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Q8K243

- TRI68_MOUSE

UniProt

Q8K243 - TRI68_MOUSE

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Protein
E3 ubiquitin-protein ligase TRIM68
Gene
Trim68, Rnf137
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity By similarity.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 6146RING-type
Add
BLAST
Zinc fingeri93 – 13442B box-type
Add
BLAST

GO - Molecular functioni

  1. histone acetyltransferase binding Source: UniProtKB
  2. ligase activity Source: UniProtKB-KW
  3. ubiquitin-protein transferase activity Source: UniProtKB
  4. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase TRIM68 (EC:6.3.2.-)
    Alternative name(s):
    RING finger protein 137
    Tripartite motif-containing protein 68
    Gene namesi
    Name:Trim68
    Synonyms:Rnf137
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2142077. Trim68.

    Subcellular locationi

    Cytoplasmperinuclear region By similarity. Nucleus By similarity
    Note: Colocalized with AR in nucleus By similarity.

    GO - Cellular componenti

    1. nucleus Source: UniProtKB
    2. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 485485E3 ubiquitin-protein ligase TRIM68
    PRO_0000249438Add
    BLAST

    Post-translational modificationi

    Auto-ubiquitinated By similarity.

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PRIDEiQ8K243.

    PTM databases

    PhosphoSiteiQ8K243.

    Expressioni

    Gene expression databases

    CleanExiMM_TRIM68.
    GenevestigatoriQ8K243.

    Interactioni

    Subunit structurei

    Interacts with AR/androgen receptor (via ligand-binding domain) By similarity. Interacts with KAT5/TIP60 By similarity.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K243.
    SMRiQ8K243. Positions 6-94, 303-481.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini285 – 483199B30.2/SPRY
    Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili144 – 22683 Reviewed prediction
    Add
    BLAST

    Domaini

    The RING domain is essential for ubiquitin E3 ligase activity By similarity.

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.
    Contains 1 B30.2/SPRY domain.

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG252602.
    HOGENOMiHOG000234133.
    HOVERGENiHBG001357.
    InParanoidiQ8K243.
    PhylomeDBiQ8K243.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00336. BBOX. 1 hit.
    SM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K243-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPAVLMEAI VEEVNCPICM TFLREPVSIS CGHTFCHSCL SGLWKLPGES    50
    QNLSYTCPLC RAPVKPRKLR PNWQLASVVD KVRLLGFCME MGLKTDVCDL 100
    HKEQLTMFCK EDDMVTCEAC KQSPEHEAHS VVPIKDVAWE YKWKLQQALE 150
    HLRKEQEEAW KLEVSEKEQA AIWKTQMERR KQSIRWEFEK YRQLLKEKEL 200
    PCQQAEEEAA AAQASLEQEK GETASKLELR REAIIRQSQV LWSMIVELEE 250
    RSQRPVRWML QGIQEALNRS ESWTLQQLEP ISLELKTDCR VLGLRETLKT 300
    FAVDVRLDPD TAYSRLVVSK DRKSVHYGVT QQNLPDNPER FYRYNIVLGS 350
    QCISSGRHYW EVEVGDRSEW GLGVCVENVD RKEVVYLSPR YGFWVIRLRK 400
    GTEYRAGTDE YPLLPLTVPP HRVGIFLDYE AHDISFYNVT DGASHIFTFP 450
    CYPFPGRLLP YFSPCYSIDT NNTTPLTICT LGGEG 485
    Length:485
    Mass (Da):56,098
    Last modified:October 1, 2002 - v1
    Checksum:i8F5428A3FDB4857D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC034249 mRNA. Translation: AAH34249.1.
    CCDSiCCDS40052.1.
    UniGeneiMm.39043.

    Genome annotation databases

    UCSCiuc009isg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC034249 mRNA. Translation: AAH34249.1 .
    CCDSi CCDS40052.1.
    UniGenei Mm.39043.

    3D structure databases

    ProteinModelPortali Q8K243.
    SMRi Q8K243. Positions 6-94, 303-481.
    ModBasei Search...

    PTM databases

    PhosphoSitei Q8K243.

    Proteomic databases

    PRIDEi Q8K243.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc009isg.2. mouse.

    Organism-specific databases

    MGIi MGI:2142077. Trim68.

    Phylogenomic databases

    eggNOGi NOG252602.
    HOGENOMi HOG000234133.
    HOVERGENi HBG001357.
    InParanoidi Q8K243.
    PhylomeDBi Q8K243.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    PROi Q8K243.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_TRIM68.
    Genevestigatori Q8K243.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00336. BBOX. 1 hit.
    SM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiTRI68_MOUSE
    AccessioniPrimary (citable) accession number: Q8K243
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: October 1, 2002
    Last modified: September 3, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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