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Protein

N-arachidonyl glycine receptor

Gene

Gpr18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
N-arachidonyl glycine receptor
Short name:
NAGly receptor
Alternative name(s):
G-protein coupled receptor 18
Gene namesi
Name:Gpr18Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:107859. Gpr18.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 56CytoplasmicSequence analysis9
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 95ExtracellularSequence analysisAdd BLAST18
Transmembranei96 – 116Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini117 – 138CytoplasmicSequence analysisAdd BLAST22
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 191ExtracellularSequence analysisAdd BLAST32
Transmembranei192 – 212Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini213 – 236CytoplasmicSequence analysisAdd BLAST24
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 268ExtracellularSequence analysisAdd BLAST11
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 331CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002781741 – 331N-arachidonyl glycine receptorAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi94 ↔ 172PROSITE-ProRule annotation
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1
Modified residuei322PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8K1Z6.
PRIDEiQ8K1Z6.

PTM databases

iPTMnetiQ8K1Z6.
PhosphoSitePlusiQ8K1Z6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000050350.
CleanExiMM_GPR18.
GenevisibleiQ8K1Z6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061410.

Structurei

3D structure databases

ProteinModelPortaliQ8K1Z6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFPC. Eukaryota.
ENOG410YP7X. LUCA.
GeneTreeiENSGT00730000110768.
HOGENOMiHOG000112785.
HOVERGENiHBG105013.
InParanoidiQ8K1Z6.
KOiK08410.
OMAiYAKGEWP.
OrthoDBiEOG091G0BF1.
PhylomeDBiQ8K1Z6.
TreeFamiTF330775.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028335. GPR18.
[Graphical view]
PANTHERiPTHR24232:SF1. PTHR24232:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K1Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLSNHNQL DLSNGSHPEE YKIAALVFYS CIFLIGLFVN VTALWVFSCT
60 70 80 90 100
TKKRTTVTIY MMNVALLDLV FILSLPFRMF YYAKGEWPFG EYFCHILGAL
110 120 130 140 150
VVFYPSLALW LLAFISADRY MAIVQPKYAK ELKNTGKAVL ACGGVWVMTL
160 170 180 190 200
TTTVPLLLLY EDPDKASSPA TCLKISDITH LKAVNVLNFT RLIFFFLIPL
210 220 230 240 250
FIMIGCYVVI IHSLLRGQTS KLKPKVKEKS IRIIMTLLLQ VLVCFVPFHI
260 270 280 290 300
CFAVLMLQGQ ENSYSPWGAF TTFLMNLSTC LDVVLYYIVS KQFQARVISV
310 320 330
MLYRNYLRSV RRKSVRSGSL RSLSNMNSEM L
Length:331
Mass (Da):37,691
Last modified:October 1, 2002 - v1
Checksum:i702FD55C911B4787
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23I → V in BAE42987 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156039 mRNA. Translation: BAE33557.1.
AK156868 mRNA. Translation: BAE33880.1.
AK157029 mRNA. Translation: BAE33938.1.
AK172401 mRNA. Translation: BAE42987.1.
BC034872 mRNA. Translation: AAH34872.1.
CCDSiCCDS27342.1.
RefSeqiNP_877958.1. NM_182806.1.
UniGeneiMm.37405.

Genome annotation databases

EnsembliENSMUST00000055475; ENSMUSP00000061410; ENSMUSG00000050350.
GeneIDi110168.
KEGGimmu:110168.
UCSCiuc007vap.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156039 mRNA. Translation: BAE33557.1.
AK156868 mRNA. Translation: BAE33880.1.
AK157029 mRNA. Translation: BAE33938.1.
AK172401 mRNA. Translation: BAE42987.1.
BC034872 mRNA. Translation: AAH34872.1.
CCDSiCCDS27342.1.
RefSeqiNP_877958.1. NM_182806.1.
UniGeneiMm.37405.

3D structure databases

ProteinModelPortaliQ8K1Z6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061410.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8K1Z6.
PhosphoSitePlusiQ8K1Z6.

Proteomic databases

PaxDbiQ8K1Z6.
PRIDEiQ8K1Z6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055475; ENSMUSP00000061410; ENSMUSG00000050350.
GeneIDi110168.
KEGGimmu:110168.
UCSCiuc007vap.1. mouse.

Organism-specific databases

CTDi2841.
MGIiMGI:107859. Gpr18.

Phylogenomic databases

eggNOGiENOG410IFPC. Eukaryota.
ENOG410YP7X. LUCA.
GeneTreeiENSGT00730000110768.
HOGENOMiHOG000112785.
HOVERGENiHBG105013.
InParanoidiQ8K1Z6.
KOiK08410.
OMAiYAKGEWP.
OrthoDBiEOG091G0BF1.
PhylomeDBiQ8K1Z6.
TreeFamiTF330775.

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ8K1Z6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050350.
CleanExiMM_GPR18.
GenevisibleiQ8K1Z6. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028335. GPR18.
[Graphical view]
PANTHERiPTHR24232:SF1. PTHR24232:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR18_MOUSE
AccessioniPrimary (citable) accession number: Q8K1Z6
Secondary accession number(s): Q3T9N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.