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Protein

Leucine-rich repeat-containing protein 25

Gene

Lrrc25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy. Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 25
Alternative name(s):
Monocyte and plasmacytoid-activated protein
Gene namesi
Name:Lrrc25
Synonyms:Mapa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2445284 Lrrc25

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 169ExtracellularSequence analysisAdd BLAST144
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 297CytoplasmicSequence analysisAdd BLAST107

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000002161426 – 297Leucine-rich repeat-containing protein 25Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei211PhosphoserineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei267PhosphoserineCombined sources1
Modified residuei289PhosphotyrosineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8K1T1
PaxDbiQ8K1T1
PRIDEiQ8K1T1

PTM databases

iPTMnetiQ8K1T1
PhosphoSitePlusiQ8K1T1

Expressioni

Gene expression databases

BgeeiENSMUSG00000049988
CleanExiMM_LRRC25
ExpressionAtlasiQ8K1T1 baseline and differential

Interactioni

Subunit structurei

Interacts with DDX58. Interacts with SQSTM1. Interacts with p65/RELA; this interaction promotes the degradation of RELA through autophagy.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049686

Structurei

3D structure databases

ProteinModelPortaliQ8K1T1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati66 – 89LRR 1Add BLAST24
Repeati90 – 113LRR 2Add BLAST24

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J965 Eukaryota
ENOG4111DR8 LUCA
GeneTreeiENSGT00390000004001
HOGENOMiHOG000237361
HOVERGENiHBG052347
InParanoidiQ8K1T1
OMAiEDNDFYM
OrthoDBiEOG091G0OLF
PhylomeDBiQ8K1T1
TreeFamiTF337414

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K1T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSIRTRLLW LCLLMLLALL HKSGSQDLTC MVHPSRVDWT QTFNGTCLNF
60 70 80 90 100
SGLGLSLPRS PLQASHAQVL DLSKNGLQVL PGAFFDKLEK LQTLIVTHNQ
110 120 130 140 150
LDSVDRSLAL RCDLELKADC SCGLASWYAL RQNCSGQQQL LCLHPATEAP
160 170 180 190 200
RNLSTFLQVS CPPSWGPGTI GALVAGTISL AVAVSGSVLA WRLLRRRRRA
210 220 230 240 250
SEHSLSKAQM SPHDIPKPVT DFLPRYSSRR PGPKAPDSPP SRFTMDYENV
260 270 280 290
FIGQPAEDCS WSAARNSPSG DSDCYMNYRS VDQDSQPVYC NLESLGR
Length:297
Mass (Da):32,673
Last modified:October 1, 2002 - v1
Checksum:i3DFB43C8D547CD2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ422149 mRNA Translation: CAD19532.1
AK080022 mRNA Translation: BAC37807.1
AK171924 mRNA Translation: BAE42733.1
CCDSiCCDS22375.1
RefSeqiNP_694714.1, NM_153074.3
UniGeneiMm.132939

Genome annotation databases

EnsembliENSMUST00000052437; ENSMUSP00000049686; ENSMUSG00000049988
GeneIDi211228
KEGGimmu:211228
UCSCiuc009maz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLRC25_MOUSE
AccessioniPrimary (citable) accession number: Q8K1T1
Secondary accession number(s): Q3TAD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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