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Protein
Submitted name:

Relb protein

Gene

Relb

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • antigen processing and presentation Source: MGI
  • I-kappaB kinase/NF-kappaB signaling Source: GO_Central
  • inflammatory response Source: GO_Central
  • innate immune response Source: GO_Central
  • myeloid dendritic cell differentiation Source: MGI
  • negative regulation of interferon-beta production Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • NIK/NF-kappaB signaling Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • response to cytokine Source: GO_Central
  • T-helper 1 cell differentiation Source: MGI
  • T-helper 1 type immune response Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Relb proteinImported
Submitted name:
Transcription factor RelBImported
Gene namesi
Name:RelbImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:103289. Relb.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • I-kappaB/NF-kappaB complex Source: GO_Central
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

ExpressionAtlasiQ8K220. baseline and differential.
GenevestigatoriQ8K220.

Structurei

3D structure databases

ProteinModelPortaliQ8K220.
SMRiQ8K220. Positions 85-380.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RHD (Rel-like) domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00500000044765.
HOGENOMiHOG000148598.
HOVERGENiHBG017021.
KOiK09253.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000451. NFkB/Dor.
IPR008967. p53-like_TF_DNA-bd.
IPR030496. RelB.
IPR011539. RHD.
IPR030492. RHD_CS.
[Graphical view]
PANTHERiPTHR24169. PTHR24169. 1 hit.
PTHR24169:SF18. PTHR24169:SF18. 1 hit.
PfamiPF00554. RHD. 1 hit.
[Graphical view]
PRINTSiPR00057. NFKBTNSCPFCT.
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS01204. REL_1. 1 hit.
PS50254. REL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSRRAARES APELGALGSS DLSSLSLTVS RTTEIIDEYI KENGFGLDGT
60 70 80 90 100
QLSEMPRLVP RGPASLSSVT LGPAAPPPPA TPSWSCTLGR LVSPGPCPRP
110 120 130 140 150
YLVITEQPKQ RGMRFRYECE GRSAGSILGE SSTEASKTLP AIELRDCGGL
160 170 180 190 200
REVEVTACLV WKDWPHRVHP HSLVGKDCTD GVCRVRLRPH VSPRHSFNNL
210 220 230 240 250
GIQCVRKKEI EAAIERKIQL GIDPYNAGSL KNHQEVDMNV VRICFQASYR
260 270 280 290 300
DQQGHLHRMD PILSEPVYDK KSTNTSELRI CRINKESGPC TGGEELYLLC
310 320 330 340 350
DKVQKEDISV VFSTASWEGR ADFSQADVHR QIAIVFKTPP YEDLEISEPV
360 370 380 390 400
TVNVFLQRLT DGVCSEPLPF TYLPRDHDSY GVDKKRKRGL PDVLGELSSS
410 420 430 440 450
DPHGIESKRR KKKPVFLDHF LPGHSSGLFL PPSALQPADS DFFPASISLP
460 470 480 490 500
GLEPPGGPDL LDDGFAYDPS APTLFTMLDL LPPAPPLASA VVGSGGAGAT
510 520 530 540 550
VVESSGPEPL SLDSFAAPGP GDVGTASLVG SNMFPNQYRE AAFGGGLLSP

GPEAT
Length:555
Mass (Da):59,948
Last modified:October 1, 2002 - v1
Checksum:i12642B8A5B9E099A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC149052 Genomic DNA. No translation available.
BC034523 mRNA. Translation: AAH34523.1.
RefSeqiNP_001277386.1. NM_001290457.1.
UniGeneiMm.1741.

Genome annotation databases

EnsembliENSMUST00000049912; ENSMUSP00000050166; ENSMUSG00000002983.
GeneIDi19698.
KEGGimmu:19698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC149052 Genomic DNA. No translation available.
BC034523 mRNA. Translation: AAH34523.1.
RefSeqiNP_001277386.1. NM_001290457.1.
UniGeneiMm.1741.

3D structure databases

ProteinModelPortaliQ8K220.
SMRiQ8K220. Positions 85-380.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049912; ENSMUSP00000050166; ENSMUSG00000002983.
GeneIDi19698.
KEGGimmu:19698.

Organism-specific databases

CTDi5971.
MGIiMGI:103289. Relb.

Phylogenomic databases

GeneTreeiENSGT00500000044765.
HOGENOMiHOG000148598.
HOVERGENiHBG017021.
KOiK09253.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

ExpressionAtlasiQ8K220. baseline and differential.
GenevestigatoriQ8K220.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000451. NFkB/Dor.
IPR008967. p53-like_TF_DNA-bd.
IPR030496. RelB.
IPR011539. RHD.
IPR030492. RHD_CS.
[Graphical view]
PANTHERiPTHR24169. PTHR24169. 1 hit.
PTHR24169:SF18. PTHR24169:SF18. 1 hit.
PfamiPF00554. RHD. 1 hit.
[Graphical view]
PRINTSiPR00057. NFKBTNSCPFCT.
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS01204. REL_1. 1 hit.
PS50254. REL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy.Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8K220_MOUSE
AccessioniPrimary (citable) accession number: Q8K220
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: May 27, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.