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Protein

Leucine-rich repeat-containing protein 25

Gene

Lrrc25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the activation of cells of innate and acquired immunity.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 25
Alternative name(s):
Monocyte and plasmacytoid-activated protein
Gene namesi
Name:Lrrc25
Synonyms:Mapa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2445284. Lrrc25.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 169ExtracellularSequence analysisAdd BLAST144
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 297CytoplasmicSequence analysisAdd BLAST107

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000002161426 – 297Leucine-rich repeat-containing protein 25Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei211PhosphoserineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei267PhosphoserineCombined sources1
Modified residuei289PhosphotyrosineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8K1T1.
PaxDbiQ8K1T1.
PRIDEiQ8K1T1.

PTM databases

iPTMnetiQ8K1T1.
PhosphoSitePlusiQ8K1T1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000049988.
CleanExiMM_LRRC25.
ExpressionAtlasiQ8K1T1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049686.

Structurei

3D structure databases

ProteinModelPortaliQ8K1T1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati66 – 89LRR 1Add BLAST24
Repeati90 – 113LRR 2Add BLAST24

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J965. Eukaryota.
ENOG4111DR8. LUCA.
GeneTreeiENSGT00390000004001.
HOGENOMiHOG000237361.
HOVERGENiHBG052347.
InParanoidiQ8K1T1.
OMAiEDNDFYM.
OrthoDBiEOG091G0OLF.
PhylomeDBiQ8K1T1.
TreeFamiTF337414.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR001611. Leu-rich_rpt.
IPR032675. LRR_dom_sf.
PfamiView protein in Pfam
PF13855. LRR_8. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K1T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSIRTRLLW LCLLMLLALL HKSGSQDLTC MVHPSRVDWT QTFNGTCLNF
60 70 80 90 100
SGLGLSLPRS PLQASHAQVL DLSKNGLQVL PGAFFDKLEK LQTLIVTHNQ
110 120 130 140 150
LDSVDRSLAL RCDLELKADC SCGLASWYAL RQNCSGQQQL LCLHPATEAP
160 170 180 190 200
RNLSTFLQVS CPPSWGPGTI GALVAGTISL AVAVSGSVLA WRLLRRRRRA
210 220 230 240 250
SEHSLSKAQM SPHDIPKPVT DFLPRYSSRR PGPKAPDSPP SRFTMDYENV
260 270 280 290
FIGQPAEDCS WSAARNSPSG DSDCYMNYRS VDQDSQPVYC NLESLGR
Length:297
Mass (Da):32,673
Last modified:October 1, 2002 - v1
Checksum:i3DFB43C8D547CD2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ422149 mRNA. Translation: CAD19532.1.
AK080022 mRNA. Translation: BAC37807.1.
AK171924 mRNA. Translation: BAE42733.1.
CCDSiCCDS22375.1.
RefSeqiNP_694714.1. NM_153074.3.
UniGeneiMm.132939.

Genome annotation databases

EnsembliENSMUST00000052437; ENSMUSP00000049686; ENSMUSG00000049988.
GeneIDi211228.
KEGGimmu:211228.
UCSCiuc009maz.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiLRC25_MOUSE
AccessioniPrimary (citable) accession number: Q8K1T1
Secondary accession number(s): Q3TAD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot