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Protein

ATP-binding cassette sub-family F member 3

Gene

Abcf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B.1 Publication

Caution

Lacks transmembrane domains and is probably not involved in transport.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi210 – 217ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi525 – 532ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiviral defense
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family F member 3
Gene namesi
Name:Abcf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1351656 Abcf3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002480432 – 709ATP-binding cassette sub-family F member 3Add BLAST708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei83PhosphoserineBy similarity1
Modified residuei155PhosphoserineBy similarity1
Modified residuei157PhosphoserineBy similarity1
Modified residuei161PhosphoserineBy similarity1
Modified residuei283PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8K268
MaxQBiQ8K268
PaxDbiQ8K268
PeptideAtlasiQ8K268
PRIDEiQ8K268

PTM databases

iPTMnetiQ8K268
PhosphoSitePlusiQ8K268

Expressioni

Gene expression databases

BgeeiENSMUSG00000003234
GenevisibleiQ8K268 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205213, 2 interactors
IntActiQ8K268, 3 interactors
MINTiQ8K268
STRINGi10090.ENSMUSP00000003319

Structurei

3D structure databases

ProteinModelPortaliQ8K268
SMRiQ8K268
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 424ABC transporter 1PROSITE-ProRule annotationAdd BLAST247
Domaini492 – 707ABC transporter 2PROSITE-ProRule annotationAdd BLAST216

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0927 Eukaryota
COG0488 LUCA
GeneTreeiENSGT00630000089843
HOGENOMiHOG000271637
HOVERGENiHBG050440
InParanoidiQ8K268
KOiK06158
OMAiEHEWAGD
OrthoDBiEOG091G031N
PhylomeDBiQ8K268
TreeFamiTF105209

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR032781 ABC_tran_Xtn
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
PF12848 ABC_tran_Xtn, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATCADILRS EFPEIDGQVF DYVTGVLHSG SADFESVDDL VEAVGELLQE
60 70 80 90 100
VSGDSKDDAG IRAVCQRMYN TLRLAEPQNQ GNSQVLLDAP IQLSKIMENY
110 120 130 140 150
DCDTKLPGLL KREQSSTVNA KKLEKAEARL KAKQEKRSEK ETLKTSNPLV
160 170 180 190 200
LEEASASQAG SRKESRLESS GKNKSYDVRI ENFDVSFGDR VLLAGADVNL
210 220 230 240 250
AWGRRYGLVG RNGLGKTTLL KMLATRSLRV PAHISLLHVE QEVAGDDTPA
260 270 280 290 300
LQSVLESDTV REDLLRQERE LSLRIAAGRA EGSEAAQLAE IYGKLEEIEA
310 320 330 340 350
DKAPARASVI LAGLGFTPKM QQQPTREFSG GWRMRLALAR ALFARPDLLL
360 370 380 390 400
LDEPTNMLDV RAILWLENYL QTWPSTILVV SHDRNFLNAI ATDIIHLHSQ
410 420 430 440 450
RLDGYRGDFE TFIKSKQERL LNQQREYEAQ QQYRQHIQVF IDRFRYNANR
460 470 480 490 500
ASQVQSKLKM LEKLPELKPV DKESEVVLKF PDGFEKFSPP ILQLDEVDFY
510 520 530 540 550
YDPKHSIFSR LSVSADLESR ICVVGENGAG KSTMLKLLMG DLSPVRGIRH
560 570 580 590 600
AHRNLKIGYF SQHHVEQLDL NVSAVELLAR KFPGLPEEEY RHQLGRYGIS
610 620 630 640 650
GELAMRPVAS LSGGQKSRVA FAQMTMPCPN FYILDEPTNH LDMETIEALG
660 670 680 690 700
QALNNFRGGV ILVSHDERFI RLVCKELWVC ENGSVTRVEG GFDQYRALLQ

EQFRREGFL
Length:709
Mass (Da):79,865
Last modified:October 1, 2002 - v1
Checksum:i03CBD4E7FD967B79
GO

Sequence cautioni

The sequence AAF31421 differs from that shown. Reason: Frameshift at position 599.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti705 – 706RE → SG in AAF31421 (PubMed:10708515).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032923 mRNA Translation: AAH32923.1
AF213381 mRNA Translation: AAF31421.1 Frameshift.
CCDSiCCDS28049.1
RefSeqiNP_038880.1, NM_013852.2
UniGeneiMm.27135

Genome annotation databases

EnsembliENSMUST00000003319; ENSMUSP00000003319; ENSMUSG00000003234
GeneIDi27406
KEGGimmu:27406
UCSCiuc007ypz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiABCF3_MOUSE
AccessioniPrimary (citable) accession number: Q8K268
Secondary accession number(s): Q9JL49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health