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Protein

ATP-binding cassette sub-family F member 3

Gene

Abcf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi210 – 2178ATP 1PROSITE-ProRule annotation
Nucleotide bindingi525 – 5328ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antiviral defense

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family F member 3
Gene namesi
Name:Abcf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1351656. Abcf3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 709708ATP-binding cassette sub-family F member 3PRO_0000248043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei283 – 2831PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8K268.
MaxQBiQ8K268.
PaxDbiQ8K268.
PRIDEiQ8K268.

PTM databases

iPTMnetiQ8K268.
PhosphoSiteiQ8K268.

Expressioni

Gene expression databases

BgeeiQ8K268.
GenevisibleiQ8K268. MM.

Interactioni

Protein-protein interaction databases

BioGridi205213. 1 interaction.
IntActiQ8K268. 3 interactions.
MINTiMINT-4117223.
STRINGi10090.ENSMUSP00000003319.

Structurei

3D structure databases

ProteinModelPortaliQ8K268.
SMRiQ8K268. Positions 114-695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini178 – 424247ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini492 – 707216ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0927. Eukaryota.
COG0488. LUCA.
GeneTreeiENSGT00630000089843.
HOGENOMiHOG000271637.
HOVERGENiHBG050440.
InParanoidiQ8K268.
KOiK06158.
OMAiFYLVHDK.
OrthoDBiEOG7WDN23.
PhylomeDBiQ8K268.
TreeFamiTF105209.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR032781. ABC_tran_Xtn.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
PF12848. ABC_tran_Xtn. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATCADILRS EFPEIDGQVF DYVTGVLHSG SADFESVDDL VEAVGELLQE
60 70 80 90 100
VSGDSKDDAG IRAVCQRMYN TLRLAEPQNQ GNSQVLLDAP IQLSKIMENY
110 120 130 140 150
DCDTKLPGLL KREQSSTVNA KKLEKAEARL KAKQEKRSEK ETLKTSNPLV
160 170 180 190 200
LEEASASQAG SRKESRLESS GKNKSYDVRI ENFDVSFGDR VLLAGADVNL
210 220 230 240 250
AWGRRYGLVG RNGLGKTTLL KMLATRSLRV PAHISLLHVE QEVAGDDTPA
260 270 280 290 300
LQSVLESDTV REDLLRQERE LSLRIAAGRA EGSEAAQLAE IYGKLEEIEA
310 320 330 340 350
DKAPARASVI LAGLGFTPKM QQQPTREFSG GWRMRLALAR ALFARPDLLL
360 370 380 390 400
LDEPTNMLDV RAILWLENYL QTWPSTILVV SHDRNFLNAI ATDIIHLHSQ
410 420 430 440 450
RLDGYRGDFE TFIKSKQERL LNQQREYEAQ QQYRQHIQVF IDRFRYNANR
460 470 480 490 500
ASQVQSKLKM LEKLPELKPV DKESEVVLKF PDGFEKFSPP ILQLDEVDFY
510 520 530 540 550
YDPKHSIFSR LSVSADLESR ICVVGENGAG KSTMLKLLMG DLSPVRGIRH
560 570 580 590 600
AHRNLKIGYF SQHHVEQLDL NVSAVELLAR KFPGLPEEEY RHQLGRYGIS
610 620 630 640 650
GELAMRPVAS LSGGQKSRVA FAQMTMPCPN FYILDEPTNH LDMETIEALG
660 670 680 690 700
QALNNFRGGV ILVSHDERFI RLVCKELWVC ENGSVTRVEG GFDQYRALLQ

EQFRREGFL
Length:709
Mass (Da):79,865
Last modified:October 1, 2002 - v1
Checksum:i03CBD4E7FD967B79
GO

Sequence cautioni

The sequence AAF31421.1 differs from that shown. Reason: Frameshift at position 599. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti705 – 7062RE → SG in AAF31421 (PubMed:10708515).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032923 mRNA. Translation: AAH32923.1.
AF213381 mRNA. Translation: AAF31421.1. Frameshift.
CCDSiCCDS28049.1.
RefSeqiNP_038880.1. NM_013852.2.
UniGeneiMm.27135.

Genome annotation databases

EnsembliENSMUST00000003319; ENSMUSP00000003319; ENSMUSG00000003234.
GeneIDi27406.
KEGGimmu:27406.
UCSCiuc007ypz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032923 mRNA. Translation: AAH32923.1.
AF213381 mRNA. Translation: AAF31421.1. Frameshift.
CCDSiCCDS28049.1.
RefSeqiNP_038880.1. NM_013852.2.
UniGeneiMm.27135.

3D structure databases

ProteinModelPortaliQ8K268.
SMRiQ8K268. Positions 114-695.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205213. 1 interaction.
IntActiQ8K268. 3 interactions.
MINTiMINT-4117223.
STRINGi10090.ENSMUSP00000003319.

PTM databases

iPTMnetiQ8K268.
PhosphoSiteiQ8K268.

Proteomic databases

EPDiQ8K268.
MaxQBiQ8K268.
PaxDbiQ8K268.
PRIDEiQ8K268.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003319; ENSMUSP00000003319; ENSMUSG00000003234.
GeneIDi27406.
KEGGimmu:27406.
UCSCiuc007ypz.1. mouse.

Organism-specific databases

CTDi55324.
MGIiMGI:1351656. Abcf3.

Phylogenomic databases

eggNOGiKOG0927. Eukaryota.
COG0488. LUCA.
GeneTreeiENSGT00630000089843.
HOGENOMiHOG000271637.
HOVERGENiHBG050440.
InParanoidiQ8K268.
KOiK06158.
OMAiFYLVHDK.
OrthoDBiEOG7WDN23.
PhylomeDBiQ8K268.
TreeFamiTF105209.

Miscellaneous databases

NextBioi305414.
PROiQ8K268.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K268.
GenevisibleiQ8K268. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR032781. ABC_tran_Xtn.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
PF12848. ABC_tran_Xtn. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  2. "Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus."
    Schriml L.M., Dean M.
    Genomics 64:24-31(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 589-709.
    Strain: CD-1.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  4. "Identification of novel host cell binding partners of Oas1b, the protein conferring resistance to flavivirus-induced disease in mice."
    Courtney S.C., Di H., Stockman B.M., Liu H., Scherbik S.V., Brinton M.A.
    J. Virol. 86:7953-7963(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH OAS1B.

Entry informationi

Entry nameiABCF3_MOUSE
AccessioniPrimary (citable) accession number: Q8K268
Secondary accession number(s): Q9JL49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2002
Last modified: April 13, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Lacks transmembrane domains and is probably not involved in transport.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.