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Q8K223

- Q8K223_MOUSE

UniProt

Q8K223 - Q8K223_MOUSE

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Protein
Submitted name:

Ercc2 protein

Gene

Ercc2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

  1. 5'-3' DNA helicase activity Source: UniProtKB
  2. ATP binding Source: UniProtKB-KW
  3. ATP-dependent DNA helicase activity Source: InterPro
  4. DNA binding Source: InterPro

GO - Biological processi

  1. aging Source: MGI
  2. apoptotic process Source: UniProtKB
  3. bone mineralization Source: MGI
  4. cell proliferation Source: MGI
  5. central nervous system myelin formation Source: MGI
  6. DNA duplex unwinding Source: GOC
  7. DNA repair Source: MGI
  8. embryonic cleavage Source: MGI
  9. erythrocyte maturation Source: MGI
  10. extracellular matrix organization Source: MGI
  11. hair cell differentiation Source: MGI
  12. hair cycle process Source: MGI
  13. hair follicle maturation Source: MGI
  14. hematopoietic stem cell differentiation Source: MGI
  15. in utero embryonic development Source: MGI
  16. multicellular organism growth Source: MGI
  17. nucleotide-excision repair Source: MGI
  18. positive regulation of DNA binding Source: MGI
  19. post-embryonic development Source: MGI
  20. response to oxidative stress Source: MGI
  21. response to UV Source: MGI
  22. skin development Source: MGI
  23. spinal cord development Source: MGI
  24. transcription-coupled nucleotide-excision repair Source: UniProtKB
  25. UV protection Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotation, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Ercc2 proteinImported
Gene namesi
Name:Ercc2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95413. Ercc2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ8K223.

Structurei

3D structure databases

ProteinModelPortaliQ8K223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains helicase ATP-binding domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000205390.
HOVERGENiHBG051498.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR010643. DUF1227.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
IPR001945. XPGD_DNA_repair.
[Graphical view]
PfamiPF06733. DEAD_2. 1 hit.
PF06777. DUF1227. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view]
PRINTSiPR00852. XRODRMPGMNTD.
SMARTiSM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
TIGRFAMsiTIGR00604. rad3. 1 hit.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K223-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLNVDGLLV YFPYDYIYPE QFSYMLELKR TLDAKGHGVL EMPSGTGKTV
60 70 80 90 100
SLLALIVAYQ RVIEELRKLL SFYEQQEGEK LPFLGLALSS RKNLCIHPEV
110 120 130 140 150
TPLRFGKDVD GKCHSLTASY VRAQYQQDAS LPHCRFYEEF DIHGRQMPLP
160 170 180 190 200
AGIYNLDDLK ALGHRQGWCP YFLARYSILH ANVVVYSYHY LLDPKIADLV
210 220 230 240 250
SKELARKAVV VFDEAHNIDN VCIDSMSVNL TRRTLDRCQS NLDTLQKTVL
260 270 280 290 300
RIKETDEQRL RDEYRRLVEG LREASVARET DAHLANPVLP DEVLQEAVPG
310 320 330 340 350
SIRTAEHFLG FLRRLLEYVK WRLRVQHVVQ ESPPAFLSGL AQRVCIQRKP
360 370 380 390 400
LRFCAERLRS LLHTLEIADL ADFSPLTLLA NFATLVSTYA KGFTIIIEPF
410 420 430 440 450
DDRTPTIANP VLHFSCMDAS LAIKPVFERF QSVIITSGTL SPLDIYPKIL
460 470 480 490 500
DFHPVTMATF TMTLARVCLC PMIIGRGNDQ VAISSKFETR EDIAVIRNYG
510 520 530 540 550
NLLLEMSAVV PDGIVAFFTS YQYMESTVAS WYEQGILENI QRNKLLFIET
560 570 580 590 600
QDGAETSVAL EKYQEACENG RGAILLSVAR GKVSEGIDFV HHYGRAVIMF
610 620 630 640 650
GVPYVYTQSR ILKARLEYLR DQFQIRENDF LTFDAMRHAA QCVGRAIRGK
660 670 680 690 700
TDYGLMVFAD KRFARADKRG KLPRWIQEHL TDSNLNLTVD EGVQVAKYFL
710 720 730
RQMAQPFHRE DQLGLSLLSL EQLQSEETLQ RIEQIAQQL
Length:739
Mass (Da):84,416
Last modified:October 1, 2002 - v1
Checksum:iE83A3461B1394645
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC034517 mRNA. Translation: AAH34517.1.
UniGeneiMm.36524.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC034517 mRNA. Translation: AAH34517.1 .
UniGenei Mm.36524.

3D structure databases

ProteinModelPortali Q8K223.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:95413. Ercc2.

Phylogenomic databases

HOGENOMi HOG000205390.
HOVERGENi HBG051498.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Genevestigatori Q8K223.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR010643. DUF1227.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
IPR001945. XPGD_DNA_repair.
[Graphical view ]
Pfami PF06733. DEAD_2. 1 hit.
PF06777. DUF1227. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view ]
PRINTSi PR00852. XRODRMPGMNTD.
SMARTi SM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 4 hits.
TIGRFAMsi TIGR00604. rad3. 1 hit.
PROSITEi PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy.Imported.

Entry informationi

Entry nameiQ8K223_MOUSE
AccessioniPrimary (citable) accession number: Q8K223
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)