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Q8K223 (Q8K223_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Ercc2 protein EMBL AAH34517.1
Gene names
Name:Ercc2 MGI 95413
OrganismMus musculus (Mouse) EMBL AAH34517.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length739 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + H2O = ADP + phosphate.

Sequence similarities

Contains 1 helicase ATP-binding domain. SAAS SAAS013020

Ontologies

Keywords
   Cellular componentNucleus SAAS SAAS014013
   LigandATP-binding
Nucleotide-binding
   Molecular functionHelicase SAAS SAAS013020
Hydrolase
Gene Ontology (GO)
   Biological_processUV protection

Inferred from mutant phenotype PubMed 9651581. Source: MGI

aging

Inferred from mutant phenotype PubMed 11950998PubMed 17020410PubMed 18545656. Source: MGI

apoptotic process

Inferred from mutant phenotype PubMed 18545656. Source: MGI

bone mineralization

Inferred from mutant phenotype PubMed 17020410. Source: MGI

cell proliferation

Inferred from mutant phenotype PubMed 17554309. Source: MGI

central nervous system myelin formation

Inferred from mutant phenotype PubMed 17952069. Source: MGI

embryonic cleavage

Inferred from mutant phenotype PubMed 9426063. Source: MGI

erythrocyte maturation

Inferred from mutant phenotype PubMed 17020410. Source: MGI

extracellular matrix organization

Inferred from mutant phenotype PubMed 9651581. Source: MGI

hair cell differentiation

Inferred from mutant phenotype PubMed 17020410. Source: MGI

hair follicle maturation

Inferred from mutant phenotype PubMed 9651581. Source: MGI

hematopoietic stem cell differentiation

Inferred from mutant phenotype PubMed 17554309. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 17020410. Source: MGI

induction of apoptosis

Inferred from sequence or structural similarity. Source: UniProtKB

multicellular organism growth

Inferred from mutant phenotype PubMed 17020410. Source: MGI

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 17554309. Source: MGI

positive regulation of DNA binding

Inferred from mutant phenotype PubMed 17952069. Source: MGI

post-embryonic development

Inferred from mutant phenotype PubMed 11950998PubMed 17020410. Source: MGI

response to oxidative stress

Inferred from mutant phenotype PubMed 11950998. Source: MGI

skin development

Inferred from mutant phenotype PubMed 17020410PubMed 9651581. Source: MGI

spinal cord development

Inferred from mutant phenotype PubMed 17020410. Source: MGI

transcription-coupled nucleotide-excision repair

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentnucleus

Inferred from direct assay PubMed 17952069. Source: MGI

   Molecular_function5'-3' DNA helicase activity

Inferred from sequence or structural similarity. Source: UniProtKB

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent DNA helicase activity

Inferred from electronic annotation. Source: InterPro

DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8K223 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: E83A3461B1394645

FASTA73984,416
        10         20         30         40         50         60 
MKLNVDGLLV YFPYDYIYPE QFSYMLELKR TLDAKGHGVL EMPSGTGKTV SLLALIVAYQ 

        70         80         90        100        110        120 
RVIEELRKLL SFYEQQEGEK LPFLGLALSS RKNLCIHPEV TPLRFGKDVD GKCHSLTASY 

       130        140        150        160        170        180 
VRAQYQQDAS LPHCRFYEEF DIHGRQMPLP AGIYNLDDLK ALGHRQGWCP YFLARYSILH 

       190        200        210        220        230        240 
ANVVVYSYHY LLDPKIADLV SKELARKAVV VFDEAHNIDN VCIDSMSVNL TRRTLDRCQS 

       250        260        270        280        290        300 
NLDTLQKTVL RIKETDEQRL RDEYRRLVEG LREASVARET DAHLANPVLP DEVLQEAVPG 

       310        320        330        340        350        360 
SIRTAEHFLG FLRRLLEYVK WRLRVQHVVQ ESPPAFLSGL AQRVCIQRKP LRFCAERLRS 

       370        380        390        400        410        420 
LLHTLEIADL ADFSPLTLLA NFATLVSTYA KGFTIIIEPF DDRTPTIANP VLHFSCMDAS 

       430        440        450        460        470        480 
LAIKPVFERF QSVIITSGTL SPLDIYPKIL DFHPVTMATF TMTLARVCLC PMIIGRGNDQ 

       490        500        510        520        530        540 
VAISSKFETR EDIAVIRNYG NLLLEMSAVV PDGIVAFFTS YQYMESTVAS WYEQGILENI 

       550        560        570        580        590        600 
QRNKLLFIET QDGAETSVAL EKYQEACENG RGAILLSVAR GKVSEGIDFV HHYGRAVIMF 

       610        620        630        640        650        660 
GVPYVYTQSR ILKARLEYLR DQFQIRENDF LTFDAMRHAA QCVGRAIRGK TDYGLMVFAD 

       670        680        690        700        710        720 
KRFARADKRG KLPRWIQEHL TDSNLNLTVD EGVQVAKYFL RQMAQPFHRE DQLGLSLLSL 

       730 
EQLQSEETLQ RIEQIAQQL

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N EMBL AAH34517.1.
Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy. EMBL AAH34517.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC034517 mRNA. Translation: AAH34517.1.
IPIIPI00310721.
UniGeneMm.36524.

3D structure databases

ProteinModelPortalQ8K223.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc009flr.1. mouse.

Organism-specific databases

MGIMGI:95413. Ercc2.

Phylogenomic databases

HOGENOMHOG000205390.
HOVERGENHBG051498.

Gene expression databases

GenevestigatorQ8K223.

Family and domain databases

InterProIPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR010643. DUF1227.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR001945. XPGD_DNA_repair.
[Graphical view]
PfamPF06733. DEAD_2. 1 hit.
PF06777. DUF1227. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view]
PRINTSPR00852. XRODRMPGMNTD.
SMARTSM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
TIGRFAMsTIGR00604. rad3. 1 hit.
PROSITEPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ8K223_MOUSE
AccessionPrimary (citable) accession number: Q8K223
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info