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UniProtKB - Q8K1S4 (UNC5A_MOUSE)

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Protein

Netrin receptor UNC5A

Gene

Unc5a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • anterior/posterior axon guidance Source: MGI
  • apoptotic process Source: UniProtKB-KW
  • axon guidance Source: MGI
  • netrin-activated signaling pathway Source: UniProtKB
  • neuron projection development Source: UniProtKB
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-373752 Netrin-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin receptor UNC5A
Alternative name(s):
Protein unc-5 homolog 1
Protein unc-5 homolog A
Gene namesi
Name:Unc5a
Synonyms:Kiaa1976, Unc5h1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:894682 Unc5a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 361ExtracellularSequence analysisAdd BLAST336
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 898CytoplasmicSequence analysisAdd BLAST516

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003606926 – 898Netrin receptor UNC5AAdd BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 126By similarity
Disulfide bondi77 ↔ 124By similarity
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi170 ↔ 221By similarity
Glycosylationi218N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi254 ↔ 291By similarity
Disulfide bondi258 ↔ 295By similarity
Disulfide bondi269 ↔ 281By similarity
Disulfide bondi310 ↔ 344By similarity
Disulfide bondi314 ↔ 349By similarity
Disulfide bondi322 ↔ 334By similarity
Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated on cytoplasmic tyrosine residues (By similarity). Phosphorylated by PKC in vitro (By similarity).By similarity
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei396 – 397Cleavage; by caspase-3By similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8K1S4
PRIDEiQ8K1S4

PTM databases

iPTMnetiQ8K1S4
PhosphoSitePlusiQ8K1S4

Expressioni

Tissue specificityi

Restricted to central nervous system.1 Publication

Gene expression databases

BgeeiENSMUSG00000025876
CleanExiMM_UNC5A
ExpressionAtlasiQ8K1S4 baseline and differential
GenevisibleiQ8K1S4 MM

Interactioni

Subunit structurei

Homodimer and homooligomer. Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC (By similarity). Interacts (via extracellular domain) with FLRT2 (via extracellular domain) (PubMed:25374360). Interacts (via extracellular domain) with FLRT3 (via extracellular domain) (PubMed:22405201).By similarity2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026994

Structurei

3D structure databases

ProteinModelPortaliQ8K1S4
SMRiQ8K1S4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 141Ig-likeAdd BLAST98
Domaini155 – 234Ig-like C2-typeAdd BLAST80
Domaini242 – 296TSP type-1 1PROSITE-ProRule annotationAdd BLAST55
Domaini298 – 350TSP type-1 2PROSITE-ProRule annotationAdd BLAST53
Domaini497 – 640ZU5PROSITE-ProRule annotationAdd BLAST144
Domaini817 – 897DeathAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni661 – 679Interaction with DCCBy similarityAdd BLAST19

Domaini

The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis.By similarity

Sequence similaritiesi

Belongs to the unc-5 family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1480 Eukaryota
ENOG410XRS6 LUCA
GeneTreeiENSGT00920000149006
HOGENOMiHOG000060306
HOVERGENiHBG056483
InParanoidiQ8K1S4
KOiK07521
OMAiGTSNMTY
OrthoDBiEOG091G040Q
PhylomeDBiQ8K1S4
TreeFamiTF316767

Family and domain databases

Gene3Di2.20.100.10, 2 hits
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR037936 UNC5
IPR033772 UPA
IPR000906 ZU5_dom
PANTHERiPTHR12582 PTHR12582, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF07679 I-set, 1 hit
PF00090 TSP_1, 2 hits
PF17217 UPA, 1 hit
PF00791 ZU5, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00409 IG, 1 hit
SM00209 TSP1, 2 hits
SM00218 ZU5, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48726 SSF48726, 2 hits
SSF82895 SSF82895, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS50092 TSP1, 2 hits
PS51145 ZU5, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K1S4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVRPGLWPA LLGIVLTAWL RGSGAQQSAT VANPVPGANP DLLPHFLVEP 
        60         70         80         90        100
EDVYIVKNKP VLLVCKAVPA TQIFFKCNGE WVRQVDHVIE RSTDGSSGLP 
       110        120        130        140        150
TMEVRINVSR QQVEKVFGLE EYWCQCVAWS SSGTTKSQKA YIRIAYLRKN 
       160        170        180        190        200
FEQEPLAKEV SLEQGIVLPC RPPEGIPPAE VEWLRNEDLV DPSLDPNVYI 
       210        220        230        240        250
TREHSLVVRQ ARLADTANYT CVAKNIVARR RSASAAVIVY VNGGWSTWTE 
       260        270        280        290        300
WSVCSASCGR GWQKRSRSCT NPAPLNGGAF CEGQNVQKTA CATLCPVDGS 
       310        320        330        340        350
WSPWSKWSAC GLDCTHWRSR ECSDPAPRNG GEECRGADLD TRNCTSDLCL 
       360        370        380        390        400
HTSSGPEDVA LYIGLVAVAV CLILLLLVLV LIYCRKKEGL DSDVADSSIL 
       410        420        430        440        450
TSGFQPVSIK PSKADNPHLL TIQPDLSTTT TTYQGSLCPR QDGPSPKFQL 
       460        470        480        490        500
SNGHLLSPLG SGRHTLHHSS PTSEAEDFVS RLSTQNYFRS LPRGTSNMAY 
       510        520        530        540        550
GTFNFLGGRL MIPNTGISLL IPPDAIPRGK IYEIYLTLHK PEDVRLPLAG 
       560        570        580        590        600
CQTLLSPIVS CGPPGVLLTR PVILAMDHCG EPSPDSWSLR LKKQSCEGSW 
       610        620        630        640        650
EDVLHLGEES PSHLYYCQLE AGACYVFTEQ LGRFALVGEA LSVAATKRLR 
       660        670        680        690        700
LLLFAPVACT SLEYNIRVYC LHDTHDALKE VVQLEKQLGG QLIQEPRVLH 
       710        720        730        740        750
FKDSYHNLRL SIHDVPSSLW KSKLLVSYQE IPFYHIWNGT QQYLHCTFTL 
       760        770        780        790        800
ERVNASTSDL ACKVWVWQVE GDGQSFNINF NITKDTRFAE MLALESEGGV 
       810        820        830        840        850
PALVGPSAFK IPFLIRQKII TSLDPPCSRG ADWRTLAQKL HLDSHLSFFA 
       860        870        880        890 
SKPSPTAMIL NLWEARHFPN GNLGQLAAAV AGLGQPDAGL FTVSEAEC
Length:898
Mass (Da):98,857
Last modified:October 1, 2002 - v1
Checksum:i59F04BA2E196C1DB
GO
Isoform 2 (identifier: Q8K1S4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-296: Missing.

Note: No experimental confirmation available.
Show »
Length:842
Mass (Da):92,924
Checksum:i2D106FCA22D7AE44
GO
Isoform 3 (identifier: Q8K1S4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-790: Missing.

Note: No experimental confirmation available.
Show »
Length:108
Mass (Da):11,482
Checksum:i2B7D02D006FB166D
GO

Sequence cautioni

The sequence BAC65857 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti217A → P in AAH58084 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0116961 – 790Missing in isoform 3. 1 PublicationAdd BLAST790
Alternative sequenceiVSP_011697241 – 296Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487852 mRNA Translation: CAD32250.1
AK122575 mRNA Translation: BAC65857.1 Different initiation.
BC058084 mRNA Translation: AAH58084.1
CCDSiCCDS26537.1 [Q8K1S4-1]
CCDS79188.1 [Q8K1S4-2]
RefSeqiNP_001298057.1, NM_001311128.1 [Q8K1S4-2]
NP_694771.1, NM_153131.3 [Q8K1S4-1]
UniGeneiMm.23573

Genome annotation databases

EnsembliENSMUST00000026994; ENSMUSP00000026994; ENSMUSG00000025876 [Q8K1S4-1]
ENSMUST00000109994; ENSMUSP00000105621; ENSMUSG00000025876 [Q8K1S4-2]
GeneIDi107448
KEGGimmu:107448
UCSCiuc007qpp.1 mouse [Q8K1S4-1]
uc007qpq.1 mouse [Q8K1S4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUNC5A_MOUSE
AccessioniPrimary (citable) accession number: Q8K1S4
Secondary accession number(s): Q6PEF7, Q80T71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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