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Q8K1S2 (UNC5D_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Netrin receptor UNC5D
Alternative name(s):
Protein unc-5 homolog 4
Protein unc-5 homolog D
Gene names
Name:Unc5d
Synonyms:Unc5h4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length956 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for netrin involved in cell migration. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand By similarity.

Subunit structure

Interacts with the cytoplasmic part of DCC By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Expressed in developing limb and mammary gland. Ref.1

Post-translational modification

Phosphorylated on cytoplasmic tyrosine residues By similarity.

Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis By similarity.

Sequence similarities

Belongs to the unc-5 family.

Contains 1 death domain.

Contains 1 Ig-like (immunoglobulin-like) domain.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 2 TSP type-1 domains.

Contains 1 ZU5 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 956926Netrin receptor UNC5D
PRO_0000036080

Regions

Topological domain31 – 382352Extracellular Potential
Transmembrane383 – 40321Helical; Potential
Topological domain404 – 956553Cytoplasmic Potential
Domain52 – 14998Ig-like
Domain151 – 24292Ig-like C2-type
Domain250 – 30455TSP type-1 1
Domain306 – 35853TSP type-1 2
Domain543 – 648106ZU5
Domain862 – 93978Death
Region706 – 72419Interaction with DCC By similarity

Sites

Site419 – 4202Cleavage; by caspase-3 By similarity

Amino acid modifications

Glycosylation1151N-linked (GlcNAc...) Potential
Glycosylation2261N-linked (GlcNAc...) Potential
Glycosylation3511N-linked (GlcNAc...) Potential
Glycosylation3791N-linked (GlcNAc...) Potential
Disulfide bond73 ↔ 132 By similarity
Disulfide bond178 ↔ 229 By similarity
Disulfide bond262 ↔ 299 By similarity
Disulfide bond266 ↔ 303 By similarity
Disulfide bond277 ↔ 289 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8K1S2 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: DFDF07839C10C68D

FASTA956106,352
        10         20         30         40         50         60 
MGTGAADGSR GARRWLPWLG LFFWAAGAAA ARGADGSEIL PDSIPSAPGT LPHFIEEPED 

        70         80         90        100        110        120 
AYIIKSNPIA LRCKARPAMQ IFFKCNGEWV HQNEHVSEES LDESSGLKVR EVFINVTRQQ 

       130        140        150        160        170        180 
VEDFHGPEDY WCQCVAWSHL GTSKSRKASV RIAYLRKNFE QDPQGREVPI EGMIVLHCRP 

       190        200        210        220        230        240 
PEGVPAAEVE WLKNEEPIDS EQDENIDTRA DHNLIIRQAR LSDSGNYTCM AANIVAKRRS 

       250        260        270        280        290        300 
LSATVVVYVN GGWSSWTEWS ACNVRCGRGW QKRSRTCTNP APLNGGAFCE GMSVQKITCT 

       310        320        330        340        350        360 
ALCPVDGSWE VWSEWSVCSP ECEHLRIREC TAPPPRNGGK FCEGLSQESE NCTDGLCILD 

       370        380        390        400        410        420 
KKPLHEIKPQ RWSRRGIENA SDIALYSGLG AAVVAVAVLV IGVTLYRRSH SDYGVDVIDS 

       430        440        450        460        470        480 
SALTGGFQTF NFKTVRQGNS LLLNPAMQPD LTVSRTYSGP ICLQDPLDKE LMTESSLFNP 

       490        500        510        520        530        540 
LSDIKVKVQS SFMVSLGVSE RAEYHGKNHS GTFPHGNNRG FSTIHPRNKT PYIQNLSSLP 

       550        560        570        580        590        600 
TRTELRTTGV FGHLGGRLVM PNTGVSLLIP HGAIPEENSW EIYMSINQGE PSLQSDGSEV 

       610        620        630        640        650        660 
LLSPEVTCGP PDMLVTTPFA LTIPHCADVS SEHWNIHLKK RTQQGKWEEV MSVEDESTSC 

       670        680        690        700        710        720 
YCLLDPFACH VLLDSFGTYA LTGEPITDCA VKQLKVAVFG CMSCNSLDYN LRVYCVDNTP 

       730        740        750        760        770        780 
CAFQEVISDE RHQGGQLLEE PKLLHFKGNT FSLQVSVLDI PPFLWRIKPF TACQEVPFSR 

       790        800        810        820        830        840 
VWSSNRQPLH CAFSLERYTP TTTQLSCKIC IRQLKGHEQI LQVQTSILES ERETITFFAQ 

       850        860        870        880        890        900 
EDSTFPAQTG PKAFKIPYSI RQRICATFDT PNAKGKDWQM LAQKNSINRN LSYFATQSSP 

       910        920        930        940        950 
SAVILNLWEA RHQQDGDLDS LACALEEIGR THTKLSNITE PQIDDADFNY SRQNGL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation."
Engelkamp D.
Mech. Dev. 118:191-197(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ487854 mRNA. Translation: CAD32252.1.
BC137615 mRNA. Translation: AAI37616.1.
RefSeqNP_694775.1. NM_153135.3.
UniGeneMm.248433.

3D structure databases

ProteinModelPortalQ8K1S2.
SMRQ8K1S2. Positions 52-247, 249-362, 548-940.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8K1S2.

Proteomic databases

PaxDbQ8K1S2.
PRIDEQ8K1S2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000168630; ENSMUSP00000128521; ENSMUSG00000063626.
GeneID210801.
KEGGmmu:210801.
UCSCuc009liz.2. mouse.

Organism-specific databases

CTD137970.
MGIMGI:2389364. Unc5d.

Phylogenomic databases

eggNOGNOG280313.
GeneTreeENSGT00640000091083.
HOGENOMHOG000060306.
HOVERGENHBG056483.
InParanoidQ8K1S2.
KOK07521.
OMAINQGEPS.
OrthoDBEOG7BGHJX.
PhylomeDBQ8K1S2.
TreeFamTF316767.

Gene expression databases

ArrayExpressQ8K1S2.
BgeeQ8K1S2.
CleanExMM_UNC5D.
GenevestigatorQ8K1S2.

Family and domain databases

Gene3D1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
InterProIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR000884. Thrombospondin_1_rpt.
IPR000906. ZU5.
[Graphical view]
PfamPF00531. Death. 1 hit.
PF07679. I-set. 1 hit.
PF00090. TSP_1. 2 hits.
PF00791. ZU5. 1 hit.
[Graphical view]
SMARTSM00005. DEATH. 1 hit.
SM00408. IGc2. 1 hit.
SM00209. TSP1. 2 hits.
[Graphical view]
SUPFAMSSF47986. SSF47986. 1 hit.
SSF82895. SSF82895. 2 hits.
PROSITEPS50835. IG_LIKE. 1 hit.
PS50092. TSP1. 2 hits.
PS51145. ZU5. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSUNC5D. mouse.
NextBio373061.
PROQ8K1S2.
SOURCESearch...

Entry information

Entry nameUNC5D_MOUSE
AccessionPrimary (citable) accession number: Q8K1S2
Secondary accession number(s): B9EHC0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot