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Q8K211

- COPT1_MOUSE

UniProt

Q8K211 - COPT1_MOUSE

Protein

High affinity copper uptake protein 1

Gene

Slc31a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    High-affinity, saturable copper transporter involved in dietary copper uptake.1 Publication

    GO - Molecular functioni

    1. copper uptake transmembrane transporter activity Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. cellular copper ion homeostasis Source: MGI
    2. copper ion import Source: MGI

    Keywords - Biological processi

    Copper transport, Ion transport, Transport

    Keywords - Ligandi

    Copper

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High affinity copper uptake protein 1
    Alternative name(s):
    Copper transporter 1
    Short name:
    CTR1
    Solute carrier family 31 member 1
    Gene namesi
    Name:Slc31a1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1333843. Slc31a1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Localizes to the apical membrane in intestinal epithelial cells.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. late endosome Source: MGI
    3. plasma membrane Source: UniProtKB-SubCell
    4. recycling endosome Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 196196High affinity copper uptake protein 1PRO_0000195041Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi34 – 341O-linked (GalNAc...)By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8K211.
    PRIDEiQ8K211.

    PTM databases

    PhosphoSiteiQ8K211.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K211.
    BgeeiQ8K211.
    CleanExiMM_SLC31A1.
    GenevestigatoriQ8K211.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000081574.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K211.
    SMRiQ8K211. Positions 138-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7474ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini96 – 13843CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 1623ExtracellularSequence Analysis
    Topological domaini184 – 19613CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei75 – 9521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG323808.
    GeneTreeiENSGT00530000063415.
    HOGENOMiHOG000195393.
    HOVERGENiHBG065767.
    InParanoidiQ8K211.
    KOiK14686.
    OMAiFFFSWKK.
    OrthoDBiEOG7S220Q.
    PhylomeDBiQ8K211.
    TreeFamiTF315142.

    Family and domain databases

    InterProiIPR007274. Cop_transporter.
    [Graphical view]
    PANTHERiPTHR12483. PTHR12483. 1 hit.
    PfamiPF04145. Ctr. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K211-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNHMGMNHME MHHHMGMNHT DDNITMPPHH HPTTSASHSH GGGDSMMMMP    50
    MTFYFDFKNV NLLFSGLVIN TPGEMAGAFV AVFLLAMFYE GLKIAREGLL 100
    RKSQVSIRYN SMPVPGPNGT ILMETHKTVG QQMLSFPHLL QTVLHIIQVV 150
    ISYFLMLIFM TYNGYLCIAV AAGAGTGYFL FSWKKAVVVD ITEHCH 196
    Length:196
    Mass (Da):21,961
    Last modified:October 1, 2002 - v1
    Checksum:iA4EDDD2A9E51AF10
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 181N → Y in BAC32891. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK046835 mRNA. Translation: BAC32891.1.
    AK151337 mRNA. Translation: BAE30315.1.
    AL732548 Genomic DNA. Translation: CAD83054.1.
    BC034674 mRNA. Translation: AAH34674.1.
    BC058227 mRNA. Translation: AAH58227.1.
    CCDSiCCDS18237.1.
    RefSeqiNP_780299.2. NM_175090.4.
    XP_006537774.1. XM_006537711.1.
    UniGeneiMm.248637.

    Genome annotation databases

    EnsembliENSMUST00000084526; ENSMUSP00000081574; ENSMUSG00000066150.
    GeneIDi20529.
    KEGGimmu:20529.
    UCSCiuc008ten.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK046835 mRNA. Translation: BAC32891.1 .
    AK151337 mRNA. Translation: BAE30315.1 .
    AL732548 Genomic DNA. Translation: CAD83054.1 .
    BC034674 mRNA. Translation: AAH34674.1 .
    BC058227 mRNA. Translation: AAH58227.1 .
    CCDSi CCDS18237.1.
    RefSeqi NP_780299.2. NM_175090.4.
    XP_006537774.1. XM_006537711.1.
    UniGenei Mm.248637.

    3D structure databases

    ProteinModelPortali Q8K211.
    SMRi Q8K211. Positions 138-163.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000081574.

    PTM databases

    PhosphoSitei Q8K211.

    Proteomic databases

    PaxDbi Q8K211.
    PRIDEi Q8K211.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000084526 ; ENSMUSP00000081574 ; ENSMUSG00000066150 .
    GeneIDi 20529.
    KEGGi mmu:20529.
    UCSCi uc008ten.2. mouse.

    Organism-specific databases

    CTDi 1317.
    MGIi MGI:1333843. Slc31a1.

    Phylogenomic databases

    eggNOGi NOG323808.
    GeneTreei ENSGT00530000063415.
    HOGENOMi HOG000195393.
    HOVERGENi HBG065767.
    InParanoidi Q8K211.
    KOi K14686.
    OMAi FFFSWKK.
    OrthoDBi EOG7S220Q.
    PhylomeDBi Q8K211.
    TreeFami TF315142.

    Miscellaneous databases

    ChiTaRSi SLC31A1. mouse.
    NextBioi 298779.
    PROi Q8K211.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K211.
    Bgeei Q8K211.
    CleanExi MM_SLC31A1.
    Genevestigatori Q8K211.

    Family and domain databases

    InterProi IPR007274. Cop_transporter.
    [Graphical view ]
    PANTHERi PTHR12483. PTHR12483. 1 hit.
    Pfami PF04145. Ctr. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow and Medulla oblongata.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor and Olfactory epithelium.
    4. "Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability."
      Nose Y., Wood L.K., Kim B.E., Prohaska J.R., Fry R.S., Spears J.W., Thiele D.J.
      J. Biol. Chem. 285:32385-32392(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiCOPT1_MOUSE
    AccessioniPrimary (citable) accession number: Q8K211
    Secondary accession number(s): Q3UAJ9, Q8BXJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3