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Q8K233

- Q8K233_MOUSE

UniProt

Q8K233 - Q8K233_MOUSE

Protein
Submitted name:

Ace protein

Gene

Ace

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation
    Binds 2 zinc ions per subunit.UniRule annotation

    GO - Molecular functioni

    1. metallopeptidase activity Source: InterPro
    2. peptidase activity Source: MGI
    3. peptidyl-dipeptidase activity Source: InterPro
    4. protein binding Source: MGI

    GO - Biological processi

    1. heart contraction Source: MGI
    2. kidney development Source: MGI
    3. neutrophil mediated immunity Source: MGI
    4. positive regulation of systemic arterial blood pressure Source: MGI
    5. spermatogenesis Source: MGI

    Keywords - Molecular functioni

    CarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease

    Keywords - Ligandi

    Metal-bindingUniRule annotation, ZincUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Ace proteinImported
    Submitted name:
    Angiotensin I converting enzyme (Peptidyl-dipeptidase A) 1, isoform CRA_bImported
    Gene namesi
    Name:AceImported
    ORF Names:mCG_4821Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:87874. Ace.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro

    PTM / Processingi

    Keywords - PTMi

    GlycoproteinUniRule annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ8K233.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M2 family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG000264.
    InParanoidiQ8K233.

    Family and domain databases

    InterProiIPR001548. Peptidase_M2.
    [Graphical view]
    PANTHERiPTHR10514. PTHR10514. 1 hit.
    PfamiPF01401. Peptidase_M2. 2 hits.
    [Graphical view]
    PRINTSiPR00791. PEPDIPTASEA.

    Sequencei

    Sequence statusi: Fragment.

    Q8K233-1 [UniParc]FASTAAdd to Basket

    « Hide

    WYESPSFEES LEHIYHQLEP LYLNLHAYVR RALHRRYGDK YVNLRGPIPA     50
    HLLGDMWAQS WENIYDMVVP FPDKPNLDVT STMVQKGWNA THMFRVSEEF 100
    FTSLGLSPMP PEFWAESMLE KPTDGREVVC HASAWDFYNR KDFRIKQCTR 150
    VTMEQLATVH HEMGHVQYYL QYKDLHVSLR RGANPGFHEA IGDVLALSVS 200
    TPAHLHKIGL LDHVTNDIES DINYLLKMAL EKIAFLPFGY LVDQWRWGVF 250
    SGRTPPSRYN FDWWYLRTKY QGICPPVARN ETHFDAGAKF HIPNVTPYIR 300
    YFVSFVLQFQ FHQALCKEAG HQGPLHQCDI YQSAQAGAKL KQVLQAGCSR 350
    PWQEVLKDLV GSDALDAKAL LEYFQPVSQW LEEQNQRNGE VLGWPENQWR 400
    PPLPDNYPEG IDLETDEAKA DRFVEEYDRT AQVLLNEYAE ANWQYNTNIT 450
    IEGSKILLEK STEVSNHTLK YGTRAKTFDV SNFQNSSIKR IIKKLQNLDR 500
    AVLPPKELEE YNQILLDMET TYSLSNICYT NGTCMPLEPD LTNMMATSRK 550
    YEELLWAWKS WRDKVGRAIL PFFPKYVEFS NKIAKLNGYT DAGDSWRSLY 600
    ESDNLEQDLE KLYQELQPLY LNLHAYVRRS LHRHYGSEYI NLDGPIPAHL 650
    LGNMWAQTWS NIYDLVAPFP SAPNIDATEA MIKQGWTPRR IFKEADNFFT 700
    SLGLLPVPPE FWNKSMLEKP TDGREVVCHP SAWDFYNGKD FRIKQCTSVN 750
    MEDLVIAHHE MGHIQYFMQY KDLPVTFREG ANPGFHEAIG DIMALSVSTP 800
    KHLYSLNLLS TEGSGYEYDI NFLMKMALDK IAFIPFSYLI DQWRWRVFDG 850
    SITKENYNQE WWSLRLKYQG LCPPVPRSQG DFDPGSKFHV PANVPYVRYF 900
    VSFIIQFQFH EALCRAAGHT GPLHKCDIYQ SKEAGKLLAD AMKLGYSKPW 950
    PEAMKLITGQ PNMSASAMMN YFKPLTEWLV TENRRHGETL GWPEYNWAPN 1000
    TGTTPTLPPA PGPSS 1015
    Length:1,015
    Mass (Da):117,509
    Last modified:October 1, 2002 - v1
    Checksum:iD097F69585553C27
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC034367 mRNA. Translation: AAH34367.1.
    CH466558 Genomic DNA. Translation: EDL34254.1.
    UniGeneiMm.754.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC034367 mRNA. Translation: AAH34367.1 .
    CH466558 Genomic DNA. Translation: EDL34254.1 .
    UniGenei Mm.754.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:87874. Ace.

    Phylogenomic databases

    HOVERGENi HBG000264.
    InParanoidi Q8K233.

    Miscellaneous databases

    ChiTaRSi ACE. mouse.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8K233.

    Family and domain databases

    InterProi IPR001548. Peptidase_M2.
    [Graphical view ]
    PANTHERi PTHR10514. PTHR10514. 1 hit.
    Pfami PF01401. Peptidase_M2. 2 hits.
    [Graphical view ]
    PRINTSi PR00791. PEPDIPTASEA.
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: Mammary tumor. C3Imported.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiQ8K233_MOUSE
    AccessioniPrimary (citable) accession number: Q8K233
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)