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Protein

High affinity copper uptake protein 1

Gene

Slc31a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

High-affinity, saturable copper transporter involved in dietary copper uptake.1 Publication

GO - Molecular functioni

  • copper uptake transmembrane transporter activity Source: MGI

GO - Biological processi

  • cellular copper ion homeostasis Source: MGI
  • cellular response to cisplatin Source: Ensembl
  • copper ion import Source: MGI
  • copper ion import into cell Source: Ensembl
  • drug transmembrane transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

Copper

Enzyme and pathway databases

ReactomeiR-MMU-425410. Metal ion SLC transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity copper uptake protein 1
Alternative name(s):
Copper transporter 1
Short name:
CTR1
Solute carrier family 31 member 1
Gene namesi
Name:Slc31a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1333843. Slc31a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 74ExtracellularSequence analysisAdd BLAST74
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Topological domaini96 – 138CytoplasmicSequence analysisAdd BLAST43
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 162ExtracellularSequence analysis3
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 196CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • late endosome Source: MGI
  • neuronal cell body Source: Ensembl
  • plasma membrane Source: UniProtKB-SubCell
  • recycling endosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001950411 – 196High affinity copper uptake protein 1Add BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...)Sequence analysis1
Glycosylationi34O-linked (GalNAc...)By similarity1
Modified residuei120PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8K211.
PaxDbiQ8K211.
PRIDEiQ8K211.

PTM databases

PhosphoSitePlusiQ8K211.

Expressioni

Gene expression databases

BgeeiENSMUSG00000066150.
CleanExiMM_SLC31A1.
ExpressionAtlasiQ8K211. baseline and differential.
GenevisibleiQ8K211. MM.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081574.

Structurei

3D structure databases

ProteinModelPortaliQ8K211.
SMRiQ8K211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3386. Eukaryota.
ENOG4111I8D. LUCA.
GeneTreeiENSGT00530000063415.
HOGENOMiHOG000195393.
HOVERGENiHBG065767.
InParanoidiQ8K211.
KOiK14686.
OMAiVGEVVHK.
OrthoDBiEOG091G0VVR.
PhylomeDBiQ8K211.
TreeFamiTF315142.

Family and domain databases

InterProiIPR007274. Cop_transporter.
[Graphical view]
PANTHERiPTHR12483. PTHR12483. 1 hit.
PfamiPF04145. Ctr. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHMGMNHME MHHHMGMNHT DDNITMPPHH HPTTSASHSH GGGDSMMMMP
60 70 80 90 100
MTFYFDFKNV NLLFSGLVIN TPGEMAGAFV AVFLLAMFYE GLKIAREGLL
110 120 130 140 150
RKSQVSIRYN SMPVPGPNGT ILMETHKTVG QQMLSFPHLL QTVLHIIQVV
160 170 180 190
ISYFLMLIFM TYNGYLCIAV AAGAGTGYFL FSWKKAVVVD ITEHCH
Length:196
Mass (Da):21,961
Last modified:October 1, 2002 - v1
Checksum:iA4EDDD2A9E51AF10
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18N → Y in BAC32891 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046835 mRNA. Translation: BAC32891.1.
AK151337 mRNA. Translation: BAE30315.1.
AL732548 Genomic DNA. Translation: CAD83054.1.
BC034674 mRNA. Translation: AAH34674.1.
BC058227 mRNA. Translation: AAH58227.1.
CCDSiCCDS18237.1.
RefSeqiNP_780299.2. NM_175090.4.
XP_006537774.1. XM_006537711.2.
UniGeneiMm.248637.

Genome annotation databases

EnsembliENSMUST00000084526; ENSMUSP00000081574; ENSMUSG00000066150.
GeneIDi20529.
KEGGimmu:20529.
UCSCiuc008ten.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046835 mRNA. Translation: BAC32891.1.
AK151337 mRNA. Translation: BAE30315.1.
AL732548 Genomic DNA. Translation: CAD83054.1.
BC034674 mRNA. Translation: AAH34674.1.
BC058227 mRNA. Translation: AAH58227.1.
CCDSiCCDS18237.1.
RefSeqiNP_780299.2. NM_175090.4.
XP_006537774.1. XM_006537711.2.
UniGeneiMm.248637.

3D structure databases

ProteinModelPortaliQ8K211.
SMRiQ8K211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081574.

PTM databases

PhosphoSitePlusiQ8K211.

Proteomic databases

MaxQBiQ8K211.
PaxDbiQ8K211.
PRIDEiQ8K211.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084526; ENSMUSP00000081574; ENSMUSG00000066150.
GeneIDi20529.
KEGGimmu:20529.
UCSCiuc008ten.2. mouse.

Organism-specific databases

CTDi1317.
MGIiMGI:1333843. Slc31a1.

Phylogenomic databases

eggNOGiKOG3386. Eukaryota.
ENOG4111I8D. LUCA.
GeneTreeiENSGT00530000063415.
HOGENOMiHOG000195393.
HOVERGENiHBG065767.
InParanoidiQ8K211.
KOiK14686.
OMAiVGEVVHK.
OrthoDBiEOG091G0VVR.
PhylomeDBiQ8K211.
TreeFamiTF315142.

Enzyme and pathway databases

ReactomeiR-MMU-425410. Metal ion SLC transporters.

Miscellaneous databases

ChiTaRSiSlc31a1. mouse.
PROiQ8K211.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066150.
CleanExiMM_SLC31A1.
ExpressionAtlasiQ8K211. baseline and differential.
GenevisibleiQ8K211. MM.

Family and domain databases

InterProiIPR007274. Cop_transporter.
[Graphical view]
PANTHERiPTHR12483. PTHR12483. 1 hit.
PfamiPF04145. Ctr. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOPT1_MOUSE
AccessioniPrimary (citable) accession number: Q8K211
Secondary accession number(s): Q3UAJ9, Q8BXJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.