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Q8K212

- PACS1_MOUSE

UniProt

Q8K212 - PACS1_MOUSE

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Protein

Phosphofurin acidic cluster sorting protein 1

Gene

Pacs1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits By similarity.By similarity

GO - Biological processi

  1. protein targeting to Golgi Source: MGI
  2. protein targeting to plasma membrane Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphofurin acidic cluster sorting protein 1
Short name:
PACS-1
Gene namesi
Name:Pacs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1277113. Pacs1.

Subcellular locationi

Golgi apparatustrans-Golgi network By similarity
Note: Localizes in the perinuclear region, probably the TGN.By similarity

GO - Cellular componenti

  1. COPI-coated vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 961960Phosphofurin acidic cluster sorting protein 1PRO_0000058172Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei377 – 3771PhosphoserineBy similarity
Modified residuei428 – 4281PhosphoserineBy similarity
Modified residuei502 – 5021PhosphothreonineBy similarity
Modified residuei527 – 5271PhosphoserineBy similarity
Modified residuei529 – 5291PhosphoserineBy similarity
Modified residuei532 – 5321PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8K212.
PaxDbiQ8K212.
PRIDEiQ8K212.

PTM databases

PhosphoSiteiQ8K212.

Expressioni

Gene expression databases

BgeeiQ8K212.
CleanExiMM_PACS1.
ExpressionAtlasiQ8K212. baseline and differential.
GenevestigatoriQ8K212.

Interactioni

Subunit structurei

Associates with AP-1 and AP-3 but not with AP-2 complexes. Forms a ternary complex with furin and AP-1 By similarity.By similarity

Protein-protein interaction databases

BioGridi223732. 3 interactions.
IntActiQ8K212. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8K212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili351 – 37525Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi53 – 8230Ser-richAdd
BLAST
Compositional biasi60 – 634Poly-Ala
Compositional biasi110 – 1134Poly-Ser
Compositional biasi277 – 2815Poly-Glu

Sequence similaritiesi

Belongs to the PACS family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG279176.
GeneTreeiENSGT00390000003281.
HOGENOMiHOG000047329.
HOVERGENiHBG053488.
InParanoidiQ8K212.
OMAiTPAPVQM.
OrthoDBiEOG7VHSX0.
PhylomeDBiQ8K212.
TreeFamiTF314240.

Family and domain databases

InterProiIPR019381. Phosphofurin_acidic_CS-1.
[Graphical view]
PfamiPF10254. Pacs-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K212-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAERGGAGGG PGGSGGGSSQ RGSGVAQSPQ QQPQQQPPQP QQPTPPKLAQ
60 70 80 90 100
ATSSSSSTSA AAASSSSSST STSMAVAVAS GSAPPGGPGP GRTPAPVQMN
110 120 130 140 150
LYATWEVDRS SSSCVPRLFS LTLKKLVMLK EMDKDLNSVV IAVKLQGSKR
160 170 180 190 200
ILRSNEIILP ASGLVETELQ LTFSLQYPHF LKRDANKLQI MLQRRKRYKN
210 220 230 240 250
RTILGYKTLA VGLINMAEVM QHPNEGALVL GLHSNVKDVS VPVAEIKIYS
260 270 280 290 300
LSSQPIDHEG IKSKLSDRSP DIDNYSEEEE ESFSSEQEGS DDPLHGQDLF
310 320 330 340 350
YEDEDLRKVK KTRRKLTSTS AITRQPNIKQ KFVALLKRFK VSDEVGFGLE
360 370 380 390 400
HVSREQIREV EEDLDELYDS LEMYNPSDSG PEMEETESIL STPKPKLKPF
410 420 430 440 450
FEGMSQSSSQ TEIGSLNSKG SLGKDTTSPM ELAALEKVKS TWIKNQDDSL
460 470 480 490 500
TETDTLEITD QDMFGDVSTS LVVPEKVKTP MKSSKADLQG SASPSKVEGT
510 520 530 540 550
HTPRQKRSTP LKERQLSKPL SERTNSSDSE RSPDLGHSTQ IPRKVVYDQL
560 570 580 590 600
NQILVSDAAL PENVILVNTT DWQGQYVAEL LQDQRKPVVC TCSTVEVQAV
610 620 630 640 650
LSALLTRIQR YCNCNSSMPR PVKVAAVGSQ SYLSSILRFF VKSLASKTPD
660 670 680 690 700
WLGYMRFLII PLGSHPVAKY LGSVDSRYSS TFLDSAWRDL FSRSEPPVSE
710 720 730 740 750
PLDVVGRVMQ YVNGATTTHQ LPVAEAMLTC RHKFPDEDSY QKFIPFIGVV
760 770 780 790 800
KVGLVEDSPS TAGDGDDSPV VSLTVPSTSP PSSSGLSRDA TATPPSSPSM
810 820 830 840 850
SSALAIVGSP NSPYGDVIGL QVDYWLGHPG ERRREGDKRD ASSKNTLKSV
860 870 880 890 900
FRSVQVSRLP HAGEAQLSGT MAMTVVTKEK NKKVPTIFLS KKPREKEVDS
910 920 930 940 950
KSQVIEGISR LICSAKQQQT MLRVSIDGVE WSDIKFFQLA AQWPTHVKHF
960
PVGLFSGSKT T
Length:961
Mass (Da):104,829
Last modified:September 13, 2004 - v2
Checksum:iA57F3D86800D9B83
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti816 – 8161D → E in AAH34670. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC062886 mRNA. Translation: AAH62886.1.
BC034670 mRNA. Translation: AAH34670.1.
CCDSiCCDS29453.1.
RefSeqiNP_694769.2. NM_153129.2.
UniGeneiMm.234923.

Genome annotation databases

EnsembliENSMUST00000025786; ENSMUSP00000025786; ENSMUSG00000024855.
GeneIDi107975.
KEGGimmu:107975.
UCSCiuc008gci.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC062886 mRNA. Translation: AAH62886.1 .
BC034670 mRNA. Translation: AAH34670.1 .
CCDSi CCDS29453.1.
RefSeqi NP_694769.2. NM_153129.2.
UniGenei Mm.234923.

3D structure databases

ProteinModelPortali Q8K212.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 223732. 3 interactions.
IntActi Q8K212. 2 interactions.

PTM databases

PhosphoSitei Q8K212.

Proteomic databases

MaxQBi Q8K212.
PaxDbi Q8K212.
PRIDEi Q8K212.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025786 ; ENSMUSP00000025786 ; ENSMUSG00000024855 .
GeneIDi 107975.
KEGGi mmu:107975.
UCSCi uc008gci.1. mouse.

Organism-specific databases

CTDi 55690.
MGIi MGI:1277113. Pacs1.

Phylogenomic databases

eggNOGi NOG279176.
GeneTreei ENSGT00390000003281.
HOGENOMi HOG000047329.
HOVERGENi HBG053488.
InParanoidi Q8K212.
OMAi TPAPVQM.
OrthoDBi EOG7VHSX0.
PhylomeDBi Q8K212.
TreeFami TF314240.

Miscellaneous databases

ChiTaRSi PACS1. mouse.
NextBioi 359807.
PROi Q8K212.
SOURCEi Search...

Gene expression databases

Bgeei Q8K212.
CleanExi MM_PACS1.
ExpressionAtlasi Q8K212. baseline and differential.
Genevestigatori Q8K212.

Family and domain databases

InterProi IPR019381. Phosphofurin_acidic_CS-1.
[Graphical view ]
Pfami PF10254. Pacs-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Mammary gland.

Entry informationi

Entry nameiPACS1_MOUSE
AccessioniPrimary (citable) accession number: Q8K212
Secondary accession number(s): Q6P5H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3