UniProtKB - Q8K1S4 (UNC5A_MOUSE)
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Protein
Netrin receptor UNC5A
Gene
Unc5a
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.By similarity
GO - Molecular functioni
- netrin receptor activity Source: InterPro
GO - Biological processi
- anterior/posterior axon guidance Source: MGI
- apoptotic process Source: UniProtKB-KW
- netrin-activated signaling pathway Source: UniProtKB
- neuron projection development Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, Receptor |
Biological process | Apoptosis |
Enzyme and pathway databases
Reactomei | R-MMU-373752. Netrin-1 signaling. |
Names & Taxonomyi
Protein namesi | Recommended name: Netrin receptor UNC5AAlternative name(s): Protein unc-5 homolog 1 Protein unc-5 homolog A |
Gene namesi | Name:Unc5a Synonyms:Kiaa1976, Unc5h1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:894682. Unc5a. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 361 | ExtracellularSequence analysisAdd BLAST | 336 | |
Transmembranei | 362 – 382 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 383 – 898 | CytoplasmicSequence analysisAdd BLAST | 516 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000036069 | 26 – 898 | Netrin receptor UNC5AAdd BLAST | 873 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 65 ↔ 126 | By similarity | ||
Disulfide bondi | 77 ↔ 124 | By similarity | ||
Glycosylationi | 107 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 170 ↔ 221 | By similarity | ||
Glycosylationi | 218 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 254 ↔ 291 | By similarity | ||
Disulfide bondi | 258 ↔ 295 | By similarity | ||
Disulfide bondi | 269 ↔ 281 | By similarity | ||
Disulfide bondi | 310 ↔ 344 | By similarity | ||
Disulfide bondi | 314 ↔ 349 | By similarity | ||
Disulfide bondi | 322 ↔ 334 | By similarity | ||
Glycosylationi | 343 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Phosphorylated on cytoplasmic tyrosine residues (By similarity). Phosphorylated by PKC in vitro (By similarity).By similarity
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 396 – 397 | Cleavage; by caspase-3By similarity | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q8K1S4. |
PRIDEi | Q8K1S4. |
PTM databases
iPTMneti | Q8K1S4. |
PhosphoSitePlusi | Q8K1S4. |
Expressioni
Tissue specificityi
Restricted to central nervous system.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000025876. |
CleanExi | MM_UNC5A. |
ExpressionAtlasi | Q8K1S4. baseline and differential. |
Genevisiblei | Q8K1S4. MM. |
Interactioni
Subunit structurei
Homodimer and homooligomer. Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC (By similarity). Interacts (via extracellular domain) with FLRT2 (via extracellular domain) (PubMed:25374360). Interacts (via extracellular domain) with FLRT3 (via extracellular domain) (PubMed:22405201).By similarity2 Publications
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000026994. |
Structurei
3D structure databases
ProteinModelPortali | Q8K1S4. |
SMRi | Q8K1S4. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 141 | Ig-likeAdd BLAST | 98 | |
Domaini | 155 – 234 | Ig-like C2-typeAdd BLAST | 80 | |
Domaini | 242 – 296 | TSP type-1 1PROSITE-ProRule annotationAdd BLAST | 55 | |
Domaini | 298 – 350 | TSP type-1 2PROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 497 – 640 | ZU5PROSITE-ProRule annotationAdd BLAST | 144 | |
Domaini | 817 – 897 | DeathAdd BLAST | 81 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 661 – 679 | Interaction with DCCBy similarityAdd BLAST | 19 |
Domaini
The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis.By similarity
Sequence similaritiesi
Belongs to the unc-5 family.Curated
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1480. Eukaryota. ENOG410XRS6. LUCA. |
