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Q8K1S2

- UNC5D_MOUSE

UniProt

Q8K1S2 - UNC5D_MOUSE

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Protein

Netrin receptor UNC5D

Gene
Unc5d, Unc5h4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for netrin involved in cell migration. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei419 – 4202Cleavage; by caspase-3 By similarity

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. axon guidance Source: MGI
  3. pyramidal neuron differentiation Source: MGI
  4. regulation of neuron migration Source: MGI
  5. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin receptor UNC5D
Alternative name(s):
Protein unc-5 homolog 4
Protein unc-5 homolog D
Gene namesi
Name:Unc5d
Synonyms:Unc5h4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2389364. Unc5d.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 382352Extracellular Reviewed predictionAdd
BLAST
Transmembranei383 – 40321Helical; Reviewed predictionAdd
BLAST
Topological domaini404 – 956553Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed predictionAdd
BLAST
Chaini31 – 956926Netrin receptor UNC5DPRO_0000036080Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi73 ↔ 132 By similarity
Glycosylationi115 – 1151N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi178 ↔ 229 By similarity
Glycosylationi226 – 2261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi262 ↔ 299 By similarity
Disulfide bondi266 ↔ 303 By similarity
Disulfide bondi277 ↔ 289 By similarity
Glycosylationi351 – 3511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi379 – 3791N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylated on cytoplasmic tyrosine residues By similarity.
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8K1S2.
PRIDEiQ8K1S2.

PTM databases

PhosphoSiteiQ8K1S2.

Expressioni

Tissue specificityi

Expressed in developing limb and mammary gland.1 Publication

Gene expression databases

ArrayExpressiQ8K1S2.
BgeeiQ8K1S2.
CleanExiMM_UNC5D.
GenevestigatoriQ8K1S2.

Interactioni

Subunit structurei

Interacts with the cytoplasmic part of DCC By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8K1S2.
SMRiQ8K1S2. Positions 52-247, 249-362, 548-940.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 14998Ig-likeAdd
BLAST
Domaini151 – 24292Ig-like C2-typeAdd
BLAST
Domaini250 – 30455TSP type-1 1Add
BLAST
Domaini306 – 35853TSP type-1 2Add
BLAST
Domaini543 – 648106ZU5Add
BLAST
Domaini862 – 93978DeathAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni706 – 72419Interaction with DCC By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the unc-5 family.
Contains 1 death domain.
Contains 2 TSP type-1 domains.
Contains 1 ZU5 domain.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280313.
GeneTreeiENSGT00640000091083.
HOGENOMiHOG000060306.
HOVERGENiHBG056483.
InParanoidiQ8K1S2.
KOiK07521.
OMAiINQGEPS.
OrthoDBiEOG7BGHJX.
PhylomeDBiQ8K1S2.
TreeFamiTF316767.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR000884. Thrombospondin_1_rpt.
IPR000906. ZU5.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF07679. I-set. 1 hit.
PF00090. TSP_1. 2 hits.
PF00791. ZU5. 1 hit.
[Graphical view]
SMARTiSM00005. DEATH. 1 hit.
SM00408. IGc2. 1 hit.
SM00209. TSP1. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF82895. SSF82895. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50092. TSP1. 2 hits.
PS51145. ZU5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K1S2-1 [UniParc]FASTAAdd to Basket

« Hide

MGTGAADGSR GARRWLPWLG LFFWAAGAAA ARGADGSEIL PDSIPSAPGT    50
LPHFIEEPED AYIIKSNPIA LRCKARPAMQ IFFKCNGEWV HQNEHVSEES 100
LDESSGLKVR EVFINVTRQQ VEDFHGPEDY WCQCVAWSHL GTSKSRKASV 150
RIAYLRKNFE QDPQGREVPI EGMIVLHCRP PEGVPAAEVE WLKNEEPIDS 200
EQDENIDTRA DHNLIIRQAR LSDSGNYTCM AANIVAKRRS LSATVVVYVN 250
GGWSSWTEWS ACNVRCGRGW QKRSRTCTNP APLNGGAFCE GMSVQKITCT 300
ALCPVDGSWE VWSEWSVCSP ECEHLRIREC TAPPPRNGGK FCEGLSQESE 350
NCTDGLCILD KKPLHEIKPQ RWSRRGIENA SDIALYSGLG AAVVAVAVLV 400
IGVTLYRRSH SDYGVDVIDS SALTGGFQTF NFKTVRQGNS LLLNPAMQPD 450
LTVSRTYSGP ICLQDPLDKE LMTESSLFNP LSDIKVKVQS SFMVSLGVSE 500
RAEYHGKNHS GTFPHGNNRG FSTIHPRNKT PYIQNLSSLP TRTELRTTGV 550
FGHLGGRLVM PNTGVSLLIP HGAIPEENSW EIYMSINQGE PSLQSDGSEV 600
LLSPEVTCGP PDMLVTTPFA LTIPHCADVS SEHWNIHLKK RTQQGKWEEV 650
MSVEDESTSC YCLLDPFACH VLLDSFGTYA LTGEPITDCA VKQLKVAVFG 700
CMSCNSLDYN LRVYCVDNTP CAFQEVISDE RHQGGQLLEE PKLLHFKGNT 750
FSLQVSVLDI PPFLWRIKPF TACQEVPFSR VWSSNRQPLH CAFSLERYTP 800
TTTQLSCKIC IRQLKGHEQI LQVQTSILES ERETITFFAQ EDSTFPAQTG 850
PKAFKIPYSI RQRICATFDT PNAKGKDWQM LAQKNSINRN LSYFATQSSP 900
SAVILNLWEA RHQQDGDLDS LACALEEIGR THTKLSNITE PQIDDADFNY 950
SRQNGL 956
Length:956
Mass (Da):106,352
Last modified:October 1, 2002 - v1
Checksum:iDFDF07839C10C68D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ487854 mRNA. Translation: CAD32252.1.
BC137615 mRNA. Translation: AAI37616.1.
CCDSiCCDS40314.1.
RefSeqiNP_694775.1. NM_153135.3.
UniGeneiMm.248433.

Genome annotation databases

EnsembliENSMUST00000168630; ENSMUSP00000128521; ENSMUSG00000063626.
GeneIDi210801.
KEGGimmu:210801.
UCSCiuc009liz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ487854 mRNA. Translation: CAD32252.1 .
BC137615 mRNA. Translation: AAI37616.1 .
CCDSi CCDS40314.1.
RefSeqi NP_694775.1. NM_153135.3.
UniGenei Mm.248433.

3D structure databases

ProteinModelPortali Q8K1S2.
SMRi Q8K1S2. Positions 52-247, 249-362, 548-940.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8K1S2.

Proteomic databases

PaxDbi Q8K1S2.
PRIDEi Q8K1S2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000168630 ; ENSMUSP00000128521 ; ENSMUSG00000063626 .
GeneIDi 210801.
KEGGi mmu:210801.
UCSCi uc009liz.2. mouse.

Organism-specific databases

CTDi 137970.
MGIi MGI:2389364. Unc5d.

Phylogenomic databases

eggNOGi NOG280313.
GeneTreei ENSGT00640000091083.
HOGENOMi HOG000060306.
HOVERGENi HBG056483.
InParanoidi Q8K1S2.
KOi K07521.
OMAi INQGEPS.
OrthoDBi EOG7BGHJX.
PhylomeDBi Q8K1S2.
TreeFami TF316767.

Miscellaneous databases

ChiTaRSi UNC5D. mouse.
NextBioi 373061.
PROi Q8K1S2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8K1S2.
Bgeei Q8K1S2.
CleanExi MM_UNC5D.
Genevestigatori Q8K1S2.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
InterProi IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR000884. Thrombospondin_1_rpt.
IPR000906. ZU5.
[Graphical view ]
Pfami PF00531. Death. 1 hit.
PF07679. I-set. 1 hit.
PF00090. TSP_1. 2 hits.
PF00791. ZU5. 1 hit.
[Graphical view ]
SMARTi SM00005. DEATH. 1 hit.
SM00408. IGc2. 1 hit.
SM00209. TSP1. 2 hits.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
SSF82895. SSF82895. 2 hits.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS50092. TSP1. 2 hits.
PS51145. ZU5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation."
    Engelkamp D.
    Mech. Dev. 118:191-197(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiUNC5D_MOUSE
AccessioniPrimary (citable) accession number: Q8K1S2
Secondary accession number(s): B9EHC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi