3474.
2.7.1.172. 3474.
ReactomeiR-MMU-163841. Gamma carboxylation, hypusine formation and arylsulfatase activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ketosamine-3-kinase (EC:2.7.1.-)
Alternative name(s):
Fructosamine-3-kinase-related protein
Gene namesi
Name:Fn3krp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2679256. Fn3krp.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Ketosamine-3-kinasePRO_0000216340Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K274.
MaxQBiQ8K274.
PaxDbiQ8K274.
PRIDEiQ8K274.

PTM databases

iPTMnetiQ8K274.
PhosphoSiteiQ8K274.

Expressioni

Gene expression databases

BgeeiQ8K274.
CleanExiMM_BC032265.
GenevisibleiQ8K274. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038061.

Structurei

3D structure databases

ProteinModelPortaliQ8K274.
SMRiQ8K274. Positions 38-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fructosamine kinase family.Curated

Phylogenomic databases

eggNOGiKOG3021. Eukaryota.
COG3001. LUCA.
GeneTreeiENSGT00390000005730.
HOGENOMiHOG000023913.
HOVERGENiHBG005740.
InParanoidiQ8K274.
KOiK15523.
OMAiAKRMFEG.
OrthoDBiEOG7MH0ZF.
TreeFamiTF313452.

Family and domain databases

InterProiIPR016477. Fructo-/Ketosamine-3-kinase.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF03881. Fructosamin_kin. 1 hit.
[Graphical view]
PIRSFiPIRSF006221. Ketosamine-3-kinase. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLLKRELG CSSVKATGHS GGGCISQGQS YDTDKGRVFV KVNSKAEARR
60 70 80 90 100
MFEGEMASLT AILKTGTVKV PKPIKVVDAP GGGSMLVMEH LDMRYLSSHA
110 120 130 140 150
TKLGTQLADL HLENKRLGER LLKEAGTVGK GGEQAERQYV DQFGFDVVTC
160 170 180 190 200
CGYLPQVNDW QKNWVEFYAR QRIQPQMDMV EKKSGDREAL ELWSALQLKI
210 220 230 240 250
PDLFRDLEIV PALLHGDLWG GNVAEDSSGP IIFDPASFYG HSEYELAIAG
260 270 280 290 300
MFGGFSSSFY SAYHSKIPKT PGFEKRLQLY QLFHYLNHWN HFGSGYRGSS

LNIMRNLSK
Length:309
Mass (Da):34,468
Last modified:July 27, 2011 - v2
Checksum:i95BA25D1206E1B6E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201R → K in AAH32265 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY360466 mRNA. Translation: AAQ72345.1.
AL663088 Genomic DNA. Translation: CAM19952.1.
CH466558 Genomic DNA. Translation: EDL34839.1.
BC032265 mRNA. Translation: AAH32265.1.
CCDSiCCDS25775.1.
RefSeqiNP_852085.2. NM_181420.3.
UniGeneiMm.117394.

Genome annotation databases

EnsembliENSMUST00000038096; ENSMUSP00000038061; ENSMUSG00000039253.
GeneIDi238024.
KEGGimmu:238024.
UCSCiuc007mvv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY360466 mRNA. Translation: AAQ72345.1.
AL663088 Genomic DNA. Translation: CAM19952.1.
CH466558 Genomic DNA. Translation: EDL34839.1.
BC032265 mRNA. Translation: AAH32265.1.
CCDSiCCDS25775.1.
RefSeqiNP_852085.2. NM_181420.3.
UniGeneiMm.117394.

3D structure databases

ProteinModelPortaliQ8K274.
SMRiQ8K274. Positions 38-287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038061.

PTM databases

iPTMnetiQ8K274.
PhosphoSiteiQ8K274.

Proteomic databases

EPDiQ8K274.
MaxQBiQ8K274.
PaxDbiQ8K274.
PRIDEiQ8K274.

Protocols and materials databases

DNASUi238024.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038096; ENSMUSP00000038061; ENSMUSG00000039253.
GeneIDi238024.
KEGGimmu:238024.
UCSCiuc007mvv.2. mouse.

Organism-specific databases

CTDi79672.
MGIiMGI:2679256. Fn3krp.

Phylogenomic databases

eggNOGiKOG3021. Eukaryota.
COG3001. LUCA.
GeneTreeiENSGT00390000005730.
HOGENOMiHOG000023913.
HOVERGENiHBG005740.
InParanoidiQ8K274.
KOiK15523.
OMAiAKRMFEG.
OrthoDBiEOG7MH0ZF.
TreeFamiTF313452.

Enzyme and pathway databases

BRENDAi2.7.1.171. 3474.
2.7.1.172. 3474.
ReactomeiR-MMU-163841. Gamma carboxylation, hypusine formation and arylsulfatase activation.

Miscellaneous databases

ChiTaRSiFn3krp. mouse.
PROiQ8K274.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K274.
CleanExiMM_BC032265.
GenevisibleiQ8K274. MM.

Family and domain databases

InterProiIPR016477. Fructo-/Ketosamine-3-kinase.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF03881. Fructosamin_kin. 1 hit.
[Graphical view]
PIRSFiPIRSF006221. Ketosamine-3-kinase. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines."
    Collard F., Delpierre G., Stroobant V., Matthijs G., Van Schaftingen E.
    Diabetes 52:2888-2895(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: NMRI.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiKT3K_MOUSE
AccessioniPrimary (citable) accession number: Q8K274
Secondary accession number(s): B1ATT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.