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Q8K212 (PACS1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphofurin acidic cluster sorting protein 1

Short name=PACS-1
Gene names
Name:Pacs1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length961 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits By similarity.

Subunit structure

Associates with AP-1 and AP-3 but not with AP-2 complexes. Forms a ternary complex with furin and AP-1 By similarity.

Subcellular location

Golgi apparatustrans-Golgi network By similarity. Note: Localizes in the perinuclear region, probably the TGN By similarity.

Sequence similarities

Belongs to the PACS family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 961960Phosphofurin acidic cluster sorting protein 1
PRO_0000058172

Regions

Coiled coil351 – 37525 Potential
Compositional bias53 – 8230Ser-rich
Compositional bias60 – 634Poly-Ala
Compositional bias110 – 1134Poly-Ser
Compositional bias277 – 2815Poly-Glu

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue3771Phosphoserine By similarity
Modified residue4281Phosphoserine By similarity
Modified residue5021Phosphothreonine By similarity
Modified residue5271Phosphoserine By similarity
Modified residue5291Phosphoserine By similarity
Modified residue5321Phosphoserine By similarity

Experimental info

Sequence conflict8161D → E in AAH34670. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8K212 [UniParc].

Last modified September 13, 2004. Version 2.
Checksum: A57F3D86800D9B83

FASTA961104,829
        10         20         30         40         50         60 
MAERGGAGGG PGGSGGGSSQ RGSGVAQSPQ QQPQQQPPQP QQPTPPKLAQ ATSSSSSTSA 

        70         80         90        100        110        120 
AAASSSSSST STSMAVAVAS GSAPPGGPGP GRTPAPVQMN LYATWEVDRS SSSCVPRLFS 

       130        140        150        160        170        180 
LTLKKLVMLK EMDKDLNSVV IAVKLQGSKR ILRSNEIILP ASGLVETELQ LTFSLQYPHF 

       190        200        210        220        230        240 
LKRDANKLQI MLQRRKRYKN RTILGYKTLA VGLINMAEVM QHPNEGALVL GLHSNVKDVS 

       250        260        270        280        290        300 
VPVAEIKIYS LSSQPIDHEG IKSKLSDRSP DIDNYSEEEE ESFSSEQEGS DDPLHGQDLF 

       310        320        330        340        350        360 
YEDEDLRKVK KTRRKLTSTS AITRQPNIKQ KFVALLKRFK VSDEVGFGLE HVSREQIREV 

       370        380        390        400        410        420 
EEDLDELYDS LEMYNPSDSG PEMEETESIL STPKPKLKPF FEGMSQSSSQ TEIGSLNSKG 

       430        440        450        460        470        480 
SLGKDTTSPM ELAALEKVKS TWIKNQDDSL TETDTLEITD QDMFGDVSTS LVVPEKVKTP 

       490        500        510        520        530        540 
MKSSKADLQG SASPSKVEGT HTPRQKRSTP LKERQLSKPL SERTNSSDSE RSPDLGHSTQ 

       550        560        570        580        590        600 
IPRKVVYDQL NQILVSDAAL PENVILVNTT DWQGQYVAEL LQDQRKPVVC TCSTVEVQAV 

       610        620        630        640        650        660 
LSALLTRIQR YCNCNSSMPR PVKVAAVGSQ SYLSSILRFF VKSLASKTPD WLGYMRFLII 

       670        680        690        700        710        720 
PLGSHPVAKY LGSVDSRYSS TFLDSAWRDL FSRSEPPVSE PLDVVGRVMQ YVNGATTTHQ 

       730        740        750        760        770        780 
LPVAEAMLTC RHKFPDEDSY QKFIPFIGVV KVGLVEDSPS TAGDGDDSPV VSLTVPSTSP 

       790        800        810        820        830        840 
PSSSGLSRDA TATPPSSPSM SSALAIVGSP NSPYGDVIGL QVDYWLGHPG ERRREGDKRD 

       850        860        870        880        890        900 
ASSKNTLKSV FRSVQVSRLP HAGEAQLSGT MAMTVVTKEK NKKVPTIFLS KKPREKEVDS 

       910        920        930        940        950        960 
KSQVIEGISR LICSAKQQQT MLRVSIDGVE WSDIKFFQLA AQWPTHVKHF PVGLFSGSKT 


T 

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References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain and Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC062886 mRNA. Translation: AAH62886.1.
BC034670 mRNA. Translation: AAH34670.1.
RefSeqNP_694769.2. NM_153129.2.
UniGeneMm.234923.

3D structure databases

ProteinModelPortalQ8K212.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid223732. 3 interactions.
IntActQ8K212. 2 interactions.

PTM databases

PhosphoSiteQ8K212.

Proteomic databases

PaxDbQ8K212.
PRIDEQ8K212.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025786; ENSMUSP00000025786; ENSMUSG00000024855.
GeneID107975.
KEGGmmu:107975.
UCSCuc008gci.1. mouse.

Organism-specific databases

CTD55690.
MGIMGI:1277113. Pacs1.

Phylogenomic databases

eggNOGNOG279176.
GeneTreeENSGT00390000003281.
HOGENOMHOG000047329.
HOVERGENHBG053488.
InParanoidQ8K212.
OMATPAPVQM.
OrthoDBEOG7VHSX0.
PhylomeDBQ8K212.
TreeFamTF314240.

Gene expression databases

ArrayExpressQ8K212.
BgeeQ8K212.
CleanExMM_PACS1.
GenevestigatorQ8K212.

Family and domain databases

InterProIPR019381. Phosphofurin_acidic_CS-1.
[Graphical view]
PfamPF10254. Pacs-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPACS1. mouse.
NextBio359807.
PROQ8K212.
SOURCESearch...

Entry information

Entry namePACS1_MOUSE
AccessionPrimary (citable) accession number: Q8K212
Secondary accession number(s): Q6P5H8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot