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Q8K212

- PACS1_MOUSE

UniProt

Q8K212 - PACS1_MOUSE

Protein

Phosphofurin acidic cluster sorting protein 1

Gene

Pacs1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits By similarity.By similarity

    GO - Biological processi

    1. protein targeting to Golgi Source: MGI
    2. protein targeting to plasma membrane Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphofurin acidic cluster sorting protein 1
    Short name:
    PACS-1
    Gene namesi
    Name:Pacs1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1277113. Pacs1.

    Subcellular locationi

    Golgi apparatustrans-Golgi network By similarity
    Note: Localizes in the perinuclear region, probably the TGN.By similarity

    GO - Cellular componenti

    1. COPI-coated vesicle Source: MGI

    Keywords - Cellular componenti

    Golgi apparatus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 961960Phosphofurin acidic cluster sorting protein 1PRO_0000058172Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei377 – 3771PhosphoserineBy similarity
    Modified residuei428 – 4281PhosphoserineBy similarity
    Modified residuei502 – 5021PhosphothreonineBy similarity
    Modified residuei527 – 5271PhosphoserineBy similarity
    Modified residuei529 – 5291PhosphoserineBy similarity
    Modified residuei532 – 5321PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8K212.
    PaxDbiQ8K212.
    PRIDEiQ8K212.

    PTM databases

    PhosphoSiteiQ8K212.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K212.
    BgeeiQ8K212.
    CleanExiMM_PACS1.
    GenevestigatoriQ8K212.

    Interactioni

    Subunit structurei

    Associates with AP-1 and AP-3 but not with AP-2 complexes. Forms a ternary complex with furin and AP-1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi223732. 3 interactions.
    IntActiQ8K212. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K212.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili351 – 37525Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi53 – 8230Ser-richAdd
    BLAST
    Compositional biasi60 – 634Poly-Ala
    Compositional biasi110 – 1134Poly-Ser
    Compositional biasi277 – 2815Poly-Glu

    Sequence similaritiesi

    Belongs to the PACS family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG279176.
    GeneTreeiENSGT00390000003281.
    HOGENOMiHOG000047329.
    HOVERGENiHBG053488.
    InParanoidiQ8K212.
    OMAiTPAPVQM.
    OrthoDBiEOG7VHSX0.
    PhylomeDBiQ8K212.
    TreeFamiTF314240.

    Family and domain databases

    InterProiIPR019381. Phosphofurin_acidic_CS-1.
    [Graphical view]
    PfamiPF10254. Pacs-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8K212-1 [UniParc]FASTAAdd to Basket

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    MAERGGAGGG PGGSGGGSSQ RGSGVAQSPQ QQPQQQPPQP QQPTPPKLAQ    50
    ATSSSSSTSA AAASSSSSST STSMAVAVAS GSAPPGGPGP GRTPAPVQMN 100
    LYATWEVDRS SSSCVPRLFS LTLKKLVMLK EMDKDLNSVV IAVKLQGSKR 150
    ILRSNEIILP ASGLVETELQ LTFSLQYPHF LKRDANKLQI MLQRRKRYKN 200
    RTILGYKTLA VGLINMAEVM QHPNEGALVL GLHSNVKDVS VPVAEIKIYS 250
    LSSQPIDHEG IKSKLSDRSP DIDNYSEEEE ESFSSEQEGS DDPLHGQDLF 300
    YEDEDLRKVK KTRRKLTSTS AITRQPNIKQ KFVALLKRFK VSDEVGFGLE 350
    HVSREQIREV EEDLDELYDS LEMYNPSDSG PEMEETESIL STPKPKLKPF 400
    FEGMSQSSSQ TEIGSLNSKG SLGKDTTSPM ELAALEKVKS TWIKNQDDSL 450
    TETDTLEITD QDMFGDVSTS LVVPEKVKTP MKSSKADLQG SASPSKVEGT 500
    HTPRQKRSTP LKERQLSKPL SERTNSSDSE RSPDLGHSTQ IPRKVVYDQL 550
    NQILVSDAAL PENVILVNTT DWQGQYVAEL LQDQRKPVVC TCSTVEVQAV 600
    LSALLTRIQR YCNCNSSMPR PVKVAAVGSQ SYLSSILRFF VKSLASKTPD 650
    WLGYMRFLII PLGSHPVAKY LGSVDSRYSS TFLDSAWRDL FSRSEPPVSE 700
    PLDVVGRVMQ YVNGATTTHQ LPVAEAMLTC RHKFPDEDSY QKFIPFIGVV 750
    KVGLVEDSPS TAGDGDDSPV VSLTVPSTSP PSSSGLSRDA TATPPSSPSM 800
    SSALAIVGSP NSPYGDVIGL QVDYWLGHPG ERRREGDKRD ASSKNTLKSV 850
    FRSVQVSRLP HAGEAQLSGT MAMTVVTKEK NKKVPTIFLS KKPREKEVDS 900
    KSQVIEGISR LICSAKQQQT MLRVSIDGVE WSDIKFFQLA AQWPTHVKHF 950
    PVGLFSGSKT T 961
    Length:961
    Mass (Da):104,829
    Last modified:September 13, 2004 - v2
    Checksum:iA57F3D86800D9B83
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti816 – 8161D → E in AAH34670. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC062886 mRNA. Translation: AAH62886.1.
    BC034670 mRNA. Translation: AAH34670.1.
    CCDSiCCDS29453.1.
    RefSeqiNP_694769.2. NM_153129.2.
    UniGeneiMm.234923.

    Genome annotation databases

    EnsembliENSMUST00000025786; ENSMUSP00000025786; ENSMUSG00000024855.
    GeneIDi107975.
    KEGGimmu:107975.
    UCSCiuc008gci.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC062886 mRNA. Translation: AAH62886.1 .
    BC034670 mRNA. Translation: AAH34670.1 .
    CCDSi CCDS29453.1.
    RefSeqi NP_694769.2. NM_153129.2.
    UniGenei Mm.234923.

    3D structure databases

    ProteinModelPortali Q8K212.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 223732. 3 interactions.
    IntActi Q8K212. 2 interactions.

    PTM databases

    PhosphoSitei Q8K212.

    Proteomic databases

    MaxQBi Q8K212.
    PaxDbi Q8K212.
    PRIDEi Q8K212.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025786 ; ENSMUSP00000025786 ; ENSMUSG00000024855 .
    GeneIDi 107975.
    KEGGi mmu:107975.
    UCSCi uc008gci.1. mouse.

    Organism-specific databases

    CTDi 55690.
    MGIi MGI:1277113. Pacs1.

    Phylogenomic databases

    eggNOGi NOG279176.
    GeneTreei ENSGT00390000003281.
    HOGENOMi HOG000047329.
    HOVERGENi HBG053488.
    InParanoidi Q8K212.
    OMAi TPAPVQM.
    OrthoDBi EOG7VHSX0.
    PhylomeDBi Q8K212.
    TreeFami TF314240.

    Miscellaneous databases

    ChiTaRSi PACS1. mouse.
    NextBioi 359807.
    PROi Q8K212.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K212.
    Bgeei Q8K212.
    CleanExi MM_PACS1.
    Genevestigatori Q8K212.

    Family and domain databases

    InterProi IPR019381. Phosphofurin_acidic_CS-1.
    [Graphical view ]
    Pfami PF10254. Pacs-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Mammary gland.

    Entry informationi

    Entry nameiPACS1_MOUSE
    AccessioniPrimary (citable) accession number: Q8K212
    Secondary accession number(s): Q6P5H8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2004
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3