Unc5a

Functionⁱ

Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.By similarity

GO - Molecular functionⁱ

netrin receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterior/posterior axon guidance
Source: MGI
Inferred from mutant phenotypeⁱ
- 18479186
apoptotic process Source: UniProtKB-KW
netrin-activated signaling pathway Source: UniProtKB
neuron projection development Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Receptor
Biological process	Apoptosis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-373752. Netrin-1 signaling.

Reactomeⁱ

R-MMU-373752. Netrin-1 signaling.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Netrin receptor UNC5A Alternative name(s): Protein unc-5 homolog 1 Protein unc-5 homolog A
Gene namesⁱ	Name:Unc5a Synonyms:Kiaa1976, Unc5h1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 13

Organism-specific databases

MGIⁱ	MGI:894682. Unc5a.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	26 – 361	ExtracellularSequence analysisAdd BLAST	336
Transmembraneⁱ	362 – 382	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	383 – 898	CytoplasmicSequence analysisAdd BLAST	516

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST		25
ChainⁱPRO_0000036069	26 – 898	Netrin receptor UNC5AAdd BLAST		873

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	65 ↔ 126	By similarity
Disulfide bondⁱ	77 ↔ 124	By similarity
Glycosylationⁱ	107	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	170 ↔ 221	By similarity
Glycosylationⁱ	218	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	254 ↔ 291	By similarity
Disulfide bondⁱ	258 ↔ 295	By similarity
Disulfide bondⁱ	269 ↔ 281	By similarity
Disulfide bondⁱ	310 ↔ 344	By similarity
Disulfide bondⁱ	314 ↔ 349	By similarity
Disulfide bondⁱ	322 ↔ 334	By similarity
Glycosylationⁱ	343	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

Phosphorylated on cytoplasmic tyrosine residues (By similarity). Phosphorylated by PKC in vitro (By similarity).By similarity

Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	396 – 397	Cleavage; by caspase-3By similarity		2

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8K1S4.
PRIDEⁱ	Q8K1S4.

PTM databases

iPTMnetⁱ	Q8K1S4.
PhosphoSitePlusⁱ	Q8K1S4.

Expressionⁱ

Tissue specificityⁱ

Restricted to central nervous system.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000025876.
CleanExⁱ	MM_UNC5A.
ExpressionAtlasⁱ	Q8K1S4. baseline and differential.
Genevisibleⁱ	Q8K1S4. MM.

Interactionⁱ

Subunit structureⁱ

Homodimer and homooligomer. Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC (By similarity). Interacts (via extracellular domain) with FLRT2 (via extracellular domain) (PubMed:25374360). Interacts (via extracellular domain) with FLRT3 (via extracellular domain) (PubMed:22405201).By similarity2 Publications

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000026994.

STRINGⁱ

10090.ENSMUSP00000026994.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8K1S4.
SMRⁱ	Q8K1S4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	44 – 141	Ig-likeAdd BLAST	98
Domainⁱ	155 – 234	Ig-like C2-typeAdd BLAST	80
Domainⁱ	242 – 296	TSP type-1 1PROSITE-ProRule annotationAdd BLAST	55
Domainⁱ	298 – 350	TSP type-1 2PROSITE-ProRule annotationAdd BLAST	53
Domainⁱ	497 – 640	ZU5PROSITE-ProRule annotationAdd BLAST	144
Domainⁱ	817 – 897	DeathAdd BLAST	81

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	661 – 679	Interaction with DCCBy similarityAdd BLAST		19

Domainⁱ

The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis.By similarity

Sequence similaritiesⁱ

Belongs to the unc-5 family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1480. Eukaryota. ENOG410XRS6. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144013.
HOGENOMⁱ	HOG000060306.
HOVERGENⁱ	HBG056483.
InParanoidⁱ	Q8K1S4.
KEGG Orthology (KO) More...KOⁱ	K07521.
OMAⁱ	GTSNMTY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G040Q.
PhylomeDBⁱ	Q8K1S4.
TreeFamⁱ	TF316767.

Family and domain databases

Gene3Dⁱ	2.20.100.10. 2 hits. 2.60.40.10. 2 hits.
InterProⁱ	View protein in InterPro IPR011029. DEATH-like_dom_sf. IPR000488. Death_domain. IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR000884. TSP1_rpt. IPR036383. TSP1_rpt_sf. IPR037936. UNC5. IPR033772. UPA. IPR000906. ZU5_dom.
PANTHERⁱ	PTHR12582. PTHR12582. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00531. Death. 1 hit. PF07679. I-set. 1 hit. PF00090. TSP_1. 2 hits. PF17217. UPA. 1 hit. PF00791. ZU5. 1 hit.
SMARTⁱ	View protein in SMART SM00005. DEATH. 1 hit. SM00409. IG. 1 hit. SM00209. TSP1. 2 hits. SM00218. ZU5. 1 hit.
SUPFAMⁱ	SSF47986. SSF47986. 1 hit. SSF48726. SSF48726. 2 hits. SSF82895. SSF82895. 2 hits.
PROSITEⁱ	View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS50092. TSP1. 2 hits. PS51145. ZU5. 1 hit.

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8K1S4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MAVRPGLWPA LLGIVLTAWL RGSGAQQSAT VANPVPGANP DLLPHFLVEP 
        60         70         80         90        100
EDVYIVKNKP VLLVCKAVPA TQIFFKCNGE WVRQVDHVIE RSTDGSSGLP 
       110        120        130        140        150
TMEVRINVSR QQVEKVFGLE EYWCQCVAWS SSGTTKSQKA YIRIAYLRKN 
       160        170        180        190        200
FEQEPLAKEV SLEQGIVLPC RPPEGIPPAE VEWLRNEDLV DPSLDPNVYI 
       210        220        230        240        250
TREHSLVVRQ ARLADTANYT CVAKNIVARR RSASAAVIVY VNGGWSTWTE 
       260        270        280        290        300
WSVCSASCGR GWQKRSRSCT NPAPLNGGAF CEGQNVQKTA CATLCPVDGS 
       310        320        330        340        350
WSPWSKWSAC GLDCTHWRSR ECSDPAPRNG GEECRGADLD TRNCTSDLCL 
       360        370        380        390        400
HTSSGPEDVA LYIGLVAVAV CLILLLLVLV LIYCRKKEGL DSDVADSSIL 
       410        420        430        440        450
TSGFQPVSIK PSKADNPHLL TIQPDLSTTT TTYQGSLCPR QDGPSPKFQL 
       460        470        480        490        500
SNGHLLSPLG SGRHTLHHSS PTSEAEDFVS RLSTQNYFRS LPRGTSNMAY 
       510        520        530        540        550
GTFNFLGGRL MIPNTGISLL IPPDAIPRGK IYEIYLTLHK PEDVRLPLAG 
       560        570        580        590        600
CQTLLSPIVS CGPPGVLLTR PVILAMDHCG EPSPDSWSLR LKKQSCEGSW 
       610        620        630        640        650
EDVLHLGEES PSHLYYCQLE AGACYVFTEQ LGRFALVGEA LSVAATKRLR 
       660        670        680        690        700
LLLFAPVACT SLEYNIRVYC LHDTHDALKE VVQLEKQLGG QLIQEPRVLH 
       710        720        730        740        750
FKDSYHNLRL SIHDVPSSLW KSKLLVSYQE IPFYHIWNGT QQYLHCTFTL 
       760        770        780        790        800
ERVNASTSDL ACKVWVWQVE GDGQSFNINF NITKDTRFAE MLALESEGGV 
       810        820        830        840        850
PALVGPSAFK IPFLIRQKII TSLDPPCSRG ADWRTLAQKL HLDSHLSFFA 
       860        870        880        890 
SKPSPTAMIL NLWEARHFPN GNLGQLAAAV AGLGQPDAGL FTVSEAEC

Length:898

Mass (Da):98,857

Last modified:October 1, 2002 - v1

Checksum:ⁱ59F04BA2E196C1DB

GO

Isoform 2 (identifier: Q8K1S4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
241-296: Missing.

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        10         20         30         40         50
MAVRPGLWPA LLGIVLTAWL RGSGAQQSAT VANPVPGANP DLLPHFLVEP 
        60         70         80         90        100
EDVYIVKNKP VLLVCKAVPA TQIFFKCNGE WVRQVDHVIE RSTDGSSGLP 
       110        120        130        140        150
TMEVRINVSR QQVEKVFGLE EYWCQCVAWS SSGTTKSQKA YIRIAYLRKN 
       160        170        180        190        200
FEQEPLAKEV SLEQGIVLPC RPPEGIPPAE VEWLRNEDLV DPSLDPNVYI 
       210        220        230        240        250
TREHSLVVRQ ARLADTANYT CVAKNIVARR RSASAAVIVY VDGSWSPWSK 
       260        270        280        290        300
WSACGLDCTH WRSRECSDPA PRNGGEECRG ADLDTRNCTS DLCLHTSSGP 
       310        320        330        340        350
EDVALYIGLV AVAVCLILLL LVLVLIYCRK KEGLDSDVAD SSILTSGFQP 
       360        370        380        390        400
VSIKPSKADN PHLLTIQPDL STTTTTYQGS LCPRQDGPSP KFQLSNGHLL 
       410        420        430        440        450
SPLGSGRHTL HHSSPTSEAE DFVSRLSTQN YFRSLPRGTS NMAYGTFNFL 
       460        470        480        490        500
GGRLMIPNTG ISLLIPPDAI PRGKIYEIYL TLHKPEDVRL PLAGCQTLLS 
       510        520        530        540        550
PIVSCGPPGV LLTRPVILAM DHCGEPSPDS WSLRLKKQSC EGSWEDVLHL 
       560        570        580        590        600
GEESPSHLYY CQLEAGACYV FTEQLGRFAL VGEALSVAAT KRLRLLLFAP 
       610        620        630        640        650
VACTSLEYNI RVYCLHDTHD ALKEVVQLEK QLGGQLIQEP RVLHFKDSYH 
       660        670        680        690        700
NLRLSIHDVP SSLWKSKLLV SYQEIPFYHI WNGTQQYLHC TFTLERVNAS 
       710        720        730        740        750
TSDLACKVWV WQVEGDGQSF NINFNITKDT RFAEMLALES EGGVPALVGP 
       760        770        780        790        800
SAFKIPFLIR QKIITSLDPP CSRGADWRTL AQKLHLDSHL SFFASKPSPT 
       810        820        830        840 
AMILNLWEAR HFPNGNLGQL AAAVAGLGQP DAGLFTVSEA EC

