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Protein

E3 ubiquitin-protein ligase TRIM68

Gene

Trim68

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity (By similarity).By similarity

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 6146RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri93 – 13442B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. androgen receptor binding Source: MGI
  2. histone acetyltransferase binding Source: UniProtKB
  3. ligase activity Source: UniProtKB-KW
  4. ubiquitin-protein transferase activity Source: UniProtKB
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein autoubiquitination Source: MGI
  2. regulation of androgen receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM68 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 137
Tripartite motif-containing protein 68
Gene namesi
Name:Trim68
Synonyms:Rnf137
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2142077. Trim68.

Subcellular locationi

Cytoplasmperinuclear region By similarity. Nucleus By similarity
Note: Colocalized with AR in nucleus.By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. Golgi apparatus Source: MGI
  3. nucleolus Source: MGI
  4. nucleoplasm Source: MGI
  5. nucleus Source: UniProtKB
  6. perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485E3 ubiquitin-protein ligase TRIM68PRO_0000249438Add
BLAST

Post-translational modificationi

Auto-ubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ8K243.
PRIDEiQ8K243.

PTM databases

PhosphoSiteiQ8K243.

Expressioni

Gene expression databases

CleanExiMM_TRIM68.
GenevestigatoriQ8K243.

Interactioni

Subunit structurei

Interacts with AR/androgen receptor (via ligand-binding domain). Interacts with KAT5/TIP60.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8K243.
SMRiQ8K243. Positions 6-277, 303-481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini285 – 483199B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili144 – 22683Sequence AnalysisAdd
BLAST

Domaini

The RING domain is essential for ubiquitin E3 ligase activity.By similarity

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 6146RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri93 – 13442B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG252602.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ8K243.
PhylomeDBiQ8K243.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K243-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPAVLMEAI VEEVNCPICM TFLREPVSIS CGHTFCHSCL SGLWKLPGES
60 70 80 90 100
QNLSYTCPLC RAPVKPRKLR PNWQLASVVD KVRLLGFCME MGLKTDVCDL
110 120 130 140 150
HKEQLTMFCK EDDMVTCEAC KQSPEHEAHS VVPIKDVAWE YKWKLQQALE
160 170 180 190 200
HLRKEQEEAW KLEVSEKEQA AIWKTQMERR KQSIRWEFEK YRQLLKEKEL
210 220 230 240 250
PCQQAEEEAA AAQASLEQEK GETASKLELR REAIIRQSQV LWSMIVELEE
260 270 280 290 300
RSQRPVRWML QGIQEALNRS ESWTLQQLEP ISLELKTDCR VLGLRETLKT
310 320 330 340 350
FAVDVRLDPD TAYSRLVVSK DRKSVHYGVT QQNLPDNPER FYRYNIVLGS
360 370 380 390 400
QCISSGRHYW EVEVGDRSEW GLGVCVENVD RKEVVYLSPR YGFWVIRLRK
410 420 430 440 450
GTEYRAGTDE YPLLPLTVPP HRVGIFLDYE AHDISFYNVT DGASHIFTFP
460 470 480
CYPFPGRLLP YFSPCYSIDT NNTTPLTICT LGGEG
Length:485
Mass (Da):56,098
Last modified:October 1, 2002 - v1
Checksum:i8F5428A3FDB4857D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034249 mRNA. Translation: AAH34249.1.
CCDSiCCDS40052.1.
UniGeneiMm.39043.

Genome annotation databases

UCSCiuc009isg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034249 mRNA. Translation: AAH34249.1.
CCDSiCCDS40052.1.
UniGeneiMm.39043.

3D structure databases

ProteinModelPortaliQ8K243.
SMRiQ8K243. Positions 6-277, 303-481.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8K243.

Proteomic databases

MaxQBiQ8K243.
PRIDEiQ8K243.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc009isg.2. mouse.

Organism-specific databases

MGIiMGI:2142077. Trim68.

Phylogenomic databases

eggNOGiNOG252602.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ8K243.
PhylomeDBiQ8K243.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ8K243.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TRIM68.
GenevestigatoriQ8K243.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiTRI68_MOUSE
AccessioniPrimary (citable) accession number: Q8K243
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 1, 2002
Last modified: March 4, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.