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Q8K223

- Q8K223_MOUSE

UniProt

Q8K223 - Q8K223_MOUSE

Protein
Submitted name:

Ercc2 protein

Gene

Ercc2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + H2O = ADP + phosphate.SAAS annotation

    GO - Molecular functioni

    1. 5'-3' DNA helicase activity Source: UniProtKB
    2. ATP binding Source: UniProtKB-KW
    3. ATP-dependent DNA helicase activity Source: InterPro
    4. DNA binding Source: InterPro

    GO - Biological processi

    1. aging Source: MGI
    2. apoptotic process Source: UniProtKB
    3. bone mineralization Source: MGI
    4. cell proliferation Source: MGI
    5. central nervous system myelin formation Source: MGI
    6. DNA duplex unwinding Source: GOC
    7. DNA repair Source: MGI
    8. embryonic cleavage Source: MGI
    9. erythrocyte maturation Source: MGI
    10. extracellular matrix organization Source: MGI
    11. hair cell differentiation Source: MGI
    12. hair cycle process Source: MGI
    13. hair follicle maturation Source: MGI
    14. hematopoietic stem cell differentiation Source: MGI
    15. in utero embryonic development Source: MGI
    16. multicellular organism growth Source: MGI
    17. nucleotide-excision repair Source: MGI
    18. positive regulation of DNA binding Source: MGI
    19. post-embryonic development Source: MGI
    20. response to oxidative stress Source: MGI
    21. response to UV Source: MGI
    22. skin development Source: MGI
    23. spinal cord development Source: MGI
    24. transcription-coupled nucleotide-excision repair Source: UniProtKB
    25. UV protection Source: MGI

    Keywords - Molecular functioni

    HelicaseSAAS annotation, Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Ercc2 proteinImported
    Gene namesi
    Name:Ercc2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:95413. Ercc2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ8K223.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K223.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains helicase ATP-binding domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000205390.
    HOVERGENiHBG051498.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR006555. ATP-dep_Helicase_C.
    IPR010614. DEAD_2.
    IPR002464. DNA/RNA_helicase_DEAH_CS.
    IPR013020. DNA_helicase_DNA-repair_Rad3.
    IPR010643. DUF1227.
    IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
    IPR006554. Helicase-like_DEXD_c2.
    IPR027417. P-loop_NTPase.
    IPR001945. XPGD_DNA_repair.
    [Graphical view]
    PfamiPF06733. DEAD_2. 1 hit.
    PF06777. DUF1227. 1 hit.
    PF13307. Helicase_C_2. 1 hit.
    [Graphical view]
    PRINTSiPR00852. XRODRMPGMNTD.
    SMARTiSM00488. DEXDc2. 1 hit.
    SM00491. HELICc2. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 4 hits.
    TIGRFAMsiTIGR00604. rad3. 1 hit.
    PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
    PS51193. HELICASE_ATP_BIND_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K223-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLNVDGLLV YFPYDYIYPE QFSYMLELKR TLDAKGHGVL EMPSGTGKTV    50
    SLLALIVAYQ RVIEELRKLL SFYEQQEGEK LPFLGLALSS RKNLCIHPEV 100
    TPLRFGKDVD GKCHSLTASY VRAQYQQDAS LPHCRFYEEF DIHGRQMPLP 150
    AGIYNLDDLK ALGHRQGWCP YFLARYSILH ANVVVYSYHY LLDPKIADLV 200
    SKELARKAVV VFDEAHNIDN VCIDSMSVNL TRRTLDRCQS NLDTLQKTVL 250
    RIKETDEQRL RDEYRRLVEG LREASVARET DAHLANPVLP DEVLQEAVPG 300
    SIRTAEHFLG FLRRLLEYVK WRLRVQHVVQ ESPPAFLSGL AQRVCIQRKP 350
    LRFCAERLRS LLHTLEIADL ADFSPLTLLA NFATLVSTYA KGFTIIIEPF 400
    DDRTPTIANP VLHFSCMDAS LAIKPVFERF QSVIITSGTL SPLDIYPKIL 450
    DFHPVTMATF TMTLARVCLC PMIIGRGNDQ VAISSKFETR EDIAVIRNYG 500
    NLLLEMSAVV PDGIVAFFTS YQYMESTVAS WYEQGILENI QRNKLLFIET 550
    QDGAETSVAL EKYQEACENG RGAILLSVAR GKVSEGIDFV HHYGRAVIMF 600
    GVPYVYTQSR ILKARLEYLR DQFQIRENDF LTFDAMRHAA QCVGRAIRGK 650
    TDYGLMVFAD KRFARADKRG KLPRWIQEHL TDSNLNLTVD EGVQVAKYFL 700
    RQMAQPFHRE DQLGLSLLSL EQLQSEETLQ RIEQIAQQL 739
    Length:739
    Mass (Da):84,416
    Last modified:October 1, 2002 - v1
    Checksum:iE83A3461B1394645
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC034517 mRNA. Translation: AAH34517.1.
    UniGeneiMm.36524.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC034517 mRNA. Translation: AAH34517.1 .
    UniGenei Mm.36524.

    3D structure databases

    ProteinModelPortali Q8K223.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:95413. Ercc2.

    Phylogenomic databases

    HOGENOMi HOG000205390.
    HOVERGENi HBG051498.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8K223.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR006555. ATP-dep_Helicase_C.
    IPR010614. DEAD_2.
    IPR002464. DNA/RNA_helicase_DEAH_CS.
    IPR013020. DNA_helicase_DNA-repair_Rad3.
    IPR010643. DUF1227.
    IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
    IPR006554. Helicase-like_DEXD_c2.
    IPR027417. P-loop_NTPase.
    IPR001945. XPGD_DNA_repair.
    [Graphical view ]
    Pfami PF06733. DEAD_2. 1 hit.
    PF06777. DUF1227. 1 hit.
    PF13307. Helicase_C_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00852. XRODRMPGMNTD.
    SMARTi SM00488. DEXDc2. 1 hit.
    SM00491. HELICc2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 4 hits.
    TIGRFAMsi TIGR00604. rad3. 1 hit.
    PROSITEi PS00690. DEAH_ATP_HELICASE. 1 hit.
    PS51193. HELICASE_ATP_BIND_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy.Imported.

    Entry informationi

    Entry nameiQ8K223_MOUSE
    AccessioniPrimary (citable) accession number: Q8K223
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)