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Protein

Krueppel-like factor 11

Gene

Klf11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding sites inhibiting cell growth (By similarity). Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri384 – 408C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri414 – 438C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri444 – 466C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 11
Alternative name(s):
TGFB-inducible early growth response protein 2b
Transforming growth factor-beta-inducible early growth response protein 31 Publication
Short name:
TGFB-inducible early growth response protein 31 Publication
Short name:
TIEG-31 Publication
Gene namesi
Name:Klf11Imported
Synonyms:Tieg2bImported, Tieg3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2653368. Klf11.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice breed normally and are fertile. Hematopoiesis at all stages of development is normal and there is no effect on globin gene expression or longevity.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471891 – 502Krueppel-like factor 11Add BLAST502

Proteomic databases

PaxDbiQ8K1S5.
PRIDEiQ8K1S5.

PTM databases

PhosphoSitePlusiQ8K1S5.

Expressioni

Inductioni

By TGF-beta. Expressed in a circadian manner in the kidney and epididymal fat tissue.2 Publications

Gene expression databases

BgeeiENSMUSG00000020653.
CleanExiMM_KLF11.
ExpressionAtlasiQ8K1S5. baseline and differential.
GenevisibleiQ8K1S5. MM.

Interactioni

Subunit structurei

Interacts with SIN3A.By similarity

Protein-protein interaction databases

BioGridi228800. 1 interactor.
STRINGi10090.ENSMUSP00000020982.

Structurei

3D structure databases

ProteinModelPortaliQ8K1S5.
SMRiQ8K1S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Sp1 C2H2-type zinc-finger protein family.Sequence analysis
Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri384 – 408C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri414 – 438C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri444 – 466C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000059558.
HOVERGENiHBG052264.
InParanoidiQ8K1S5.
KOiK09209.
OMAiSCQPCLH.
OrthoDBiEOG091G1BN0.
PhylomeDBiQ8K1S5.
TreeFamiTF315506.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K1S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSPGSTGPG DGRAADIMDI CESILERKRH DSERSTCSVL EQTDIEAVEA
60 70 80 90 100
LVCMSSWGQR SQMRPLTPVS DSGDVTTAVL MDTAAPDLPK DFHSFSTLCI
110 120 130 140 150
TPPQSPELTE PSTGTPVPSQ VVNSKGCMVT ALPPSPAGGP RTLSKREPLE
160 170 180 190 200
PASGSSCRAV MTSVIRHTGE SPAPTRFPTG PTQEQRASDS GEGQERLLDH
210 220 230 240 250
LEALQDTRLA NGLLVTNLVS CQPCLHKSGG SFPTDKGQQT GWPAAVQTCL
260 270 280 290 300
PKNPESDLSR KITPLISVPV SSPPVLCQMI PVAGQNGLFS AFLKPPTQLP
310 320 330 340 350
AGTIKPILPQ AASMSQPVFM GPPVPQGTVM LVLPQNTFPQ PAACPSSVMA
360 370 380 390 400
IGNTKLLPLA PAPVFLASSQ NCAPQVDFSR RRNYVCNFPG CRKTYFKSSH
410 420 430 440 450
LKAHLRTHTG EKPFTCSWDG CDKKFARSDE LSRHRRTHTG EKKFVCPVCD
460 470 480 490 500
RRFMRSDHLT KHARRHMTTK KIPGWQAEVG KLNRITLAES PGSILEPLPA

SG
Length:502
Mass (Da):54,054
Last modified:September 2, 2008 - v3
Checksum:i158CD440B487F735
GO

Sequence cautioni

The sequence BAC34099 differs from that shown. Reason: Frameshift at position 108.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti262 – 263IT → TA in CAD30835 (PubMed:14697507).Curated2
Sequence conflicti262 – 263IT → TA in BAC40717 (PubMed:16141072).Curated2
Sequence conflicti368S → P in CAD30835 (PubMed:14697507).Curated1
Sequence conflicti373A → V in CAD30835 (PubMed:14697507).Curated1
Sequence conflicti373A → V in BAC40717 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ459773 mRNA. Translation: CAD30835.1.
AK036618 mRNA. Translation: BAC29509.1.
AK038397 mRNA. Translation: BAC29984.1.
AK050156 mRNA. Translation: BAC34099.1. Frameshift.
AK054170 mRNA. Translation: BAC35678.1.
AK082838 mRNA. Translation: BAC38647.1.
AK084913 mRNA. Translation: BAC39307.1.
AK089044 mRNA. Translation: BAC40717.1.
AK161233 mRNA. Translation: BAE36256.1.
BC060642 mRNA. Translation: AAH60642.1.
CCDSiCCDS25842.1.
RefSeqiNP_848134.1. NM_178357.3.
UniGeneiMm.9616.

Genome annotation databases

EnsembliENSMUST00000020982; ENSMUSP00000020982; ENSMUSG00000020653.
GeneIDi194655.
KEGGimmu:194655.
UCSCiuc007neo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ459773 mRNA. Translation: CAD30835.1.
AK036618 mRNA. Translation: BAC29509.1.
AK038397 mRNA. Translation: BAC29984.1.
AK050156 mRNA. Translation: BAC34099.1. Frameshift.
AK054170 mRNA. Translation: BAC35678.1.
AK082838 mRNA. Translation: BAC38647.1.
AK084913 mRNA. Translation: BAC39307.1.
AK089044 mRNA. Translation: BAC40717.1.
AK161233 mRNA. Translation: BAE36256.1.
BC060642 mRNA. Translation: AAH60642.1.
CCDSiCCDS25842.1.
RefSeqiNP_848134.1. NM_178357.3.
UniGeneiMm.9616.

3D structure databases

ProteinModelPortaliQ8K1S5.
SMRiQ8K1S5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228800. 1 interactor.
STRINGi10090.ENSMUSP00000020982.

PTM databases

PhosphoSitePlusiQ8K1S5.

Proteomic databases

PaxDbiQ8K1S5.
PRIDEiQ8K1S5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020982; ENSMUSP00000020982; ENSMUSG00000020653.
GeneIDi194655.
KEGGimmu:194655.
UCSCiuc007neo.2. mouse.

Organism-specific databases

CTDi8462.
MGIiMGI:2653368. Klf11.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000059558.
HOVERGENiHBG052264.
InParanoidiQ8K1S5.
KOiK09209.
OMAiSCQPCLH.
OrthoDBiEOG091G1BN0.
PhylomeDBiQ8K1S5.
TreeFamiTF315506.

Miscellaneous databases

ChiTaRSiKlf11. mouse.
PROiQ8K1S5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020653.
CleanExiMM_KLF11.
ExpressionAtlasiQ8K1S5. baseline and differential.
GenevisibleiQ8K1S5. MM.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLF11_MOUSE
AccessioniPrimary (citable) accession number: Q8K1S5
Secondary accession number(s): Q8BHJ1, Q8BI37, Q8BI70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: September 2, 2008
Last modified: November 2, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.