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Q8K1Z0

- COQ9_MOUSE

UniProt

Q8K1Z0 - COQ9_MOUSE

Protein

Ubiquinone biosynthesis protein COQ9, mitochondrial

Gene

Coq9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of coenzyme Q.By similarity

    Pathwayi

    GO - Biological processi

    1. mitochondrial electron transport, NADH to ubiquinone Source: MGI
    2. ubiquinone biosynthetic process Source: MGI

    Keywords - Biological processi

    Ubiquinone biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00232.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquinone biosynthesis protein COQ9, mitochondrial
    Gene namesi
    Name:Coq9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1915164. Coq9.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4545MitochondrionSequence AnalysisAdd
    BLAST
    Chaini46 – 313268Ubiquinone biosynthesis protein COQ9, mitochondrialPRO_0000228638Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei81 – 811Phosphoserine1 Publication
    Modified residuei170 – 1701N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8K1Z0.
    PaxDbiQ8K1Z0.
    PRIDEiQ8K1Z0.

    PTM databases

    PhosphoSiteiQ8K1Z0.

    Expressioni

    Gene expression databases

    BgeeiQ8K1Z0.
    CleanExiMM_COQ9.
    GenevestigatoriQ8K1Z0.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8K1Z0. 1 interaction.
    MINTiMINT-1851066.
    STRINGi10090.ENSMUSP00000034234.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K1Z0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the COQ9 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG5590.
    GeneTreeiENSGT00390000009328.
    HOGENOMiHOG000231991.
    HOVERGENiHBG079760.
    InParanoidiQ8K1Z0.
    OMAiTGEAVVQ.
    OrthoDBiEOG75B85W.
    PhylomeDBiQ8K1Z0.
    TreeFamiTF324653.

    Family and domain databases

    InterProiIPR013718. COQ9.
    IPR012762. Ubiq_biosynth_COQ9.
    [Graphical view]
    PfamiPF08511. COQ9. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02396. diverge_rpsU. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8K1Z0-1 [UniParc]FASTAAdd to Basket

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    MAATAAVSGV LGRLGWRLLQ LRCLPVARCR PALVPRAFHT AVGFRSSEEQ    50
    KQQPPHSSSQ QHSETQGPEF SRPPPRYTDQ SGEEEEDYES EEQLQHRILT 100
    AALEFVPAHG WTAEAIAEGA QSLGLSSAAA SMFGSDGSEL ILHFVTQCNA 150
    RLNQVLEEEQ KLVQLGQAEK RKTDQFLRDA VETRLRMLIP YIEHWPRALS 200
    ILLLPHNIPP SLNLLTSMVD DMWHYAGDQS TDFNWYTRRA VLAGIYNTTE 250
    LVMMQDSSPD FEDTWRFLEN RINDAMNMGH TAKQVKSTGE ALVQGLMGAA 300
    VTLKNLTGLN QRR 313
    Length:313
    Mass (Da):35,083
    Last modified:October 1, 2002 - v1
    Checksum:i9B8D8FED0724F138
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti208 – 2081I → N in BAB23347. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004527 mRNA. Translation: BAB23347.1.
    AK154343 mRNA. Translation: BAE32528.1.
    AK158979 mRNA. Translation: BAE34754.1.
    BC036386 mRNA. Translation: AAH36386.1.
    CCDSiCCDS22550.1.
    RefSeqiNP_080728.1. NM_026452.2.
    UniGeneiMm.169234.

    Genome annotation databases

    EnsembliENSMUST00000034234; ENSMUSP00000034234; ENSMUSG00000031782.
    GeneIDi67914.
    KEGGimmu:67914.
    UCSCiuc009mxd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004527 mRNA. Translation: BAB23347.1 .
    AK154343 mRNA. Translation: BAE32528.1 .
    AK158979 mRNA. Translation: BAE34754.1 .
    BC036386 mRNA. Translation: AAH36386.1 .
    CCDSi CCDS22550.1.
    RefSeqi NP_080728.1. NM_026452.2.
    UniGenei Mm.169234.

    3D structure databases

    ProteinModelPortali Q8K1Z0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8K1Z0. 1 interaction.
    MINTi MINT-1851066.
    STRINGi 10090.ENSMUSP00000034234.

    PTM databases

    PhosphoSitei Q8K1Z0.

    Proteomic databases

    MaxQBi Q8K1Z0.
    PaxDbi Q8K1Z0.
    PRIDEi Q8K1Z0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034234 ; ENSMUSP00000034234 ; ENSMUSG00000031782 .
    GeneIDi 67914.
    KEGGi mmu:67914.
    UCSCi uc009mxd.1. mouse.

    Organism-specific databases

    CTDi 57017.
    MGIi MGI:1915164. Coq9.

    Phylogenomic databases

    eggNOGi COG5590.
    GeneTreei ENSGT00390000009328.
    HOGENOMi HOG000231991.
    HOVERGENi HBG079760.
    InParanoidi Q8K1Z0.
    OMAi TGEAVVQ.
    OrthoDBi EOG75B85W.
    PhylomeDBi Q8K1Z0.
    TreeFami TF324653.

    Enzyme and pathway databases

    UniPathwayi UPA00232 .

    Miscellaneous databases

    NextBioi 325934.
    PROi Q8K1Z0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K1Z0.
    CleanExi MM_COQ9.
    Genevestigatori Q8K1Z0.

    Family and domain databases

    InterProi IPR013718. COQ9.
    IPR012762. Ubiq_biosynth_COQ9.
    [Graphical view ]
    Pfami PF08511. COQ9. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02396. diverge_rpsU. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Visual cortex.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-170, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiCOQ9_MOUSE
    AccessioniPrimary (citable) accession number: Q8K1Z0
    Secondary accession number(s): Q9CT61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3