Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Krueppel-like factor 11

Gene

Klf11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding sites inhibiting cell growth (By similarity). Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri384 – 408C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri414 – 438C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri444 – 466C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processApoptosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 11
Alternative name(s):
TGFB-inducible early growth response protein 2b
Transforming growth factor-beta-inducible early growth response protein 31 Publication
Short name:
TGFB-inducible early growth response protein 31 Publication
Short name:
TIEG-31 Publication
Gene namesi
Name:Klf11Imported
Synonyms:Tieg2bImported, Tieg3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2653368 Klf11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice breed normally and are fertile. Hematopoiesis at all stages of development is normal and there is no effect on globin gene expression or longevity.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471891 – 502Krueppel-like factor 11Add BLAST502

Proteomic databases

PaxDbiQ8K1S5
PRIDEiQ8K1S5

PTM databases

PhosphoSitePlusiQ8K1S5

Expressioni

Inductioni

By TGF-beta. Expressed in a circadian manner in the kidney and epididymal fat tissue.2 Publications

Gene expression databases

BgeeiENSMUSG00000020653
CleanExiMM_KLF11
ExpressionAtlasiQ8K1S5 baseline and differential
GenevisibleiQ8K1S5 MM

Interactioni

Subunit structurei

Interacts with SIN3A.By similarity

Protein-protein interaction databases

BioGridi228800, 1 interactor
STRINGi10090.ENSMUSP00000020982

Structurei

3D structure databases

ProteinModelPortaliQ8K1S5
SMRiQ8K1S5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Sp1 C2H2-type zinc-finger protein family.Sequence analysis

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri384 – 408C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri414 – 438C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri444 – 466C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000059558
HOVERGENiHBG052264
InParanoidiQ8K1S5
KOiK09209
OMAiSCQPCLH
OrthoDBiEOG091G1BN0
PhylomeDBiQ8K1S5
TreeFamiTF315506

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q8K1S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSPGSTGPG DGRAADIMDI CESILERKRH DSERSTCSVL EQTDIEAVEA
60 70 80 90 100
LVCMSSWGQR SQMRPLTPVS DSGDVTTAVL MDTAAPDLPK DFHSFSTLCI
110 120 130 140 150
TPPQSPELTE PSTGTPVPSQ VVNSKGCMVT ALPPSPAGGP RTLSKREPLE
160 170 180 190 200
PASGSSCRAV MTSVIRHTGE SPAPTRFPTG PTQEQRASDS GEGQERLLDH
210 220 230 240 250
LEALQDTRLA NGLLVTNLVS CQPCLHKSGG SFPTDKGQQT GWPAAVQTCL
260 270 280 290 300
PKNPESDLSR KITPLISVPV SSPPVLCQMI PVAGQNGLFS AFLKPPTQLP
310 320 330 340 350
AGTIKPILPQ AASMSQPVFM GPPVPQGTVM LVLPQNTFPQ PAACPSSVMA
360 370 380 390 400
IGNTKLLPLA PAPVFLASSQ NCAPQVDFSR RRNYVCNFPG CRKTYFKSSH
410 420 430 440 450
LKAHLRTHTG EKPFTCSWDG CDKKFARSDE LSRHRRTHTG EKKFVCPVCD
460 470 480 490 500
RRFMRSDHLT KHARRHMTTK KIPGWQAEVG KLNRITLAES PGSILEPLPA

SG
Length:502
Mass (Da):54,054
Last modified:September 2, 2008 - v3
Checksum:i158CD440B487F735
GO

Sequence cautioni

The sequence BAC34099 differs from that shown. Reason: Frameshift at position 108.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti262 – 263IT → TA in CAD30835 (PubMed:14697507).Curated2
Sequence conflicti262 – 263IT → TA in BAC40717 (PubMed:16141072).Curated2
Sequence conflicti368S → P in CAD30835 (PubMed:14697507).Curated1
Sequence conflicti373A → V in CAD30835 (PubMed:14697507).Curated1
Sequence conflicti373A → V in BAC40717 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ459773 mRNA Translation: CAD30835.1
AK036618 mRNA Translation: BAC29509.1
AK038397 mRNA Translation: BAC29984.1
AK050156 mRNA Translation: BAC34099.1 Frameshift.
AK054170 mRNA Translation: BAC35678.1
AK082838 mRNA Translation: BAC38647.1
AK084913 mRNA Translation: BAC39307.1
AK089044 mRNA Translation: BAC40717.1
AK161233 mRNA Translation: BAE36256.1
BC060642 mRNA Translation: AAH60642.1
CCDSiCCDS25842.1
RefSeqiNP_848134.1, NM_178357.3
UniGeneiMm.9616

Genome annotation databases

EnsembliENSMUST00000020982; ENSMUSP00000020982; ENSMUSG00000020653
GeneIDi194655
KEGGimmu:194655
UCSCiuc007neo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKLF11_MOUSE
AccessioniPrimary (citable) accession number: Q8K1S5
Secondary accession number(s): Q8BHJ1, Q8BI37, Q8BI70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: September 2, 2008
Last modified: April 25, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health