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Q8K1S5 (KLF11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Krueppel-like factor 11
Alternative name(s):
TGFB-inducible early growth response protein 2b
Transforming growth factor-beta-inducible early growth response protein 3
Short name=TGFB-inducible early growth response protein 3
Short name=TIEG-3
Gene names
Name:Klf11
Synonyms:Tieg2b, Tieg3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding sites inhibiting cell growth By similarity. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. Ref.1 Ref.5 UniProtKB O14901

Subunit structure

May interact with SIN3A By similarity.

Subcellular location

Nucleus Probable Ref.5.

Induction

By TGF-beta. Ref.1

Disruption phenotype

Mice breed normally and are fertile. Hematopoiesis at all stages of development is normal and there is no effect on globin gene expression or longevity. Ref.4

Sequence similarities

Belongs to the Sp1 C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Sequence caution

The sequence BAC34099.1 differs from that shown. Reason: Frameshift at position 108.

Ontologies

Keywords
   Biological processApoptosis
Transcription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
Repressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

cellular response to peptide

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription, DNA-templated

Inferred from direct assay Ref.1. Source: UniProtKB

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

regulation of transcription involved in G1/S transition of mitotic cell cycle

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnucleus

Inferred by curator Ref.1. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from sequence or structural similarity PubMed 15820306. Source: MGI

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding RNA polymerase II transcription factor activity

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Inferred from direct assay Ref.1. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 502502Krueppel-like factor 11
PRO_0000047189

Regions

Zinc finger384 – 40825C2H2-type 1
Zinc finger414 – 43825C2H2-type 2
Zinc finger444 – 46623C2H2-type 3

Experimental info

Sequence conflict262 – 2632IT → TA in CAD30835. Ref.1
Sequence conflict262 – 2632IT → TA in BAC40717. Ref.2
Sequence conflict3681S → P in CAD30835. Ref.1
Sequence conflict3731A → V in CAD30835. Ref.1
Sequence conflict3731A → V in BAC40717. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8K1S5 [UniParc].

Last modified September 2, 2008. Version 3.
Checksum: 158CD440B487F735

FASTA50254,054
        10         20         30         40         50         60 
MHSPGSTGPG DGRAADIMDI CESILERKRH DSERSTCSVL EQTDIEAVEA LVCMSSWGQR 

        70         80         90        100        110        120 
SQMRPLTPVS DSGDVTTAVL MDTAAPDLPK DFHSFSTLCI TPPQSPELTE PSTGTPVPSQ 

       130        140        150        160        170        180 
VVNSKGCMVT ALPPSPAGGP RTLSKREPLE PASGSSCRAV MTSVIRHTGE SPAPTRFPTG 

       190        200        210        220        230        240 
PTQEQRASDS GEGQERLLDH LEALQDTRLA NGLLVTNLVS CQPCLHKSGG SFPTDKGQQT 

       250        260        270        280        290        300 
GWPAAVQTCL PKNPESDLSR KITPLISVPV SSPPVLCQMI PVAGQNGLFS AFLKPPTQLP 

       310        320        330        340        350        360 
AGTIKPILPQ AASMSQPVFM GPPVPQGTVM LVLPQNTFPQ PAACPSSVMA IGNTKLLPLA 

       370        380        390        400        410        420 
PAPVFLASSQ NCAPQVDFSR RRNYVCNFPG CRKTYFKSSH LKAHLRTHTG EKPFTCSWDG 

       430        440        450        460        470        480 
CDKKFARSDE LSRHRRTHTG EKKFVCPVCD RRFMRSDHLT KHARRHMTTK KIPGWQAEVG 

       490        500 
KLNRITLAES PGSILEPLPA SG 

« Hide

References

« Hide 'large scale' references
[1]"Gene structure and evolution of Tieg3, a new member of the Tieg family of proteins."
Wang Z., Peters B., Klussmann S., Bender H., Herb A., Krieglstein K.
Gene 325:25-34(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
Strain: NMRI.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Bone, Embryonic stem cell, Head, Hypothalamus, Liver, Lung, Oviduct and Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[4]"Functional study of transcription factor KLF11 by targeted gene inactivation."
Song C.Z., Gavriilidis G., Asano H., Stamatoyannopoulos G.
Blood Cells Mol. Dis. 34:53-59(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
[5]"Tieg3/Klf11 induces apoptosis in OLI-neu cells and enhances the TGF-beta signaling pathway by transcriptional repression of Smad7."
Gohla G., Krieglstein K., Spittau B.
J. Cell. Biochem. 104:850-861(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ459773 mRNA. Translation: CAD30835.1.
AK036618 mRNA. Translation: BAC29509.1.
AK038397 mRNA. Translation: BAC29984.1.
AK050156 mRNA. Translation: BAC34099.1. Frameshift.
AK054170 mRNA. Translation: BAC35678.1.
AK082838 mRNA. Translation: BAC38647.1.
AK084913 mRNA. Translation: BAC39307.1.
AK089044 mRNA. Translation: BAC40717.1.
AK161233 mRNA. Translation: BAE36256.1.
BC060642 mRNA. Translation: AAH60642.1.
CCDSCCDS25842.1.
RefSeqNP_848134.1. NM_178357.3.
UniGeneMm.9616.

3D structure databases

ProteinModelPortalQ8K1S5.
SMRQ8K1S5. Positions 367-492.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid228800. 1 interaction.

Proteomic databases

PRIDEQ8K1S5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020982; ENSMUSP00000020982; ENSMUSG00000020653.
GeneID194655.
KEGGmmu:194655.
UCSCuc007neo.2. mouse.

Organism-specific databases

CTD8462.
MGIMGI:2653368. Klf11.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00750000117414.
HOGENOMHOG000059558.
HOVERGENHBG052264.
InParanoidQ8K1S5.
KOK09209.
OMAQNCAPQV.
OrthoDBEOG7FJH0Q.
PhylomeDBQ8K1S5.
TreeFamTF315506.

Gene expression databases

ArrayExpressQ8K1S5.
BgeeQ8K1S5.
CleanExMM_KLF11.
GenevestigatorQ8K1S5.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKLF11. mouse.
NextBio371634.
PROQ8K1S5.
SOURCESearch...

Entry information

Entry nameKLF11_MOUSE
AccessionPrimary (citable) accession number: Q8K1S5
Secondary accession number(s): Q8BHJ1, Q8BI37, Q8BI70
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot