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Q8K212

- PACS1_MOUSE

UniProt

Q8K212 - PACS1_MOUSE

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Protein

Phosphofurin acidic cluster sorting protein 1

Gene
Pacs1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits By similarity.

GO - Biological processi

  1. protein targeting to Golgi Source: MGI
  2. protein targeting to plasma membrane Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphofurin acidic cluster sorting protein 1
Short name:
PACS-1
Gene namesi
Name:Pacs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1277113. Pacs1.

Subcellular locationi

Golgi apparatustrans-Golgi network By similarity
Note: Localizes in the perinuclear region, probably the TGN By similarity.

GO - Cellular componenti

  1. COPI-coated vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 961960Phosphofurin acidic cluster sorting protein 1PRO_0000058172Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei377 – 3771Phosphoserine By similarity
Modified residuei428 – 4281Phosphoserine By similarity
Modified residuei502 – 5021Phosphothreonine By similarity
Modified residuei527 – 5271Phosphoserine By similarity
Modified residuei529 – 5291Phosphoserine By similarity
Modified residuei532 – 5321Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8K212.
PaxDbiQ8K212.
PRIDEiQ8K212.

PTM databases

PhosphoSiteiQ8K212.

Expressioni

Gene expression databases

ArrayExpressiQ8K212.
BgeeiQ8K212.
CleanExiMM_PACS1.
GenevestigatoriQ8K212.

Interactioni

Subunit structurei

Associates with AP-1 and AP-3 but not with AP-2 complexes. Forms a ternary complex with furin and AP-1 By similarity.

Protein-protein interaction databases

BioGridi223732. 3 interactions.
IntActiQ8K212. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8K212.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili351 – 37525 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi53 – 8230Ser-richAdd
BLAST
Compositional biasi60 – 634Poly-Ala
Compositional biasi110 – 1134Poly-Ser
Compositional biasi277 – 2815Poly-Glu

Sequence similaritiesi

Belongs to the PACS family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG279176.
GeneTreeiENSGT00390000003281.
HOGENOMiHOG000047329.
HOVERGENiHBG053488.
InParanoidiQ8K212.
OMAiTPAPVQM.
OrthoDBiEOG7VHSX0.
PhylomeDBiQ8K212.
TreeFamiTF314240.

Family and domain databases

InterProiIPR019381. Phosphofurin_acidic_CS-1.
[Graphical view]
PfamiPF10254. Pacs-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K212-1 [UniParc]FASTAAdd to Basket

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MAERGGAGGG PGGSGGGSSQ RGSGVAQSPQ QQPQQQPPQP QQPTPPKLAQ    50
ATSSSSSTSA AAASSSSSST STSMAVAVAS GSAPPGGPGP GRTPAPVQMN 100
LYATWEVDRS SSSCVPRLFS LTLKKLVMLK EMDKDLNSVV IAVKLQGSKR 150
ILRSNEIILP ASGLVETELQ LTFSLQYPHF LKRDANKLQI MLQRRKRYKN 200
RTILGYKTLA VGLINMAEVM QHPNEGALVL GLHSNVKDVS VPVAEIKIYS 250
LSSQPIDHEG IKSKLSDRSP DIDNYSEEEE ESFSSEQEGS DDPLHGQDLF 300
YEDEDLRKVK KTRRKLTSTS AITRQPNIKQ KFVALLKRFK VSDEVGFGLE 350
HVSREQIREV EEDLDELYDS LEMYNPSDSG PEMEETESIL STPKPKLKPF 400
FEGMSQSSSQ TEIGSLNSKG SLGKDTTSPM ELAALEKVKS TWIKNQDDSL 450
TETDTLEITD QDMFGDVSTS LVVPEKVKTP MKSSKADLQG SASPSKVEGT 500
HTPRQKRSTP LKERQLSKPL SERTNSSDSE RSPDLGHSTQ IPRKVVYDQL 550
NQILVSDAAL PENVILVNTT DWQGQYVAEL LQDQRKPVVC TCSTVEVQAV 600
LSALLTRIQR YCNCNSSMPR PVKVAAVGSQ SYLSSILRFF VKSLASKTPD 650
WLGYMRFLII PLGSHPVAKY LGSVDSRYSS TFLDSAWRDL FSRSEPPVSE 700
PLDVVGRVMQ YVNGATTTHQ LPVAEAMLTC RHKFPDEDSY QKFIPFIGVV 750
KVGLVEDSPS TAGDGDDSPV VSLTVPSTSP PSSSGLSRDA TATPPSSPSM 800
SSALAIVGSP NSPYGDVIGL QVDYWLGHPG ERRREGDKRD ASSKNTLKSV 850
FRSVQVSRLP HAGEAQLSGT MAMTVVTKEK NKKVPTIFLS KKPREKEVDS 900
KSQVIEGISR LICSAKQQQT MLRVSIDGVE WSDIKFFQLA AQWPTHVKHF 950
PVGLFSGSKT T 961
Length:961
Mass (Da):104,829
Last modified:September 13, 2004 - v2
Checksum:iA57F3D86800D9B83
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti816 – 8161D → E in AAH34670. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC062886 mRNA. Translation: AAH62886.1.
BC034670 mRNA. Translation: AAH34670.1.
CCDSiCCDS29453.1.
RefSeqiNP_694769.2. NM_153129.2.
UniGeneiMm.234923.

Genome annotation databases

EnsembliENSMUST00000025786; ENSMUSP00000025786; ENSMUSG00000024855.
GeneIDi107975.
KEGGimmu:107975.
UCSCiuc008gci.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC062886 mRNA. Translation: AAH62886.1 .
BC034670 mRNA. Translation: AAH34670.1 .
CCDSi CCDS29453.1.
RefSeqi NP_694769.2. NM_153129.2.
UniGenei Mm.234923.

3D structure databases

ProteinModelPortali Q8K212.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 223732. 3 interactions.
IntActi Q8K212. 2 interactions.

PTM databases

PhosphoSitei Q8K212.

Proteomic databases

MaxQBi Q8K212.
PaxDbi Q8K212.
PRIDEi Q8K212.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025786 ; ENSMUSP00000025786 ; ENSMUSG00000024855 .
GeneIDi 107975.
KEGGi mmu:107975.
UCSCi uc008gci.1. mouse.

Organism-specific databases

CTDi 55690.
MGIi MGI:1277113. Pacs1.

Phylogenomic databases

eggNOGi NOG279176.
GeneTreei ENSGT00390000003281.
HOGENOMi HOG000047329.
HOVERGENi HBG053488.
InParanoidi Q8K212.
OMAi TPAPVQM.
OrthoDBi EOG7VHSX0.
PhylomeDBi Q8K212.
TreeFami TF314240.

Miscellaneous databases

ChiTaRSi PACS1. mouse.
NextBioi 359807.
PROi Q8K212.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8K212.
Bgeei Q8K212.
CleanExi MM_PACS1.
Genevestigatori Q8K212.

Family and domain databases

InterProi IPR019381. Phosphofurin_acidic_CS-1.
[Graphical view ]
Pfami PF10254. Pacs-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Mammary gland.

Entry informationi

Entry nameiPACS1_MOUSE
AccessioniPrimary (citable) accession number: Q8K212
Secondary accession number(s): Q6P5H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi