Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8K203

- NEIL3_MOUSE

UniProt

Q8K203 - NEIL3_MOUSE

Protein

Endonuclease 8-like 3

Gene

Neil3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.6 Publications

    Catalytic activityi

    Removes damaged bases from DNA, leaving an abasic site.
    The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Schiff-base intermediate with DNA; via amino nitrogen1 Publication
    Sitei2 – 21Important for monofunctional glycosylase activityBy similarity
    Sitei82 – 821Required for glycosylase activityBy similarity
    Binding sitei193 – 1931DNABy similarity
    Binding sitei272 – 2721DNABy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri248 – 28235FPG-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri318 – 34730RanBP2-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. bubble DNA binding Source: UniProtKB
    2. damaged DNA binding Source: InterPro
    3. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB
    4. DNA N-glycosylase activity Source: UniProtKB
    5. double-stranded DNA binding Source: UniProtKB
    6. single-stranded DNA binding Source: UniProtKB
    7. zinc ion binding Source: InterPro

    GO - Biological processi

    1. base-excision repair Source: UniProtKB
    2. DNA catabolic process, endonucleolytic Source: GOC
    3. nucleotide-excision repair Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase, Lyase

    Keywords - Biological processi

    DNA damage, DNA repair

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endonuclease 8-like 3 (EC:3.2.2.-, EC:4.2.99.18)
    Alternative name(s):
    DNA glycosylase FPG2
    DNA glycosylase/AP lyase Neil3
    Endonuclease VIII-like 3
    Nei-like protein 3
    Gene namesi
    Name:Neil3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2384588. Neil3.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Perinatal mice show reduced regeneration of neural tissue following ischemic brain damage (stroke), associated with fewer activated microglia and impaired neural stem cell proliferation. Aged mice show deficits in learning and memory, decreased anxiety-like behavior, and changes in hippocampal synapse composition. Otherwise viable and fertile.4 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedCurated
    Chaini2 – 606605Endonuclease 8-like 3PRO_0000170911Add
    BLAST

    Proteomic databases

    PRIDEiQ8K203.

    PTM databases

    PhosphoSiteiQ8K203.

    Expressioni

    Tissue specificityi

    Expressed in testis, thymus, spleen and bone marrow. In young mice, expressed at higher levels in thymocytes than splenocytes. At E12, abundant in the subventricular zone (SVZ) of the lateral ventricles. At E17.5 and P0, expression is limited to distinct cells in the cortical SVZ, in cells of the secondary matrix, the dentate gyrus migratory route and the dentate gyrus.4 Publications

    Developmental stagei

    Highly expressed in the developing brain at E12-E13 when neurogenesis starts. Expression decreases during later development and is undetectable in adult brain.2 Publications

    Inductioni

    By mitogen stimulation in splenocytes, and by hypoxic-ischemic injury in the striatum and hippocampus.2 Publications

    Gene expression databases

    ArrayExpressiQ8K203.
    BgeeiQ8K203.
    CleanExiMM_NEIL3.
    GenevestigatoriQ8K203.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000041909.

    Structurei

    Secondary structure

    1
    606
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 1714
    Beta strandi23 – 286
    Helixi30 – 345
    Helixi64 – 685
    Turni69 – 713
    Beta strandi73 – 808
    Beta strandi83 – 886
    Beta strandi91 – 10616
    Beta strandi119 – 1268
    Beta strandi128 – 14013
    Helixi141 – 15111
    Helixi152 – 1543
    Helixi163 – 1719
    Beta strandi175 – 1773
    Helixi178 – 1836
    Turni185 – 1873
    Helixi193 – 20311
    Helixi211 – 2133
    Helixi216 – 23924
    Helixi243 – 2464
    Turni256 – 2583
    Beta strandi263 – 2653
    Beta strandi274 – 2763
    Turni278 – 2803

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3W0FX-ray2.00A2-282[»]
    ProteinModelPortaliQ8K203.
    SMRiQ8K203. Positions 2-282.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The N-terminal region (2-282) contains the glycosylase and lyase activities.

    Sequence similaritiesi

    Belongs to the FPG family.PROSITE-ProRule annotation
    Contains 1 FPG-type zinc finger.PROSITE-ProRule annotation
    Contains 1 RanBP2-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri248 – 28235FPG-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri318 – 34730RanBP2-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0266.
    GeneTreeiENSGT00730000110955.
    HOGENOMiHOG000113754.
    HOVERGENiHBG052594.
    InParanoidiQ8K203.
    KOiK10569.
    OMAiICFFDSS.
    OrthoDBiEOG7W153D.
    PhylomeDBiQ8K203.
    TreeFamiTF331502.

    Family and domain databases

    InterProiIPR015886. DNA_glyclase/AP_lyase_DNA-bd.
    IPR015887. DNA_glyclase_Znf_dom_DNA_BS.
    IPR012319. DNA_glycosylase/AP_lyase_cat.
    IPR010979. Ribosomal_S13-like_H2TH.
    IPR000214. Znf_DNA_glyclase/AP_lyase.
    IPR010666. Znf_GRF.
    IPR001876. Znf_RanBP2.
    [Graphical view]
    PfamiPF06831. H2TH. 1 hit.
    PF06839. zf-GRF. 2 hits.
    PF00641. zf-RanBP. 1 hit.
    [Graphical view]
    SMARTiSM00547. ZnF_RBZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46946. SSF46946. 1 hit.
    SSF81624. SSF81624. 1 hit.
    PROSITEiPS51068. FPG_CAT. 1 hit.
    PS01242. ZF_FPG_1. 1 hit.
    PS51066. ZF_FPG_2. 1 hit.
    PS01358. ZF_RANBP2_1. 1 hit.
    PS50199. ZF_RANBP2_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8K203-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVEGPGCTLN GEKIRARVLP GQAVTGVRGT ALQSLLGPAM SPAASLADVA    50
    TSAAPMNAKD SGWKLLRLFN GYVYSGVETL GKELFMYFGP RALRIHFGMK 100
    GSILINPREG ENRAGASPAL AVQLTRDLIC FYDSSVELRN SVESQQRVRV 150
    MEELDICSPK FSFSRAESEV KKQGDRMLCD VLLDQRVLPG VGNIIKNEAL 200
    FDSGLHPAVK VCQLSDKQAC HLVKMTRDFS ILFYRCCKAG SAISKHCKVY 250
    KRPNCDQCHS KITVCRFGEN SRMTYFCPHC QKENPQCVQV CQLPTRNTEI 300
    SWTPRGEDCF TDSVARKSEE QWSCVVCTLI NRPSAKACDA CLTTRPLDSV 350
    LKNRENSIAF NNLVKYPCNN FENTHTEVKI NRKTAFGNTT LVLTDLSNKS 400
    SALARKKRAN HTIDGESQMF LPTDIGFSDS QHPSKEGINY ITQPSNKVNI 450
    SPTVCAQSKL FSSAHKKFKP AHTSATELKS YNSGLSNSEL QTNRTRGHHS 500
    KSDGSPLCKM HHRRCVLRVV RKDGENKGRQ FYACSLPRGA QCGFFEWADL 550
    SFPFCRHGKR SIMKTVLKIG PNNGKNFFVC PLEKKKQCNF FQWAENGPGM 600
    EIVPGC 606
    Length:606
    Mass (Da):67,416
    Last modified:October 1, 2002 - v1
    Checksum:i941C38FA8538BAA8
    GO
    Isoform 2 (identifier: Q8K203-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         212-606: Missing.

    Note: May be due to an intron retention.

    Show »
    Length:211
    Mass (Da):22,840
    Checksum:iE7643F8B173F69CE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti46 – 461L → P in strain: Czech II. 1 Publication
    Natural varianti90 – 901P → H in strain: Czech II. 1 Publication
    Natural varianti114 – 1141A → G in strain: Czech II. 1 Publication
    Natural varianti150 – 1501V → E in strain: Czech II. 1 Publication
    Natural varianti220 – 2201C → R in strain: Czech II. 1 Publication
    Natural varianti256 – 2561D → G in strain: Czech II. 1 Publication
    Natural varianti287 – 2871C → R in strain: Czech II. 1 Publication
    Natural varianti325 – 3251V → A in strain: Czech II. 1 Publication
    Natural varianti556 – 5561R → K in strain: Czech II. 1 Publication
    Natural varianti585 – 5851K → E in strain: Czech II. 1 Publication

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei212 – 606395Missing in isoform 2. 1 PublicationVSP_012210Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB072931 mRNA. Translation: BAC22661.1.
    AK031027 mRNA. Translation: BAC27219.1.
    BC024921 mRNA. Translation: AAH24921.1.
    BC034753 mRNA. Translation: AAH34753.1.
    AB202125 Genomic DNA. Translation: BAE16548.1.
    CCDSiCCDS22305.1. [Q8K203-1]
    RefSeqiNP_666320.1. NM_146208.2. [Q8K203-1]
    UniGeneiMm.281749.

    Genome annotation databases

    EnsembliENSMUST00000047768; ENSMUSP00000041909; ENSMUSG00000039396. [Q8K203-1]
    GeneIDi234258.
    KEGGimmu:234258.
    UCSCiuc009lsa.2. mouse. [Q8K203-1]
    uc009lsb.2. mouse. [Q8K203-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB072931 mRNA. Translation: BAC22661.1 .
    AK031027 mRNA. Translation: BAC27219.1 .
    BC024921 mRNA. Translation: AAH24921.1 .
    BC034753 mRNA. Translation: AAH34753.1 .
    AB202125 Genomic DNA. Translation: BAE16548.1 .
    CCDSi CCDS22305.1. [Q8K203-1 ]
    RefSeqi NP_666320.1. NM_146208.2. [Q8K203-1 ]
    UniGenei Mm.281749.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3W0F X-ray 2.00 A 2-282 [» ]
    ProteinModelPortali Q8K203.
    SMRi Q8K203. Positions 2-282.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000041909.

    PTM databases

    PhosphoSitei Q8K203.

    Proteomic databases

    PRIDEi Q8K203.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000047768 ; ENSMUSP00000041909 ; ENSMUSG00000039396 . [Q8K203-1 ]
    GeneIDi 234258.
    KEGGi mmu:234258.
    UCSCi uc009lsa.2. mouse. [Q8K203-1 ]
    uc009lsb.2. mouse. [Q8K203-2 ]

    Organism-specific databases

    CTDi 55247.
    MGIi MGI:2384588. Neil3.

    Phylogenomic databases

    eggNOGi COG0266.
    GeneTreei ENSGT00730000110955.
    HOGENOMi HOG000113754.
    HOVERGENi HBG052594.
    InParanoidi Q8K203.
    KOi K10569.
    OMAi ICFFDSS.
    OrthoDBi EOG7W153D.
    PhylomeDBi Q8K203.
    TreeFami TF331502.

    Miscellaneous databases

    ChiTaRSi NEIL3. mouse.
    NextBioi 382073.
    PROi Q8K203.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K203.
    Bgeei Q8K203.
    CleanExi MM_NEIL3.
    Genevestigatori Q8K203.

