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Q8K1S2

- UNC5D_MOUSE

UniProt

Q8K1S2 - UNC5D_MOUSE

Protein

Netrin receptor UNC5D

Gene

Unc5d

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Receptor for netrin involved in cell migration. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei419 – 4202Cleavage; by caspase-3By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. axon guidance Source: MGI
    3. pyramidal neuron differentiation Source: MGI
    4. regulation of neuron migration Source: MGI
    5. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Netrin receptor UNC5D
    Alternative name(s):
    Protein unc-5 homolog 4
    Protein unc-5 homolog D
    Gene namesi
    Name:Unc5d
    Synonyms:Unc5h4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2389364. Unc5d.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 956926Netrin receptor UNC5DPRO_0000036080Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi73 ↔ 132By similarity
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi178 ↔ 229By similarity
    Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi262 ↔ 299By similarity
    Disulfide bondi266 ↔ 303By similarity
    Disulfide bondi277 ↔ 289By similarity
    Glycosylationi351 – 3511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated on cytoplasmic tyrosine residues.By similarity
    Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ8K1S2.
    PRIDEiQ8K1S2.

    PTM databases

    PhosphoSiteiQ8K1S2.

    Expressioni

    Tissue specificityi

    Expressed in developing limb and mammary gland.1 Publication

    Gene expression databases

    ArrayExpressiQ8K1S2.
    BgeeiQ8K1S2.
    CleanExiMM_UNC5D.
    GenevestigatoriQ8K1S2.

    Interactioni

    Subunit structurei

    Interacts with the cytoplasmic part of DCC.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K1S2.
    SMRiQ8K1S2. Positions 52-247, 249-362, 548-940.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 382352ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini404 – 956553CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei383 – 40321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 14998Ig-likeAdd
    BLAST
    Domaini151 – 24292Ig-like C2-typeAdd
    BLAST
    Domaini250 – 30455TSP type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini306 – 35853TSP type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini543 – 648106ZU5PROSITE-ProRule annotationAdd
    BLAST
    Domaini862 – 93978DeathAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni706 – 72419Interaction with DCCBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the unc-5 family.Curated
    Contains 1 death domain.Curated
    Contains 2 TSP type-1 domains.PROSITE-ProRule annotation
    Contains 1 ZU5 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG280313.
    GeneTreeiENSGT00640000091083.
    HOGENOMiHOG000060306.
    HOVERGENiHBG056483.
    InParanoidiQ8K1S2.
    KOiK07521.
    OMAiINQGEPS.
    OrthoDBiEOG7BGHJX.
    PhylomeDBiQ8K1S2.
    TreeFamiTF316767.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    2.60.40.10. 2 hits.
    InterProiIPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR000884. Thrombospondin_1_rpt.
    IPR000906. ZU5.
    [Graphical view]
    PfamiPF00531. Death. 1 hit.
    PF07679. I-set. 1 hit.
    PF00090. TSP_1. 2 hits.
    PF00791. ZU5. 1 hit.
    [Graphical view]
    SMARTiSM00005. DEATH. 1 hit.
    SM00408. IGc2. 1 hit.
    SM00209. TSP1. 2 hits.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    SSF82895. SSF82895. 2 hits.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS50092. TSP1. 2 hits.
    PS51145. ZU5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8K1S2-1 [UniParc]FASTAAdd to Basket

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    MGTGAADGSR GARRWLPWLG LFFWAAGAAA ARGADGSEIL PDSIPSAPGT    50
    LPHFIEEPED AYIIKSNPIA LRCKARPAMQ IFFKCNGEWV HQNEHVSEES 100
    LDESSGLKVR EVFINVTRQQ VEDFHGPEDY WCQCVAWSHL GTSKSRKASV 150
    RIAYLRKNFE QDPQGREVPI EGMIVLHCRP PEGVPAAEVE WLKNEEPIDS 200
    EQDENIDTRA DHNLIIRQAR LSDSGNYTCM AANIVAKRRS LSATVVVYVN 250
    GGWSSWTEWS ACNVRCGRGW QKRSRTCTNP APLNGGAFCE GMSVQKITCT 300
    ALCPVDGSWE VWSEWSVCSP ECEHLRIREC TAPPPRNGGK FCEGLSQESE 350
    NCTDGLCILD KKPLHEIKPQ RWSRRGIENA SDIALYSGLG AAVVAVAVLV 400
    IGVTLYRRSH SDYGVDVIDS SALTGGFQTF NFKTVRQGNS LLLNPAMQPD 450
    LTVSRTYSGP ICLQDPLDKE LMTESSLFNP LSDIKVKVQS SFMVSLGVSE 500
    RAEYHGKNHS GTFPHGNNRG FSTIHPRNKT PYIQNLSSLP TRTELRTTGV 550
    FGHLGGRLVM PNTGVSLLIP HGAIPEENSW EIYMSINQGE PSLQSDGSEV 600
    LLSPEVTCGP PDMLVTTPFA LTIPHCADVS SEHWNIHLKK RTQQGKWEEV 650
    MSVEDESTSC YCLLDPFACH VLLDSFGTYA LTGEPITDCA VKQLKVAVFG 700
    CMSCNSLDYN LRVYCVDNTP CAFQEVISDE RHQGGQLLEE PKLLHFKGNT 750
    FSLQVSVLDI PPFLWRIKPF TACQEVPFSR VWSSNRQPLH CAFSLERYTP 800
    TTTQLSCKIC IRQLKGHEQI LQVQTSILES ERETITFFAQ EDSTFPAQTG 850
    PKAFKIPYSI RQRICATFDT PNAKGKDWQM LAQKNSINRN LSYFATQSSP 900
    SAVILNLWEA RHQQDGDLDS LACALEEIGR THTKLSNITE PQIDDADFNY 950
    SRQNGL 956
    Length:956
    Mass (Da):106,352
    Last modified:October 1, 2002 - v1
    Checksum:iDFDF07839C10C68D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ487854 mRNA. Translation: CAD32252.1.
    BC137615 mRNA. Translation: AAI37616.1.
    CCDSiCCDS40314.1.
    RefSeqiNP_694775.1. NM_153135.3.
    UniGeneiMm.248433.

    Genome annotation databases

    EnsembliENSMUST00000168630; ENSMUSP00000128521; ENSMUSG00000063626.
    GeneIDi210801.
    KEGGimmu:210801.
    UCSCiuc009liz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ487854 mRNA. Translation: CAD32252.1 .
    BC137615 mRNA. Translation: AAI37616.1 .
    CCDSi CCDS40314.1.
    RefSeqi NP_694775.1. NM_153135.3.
    UniGenei Mm.248433.

    3D structure databases

    ProteinModelPortali Q8K1S2.
    SMRi Q8K1S2. Positions 52-247, 249-362, 548-940.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8K1S2.

    Proteomic databases

    PaxDbi Q8K1S2.
    PRIDEi Q8K1S2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000168630 ; ENSMUSP00000128521 ; ENSMUSG00000063626 .
    GeneIDi 210801.
    KEGGi mmu:210801.
    UCSCi uc009liz.2. mouse.

    Organism-specific databases

    CTDi 137970.
    MGIi MGI:2389364. Unc5d.

    Phylogenomic databases

    eggNOGi NOG280313.
    GeneTreei ENSGT00640000091083.
    HOGENOMi HOG000060306.
    HOVERGENi HBG056483.
    InParanoidi Q8K1S2.
    KOi K07521.
    OMAi INQGEPS.
    OrthoDBi EOG7BGHJX.
    PhylomeDBi Q8K1S2.
    TreeFami TF316767.

    Miscellaneous databases

    ChiTaRSi UNC5D. mouse.
    NextBioi 373061.
    PROi Q8K1S2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K1S2.
    Bgeei Q8K1S2.
    CleanExi MM_UNC5D.
    Genevestigatori Q8K1S2.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    2.60.40.10. 2 hits.
    InterProi IPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR000884. Thrombospondin_1_rpt.
    IPR000906. ZU5.
    [Graphical view ]
    Pfami PF00531. Death. 1 hit.
    PF07679. I-set. 1 hit.
    PF00090. TSP_1. 2 hits.
    PF00791. ZU5. 1 hit.
    [Graphical view ]
    SMARTi SM00005. DEATH. 1 hit.
    SM00408. IGc2. 1 hit.
    SM00209. TSP1. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    SSF82895. SSF82895. 2 hits.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS50092. TSP1. 2 hits.
    PS51145. ZU5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation."
      Engelkamp D.
      Mech. Dev. 118:191-197(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiUNC5D_MOUSE
    AccessioniPrimary (citable) accession number: Q8K1S2
    Secondary accession number(s): B9EHC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3