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Q8K1S5

- KLF11_MOUSE

UniProt

Q8K1S5 - KLF11_MOUSE

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Protein

Krueppel-like factor 11

Gene

Klf11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding sites inhibiting cell growth (By similarity). Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.By similarity2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri384 – 40825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  5. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cellular response to peptide Source: Ensembl
  3. negative regulation of cell proliferation Source: Ensembl
  4. negative regulation of transcription, DNA-templated Source: UniProtKB
  5. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  6. positive regulation of apoptotic process Source: Ensembl
  7. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 11
Alternative name(s):
TGFB-inducible early growth response protein 2b
Transforming growth factor-beta-inducible early growth response protein 31 Publication
Short name:
TGFB-inducible early growth response protein 31 Publication
Short name:
TIEG-31 Publication
Gene namesi
Name:Klf11Imported
Synonyms:Tieg2bImported, Tieg3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:2653368. Klf11.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice breed normally and are fertile. Hematopoiesis at all stages of development is normal and there is no effect on globin gene expression or longevity.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Krueppel-like factor 11PRO_0000047189Add
BLAST

Proteomic databases

PRIDEiQ8K1S5.

Expressioni

Inductioni

By TGF-beta. Expressed in a circadian manner in the kidney and epididymal fat tissue.2 Publications

Gene expression databases

BgeeiQ8K1S5.
CleanExiMM_KLF11.
ExpressionAtlasiQ8K1S5. baseline and differential.
GenevestigatoriQ8K1S5.

Interactioni

Subunit structurei

Interacts with SIN3A.By similarity

Protein-protein interaction databases

BioGridi228800. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8K1S5.
SMRiQ8K1S5. Positions 367-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Sp1 C2H2-type zinc-finger protein family.Sequence Analysis
Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri384 – 40825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000059558.
HOVERGENiHBG052264.
InParanoidiQ8K1S5.
KOiK09209.
OMAiQNCAPQV.
OrthoDBiEOG7FJH0Q.
PhylomeDBiQ8K1S5.
TreeFamiTF315506.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K1S5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHSPGSTGPG DGRAADIMDI CESILERKRH DSERSTCSVL EQTDIEAVEA
60 70 80 90 100
LVCMSSWGQR SQMRPLTPVS DSGDVTTAVL MDTAAPDLPK DFHSFSTLCI
110 120 130 140 150
TPPQSPELTE PSTGTPVPSQ VVNSKGCMVT ALPPSPAGGP RTLSKREPLE
160 170 180 190 200
PASGSSCRAV MTSVIRHTGE SPAPTRFPTG PTQEQRASDS GEGQERLLDH
210 220 230 240 250
LEALQDTRLA NGLLVTNLVS CQPCLHKSGG SFPTDKGQQT GWPAAVQTCL
260 270 280 290 300
PKNPESDLSR KITPLISVPV SSPPVLCQMI PVAGQNGLFS AFLKPPTQLP
310 320 330 340 350
AGTIKPILPQ AASMSQPVFM GPPVPQGTVM LVLPQNTFPQ PAACPSSVMA
360 370 380 390 400
IGNTKLLPLA PAPVFLASSQ NCAPQVDFSR RRNYVCNFPG CRKTYFKSSH
410 420 430 440 450
LKAHLRTHTG EKPFTCSWDG CDKKFARSDE LSRHRRTHTG EKKFVCPVCD
460 470 480 490 500
RRFMRSDHLT KHARRHMTTK KIPGWQAEVG KLNRITLAES PGSILEPLPA

SG
Length:502
Mass (Da):54,054
Last modified:September 2, 2008 - v3
Checksum:i158CD440B487F735
GO