Note: No experimental confirmation available.

Show »

Length:842

Mass (Da):92,924

Checksum:ⁱ2D106FCA22D7AE44

GO

Isoform 3 (identifier: Q8K1S4-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-790: Missing.

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        10         20         30         40         50
MLALESEGGV PALVGPSAFK IPFLIRQKII TSLDPPCSRG ADWRTLAQKL 
        60         70         80         90        100
HLDSHLSFFA SKPSPTAMIL NLWEARHFPN GNLGQLAAAV AGLGQPDAGL 

FTVSEAEC

Note: No experimental confirmation available.

Show »

Length:108

Mass (Da):11,482

Checksum:ⁱ2B7D02D006FB166D

GO

Sequence cautionⁱ

The sequence BAC65857 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	217	A → P in AAH58084 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_011696	1 – 790	Missing in isoform 3. 1 PublicationAdd BLAST		790
Alternative sequenceⁱVSP_011697	241 – 296	Missing in isoform 2. 1 PublicationAdd BLAST		56

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ487852 mRNA. Translation: CAD32250.1. AK122575 mRNA. Translation: BAC65857.1. Different initiation. BC058084 mRNA. Translation: AAH58084.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS26537.1. [Q8K1S4-1] CCDS79188.1. [Q8K1S4-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001298057.1. NM_001311128.1. [Q8K1S4-2] NP_694771.1. NM_153131.3. [Q8K1S4-1]
UniGeneⁱ	Mm.23573.

Genome annotation databases

Ensemblⁱ	ENSMUST00000026994; ENSMUSP00000026994; ENSMUSG00000025876. [Q8K1S4-1] ENSMUST00000109994; ENSMUSP00000105621; ENSMUSG00000025876. [Q8K1S4-2]
GeneIDⁱ	107448.
KEGGⁱ	mmu:107448.
UCSC genome browser More...UCSCⁱ	uc007qpp.1. mouse. [Q8K1S4-1] uc007qpq.1. mouse. [Q8K1S4-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8K1S4	O08721 UPI00072DA402 A0A2I3GI88 UPI00038ED287 A0A1A6GGZ0 UPI0003BB9B48 A0A2I2Z6T8 UPI00045D7F3D A0A096NAG0 L5JY15 +86	Rattus norvegicus (Rat) Acinonyx jubatus (Cheetah) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) Neotoma lepida (Desert woodrat) Myotis brandtii (Brandt's bat) Gorilla gorilla gorilla (Western lowland gorilla) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Papio anubis (Olive baboon) Pteropus alecto (Black flying fox) And more	898	UniRef90_O08721	Cluster: Netrin receptor UNC5A	97
Q8K1S4-2	Q6ZN44 A0A2K6AT07 UPI00076230DA UPI00038EA915 UPI000A31F051 UPI00064381B7 A0A2J8RDL0 UPI00057BA1F0 UPI00029D7701 A0A2K6MFU9 +100	Homo sapiens (Human) Macaca nemestrina (Pig-tailed macaque) Marmota marmota marmota (Alpine marmot) Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) Mesocricetus auratus (Golden hamster) Condylura cristata (Star-nosed mole) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Camelus dromedarius (Dromedary) (Arabian camel) Ovis aries (Sheep) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) And more	842	UniRef90_Q6ZN44	Cluster: Netrin receptor UNC5A	111

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8K1S4	O08721 UPI00072DA402 A0A2I3GI88 UPI00038ED287 UPI0003BB9B48 A0A1A6GGZ0 A0A2I2Z6T8 UPI00045D7F3D L5JY15 A0A096NAG0 +192	Rattus norvegicus (Rat) Acinonyx jubatus (Cheetah) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) Myotis brandtii (Brandt's bat) Neotoma lepida (Desert woodrat) Gorilla gorilla gorilla (Western lowland gorilla) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Pteropus alecto (Black flying fox) Papio anubis (Olive baboon) And more	898	UniRef50_O08721	Cluster: Netrin receptor UNC5A	203
Q8K1S4-2	Q6ZN44 A0A2K6AT07 UPI00076230DA UPI00038EA915 UPI000A31F051 UPI00064381B7 UPI00057BA1F0 A0A2J8RDL0 UPI00029D7701 A0A2K6MFU9 +122	Homo sapiens (Human) Macaca nemestrina (Pig-tailed macaque) Marmota marmota marmota (Alpine marmot) Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) Mesocricetus auratus (Golden hamster) Condylura cristata (Star-nosed mole) Camelus dromedarius (Dromedary) (Arabian camel) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Ovis aries (Sheep) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) And more	842	UniRef50_Q6ZN44	Cluster: Netrin receptor UNC5A	133

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ487852 mRNA. Translation: CAD32250.1. AK122575 mRNA. Translation: BAC65857.1. Different initiation. BC058084 mRNA. Translation: AAH58084.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS26537.1. [Q8K1S4-1] CCDS79188.1. [Q8K1S4-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001298057.1. NM_001311128.1. [Q8K1S4-2] NP_694771.1. NM_153131.3. [Q8K1S4-1]
UniGeneⁱ	Mm.23573.

3D structure databases

ProteinModelPortalⁱ	Q8K1S4.
SMRⁱ	Q8K1S4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000026994.

STRINGⁱ

10090.ENSMUSP00000026994.

PTM databases

iPTMnetⁱ	Q8K1S4.
PhosphoSitePlusⁱ	Q8K1S4.

Proteomic databases

PaxDbⁱ	Q8K1S4.
PRIDEⁱ	Q8K1S4.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000026994; ENSMUSP00000026994; ENSMUSG00000025876. [Q8K1S4-1] ENSMUST00000109994; ENSMUSP00000105621; ENSMUSG00000025876. [Q8K1S4-2]
GeneIDⁱ	107448.
KEGGⁱ	mmu:107448.
UCSC genome browser More...UCSCⁱ	uc007qpp.1. mouse. [Q8K1S4-1] uc007qpq.1. mouse. [Q8K1S4-2]

Organism-specific databases

CTDⁱ	90249.
MGIⁱ	MGI:894682. Unc5a.
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1480. Eukaryota. ENOG410XRS6. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144013.
HOGENOMⁱ	HOG000060306.
HOVERGENⁱ	HBG056483.
InParanoidⁱ	Q8K1S4.
KEGG Orthology (KO) More...KOⁱ	K07521.
OMAⁱ	GTSNMTY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G040Q.
PhylomeDBⁱ	Q8K1S4.
TreeFamⁱ	TF316767.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-373752. Netrin-1 signaling.

Reactomeⁱ

R-MMU-373752. Netrin-1 signaling.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8K1S4.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000025876.
CleanExⁱ	MM_UNC5A.
ExpressionAtlasⁱ	Q8K1S4. baseline and differential.
Genevisibleⁱ	Q8K1S4. MM.

Family and domain databases

Gene3Dⁱ	2.20.100.10. 2 hits. 2.60.40.10. 2 hits.
InterProⁱ	View protein in InterPro IPR011029. DEATH-like_dom_sf. IPR000488. Death_domain. IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR000884. TSP1_rpt. IPR036383. TSP1_rpt_sf. IPR037936. UNC5. IPR033772. UPA. IPR000906. ZU5_dom.
PANTHERⁱ	PTHR12582. PTHR12582. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00531. Death. 1 hit. PF07679. I-set. 1 hit. PF00090. TSP_1. 2 hits. PF17217. UPA. 1 hit. PF00791. ZU5. 1 hit.
SMARTⁱ	View protein in SMART SM00005. DEATH. 1 hit. SM00409. IG. 1 hit. SM00209. TSP1. 2 hits. SM00218. ZU5. 1 hit.
SUPFAMⁱ	SSF47986. SSF47986. 1 hit. SSF48726. SSF48726. 2 hits. SSF82895. SSF82895. 2 hits.
PROSITEⁱ	View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS50092. TSP1. 2 hits. PS51145. ZU5. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UNC5A_MOUSE
Accessionⁱ	Q8K1S4Primary (citable) accession number: Q8K1S4 Secondary accession number(s): Q6PEF7, Q80T71
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
	Last sequence update:	October 1, 2002
	Last modified:	March 28, 2018
	This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8K1S4 (UNC5A_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Netrin receptor UNC5A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Cytosol

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