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Q8K1Z6

- GPR18_MOUSE

UniProt

Q8K1Z6 - GPR18_MOUSE

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Protein

N-arachidonyl glycine receptor

Gene
Gpr18
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system By similarity.By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
N-arachidonyl glycine receptor
Short name:
NAGly receptor
Alternative name(s):
G-protein coupled receptor 18
Gene namesi
Name:Gpr18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:107859. Gpr18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Extracellular Reviewed predictionAdd
BLAST
Transmembranei27 – 4721Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini48 – 569Cytoplasmic Reviewed prediction
Transmembranei57 – 7721Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini78 – 9518Extracellular Reviewed predictionAdd
BLAST
Transmembranei96 – 11621Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini117 – 13822Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei139 – 15921Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini160 – 19132Extracellular Reviewed predictionAdd
BLAST
Transmembranei192 – 21221Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini213 – 23624Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei237 – 25721Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini258 – 26811Extracellular Reviewed predictionAdd
BLAST
Transmembranei269 – 28921Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini290 – 33142Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331N-arachidonyl glycine receptorPRO_0000278174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi94 ↔ 172 By similarity
Glycosylationi188 – 1881N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8K1Z6.

PTM databases

PhosphoSiteiQ8K1Z6.

Expressioni

Gene expression databases

BgeeiQ8K1Z6.
CleanExiMM_GPR18.
GenevestigatoriQ8K1Z6.

Structurei

3D structure databases

ProteinModelPortaliQ8K1Z6.
SMRiQ8K1Z6. Positions 22-301.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG116115.
GeneTreeiENSGT00730000110768.
HOGENOMiHOG000112785.
HOVERGENiHBG105013.
InParanoidiQ8K1Z6.
KOiK08410.
OMAiYAKGEWP.
OrthoDBiEOG7SBNP4.
PhylomeDBiQ8K1Z6.
TreeFamiTF330775.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028335. GPR18.
[Graphical view]
PANTHERiPTHR24232:SF1. PTHR24232:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K1Z6-1 [UniParc]FASTAAdd to Basket

« Hide

MATLSNHNQL DLSNGSHPEE YKIAALVFYS CIFLIGLFVN VTALWVFSCT    50
TKKRTTVTIY MMNVALLDLV FILSLPFRMF YYAKGEWPFG EYFCHILGAL 100
VVFYPSLALW LLAFISADRY MAIVQPKYAK ELKNTGKAVL ACGGVWVMTL 150
TTTVPLLLLY EDPDKASSPA TCLKISDITH LKAVNVLNFT RLIFFFLIPL 200
FIMIGCYVVI IHSLLRGQTS KLKPKVKEKS IRIIMTLLLQ VLVCFVPFHI 250
CFAVLMLQGQ ENSYSPWGAF TTFLMNLSTC LDVVLYYIVS KQFQARVISV 300
MLYRNYLRSV RRKSVRSGSL RSLSNMNSEM L 331
Length:331
Mass (Da):37,691
Last modified:October 1, 2002 - v1
Checksum:i702FD55C911B4787
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231I → V in BAE42987. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK156039 mRNA. Translation: BAE33557.1.
AK156868 mRNA. Translation: BAE33880.1.
AK157029 mRNA. Translation: BAE33938.1.
AK172401 mRNA. Translation: BAE42987.1.
BC034872 mRNA. Translation: AAH34872.1.
CCDSiCCDS27342.1.
RefSeqiNP_877958.1. NM_182806.1.
UniGeneiMm.37405.

Genome annotation databases

EnsembliENSMUST00000055475; ENSMUSP00000061410; ENSMUSG00000050350.
GeneIDi110168.
KEGGimmu:110168.
UCSCiuc007vap.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK156039 mRNA. Translation: BAE33557.1 .
AK156868 mRNA. Translation: BAE33880.1 .
AK157029 mRNA. Translation: BAE33938.1 .
AK172401 mRNA. Translation: BAE42987.1 .
BC034872 mRNA. Translation: AAH34872.1 .
CCDSi CCDS27342.1.
RefSeqi NP_877958.1. NM_182806.1.
UniGenei Mm.37405.

3D structure databases

ProteinModelPortali Q8K1Z6.
SMRi Q8K1Z6. Positions 22-301.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 89.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8K1Z6.

Proteomic databases

PRIDEi Q8K1Z6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055475 ; ENSMUSP00000061410 ; ENSMUSG00000050350 .
GeneIDi 110168.
KEGGi mmu:110168.
UCSCi uc007vap.1. mouse.

Organism-specific databases

CTDi 2841.
MGIi MGI:107859. Gpr18.

Phylogenomic databases

eggNOGi NOG116115.
GeneTreei ENSGT00730000110768.
HOGENOMi HOG000112785.
HOVERGENi HBG105013.
InParanoidi Q8K1Z6.
KOi K08410.
OMAi YAKGEWP.
OrthoDBi EOG7SBNP4.
PhylomeDBi Q8K1Z6.
TreeFami TF330775.

Miscellaneous databases

NextBioi 363451.
PROi Q8K1Z6.
SOURCEi Search...

Gene expression databases

Bgeei Q8K1Z6.
CleanExi MM_GPR18.
Genevestigatori Q8K1Z6.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028335. GPR18.
[Graphical view ]
PANTHERi PTHR24232:SF1. PTHR24232:SF1. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiGPR18_MOUSE
AccessioniPrimary (citable) accession number: Q8K1Z6
Secondary accession number(s): Q3T9N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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