ID   Q8K220_MOUSE            Unreviewed;       555 AA.
AC   Q8K220;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 147.
DE   SubName: Full=Avian reticuloendotheliosis viral (v-rel) oncogene related B {ECO:0000313|Ensembl:ENSMUSP00000050166.9};
DE   SubName: Full=Relb protein {ECO:0000313|EMBL:AAH34523.1};
GN   Name=Relb {ECO:0000313|EMBL:AAH34523.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000050166.9, ECO:0000313|MGI:MGI:103289};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH34523.1};
RN   [1] {ECO:0000313|EMBL:AAH34523.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N {ECO:0000313|EMBL:AAH34523.1};
RC   TISSUE=Mammary tumor. Metallothionien-TGF alpha model. 10 month old
RC   virgin mouse. Taken by biopsy. {ECO:0000313|EMBL:AAH34523.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000050166.9, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000050166.9,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000050166.9}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000050166.9};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; BC034523; AAH34523.1; -; mRNA.
DR   RefSeq; NP_001277386.1; NM_001290457.1.
DR   ProteomicsDB; 332691; -.
DR   Antibodypedia; 3573; 768 antibodies from 43 providers.
DR   DNASU; 19698; -.
DR   Ensembl; ENSMUST00000049912.15; ENSMUSP00000050166.9; ENSMUSG00000002983.18.
DR   GeneID; 19698; -.
DR   UCSC; uc033ixc.1; mouse.
DR   AGR; MGI:103289; -.
DR   CTD; 5971; -.
DR   MGI; MGI:103289; Relb.
DR   VEuPathDB; HostDB:ENSMUSG00000002983; -.
DR   GeneTree; ENSGT00940000160230; -.
DR   HOGENOM; CLU_046955_0_0_1; -.
DR   OrthoDB; 1059550at2759; -.
DR   BioGRID-ORCS; 19698; 3 hits in 81 CRISPR screens.
DR   ChiTaRS; Relb; mouse.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000002983; Expressed in peripheral lymph node and 139 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IMP:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IMP:NTNU_SB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:NTNU_SB.
DR   CDD; cd01177; IPT_NFkappaB; 1.
DR   CDD; cd07886; RHD-n_RelB; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR033926; IPT_NFkappaB.
DR   InterPro; IPR000451; NFkB/Dor.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR032399; RelB_leu_zip.
DR   InterPro; IPR030496; RelB_RHD_N.
DR   InterPro; IPR032400; RelB_transact.
DR   InterPro; IPR030492; RHD_CS.
DR   InterPro; IPR032397; RHD_dimer.
DR   InterPro; IPR011539; RHD_DNA_bind_dom.
DR   InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR   PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR   PANTHER; PTHR24169:SF18; TRANSCRIPTION FACTOR RELB; 1.
DR   Pfam; PF16180; RelB_leu_zip; 1.
DR   Pfam; PF16181; RelB_transactiv; 1.
DR   Pfam; PF16179; RHD_dimer; 1.
DR   Pfam; PF00554; RHD_DNA_bind; 1.
DR   PRINTS; PR00057; NFKBTNSCPFCT.
DR   SMART; SM00429; IPT; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   PROSITE; PS01204; REL_1; 1.
DR   PROSITE; PS50254; REL_2; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:Q8K220,
KW   ECO:0007829|MaxQB:Q8K220};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          97..274
FT                   /note="RHD"
FT                   /evidence="ECO:0000259|PROSITE:PS50254"
SQ   SEQUENCE   555 AA;  59948 MW;  12642B8A5B9E099A CRC64;
     MPSRRAARES APELGALGSS DLSSLSLTVS RTTEIIDEYI KENGFGLDGT QLSEMPRLVP
     RGPASLSSVT LGPAAPPPPA TPSWSCTLGR LVSPGPCPRP YLVITEQPKQ RGMRFRYECE
     GRSAGSILGE SSTEASKTLP AIELRDCGGL REVEVTACLV WKDWPHRVHP HSLVGKDCTD
     GVCRVRLRPH VSPRHSFNNL GIQCVRKKEI EAAIERKIQL GIDPYNAGSL KNHQEVDMNV
     VRICFQASYR DQQGHLHRMD PILSEPVYDK KSTNTSELRI CRINKESGPC TGGEELYLLC
     DKVQKEDISV VFSTASWEGR ADFSQADVHR QIAIVFKTPP YEDLEISEPV TVNVFLQRLT
     DGVCSEPLPF TYLPRDHDSY GVDKKRKRGL PDVLGELSSS DPHGIESKRR KKKPVFLDHF
     LPGHSSGLFL PPSALQPADS DFFPASISLP GLEPPGGPDL LDDGFAYDPS APTLFTMLDL
     LPPAPPLASA VVGSGGAGAT VVESSGPEPL SLDSFAAPGP GDVGTASLVG SNMFPNQYRE
     AAFGGGLLSP GPEAT
//