Sequence cautioni

The sequence BAC34099.1 differs from that shown. Reason: Frameshift at position 108.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti262 – 2632IT → TA in CAD30835. (PubMed:14697507)Curated
Sequence conflicti262 – 2632IT → TA in BAC40717. (PubMed:16141072)Curated
Sequence conflicti368 – 3681S → P in CAD30835. (PubMed:14697507)Curated
Sequence conflicti373 – 3731A → V in CAD30835. (PubMed:14697507)Curated
Sequence conflicti373 – 3731A → V in BAC40717. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ459773 mRNA. Translation: CAD30835.1.
AK036618 mRNA. Translation: BAC29509.1.
AK038397 mRNA. Translation: BAC29984.1.
AK050156 mRNA. Translation: BAC34099.1. Frameshift.
AK054170 mRNA. Translation: BAC35678.1.
AK082838 mRNA. Translation: BAC38647.1.
AK084913 mRNA. Translation: BAC39307.1.
AK089044 mRNA. Translation: BAC40717.1.
AK161233 mRNA. Translation: BAE36256.1.
BC060642 mRNA. Translation: AAH60642.1.
CCDSiCCDS25842.1.
RefSeqiNP_848134.1. NM_178357.3.
UniGeneiMm.9616.

Genome annotation databases

EnsembliENSMUST00000020982; ENSMUSP00000020982; ENSMUSG00000020653.
GeneIDi194655.
KEGGimmu:194655.
UCSCiuc007neo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ459773 mRNA. Translation: CAD30835.1 .
AK036618 mRNA. Translation: BAC29509.1 .
AK038397 mRNA. Translation: BAC29984.1 .
AK050156 mRNA. Translation: BAC34099.1 . Frameshift.
AK054170 mRNA. Translation: BAC35678.1 .
AK082838 mRNA. Translation: BAC38647.1 .
AK084913 mRNA. Translation: BAC39307.1 .
AK089044 mRNA. Translation: BAC40717.1 .
AK161233 mRNA. Translation: BAE36256.1 .
BC060642 mRNA. Translation: AAH60642.1 .
CCDSi CCDS25842.1.
RefSeqi NP_848134.1. NM_178357.3.
UniGenei Mm.9616.

3D structure databases

ProteinModelPortali Q8K1S5.
SMRi Q8K1S5. Positions 367-466.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 228800. 1 interaction.

Proteomic databases

PRIDEi Q8K1S5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020982 ; ENSMUSP00000020982 ; ENSMUSG00000020653 .
GeneIDi 194655.
KEGGi mmu:194655.
UCSCi uc007neo.2. mouse.

Organism-specific databases

CTDi 8462.
MGIi MGI:2653368. Klf11.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118984.
HOGENOMi HOG000059558.
HOVERGENi HBG052264.
InParanoidi Q8K1S5.
KOi K09209.
OMAi QNCAPQV.
OrthoDBi EOG7FJH0Q.
PhylomeDBi Q8K1S5.
TreeFami TF315506.

Miscellaneous databases

ChiTaRSi KLF11. mouse.
NextBioi 371634.
PROi Q8K1S5.
SOURCEi Search...

Gene expression databases

Bgeei Q8K1S5.
CleanExi MM_KLF11.
ExpressionAtlasi Q8K1S5. baseline and differential.
Genevestigatori Q8K1S5.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene structure and evolution of Tieg3, a new member of the Tieg family of proteins."
    Wang Z., Peters B., Klussmann S., Bender H., Herb A., Krieglstein K.
    Gene 325:25-34(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
    Strain: NMRIImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported and NODImported.
    Tissue: BoneImported, Embryonic stem cellImported, HeadImported, HypothalamusImported, LiverImported, LungImported, OviductImported and ThymusImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  4. "Functional study of transcription factor KLF11 by targeted gene inactivation."
    Song C.Z., Gavriilidis G., Asano H., Stamatoyannopoulos G.
    Blood Cells Mol. Dis. 34:53-59(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  5. "Tieg3/Klf11 induces apoptosis in OLI-neu cells and enhances the TGF-beta signaling pathway by transcriptional repression of Smad7."
    Gohla G., Krieglstein K., Spittau B.
    J. Cell. Biochem. 104:850-861(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: INDUCTION.

Entry informationi

Entry nameiKLF11_MOUSE
AccessioniPrimary (citable) accession number: Q8K1S5
Secondary accession number(s): Q8BHJ1, Q8BI37, Q8BI70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: September 2, 2008
Last modified: October 29, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3