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Q8K243

- TRI68_MOUSE

UniProt

Q8K243 - TRI68_MOUSE

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Protein

E3 ubiquitin-protein ligase TRIM68

Gene

Trim68

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity (By similarity).By similarity

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 6146RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri93 – 13442B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. histone acetyltransferase binding Source: UniProtKB
  2. ligase activity Source: UniProtKB-KW
  3. ubiquitin-protein transferase activity Source: UniProtKB
  4. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM68 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 137
Tripartite motif-containing protein 68
Gene namesi
Name:Trim68
Synonyms:Rnf137
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2142077. Trim68.

Subcellular locationi

Cytoplasmperinuclear region By similarity. Nucleus By similarity
Note: Colocalized with AR in nucleus.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485E3 ubiquitin-protein ligase TRIM68PRO_0000249438Add
BLAST

Post-translational modificationi

Auto-ubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ8K243.
PRIDEiQ8K243.

PTM databases

PhosphoSiteiQ8K243.

Expressioni

Gene expression databases

CleanExiMM_TRIM68.
GenevestigatoriQ8K243.

Interactioni

Subunit structurei

Interacts with AR/androgen receptor (via ligand-binding domain). Interacts with KAT5/TIP60.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8K243.
SMRiQ8K243. Positions 6-94, 303-481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini285 – 483199B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili144 – 22683Sequence AnalysisAdd
BLAST

Domaini

The RING domain is essential for ubiquitin E3 ligase activity.By similarity

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 6146RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri93 – 13442B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG252602.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ8K243.
PhylomeDBiQ8K243.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K243-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPAVLMEAI VEEVNCPICM TFLREPVSIS CGHTFCHSCL SGLWKLPGES
60 70 80 90 100
QNLSYTCPLC RAPVKPRKLR PNWQLASVVD KVRLLGFCME MGLKTDVCDL
110 120 130 140 150
HKEQLTMFCK EDDMVTCEAC KQSPEHEAHS VVPIKDVAWE YKWKLQQALE
160 170 180 190 200
HLRKEQEEAW KLEVSEKEQA AIWKTQMERR KQSIRWEFEK YRQLLKEKEL
210 220 230 240 250
PCQQAEEEAA AAQASLEQEK GETASKLELR REAIIRQSQV LWSMIVELEE
260 270 280 290 300
RSQRPVRWML QGIQEALNRS ESWTLQQLEP ISLELKTDCR VLGLRETLKT
310 320 330 340 350
FAVDVRLDPD TAYSRLVVSK DRKSVHYGVT QQNLPDNPER FYRYNIVLGS
360 370 380 390 400
QCISSGRHYW EVEVGDRSEW GLGVCVENVD RKEVVYLSPR YGFWVIRLRK
410 420 430 440 450
GTEYRAGTDE YPLLPLTVPP HRVGIFLDYE AHDISFYNVT DGASHIFTFP
460 470 480
CYPFPGRLLP YFSPCYSIDT NNTTPLTICT LGGEG
Length:485
Mass (Da):56,098
Last modified:October 1, 2002 - v1
Checksum:i8F5428A3FDB4857D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC034249 mRNA. Translation: AAH34249.1.
CCDSiCCDS40052.1.
UniGeneiMm.39043.

Genome annotation databases

UCSCiuc009isg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC034249 mRNA. Translation: AAH34249.1 .
CCDSi CCDS40052.1.
UniGenei Mm.39043.

3D structure databases

ProteinModelPortali Q8K243.
SMRi Q8K243. Positions 6-94, 303-481.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8K243.

Proteomic databases

MaxQBi Q8K243.
PRIDEi Q8K243.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc009isg.2. mouse.

Organism-specific databases

MGIi MGI:2142077. Trim68.

Phylogenomic databases

eggNOGi NOG252602.
HOGENOMi HOG000234133.
HOVERGENi HBG001357.
InParanoidi Q8K243.
PhylomeDBi Q8K243.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

PROi Q8K243.
SOURCEi Search...

Gene expression databases

CleanExi MM_TRIM68.
Genevestigatori Q8K243.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view ]
PRINTSi PR01407. BUTYPHLNCDUF.
SMARTi SM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiTRI68_MOUSE
AccessioniPrimary (citable) accession number: Q8K243
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3