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Protein

Arfaptin-2

Gene

Arfip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Arfaptin-2
Alternative name(s):
ADP-ribosylation factor-interacting protein 2
Gene namesi
Name:Arfip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1924182. Arfip2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Arfaptin-2PRO_0000064668Add
BLAST

Proteomic databases

EPDiQ8K221.
MaxQBiQ8K221.
PaxDbiQ8K221.
PRIDEiQ8K221.

PTM databases

iPTMnetiQ8K221.
PhosphoSiteiQ8K221.

Expressioni

Gene expression databases

BgeeiQ8K221.
CleanExiMM_ARFIP2.
ExpressionAtlasiQ8K221. baseline and differential.
GenevisibleiQ8K221. MM.

Interactioni

Subunit structurei

Interacts with RAC1 by binding directly to it. Specifically binds to GTP-bound ARF1 and ARF6, but binds to RAC1.GTP and RAC1.GDP with similar affinities (By similarity). Directly interacts with ARL1 GTP-bound form; this interaction leads to an increase in the amount of bound GTP at steady state level (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218408. 1 interaction.
IntActiQ8K221. 2 interactions.
MINTiMINT-4117149.
STRINGi10090.ENSMUSP00000081840.

Structurei

3D structure databases

ProteinModelPortaliQ8K221.
SMRiQ8K221. Positions 119-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 321201AHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 AH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3876. Eukaryota.
ENOG410YJUM. LUCA.
GeneTreeiENSGT00500000044828.
HOGENOMiHOG000236308.
HOVERGENiHBG050564.
InParanoidiQ8K221.
OMAiYFSGNQQ.
OrthoDBiEOG7VQJD9.
PhylomeDBiQ8K221.
TreeFamiTF314945.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR010504. AH_dom.
IPR030798. Arfaptin_fam.
[Graphical view]
PANTHERiPTHR12141. PTHR12141. 1 hit.
PfamiPF06456. Arfaptin. 1 hit.
[Graphical view]
SMARTiSM01015. Arfaptin. 1 hit.
[Graphical view]
PROSITEiPS50870. AH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDGILGKAA TMEIPIHGNG EAGQLPEDDG LEQDLQQVMV SGPNLNETSI
60 70 80 90 100
VSGGYGGSGD GLIPTGSGRH PSHSTSPSGP GDEVARGIAG EKFDIVKKWG
110 120 130 140 150
INTYKCTKQL LSERFGRGSR TVDLELELQI ELLRETKRKY ESVLQLGRAL
160 170 180 190 200
TAHLYSLLQT QHALGDAFAD LSQKSPELQE EFGYNAETQK LLCKNGETLL
210 220 230 240 250
GAVNFFVSSI NTLVTKTMED TLMTVKQYEA ARLEYDAYRT DLEELSLGPR
260 270 280 290 300
DAGTRGRLES AQATFQTHRD KYEKLRGDVA IKLKFLEENK IKVMHKQLLL
310 320 330 340
FHNAVSAYFA GNQKQLEQTL QQFNIKLRPP GAEKPSWLEE Q
Length:341
Mass (Da):37,773
Last modified:June 7, 2005 - v2
Checksum:iAA3BE39EF0C75037
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti107 – 1071T → K in AAH34520 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009100 mRNA. Translation: BAB26070.1.
AK154772 mRNA. Translation: BAE32820.1.
BC013794 mRNA. Translation: AAH13794.1.
BC022942 mRNA. Translation: AAH22942.1.
BC034520 mRNA. Translation: AAH34520.1.
CCDSiCCDS21656.1.
RefSeqiNP_084078.3. NM_029802.4.
UniGeneiMm.41637.

Genome annotation databases

EnsembliENSMUST00000084782; ENSMUSP00000081840; ENSMUSG00000030881.
ENSMUST00000131446; ENSMUSP00000120387; ENSMUSG00000030881.
GeneIDi76932.
KEGGimmu:76932.
UCSCiuc009iyr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009100 mRNA. Translation: BAB26070.1.
AK154772 mRNA. Translation: BAE32820.1.
BC013794 mRNA. Translation: AAH13794.1.
BC022942 mRNA. Translation: AAH22942.1.
BC034520 mRNA. Translation: AAH34520.1.
CCDSiCCDS21656.1.
RefSeqiNP_084078.3. NM_029802.4.
UniGeneiMm.41637.

3D structure databases

ProteinModelPortaliQ8K221.
SMRiQ8K221. Positions 119-319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218408. 1 interaction.
IntActiQ8K221. 2 interactions.
MINTiMINT-4117149.
STRINGi10090.ENSMUSP00000081840.

PTM databases

iPTMnetiQ8K221.
PhosphoSiteiQ8K221.

Proteomic databases

EPDiQ8K221.
MaxQBiQ8K221.
PaxDbiQ8K221.
PRIDEiQ8K221.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084782; ENSMUSP00000081840; ENSMUSG00000030881.
ENSMUST00000131446; ENSMUSP00000120387; ENSMUSG00000030881.
GeneIDi76932.
KEGGimmu:76932.
UCSCiuc009iyr.2. mouse.

Organism-specific databases

CTDi23647.
MGIiMGI:1924182. Arfip2.

Phylogenomic databases

eggNOGiKOG3876. Eukaryota.
ENOG410YJUM. LUCA.
GeneTreeiENSGT00500000044828.
HOGENOMiHOG000236308.
HOVERGENiHBG050564.
InParanoidiQ8K221.
OMAiYFSGNQQ.
OrthoDBiEOG7VQJD9.
PhylomeDBiQ8K221.
TreeFamiTF314945.

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

ChiTaRSiArfip2. mouse.
PROiQ8K221.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K221.
CleanExiMM_ARFIP2.
ExpressionAtlasiQ8K221. baseline and differential.
GenevisibleiQ8K221. MM.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR010504. AH_dom.
IPR030798. Arfaptin_fam.
[Graphical view]
PANTHERiPTHR12141. PTHR12141. 1 hit.
PfamiPF06456. Arfaptin. 1 hit.
[Graphical view]
SMARTiSM01015. Arfaptin. 1 hit.
[Graphical view]
PROSITEiPS50870. AH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiARFP2_MOUSE
AccessioniPrimary (citable) accession number: Q8K221
Secondary accession number(s): Q3U3G6, Q9D7M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: June 8, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.