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Protein
Submitted name:

Ercc2 protein

Gene

Ercc2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

  1. 5'-3' DNA helicase activity Source: UniProtKB
  2. ATP binding Source: UniProtKB-KW
  3. ATP-dependent DNA helicase activity Source: InterPro
  4. DNA binding Source: InterPro
  5. protein C-terminus binding Source: MGI
  6. protein N-terminus binding Source: MGI

GO - Biological processi

  1. aging Source: MGI
  2. apoptotic process Source: UniProtKB
  3. ATP catabolic process Source: MGI
  4. bone mineralization Source: MGI
  5. cell proliferation Source: MGI
  6. central nervous system myelin formation Source: MGI
  7. chromosome segregation Source: MGI
  8. DNA duplex unwinding Source: MGI
  9. DNA repair Source: MGI
  10. embryonic cleavage Source: MGI
  11. erythrocyte maturation Source: MGI
  12. extracellular matrix organization Source: MGI
  13. hair cell differentiation Source: MGI
  14. hair cycle process Source: MGI
  15. hair follicle maturation Source: MGI
  16. hematopoietic stem cell differentiation Source: MGI
  17. in utero embryonic development Source: MGI
  18. multicellular organism growth Source: MGI
  19. nucleotide-excision repair Source: MGI
  20. nucleotide-excision repair, DNA incision Source: MGI
  21. positive regulation of DNA binding Source: MGI
  22. positive regulation of transcription, DNA-templated Source: MGI
  23. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  24. post-embryonic development Source: MGI
  25. protein phosphorylation Source: MGI
  26. regulation of mitotic cell cycle phase transition Source: MGI
  27. response to oxidative stress Source: MGI
  28. response to UV Source: MGI
  29. skin development Source: MGI
  30. spinal cord development Source: MGI
  31. transcription-coupled nucleotide-excision repair Source: UniProtKB
  32. transcription from RNA polymerase II promoter Source: MGI
  33. UV protection Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotation, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Ercc2 proteinImported
Gene namesi
Name:Ercc2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95413. Ercc2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. holo TFIIH complex Source: MGI
  3. MMXD complex Source: MGI
  4. nucleus Source: MGI
  5. spindle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ8K223.

Family & Domainsi

Sequence similaritiesi

Contains helicase ATP-binding domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000205390.
HOVERGENiHBG051498.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR010643. DUF1227.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
IPR001945. XPGD_DNA_repair.
[Graphical view]
PfamiPF06733. DEAD_2. 1 hit.
PF06777. DUF1227. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view]
PRINTSiPR00852. XRODRMPGMNTD.
SMARTiSM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
TIGRFAMsiTIGR00604. rad3. 1 hit.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K223-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNVDGLLV YFPYDYIYPE QFSYMLELKR TLDAKGHGVL EMPSGTGKTV
60 70 80 90 100
SLLALIVAYQ RVIEELRKLL SFYEQQEGEK LPFLGLALSS RKNLCIHPEV
110 120 130 140 150
TPLRFGKDVD GKCHSLTASY VRAQYQQDAS LPHCRFYEEF DIHGRQMPLP
160 170 180 190 200
AGIYNLDDLK ALGHRQGWCP YFLARYSILH ANVVVYSYHY LLDPKIADLV
210 220 230 240 250
SKELARKAVV VFDEAHNIDN VCIDSMSVNL TRRTLDRCQS NLDTLQKTVL
260 270 280 290 300
RIKETDEQRL RDEYRRLVEG LREASVARET DAHLANPVLP DEVLQEAVPG
310 320 330 340 350
SIRTAEHFLG FLRRLLEYVK WRLRVQHVVQ ESPPAFLSGL AQRVCIQRKP
360 370 380 390 400
LRFCAERLRS LLHTLEIADL ADFSPLTLLA NFATLVSTYA KGFTIIIEPF
410 420 430 440 450
DDRTPTIANP VLHFSCMDAS LAIKPVFERF QSVIITSGTL SPLDIYPKIL
460 470 480 490 500
DFHPVTMATF TMTLARVCLC PMIIGRGNDQ VAISSKFETR EDIAVIRNYG
510 520 530 540 550
NLLLEMSAVV PDGIVAFFTS YQYMESTVAS WYEQGILENI QRNKLLFIET
560 570 580 590 600
QDGAETSVAL EKYQEACENG RGAILLSVAR GKVSEGIDFV HHYGRAVIMF
610 620 630 640 650
GVPYVYTQSR ILKARLEYLR DQFQIRENDF LTFDAMRHAA QCVGRAIRGK
660 670 680 690 700
TDYGLMVFAD KRFARADKRG KLPRWIQEHL TDSNLNLTVD EGVQVAKYFL
710 720 730
RQMAQPFHRE DQLGLSLLSL EQLQSEETLQ RIEQIAQQL
Length:739
Mass (Da):84,416
Last modified:October 1, 2002 - v1
Checksum:iE83A3461B1394645
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034517 mRNA. Translation: AAH34517.1.
UniGeneiMm.36524.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034517 mRNA. Translation: AAH34517.1.
UniGeneiMm.36524.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95413. Ercc2.

Phylogenomic databases

HOGENOMiHOG000205390.
HOVERGENiHBG051498.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

GenevestigatoriQ8K223.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR010643. DUF1227.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
IPR001945. XPGD_DNA_repair.
[Graphical view]
PfamiPF06733. DEAD_2. 1 hit.
PF06777. DUF1227. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view]
PRINTSiPR00852. XRODRMPGMNTD.
SMARTiSM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
TIGRFAMsiTIGR00604. rad3. 1 hit.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy.Imported.

Entry informationi

Entry nameiQ8K223_MOUSE
AccessioniPrimary (citable) accession number: Q8K223
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: March 4, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.