    Family and domain databases

    InterProi IPR015886. DNA_glyclase/AP_lyase_DNA-bd.
    IPR015887. DNA_glyclase_Znf_dom_DNA_BS.
    IPR012319. DNA_glycosylase/AP_lyase_cat.
    IPR010979. Ribosomal_S13-like_H2TH.
    IPR000214. Znf_DNA_glyclase/AP_lyase.
    IPR010666. Znf_GRF.
    IPR001876. Znf_RanBP2.
    [Graphical view ]
    Pfami PF06831. H2TH. 1 hit.
    PF06839. zf-GRF. 2 hits.
    PF00641. zf-RanBP. 1 hit.
    [Graphical view ]
    SMARTi SM00547. ZnF_RBZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46946. SSF46946. 1 hit.
    SSF81624. SSF81624. 1 hit.
    PROSITEi PS51068. FPG_CAT. 1 hit.
    PS01242. ZF_FPG_1. 1 hit.
    PS51066. ZF_FPG_2. 1 hit.
    PS01358. ZF_RANBP2_1. 1 hit.
    PS50199. ZF_RANBP2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein."
      Torisu K., Tsuchimoto D., Ohnishi Y., Nakabeppu Y.
      J. Biochem. 138:763-772(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE.
      Tissue: Splenocyte.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS PRO-46; HIS-90; GLY-114; GLU-150; ARG-220; GLY-256; ARG-287; ALA-325; LYS-556 AND GLU-585.
      Strain: Czech II and FVB/N.
      Tissue: Mammary tumor.
    4. "Molecular cloning and chracterization of mouse DNA glycosylase gene, nei like 3 (Neil3); its regulated expression in lymphoid organs."
      Torisu K., Tsuchimoto D., Ohnishi Y., Nakabeppu Y.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-52.
      Strain: 129/SvJ.
    5. "Expression and purification of active mouse and human NEIL3 proteins."
      Liu M., Bandaru V., Holmes A., Averill A.M., Cannan W., Wallace S.S.
      Protein Expr. Purif. 84:130-139(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS A GLYCOSYLASE/LYASE, CHARACTERIZATION OF N-TERMINAL DOMAIN, PROBABLE CLEAVAGE OF INITIATOR METHIONINE.
    6. Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVE SITE.
    7. "Expression patterns of Neil3 during embryonic brain development and neoplasia."
      Hildrestrand G.A., Neurauter C.G., Diep D.B., Castellanos C.G., Krauss S., Bjoras M., Luna L.
      BMC Neurosci. 10:45-45(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    8. "Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant."
      Takao M., Oohata Y., Kitadokoro K., Kobayashi K., Iwai S., Yasui A., Yonei S., Zhang Q.M.
      Genes Cells 14:261-270(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    9. Cited for: FUNCTION, CATALYTIC ACTIVITY, INDUCTION, DISRUPTION PHENOTYPE.
    10. "Hippocampal adult neurogenesis is maintained by Neil3-dependent repair of oxidative DNA lesions in neural progenitor cells."
      Regnell C.E., Hildrestrand G.A., Sejersted Y., Medin T., Moldestad O., Rolseth V., Krokeide S.Z., Suganthan R., Luna L., Bjoras M., Bergersen L.H.
      Cell Rep. 2:503-510(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    11. "Loss of Neil3, the major DNA glycosylase activity for removal of hydantoins in single stranded DNA, reduces cellular proliferation and sensitizes cells to genotoxic stress."
      Rolseth V., Krokeide S.Z., Kunke D., Neurauter C.G., Suganthan R., Sejersted Y., Hildrestrand G.A., Bjoras M., Luna L.
      Biochim. Biophys. Acta 1833:1157-1164(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    12. "Structural characterization of a mouse ortholog of human NEIL3 with a marked preference for single-stranded DNA."
      Liu M., Imamura K., Averill A.M., Wallace S.S., Doublie S.
      Structure 21:247-256(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 2-282 IN COMPLEX WITH ZINC, FUNCTION, CATALYTIC ACTIVITY.

    Entry informationi

    Entry nameiNEIL3_MOUSE
    AccessioniPrimary (citable) accession number: Q8K203
    Secondary accession number(s): Q4ADY6, Q8CD85, Q8R3P4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3