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Protein

Netrin receptor UNC5D

Gene

Unc5d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for netrin involved in cell migration. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei419 – 4202Cleavage; by caspase-3By similarity

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • axon guidance Source: MGI
  • pyramidal neuron differentiation Source: MGI
  • regulation of neuron migration Source: MGI
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiREACT_337259. Netrin mediated repulsion signals.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin receptor UNC5D
Alternative name(s):
Protein unc-5 homolog 4
Protein unc-5 homolog D
Gene namesi
Name:Unc5d
Synonyms:Unc5h4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2389364. Unc5d.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 382352ExtracellularSequence AnalysisAdd
BLAST
Transmembranei383 – 40321HelicalSequence AnalysisAdd
BLAST
Topological domaini404 – 956553CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 956926Netrin receptor UNC5DPRO_0000036080Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi73 ↔ 132By similarity
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi178 ↔ 229By similarity
Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi262 ↔ 299By similarity
Disulfide bondi266 ↔ 303By similarity
Disulfide bondi277 ↔ 289By similarity
Glycosylationi351 – 3511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated on cytoplasmic tyrosine residues.By similarity
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8K1S2.
PaxDbiQ8K1S2.
PRIDEiQ8K1S2.

PTM databases

PhosphoSiteiQ8K1S2.

Expressioni

Tissue specificityi

Expressed in developing limb and mammary gland.1 Publication

Gene expression databases

BgeeiQ8K1S2.
CleanExiMM_UNC5D.
ExpressionAtlasiQ8K1S2. baseline and differential.
GenevisibleiQ8K1S2. MM.

Interactioni

Subunit structurei

Interacts with the cytoplasmic part of DCC.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128521.

Structurei

3D structure databases

ProteinModelPortaliQ8K1S2.
SMRiQ8K1S2. Positions 50-362, 548-940.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 14998Ig-likeAdd
BLAST
Domaini151 – 24292Ig-like C2-typeAdd
BLAST
Domaini250 – 30455TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini306 – 35853TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini543 – 648106ZU5PROSITE-ProRule annotationAdd
BLAST
Domaini862 – 93978DeathAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni706 – 72419Interaction with DCCBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the unc-5 family.Curated
Contains 1 death domain.Curated
Contains 2 TSP type-1 domains.PROSITE-ProRule annotation
Contains 1 ZU5 domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280313.
GeneTreeiENSGT00800000124017.
HOGENOMiHOG000060306.
HOVERGENiHBG056483.
InParanoidiQ8K1S2.
KOiK07521.
OMAiINQGEPS.
OrthoDBiEOG7BGHJX.
PhylomeDBiQ8K1S2.
TreeFamiTF316767.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR000884. Thrombospondin_1_rpt.
IPR000906. ZU5_dom.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF07679. I-set. 1 hit.
PF00090. TSP_1. 2 hits.
PF00791. ZU5. 1 hit.
[Graphical view]
SMARTiSM00005. DEATH. 1 hit.
SM00408. IGc2. 1 hit.
SM00209. TSP1. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF82895. SSF82895. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50092. TSP1. 2 hits.
PS51145. ZU5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K1S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTGAADGSR GARRWLPWLG LFFWAAGAAA ARGADGSEIL PDSIPSAPGT
60 70 80 90 100
LPHFIEEPED AYIIKSNPIA LRCKARPAMQ IFFKCNGEWV HQNEHVSEES
110 120 130 140 150
LDESSGLKVR EVFINVTRQQ VEDFHGPEDY WCQCVAWSHL GTSKSRKASV
160 170 180 190 200
RIAYLRKNFE QDPQGREVPI EGMIVLHCRP PEGVPAAEVE WLKNEEPIDS
210 220 230 240 250
EQDENIDTRA DHNLIIRQAR LSDSGNYTCM AANIVAKRRS LSATVVVYVN
260 270 280 290 300
GGWSSWTEWS ACNVRCGRGW QKRSRTCTNP APLNGGAFCE GMSVQKITCT
310 320 330 340 350
ALCPVDGSWE VWSEWSVCSP ECEHLRIREC TAPPPRNGGK FCEGLSQESE
360 370 380 390 400
NCTDGLCILD KKPLHEIKPQ RWSRRGIENA SDIALYSGLG AAVVAVAVLV
410 420 430 440 450
IGVTLYRRSH SDYGVDVIDS SALTGGFQTF NFKTVRQGNS LLLNPAMQPD
460 470 480 490 500
LTVSRTYSGP ICLQDPLDKE LMTESSLFNP LSDIKVKVQS SFMVSLGVSE
510 520 530 540 550
RAEYHGKNHS GTFPHGNNRG FSTIHPRNKT PYIQNLSSLP TRTELRTTGV
560 570 580 590 600
FGHLGGRLVM PNTGVSLLIP HGAIPEENSW EIYMSINQGE PSLQSDGSEV
610 620 630 640 650
LLSPEVTCGP PDMLVTTPFA LTIPHCADVS SEHWNIHLKK RTQQGKWEEV
660 670 680 690 700
MSVEDESTSC YCLLDPFACH VLLDSFGTYA LTGEPITDCA VKQLKVAVFG
710 720 730 740 750
CMSCNSLDYN LRVYCVDNTP CAFQEVISDE RHQGGQLLEE PKLLHFKGNT
760 770 780 790 800
FSLQVSVLDI PPFLWRIKPF TACQEVPFSR VWSSNRQPLH CAFSLERYTP
810 820 830 840 850
TTTQLSCKIC IRQLKGHEQI LQVQTSILES ERETITFFAQ EDSTFPAQTG
860 870 880 890 900
PKAFKIPYSI RQRICATFDT PNAKGKDWQM LAQKNSINRN LSYFATQSSP
910 920 930 940 950
SAVILNLWEA RHQQDGDLDS LACALEEIGR THTKLSNITE PQIDDADFNY

SRQNGL
Length:956
Mass (Da):106,352
Last modified:October 1, 2002 - v1
Checksum:iDFDF07839C10C68D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487854 mRNA. Translation: CAD32252.1.
BC137615 mRNA. Translation: AAI37616.1.
CCDSiCCDS40314.1.
RefSeqiNP_694775.1. NM_153135.3.
UniGeneiMm.248433.

Genome annotation databases

EnsembliENSMUST00000168630; ENSMUSP00000128521; ENSMUSG00000063626.
GeneIDi210801.
KEGGimmu:210801.
UCSCiuc009liz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487854 mRNA. Translation: CAD32252.1.
BC137615 mRNA. Translation: AAI37616.1.
CCDSiCCDS40314.1.
RefSeqiNP_694775.1. NM_153135.3.
UniGeneiMm.248433.

3D structure databases

ProteinModelPortaliQ8K1S2.
SMRiQ8K1S2. Positions 50-362, 548-940.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128521.

Protein family/group databases

MEROPSiI43.001.

PTM databases

PhosphoSiteiQ8K1S2.

Proteomic databases

MaxQBiQ8K1S2.
PaxDbiQ8K1S2.
PRIDEiQ8K1S2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000168630; ENSMUSP00000128521; ENSMUSG00000063626.
GeneIDi210801.
KEGGimmu:210801.
UCSCiuc009liz.2. mouse.

Organism-specific databases

CTDi137970.
MGIiMGI:2389364. Unc5d.

Phylogenomic databases

eggNOGiNOG280313.
GeneTreeiENSGT00800000124017.
HOGENOMiHOG000060306.
HOVERGENiHBG056483.
InParanoidiQ8K1S2.
KOiK07521.
OMAiINQGEPS.
OrthoDBiEOG7BGHJX.
PhylomeDBiQ8K1S2.
TreeFamiTF316767.

Enzyme and pathway databases

ReactomeiREACT_337259. Netrin mediated repulsion signals.

Miscellaneous databases

ChiTaRSiUnc5d. mouse.
NextBioi373061.
PROiQ8K1S2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K1S2.
CleanExiMM_UNC5D.
ExpressionAtlasiQ8K1S2. baseline and differential.
GenevisibleiQ8K1S2. MM.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR000884. Thrombospondin_1_rpt.
IPR000906. ZU5_dom.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF07679. I-set. 1 hit.
PF00090. TSP_1. 2 hits.
PF00791. ZU5. 1 hit.
[Graphical view]
SMARTiSM00005. DEATH. 1 hit.
SM00408. IGc2. 1 hit.
SM00209. TSP1. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF82895. SSF82895. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50092. TSP1. 2 hits.
PS51145. ZU5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation."
    Engelkamp D.
    Mech. Dev. 118:191-197(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiUNC5D_MOUSE
AccessioniPrimary (citable) accession number: Q8K1S2
Secondary accession number(s): B9EHC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.