GeneTreei | ENSGT00910000144013. |
HOGENOMi | HOG000060306. |
HOVERGENi | HBG056483. |
InParanoidi | Q8K1S4. |
KOi | K07521. |
OMAi | GTSNMTY. |
OrthoDBi | EOG091G040Q. |
PhylomeDBi | Q8K1S4. |
TreeFami | TF316767. |
Family and domain databases
Gene3Di | 2.20.100.10. 2 hits. 2.60.40.10. 2 hits. |
InterProi | View protein in InterPro IPR011029. DEATH-like_dom_sf. IPR000488. Death_domain. IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR000884. TSP1_rpt. IPR036383. TSP1_rpt_sf. IPR037936. UNC5. IPR033772. UPA. IPR000906. ZU5_dom. |
PANTHERi | PTHR12582. PTHR12582. 1 hit. |
Pfami | View protein in Pfam PF00531. Death. 1 hit. PF07679. I-set. 1 hit. PF00090. TSP_1. 2 hits. PF17217. UPA. 1 hit. PF00791. ZU5. 1 hit. |
SMARTi | View protein in SMART SM00005. DEATH. 1 hit. SM00409. IG. 1 hit. SM00209. TSP1. 2 hits. SM00218. ZU5. 1 hit. |
SUPFAMi | SSF47986. SSF47986. 1 hit. SSF48726. SSF48726. 2 hits. SSF82895. SSF82895. 2 hits. |
PROSITEi | View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS50092. TSP1. 2 hits. PS51145. ZU5. 1 hit. |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8K1S4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MAVRPGLWPA LLGIVLTAWL RGSGAQQSAT VANPVPGANP DLLPHFLVEP
60 70 80 90 100
EDVYIVKNKP VLLVCKAVPA TQIFFKCNGE WVRQVDHVIE RSTDGSSGLP
110 120 130 140 150
TMEVRINVSR QQVEKVFGLE EYWCQCVAWS SSGTTKSQKA YIRIAYLRKN
160 170 180 190 200
FEQEPLAKEV SLEQGIVLPC RPPEGIPPAE VEWLRNEDLV DPSLDPNVYI
210 220 230 240 250
TREHSLVVRQ ARLADTANYT CVAKNIVARR RSASAAVIVY VNGGWSTWTE
260 270 280 290 300
WSVCSASCGR GWQKRSRSCT NPAPLNGGAF CEGQNVQKTA CATLCPVDGS
310 320 330 340 350
WSPWSKWSAC GLDCTHWRSR ECSDPAPRNG GEECRGADLD TRNCTSDLCL
360 370 380 390 400
HTSSGPEDVA LYIGLVAVAV CLILLLLVLV LIYCRKKEGL DSDVADSSIL
410 420 430 440 450
TSGFQPVSIK PSKADNPHLL TIQPDLSTTT TTYQGSLCPR QDGPSPKFQL
460 470 480 490 500
SNGHLLSPLG SGRHTLHHSS PTSEAEDFVS RLSTQNYFRS LPRGTSNMAY
510 520 530 540 550
GTFNFLGGRL MIPNTGISLL IPPDAIPRGK IYEIYLTLHK PEDVRLPLAG
560 570 580 590 600
CQTLLSPIVS CGPPGVLLTR PVILAMDHCG EPSPDSWSLR LKKQSCEGSW
610 620 630 640 650
EDVLHLGEES PSHLYYCQLE AGACYVFTEQ LGRFALVGEA LSVAATKRLR
660 670 680 690 700
LLLFAPVACT SLEYNIRVYC LHDTHDALKE VVQLEKQLGG QLIQEPRVLH
710 720 730 740 750
FKDSYHNLRL SIHDVPSSLW KSKLLVSYQE IPFYHIWNGT QQYLHCTFTL
760 770 780 790 800
ERVNASTSDL ACKVWVWQVE GDGQSFNINF NITKDTRFAE MLALESEGGV
810 820 830 840 850
PALVGPSAFK IPFLIRQKII TSLDPPCSRG ADWRTLAQKL HLDSHLSFFA
860 870 880 890
SKPSPTAMIL NLWEARHFPN GNLGQLAAAV AGLGQPDAGL FTVSEAEC
Sequence cautioni
The sequence BAC65857 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 217 | A → P in AAH58084 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011696 | 1 – 790 | Missing in isoform 3. 1 PublicationAdd BLAST | 790 | |
Alternative sequenceiVSP_011697 | 241 – 296 | Missing in isoform 2. 1 PublicationAdd BLAST | 56 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ487852 mRNA. Translation: CAD32250.1. AK122575 mRNA. Translation: BAC65857.1. Different initiation. BC058084 mRNA. Translation: AAH58084.1. |
CCDSi | CCDS26537.1. [Q8K1S4-1] CCDS79188.1. [Q8K1S4-2] |
RefSeqi | NP_001298057.1. NM_001311128.1. [Q8K1S4-2] NP_694771.1. NM_153131.3. [Q8K1S4-1] |
UniGenei | Mm.23573. |
Genome annotation databases
Ensembli | ENSMUST00000026994; ENSMUSP00000026994; ENSMUSG00000025876. [Q8K1S4-1] ENSMUST00000109994; ENSMUSP00000105621; ENSMUSG00000025876. [Q8K1S4-2] |
GeneIDi | 107448. |
KEGGi | mmu:107448. |
UCSCi | uc007qpp.1. mouse. [Q8K1S4-1] uc007qpq.1. mouse. [Q8K1S4-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | UNC5A_MOUSE | |
Accessioni | Q8K1S4Primary (citable) accession number: Q8K1S4 Secondary accession number(s): Q6PEF7, Q80T71 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | October 1, 2002 | |
Last modified: | March 28, 2018 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |