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Q8K211

- COPT1_MOUSE

UniProt

Q8K211 - COPT1_MOUSE

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Protein

High affinity copper uptake protein 1

Gene

Slc31a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

High-affinity, saturable copper transporter involved in dietary copper uptake.1 Publication

GO - Molecular functioni

  1. copper uptake transmembrane transporter activity Source: MGI

GO - Biological processi

  1. cellular copper ion homeostasis Source: MGI
  2. copper ion import Source: MGI
Complete GO annotation...

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

Copper

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity copper uptake protein 1
Alternative name(s):
Copper transporter 1
Short name:
CTR1
Solute carrier family 31 member 1
Gene namesi
Name:Slc31a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1333843. Slc31a1.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Localizes to the apical membrane in intestinal epithelial cells.

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. late endosome Source: MGI
  3. plasma membrane Source: UniProtKB-KW
  4. recycling endosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196High affinity copper uptake protein 1PRO_0000195041Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi34 – 341O-linked (GalNAc...)By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8K211.
PaxDbiQ8K211.
PRIDEiQ8K211.

PTM databases

PhosphoSiteiQ8K211.

Expressioni

Gene expression databases

BgeeiQ8K211.
CleanExiMM_SLC31A1.
ExpressionAtlasiQ8K211. baseline and differential.
GenevestigatoriQ8K211.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081574.

Structurei

3D structure databases

ProteinModelPortaliQ8K211.
SMRiQ8K211. Positions 138-163.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7474ExtracellularSequence AnalysisAdd
BLAST
Topological domaini96 – 13843CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini160 – 1623ExtracellularSequence Analysis
Topological domaini184 – 19613CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei75 – 9521HelicalSequence AnalysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence AnalysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG323808.
GeneTreeiENSGT00530000063415.
HOGENOMiHOG000195393.
HOVERGENiHBG065767.
InParanoidiQ8K211.
KOiK14686.
OMAiFFFSWKK.
OrthoDBiEOG7S220Q.
PhylomeDBiQ8K211.
TreeFamiTF315142.

Family and domain databases

InterProiIPR007274. Cop_transporter.
[Graphical view]
PANTHERiPTHR12483. PTHR12483. 1 hit.
PfamiPF04145. Ctr. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K211-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNHMGMNHME MHHHMGMNHT DDNITMPPHH HPTTSASHSH GGGDSMMMMP
60 70 80 90 100
MTFYFDFKNV NLLFSGLVIN TPGEMAGAFV AVFLLAMFYE GLKIAREGLL
110 120 130 140 150
RKSQVSIRYN SMPVPGPNGT ILMETHKTVG QQMLSFPHLL QTVLHIIQVV
160 170 180 190
ISYFLMLIFM TYNGYLCIAV AAGAGTGYFL FSWKKAVVVD ITEHCH
Length:196
Mass (Da):21,961
Last modified:October 1, 2002 - v1
Checksum:iA4EDDD2A9E51AF10
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181N → Y in BAC32891. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK046835 mRNA. Translation: BAC32891.1.
AK151337 mRNA. Translation: BAE30315.1.
AL732548 Genomic DNA. Translation: CAD83054.1.
BC034674 mRNA. Translation: AAH34674.1.
BC058227 mRNA. Translation: AAH58227.1.
CCDSiCCDS18237.1.
RefSeqiNP_780299.2. NM_175090.4.
XP_006537774.1. XM_006537711.1.
UniGeneiMm.248637.

Genome annotation databases

EnsembliENSMUST00000084526; ENSMUSP00000081574; ENSMUSG00000066150.
GeneIDi20529.
KEGGimmu:20529.
UCSCiuc008ten.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK046835 mRNA. Translation: BAC32891.1 .
AK151337 mRNA. Translation: BAE30315.1 .
AL732548 Genomic DNA. Translation: CAD83054.1 .
BC034674 mRNA. Translation: AAH34674.1 .
BC058227 mRNA. Translation: AAH58227.1 .
CCDSi CCDS18237.1.
RefSeqi NP_780299.2. NM_175090.4.
XP_006537774.1. XM_006537711.1.
UniGenei Mm.248637.

3D structure databases

ProteinModelPortali Q8K211.
SMRi Q8K211. Positions 138-163.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000081574.

PTM databases

PhosphoSitei Q8K211.

Proteomic databases

MaxQBi Q8K211.
PaxDbi Q8K211.
PRIDEi Q8K211.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084526 ; ENSMUSP00000081574 ; ENSMUSG00000066150 .
GeneIDi 20529.
KEGGi mmu:20529.
UCSCi uc008ten.2. mouse.

Organism-specific databases

CTDi 1317.
MGIi MGI:1333843. Slc31a1.

Phylogenomic databases

eggNOGi NOG323808.
GeneTreei ENSGT00530000063415.
HOGENOMi HOG000195393.
HOVERGENi HBG065767.
InParanoidi Q8K211.
KOi K14686.
OMAi FFFSWKK.
OrthoDBi EOG7S220Q.
PhylomeDBi Q8K211.
TreeFami TF315142.

Miscellaneous databases

ChiTaRSi SLC31A1. mouse.
NextBioi 298779.
PROi Q8K211.
SOURCEi Search...

Gene expression databases

Bgeei Q8K211.
CleanExi MM_SLC31A1.
ExpressionAtlasi Q8K211. baseline and differential.
Genevestigatori Q8K211.

Family and domain databases

InterProi IPR007274. Cop_transporter.
[Graphical view ]
PANTHERi PTHR12483. PTHR12483. 1 hit.
Pfami PF04145. Ctr. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Medulla oblongata.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor and Olfactory epithelium.
  4. "Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability."
    Nose Y., Wood L.K., Kim B.E., Prohaska J.R., Fry R.S., Spears J.W., Thiele D.J.
    J. Biol. Chem. 285:32385-32392(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCOPT1_MOUSE
AccessioniPrimary (citable) accession number: Q8K211
Secondary accession number(s): Q3UAJ9, Q8BXJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3