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Q8K1Z6 (GPR18_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-arachidonyl glycine receptor
Short name=NAGly receptor
Alternative name(s):
G-protein coupled receptor 18
Gene names
Name:Gpr18
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system By similarity. UniProtKB Q14330

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331N-arachidonyl glycine receptor
PRO_0000278174

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 4721Helical; Name=1; Potential
Topological domain48 – 569Cytoplasmic Potential
Transmembrane57 – 7721Helical; Name=2; Potential
Topological domain78 – 9518Extracellular Potential
Transmembrane96 – 11621Helical; Name=3; Potential
Topological domain117 – 13822Cytoplasmic Potential
Transmembrane139 – 15921Helical; Name=4; Potential
Topological domain160 – 19132Extracellular Potential
Transmembrane192 – 21221Helical; Name=5; Potential
Topological domain213 – 23624Cytoplasmic Potential
Transmembrane237 – 25721Helical; Name=6; Potential
Topological domain258 – 26811Extracellular Potential
Transmembrane269 – 28921Helical; Name=7; Potential
Topological domain290 – 33142Cytoplasmic Potential

Amino acid modifications

Glycosylation141N-linked (GlcNAc...) Potential
Glycosylation1881N-linked (GlcNAc...) Potential
Disulfide bond94 ↔ 172 By similarity

Experimental info

Sequence conflict231I → V in BAE42987. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8K1Z6 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 702FD55C911B4787

FASTA33137,691
        10         20         30         40         50         60 
MATLSNHNQL DLSNGSHPEE YKIAALVFYS CIFLIGLFVN VTALWVFSCT TKKRTTVTIY 

        70         80         90        100        110        120 
MMNVALLDLV FILSLPFRMF YYAKGEWPFG EYFCHILGAL VVFYPSLALW LLAFISADRY 

       130        140        150        160        170        180 
MAIVQPKYAK ELKNTGKAVL ACGGVWVMTL TTTVPLLLLY EDPDKASSPA TCLKISDITH 

       190        200        210        220        230        240 
LKAVNVLNFT RLIFFFLIPL FIMIGCYVVI IHSLLRGQTS KLKPKVKEKS IRIIMTLLLQ 

       250        260        270        280        290        300 
VLVCFVPFHI CFAVLMLQGQ ENSYSPWGAF TTFLMNLSTC LDVVLYYIVS KQFQARVISV 

       310        320        330 
MLYRNYLRSV RRKSVRSGSL RSLSNMNSEM L

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NOD.
Tissue: Spleen.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK156039 mRNA. Translation: BAE33557.1.
AK156868 mRNA. Translation: BAE33880.1.
AK157029 mRNA. Translation: BAE33938.1.
AK172401 mRNA. Translation: BAE42987.1.
BC034872 mRNA. Translation: AAH34872.1.
IPIIPI00169867.
RefSeqNP_877958.1. NM_182806.1.
UniGeneMm.37405.

3D structure databases

ProteinModelPortalQ8K1Z6.
SMRQ8K1Z6. Positions 22-301.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8K1Z6.

Proteomic databases

PRIDEQ8K1Z6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000055475; ENSMUSP00000061410; ENSMUSG00000050350.
GeneID110168.
KEGGmmu:110168.
UCSCuc007vap.1. mouse.

Organism-specific databases

CTD2841.
MGIMGI:107859. Gpr18.

Phylogenomic databases

eggNOGNOG116115.
GeneTreeENSGT00680000099997.
HOGENOMHOG000112785.
HOVERGENHBG105013.
InParanoidQ8K1Z6.
KOK08410.
OMAYAKGEWP.
OrthoDBEOG47H5QJ.

Gene expression databases

BgeeQ8K1Z6.
CleanExMM_GPR18.
GenevestigatorQ8K1Z6.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002286. purinergic_P2Y_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01157. P2YPURNOCPTR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio363451.
SOURCESearch...

Entry information

Entry nameGPR18_MOUSE
AccessionPrimary (citable) accession number: Q8K1Z6
Secondary accession number(s): Q3T9N3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 1, 2002
Last modified: May 29, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents