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Q8K233

- Q8K233_MOUSE

UniProt

Q8K233 - Q8K233_MOUSE

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Protein
Submitted name:

Ace protein

Gene
Ace, mCG_4821
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation
Binds 2 zinc ions per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. metallopeptidase activity Source: InterPro
  2. peptidase activity Source: MGI
  3. peptidyl-dipeptidase activity Source: InterPro
  4. protein binding Source: MGI

GO - Biological processi

  1. heart contraction Source: MGI
  2. kidney development Source: MGI
  3. neutrophil mediated immunity Source: MGI
  4. positive regulation of systemic arterial blood pressure Source: MGI
  5. spermatogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

CarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Ace proteinImported
Submitted name:
Angiotensin I converting enzyme (Peptidyl-dipeptidase A) 1, isoform CRA_bImported
Gene namesi
Name:AceImported
ORF Names:mCG_4821Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:87874. Ace.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

GlycoproteinUniRule annotation

Expressioni

Gene expression databases

GenevestigatoriQ8K233.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M2 family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG000264.
InParanoidiQ8K233.

Family and domain databases

InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 2 hits.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.

Sequencei

Sequence statusi: Fragment.

Q8K233-1 [UniParc]FASTAAdd to Basket

« Hide

WYESPSFEES LEHIYHQLEP LYLNLHAYVR RALHRRYGDK YVNLRGPIPA     50
HLLGDMWAQS WENIYDMVVP FPDKPNLDVT STMVQKGWNA THMFRVSEEF 100
FTSLGLSPMP PEFWAESMLE KPTDGREVVC HASAWDFYNR KDFRIKQCTR 150
VTMEQLATVH HEMGHVQYYL QYKDLHVSLR RGANPGFHEA IGDVLALSVS 200
TPAHLHKIGL LDHVTNDIES DINYLLKMAL EKIAFLPFGY LVDQWRWGVF 250
SGRTPPSRYN FDWWYLRTKY QGICPPVARN ETHFDAGAKF HIPNVTPYIR 300
YFVSFVLQFQ FHQALCKEAG HQGPLHQCDI YQSAQAGAKL KQVLQAGCSR 350
PWQEVLKDLV GSDALDAKAL LEYFQPVSQW LEEQNQRNGE VLGWPENQWR 400
PPLPDNYPEG IDLETDEAKA DRFVEEYDRT AQVLLNEYAE ANWQYNTNIT 450
IEGSKILLEK STEVSNHTLK YGTRAKTFDV SNFQNSSIKR IIKKLQNLDR 500
AVLPPKELEE YNQILLDMET TYSLSNICYT NGTCMPLEPD LTNMMATSRK 550
YEELLWAWKS WRDKVGRAIL PFFPKYVEFS NKIAKLNGYT DAGDSWRSLY 600
ESDNLEQDLE KLYQELQPLY LNLHAYVRRS LHRHYGSEYI NLDGPIPAHL 650
LGNMWAQTWS NIYDLVAPFP SAPNIDATEA MIKQGWTPRR IFKEADNFFT 700
SLGLLPVPPE FWNKSMLEKP TDGREVVCHP SAWDFYNGKD FRIKQCTSVN 750
MEDLVIAHHE MGHIQYFMQY KDLPVTFREG ANPGFHEAIG DIMALSVSTP 800
KHLYSLNLLS TEGSGYEYDI NFLMKMALDK IAFIPFSYLI DQWRWRVFDG 850
SITKENYNQE WWSLRLKYQG LCPPVPRSQG DFDPGSKFHV PANVPYVRYF 900
VSFIIQFQFH EALCRAAGHT GPLHKCDIYQ SKEAGKLLAD AMKLGYSKPW 950
PEAMKLITGQ PNMSASAMMN YFKPLTEWLV TENRRHGETL GWPEYNWAPN 1000
TGTTPTLPPA PGPSS 1015
Length:1,015
Mass (Da):117,509
Last modified:October 1, 2002 - v1
Checksum:iD097F69585553C27
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC034367 mRNA. Translation: AAH34367.1.
CH466558 Genomic DNA. Translation: EDL34254.1.
UniGeneiMm.754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC034367 mRNA. Translation: AAH34367.1 .
CH466558 Genomic DNA. Translation: EDL34254.1 .
UniGenei Mm.754.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:87874. Ace.

Phylogenomic databases

HOVERGENi HBG000264.
InParanoidi Q8K233.

Miscellaneous databases

ChiTaRSi ACE. mouse.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8K233.

Family and domain databases

InterProi IPR001548. Peptidase_M2.
[Graphical view ]
PANTHERi PTHR10514. PTHR10514. 1 hit.
Pfami PF01401. Peptidase_M2. 2 hits.
[Graphical view ]
PRINTSi PR00791. PEPDIPTASEA.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. C3Imported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ8K233_MOUSE
AccessioniPrimary (citable) accession number: Q8K233
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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