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Q8K211 (COPT1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
High affinity copper uptake protein 1
Alternative name(s):
Copper transporter 1
Short name=CTR1
Solute carrier family 31 member 1
Gene names
Name:Slc31a1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length196 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

High-affinity, saturable copper transporter involved in dietary copper uptake. Ref.4

Subunit structure

Homotrimer By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Note: Localizes to the apical membrane in intestinal epithelial cells. Ref.4

Sequence similarities

Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 196196High affinity copper uptake protein 1
PRO_0000195041

Regions

Topological domain1 – 7474Extracellular Potential
Transmembrane75 – 9521Helical; Potential
Topological domain96 – 13843Cytoplasmic Potential
Transmembrane139 – 15921Helical; Potential
Topological domain160 – 1623Extracellular Potential
Transmembrane163 – 18321Helical; Potential
Topological domain184 – 19613Cytoplasmic Potential

Amino acid modifications

Glycosylation231N-linked (GlcNAc...) Potential
Glycosylation341O-linked (GalNAc...) By similarity

Experimental info

Sequence conflict181N → Y in BAC32891. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8K211 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: A4EDDD2A9E51AF10

FASTA19621,961
        10         20         30         40         50         60 
MNHMGMNHME MHHHMGMNHT DDNITMPPHH HPTTSASHSH GGGDSMMMMP MTFYFDFKNV 

        70         80         90        100        110        120 
NLLFSGLVIN TPGEMAGAFV AVFLLAMFYE GLKIAREGLL RKSQVSIRYN SMPVPGPNGT 

       130        140        150        160        170        180 
ILMETHKTVG QQMLSFPHLL QTVLHIIQVV ISYFLMLIFM TYNGYLCIAV AAGAGTGYFL 

       190 
FSWKKAVVVD ITEHCH 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow and Medulla oblongata.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor and Olfactory epithelium.
[4]"Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability."
Nose Y., Wood L.K., Kim B.E., Prohaska J.R., Fry R.S., Spears J.W., Thiele D.J.
J. Biol. Chem. 285:32385-32392(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK046835 mRNA. Translation: BAC32891.1.
AK151337 mRNA. Translation: BAE30315.1.
AL732548 Genomic DNA. Translation: CAD83054.1.
BC034674 mRNA. Translation: AAH34674.1.
BC058227 mRNA. Translation: AAH58227.1.
RefSeqNP_780299.2. NM_175090.4.
XP_006537774.1. XM_006537711.1.
UniGeneMm.248637.

3D structure databases

ProteinModelPortalQ8K211.
SMRQ8K211. Positions 138-163.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000081574.

PTM databases

PhosphoSiteQ8K211.

Proteomic databases

PaxDbQ8K211.
PRIDEQ8K211.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000084526; ENSMUSP00000081574; ENSMUSG00000066150.
GeneID20529.
KEGGmmu:20529.
UCSCuc008ten.2. mouse.

Organism-specific databases

CTD1317.
MGIMGI:1333843. Slc31a1.

Phylogenomic databases

eggNOGNOG323808.
GeneTreeENSGT00530000063415.
HOGENOMHOG000195393.
HOVERGENHBG065767.
InParanoidQ8K211.
KOK14686.
OMAHMGMNHT.
OrthoDBEOG7S220Q.
PhylomeDBQ8K211.
TreeFamTF315142.

Gene expression databases

ArrayExpressQ8K211.
BgeeQ8K211.
CleanExMM_SLC31A1.
GenevestigatorQ8K211.

Family and domain databases

InterProIPR007274. Cop_transporter.
[Graphical view]
PANTHERPTHR12483. PTHR12483. 1 hit.
PfamPF04145. Ctr. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC31A1. mouse.
NextBio298779.
PROQ8K211.
SOURCESearch...

Entry information

Entry nameCOPT1_MOUSE
AccessionPrimary (citable) accession number: Q8K211
Secondary accession number(s): Q3UAJ9, Q8BXJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot