Netrin receptor UNC5D precursor - Mus musculus (Mouse)

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Q8K1S2 (UNC5D_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 84. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Netrin receptor UNC5D

Alternative name(s):
Protein unc-5 homolog 4
Protein unc-5 homolog D

Gene names

Name:	Unc5d
Synonyms:	Unc5h4

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	956 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for netrin involved in cell migration. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand By similarity.
Subunit structure	Interacts with the cytoplasmic part of DCC By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Tissue specificity	Expressed in developing limb and mammary gland. Ref.1
Post-translational modification	Phosphorylated on cytoplasmic tyrosine residues By similarity. Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis By similarity.
Sequence similarities	Belongs to the unc-5 family. Contains 1 death domain. Contains 1 Ig-like (immunoglobulin-like) domain. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 2 TSP type-1 domains. Contains 1 ZU5 domain.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Membrane
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Developmental protein Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cell surface Inferred from direct assay PubMed 18547816. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 30

Potential

Chain

31 – 956

926

Netrin receptor UNC5D

PRO_0000036080

Regions

Topological domain

31 – 382

352

Extracellular Potential

Transmembrane

383 – 403

Helical; Potential

Topological domain

404 – 956

553

Cytoplasmic Potential

Domain

52 – 149

Ig-like

Domain

151 – 242

Ig-like C2-type

Domain

250 – 304

TSP type-1 1

Domain

306 – 358

TSP type-1 2

Domain

543 – 648

106

ZU5

Domain

862 – 939

Death

Region

706 – 724

Interaction with DCC By similarity

Sites

Site

419 – 420

Cleavage; by caspase-3 By similarity

Amino acid modifications

Glycosylation

115

N-linked (GlcNAc...) Potential

Glycosylation

226

N-linked (GlcNAc...) Potential

Glycosylation

351

N-linked (GlcNAc...) Potential

Glycosylation

379

N-linked (GlcNAc...) Potential

Disulfide bond

73 ↔ 132

By similarity

Disulfide bond

178 ↔ 229

By similarity

Disulfide bond

262 ↔ 299

By similarity

Disulfide bond

266 ↔ 303

By similarity

Disulfide bond

277 ↔ 289

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q8K1S2 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: DFDF07839C10C68D
Show »

FASTA

956

106,352

        10         20         30         40         50         60 
MGTGAADGSR GARRWLPWLG LFFWAAGAAA ARGADGSEIL PDSIPSAPGT LPHFIEEPED 

        70         80         90        100        110        120 
AYIIKSNPIA LRCKARPAMQ IFFKCNGEWV HQNEHVSEES LDESSGLKVR EVFINVTRQQ 

       130        140        150        160        170        180 
VEDFHGPEDY WCQCVAWSHL GTSKSRKASV RIAYLRKNFE QDPQGREVPI EGMIVLHCRP 

       190        200        210        220        230        240 
PEGVPAAEVE WLKNEEPIDS EQDENIDTRA DHNLIIRQAR LSDSGNYTCM AANIVAKRRS 

       250        260        270        280        290        300 
LSATVVVYVN GGWSSWTEWS ACNVRCGRGW QKRSRTCTNP APLNGGAFCE GMSVQKITCT 

       310        320        330        340        350        360 
ALCPVDGSWE VWSEWSVCSP ECEHLRIREC TAPPPRNGGK FCEGLSQESE NCTDGLCILD 

       370        380        390        400        410        420 
KKPLHEIKPQ RWSRRGIENA SDIALYSGLG AAVVAVAVLV IGVTLYRRSH SDYGVDVIDS 

       430        440        450        460        470        480 
SALTGGFQTF NFKTVRQGNS LLLNPAMQPD LTVSRTYSGP ICLQDPLDKE LMTESSLFNP 

       490        500        510        520        530        540 
LSDIKVKVQS SFMVSLGVSE RAEYHGKNHS GTFPHGNNRG FSTIHPRNKT PYIQNLSSLP 

       550        560        570        580        590        600 
TRTELRTTGV FGHLGGRLVM PNTGVSLLIP HGAIPEENSW EIYMSINQGE PSLQSDGSEV 

       610        620        630        640        650        660 
LLSPEVTCGP PDMLVTTPFA LTIPHCADVS SEHWNIHLKK RTQQGKWEEV MSVEDESTSC 

       670        680        690        700        710        720 
YCLLDPFACH VLLDSFGTYA LTGEPITDCA VKQLKVAVFG CMSCNSLDYN LRVYCVDNTP 

       730        740        750        760        770        780 
CAFQEVISDE RHQGGQLLEE PKLLHFKGNT FSLQVSVLDI PPFLWRIKPF TACQEVPFSR 

       790        800        810        820        830        840 
VWSSNRQPLH CAFSLERYTP TTTQLSCKIC IRQLKGHEQI LQVQTSILES ERETITFFAQ 

       850        860        870        880        890        900 
EDSTFPAQTG PKAFKIPYSI RQRICATFDT PNAKGKDWQM LAQKNSINRN LSYFATQSSP 

       910        920        930        940        950 
SAVILNLWEA RHQQDGDLDS LACALEEIGR THTKLSNITE PQIDDADFNY SRQNGL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation." Engelkamp D. Mech. Dev. 118:191-197(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ487854 mRNA. Translation: CAD32252.1. BC137615 mRNA. Translation: AAI37616.1.
IPI	IPI00470031.
RefSeq	NP_694775.1. NM_153135.3.
UniGene	Mm.248433.
3D structure databases
ProteinModelPortal	Q8K1S2.
SMR	Q8K1S2. Positions 52-247, 249-362, 548-940.
ModBase	Search...
PTM databases
PhosphoSite	Q8K1S2.
Proteomic databases
PaxDb	Q8K1S2.
PRIDE	Q8K1S2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000168630; ENSMUSP00000128521; ENSMUSG00000063626.
GeneID	210801.
KEGG	mmu:210801.
UCSC	uc009liz.2. mouse.
Organism-specific databases
CTD	137970.
MGI	MGI:2389364. Unc5d.
Phylogenomic databases
eggNOG	NOG280313.
GeneTree	ENSGT00640000091083.
HOGENOM	HOG000060306.
HOVERGEN	HBG056483.
InParanoid	Q8K1S2.
KO	K07521.
OMA	INQGEPS.
OrthoDB	EOG4NCMC0.
Gene expression databases
ArrayExpress	Q8K1S2.
Bgee	Q8K1S2.
CleanEx	MM_UNC5D.
Genevestigator	Q8K1S2.
Family and domain databases
Gene3D	1.10.533.10. 1 hit. 2.60.40.10. 2 hits.
InterPro	IPR011029. DEATH-like_dom. IPR000488. Death_domain. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. IPR000884. Thrombospondin_1_rpt. IPR000906. ZU5. [Graphical view]
Pfam	PF00531. Death. 1 hit. PF07679. I-set. 1 hit. PF00090. TSP_1. 2 hits. PF00791. ZU5. 1 hit. [Graphical view]
SMART	SM00005. DEATH. 1 hit. SM00408. IGc2. 1 hit. SM00209. TSP1. 2 hits. [Graphical view]
SUPFAM	SSF47986. DEATH_like. 1 hit. SSF82895. TSP1. 2 hits.
PROSITE	PS50017. DEATH_DOMAIN. False negative. PS50835. IG_LIKE. 1 hit. PS50092. TSP1. 2 hits. PS51145. ZU5. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	UNC5D. mouse.
NextBio	373061.
SOURCE	Search...

Entry information

Entry name

UNC5D_MOUSE

Accession

Primary (citable) accession number: Q8K1S2
Secondary accession number(s): B9EHC0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents