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Protein
Submitted name:

Ercc2 protein

Gene

Ercc2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseSAAS annotation, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Ercc2 proteinImported
Gene namesi
Name:Ercc2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95413 Ercc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiQ8K223

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 262Helicase ATP-bindingInterPro annotationAdd BLAST256

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili56 – 76Sequence analysisAdd BLAST21
Coiled coili235 – 255Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1131 Eukaryota
COG1199 LUCA
HOGENOMiHOG000205390
HOVERGENiHBG051498

Family and domain databases

InterProiView protein in InterPro
IPR006555 ATP-dep_Helicase_C
IPR010614 DEAD_2
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR010643 HBB
IPR014013 Helic_SF1/SF2_ATP-bd_DinG/Rad3
IPR006554 Helicase-like_DEXD_c2
IPR027417 P-loop_NTPase
IPR013020 Rad3/Chl1-like
IPR001945 RAD3/XPD
PANTHERiPTHR11472:SF1 PTHR11472:SF1, 1 hit
PfamiView protein in Pfam
PF06733 DEAD_2, 1 hit
PF06777 HBB, 1 hit
PF13307 Helicase_C_2, 1 hit
PRINTSiPR00852 XRODRMPGMNTD
SMARTiView protein in SMART
SM00488 DEXDc2, 1 hit
SM00491 HELICc2, 1 hit
SUPFAMiSSF52540 SSF52540, 4 hits
TIGRFAMsiTIGR00604 rad3, 1 hit
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51193 HELICASE_ATP_BIND_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K223-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNVDGLLV YFPYDYIYPE QFSYMLELKR TLDAKGHGVL EMPSGTGKTV
60 70 80 90 100
SLLALIVAYQ RVIEELRKLL SFYEQQEGEK LPFLGLALSS RKNLCIHPEV
110 120 130 140 150
TPLRFGKDVD GKCHSLTASY VRAQYQQDAS LPHCRFYEEF DIHGRQMPLP
160 170 180 190 200
AGIYNLDDLK ALGHRQGWCP YFLARYSILH ANVVVYSYHY LLDPKIADLV
210 220 230 240 250
SKELARKAVV VFDEAHNIDN VCIDSMSVNL TRRTLDRCQS NLDTLQKTVL
260 270 280 290 300
RIKETDEQRL RDEYRRLVEG LREASVARET DAHLANPVLP DEVLQEAVPG
310 320 330 340 350
SIRTAEHFLG FLRRLLEYVK WRLRVQHVVQ ESPPAFLSGL AQRVCIQRKP
360 370 380 390 400
LRFCAERLRS LLHTLEIADL ADFSPLTLLA NFATLVSTYA KGFTIIIEPF
410 420 430 440 450
DDRTPTIANP VLHFSCMDAS LAIKPVFERF QSVIITSGTL SPLDIYPKIL
460 470 480 490 500
DFHPVTMATF TMTLARVCLC PMIIGRGNDQ VAISSKFETR EDIAVIRNYG
510 520 530 540 550
NLLLEMSAVV PDGIVAFFTS YQYMESTVAS WYEQGILENI QRNKLLFIET
560 570 580 590 600
QDGAETSVAL EKYQEACENG RGAILLSVAR GKVSEGIDFV HHYGRAVIMF
610 620 630 640 650
GVPYVYTQSR ILKARLEYLR DQFQIRENDF LTFDAMRHAA QCVGRAIRGK
660 670 680 690 700
TDYGLMVFAD KRFARADKRG KLPRWIQEHL TDSNLNLTVD EGVQVAKYFL
710 720 730
RQMAQPFHRE DQLGLSLLSL EQLQSEETLQ RIEQIAQQL
Length:739
Mass (Da):84,416
Last modified:October 1, 2002 - v1
Checksum:iE83A3461B1394645
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034517 mRNA Translation: AAH34517.1
UniGeneiMm.36524

Similar proteinsi

Entry informationi

Entry nameiQ8K223_MOUSE
AccessioniPrimary (citable) accession number: Q8K223
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health