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Q8K1Q3

- GPR3_RAT

UniProt

Q8K1Q3 - GPR3_RAT

Protein

G-protein coupled receptor 3

Gene

Gpr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress By similarity, amyloid-beta peptide generation in neurons By similarity and neurite outgrowth. Maintains also meiotic arrest in oocytes By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. positive regulation of cAMP metabolic process Source: RGD
    2. positive regulation of cytosolic calcium ion concentration Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 3
    Alternative name(s):
    G-protein-coupled receptor R4
    Gene namesi
    Name:Gpr3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi628686. Gpr3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 329329G-protein coupled receptor 3PRO_0000379597Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
    Lipidationi312 – 3121S-palmitoyl cysteineBy similarity
    Modified residuei323 – 3231PhosphoserineSequence Analysis
    Modified residuei325 – 3251PhosphoserineSequence Analysis
    Modified residuei327 – 3271PhosphoserineSequence Analysis

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Expressioni

    Tissue specificityi

    Abundantly expressed in granule neurons at all development stages.1 Publication

    Gene expression databases

    GenevestigatoriQ8K1Q3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K1Q3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini65 – 739CytoplasmicSequence Analysis
    Topological domaini95 – 10814ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini130 – 15324CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini175 – 19218ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini214 – 24734CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini269 – 2779ExtracellularSequence Analysis
    Topological domaini299 – 32931CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei74 – 9421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei193 – 21321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 26821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi311 – 3144Poly-Cys

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320944.
    HOGENOMiHOG000294075.
    KOiK04311.
    PhylomeDBiQ8K1Q3.
    TreeFamiTF330052.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000984. GPR3.
    IPR000723. GPR_3/6/12_orphan.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00648. GPR3ORPHANR.
    PR00644. GPRORPHANR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K1Q3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMWGAGRSMA WFSAGSGSVN VSIDPAEEPT GPATLLPSPR AWDVVLCISG    50
    TLVSCENALV VAIIVGTPAF RAPMFLLVGS LAVADLLAGL GLVLHFAADF 100
    CIGSPEMSLV LVGVLATAFT ASIGSLLAIT VDRYLSLYNA LTYYSETTVT 150
    RTYVMLALVW VGALGLGLVP VLAWNCRDGL TTCGVVYPLS KNHLVVLAIV 200
    FFMVFGIMLQ LYAQICRIVC RHAQQIALQR HLLPASHYVA TRKGIATLAV 250
    VLGAFAACWL PFTVYCLLGD ANSPPLYTYL TLLPATYNSM INPVIYAFRN 300
    QDVQKVLWAI CCCCSTSKIP FRSRSPSDV 329
    Length:329
    Mass (Da):35,327
    Last modified:July 28, 2009 - v2
    Checksum:i96E347B2059BD85A
    GO

    Sequence cautioni

    The sequence CAD20634.1 differs from that shown. Reason: Frameshift at positions 210, 224 and 225.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti61 – 611V → M in AAA73559. (PubMed:7698767)Curated
    Sequence conflicti117 – 1171T → M in AAA73559. (PubMed:7698767)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473968 Genomic DNA. Translation: EDL80660.1.
    L32829 mRNA. Translation: AAA73559.1.
    AJ427482 mRNA. Translation: CAD20634.1. Frameshift.
    RefSeqiNP_714949.1. NM_153727.1.
    XP_006239068.1. XM_006239006.1.
    XP_006239069.1. XM_006239007.1.
    XP_006239070.1. XM_006239008.1.
    UniGeneiRn.83629.

    Genome annotation databases

    GeneIDi266769.
    KEGGirno:266769.
    UCSCiRGD:628686. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473968 Genomic DNA. Translation: EDL80660.1 .
    L32829 mRNA. Translation: AAA73559.1 .
    AJ427482 mRNA. Translation: CAD20634.1 . Frameshift.
    RefSeqi NP_714949.1. NM_153727.1.
    XP_006239068.1. XM_006239006.1.
    XP_006239069.1. XM_006239007.1.
    XP_006239070.1. XM_006239008.1.
    UniGenei Rn.83629.

    3D structure databases

    ProteinModelPortali Q8K1Q3.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 83.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 266769.
    KEGGi rno:266769.
    UCSCi RGD:628686. rat.

    Organism-specific databases

    CTDi 2827.
    RGDi 628686. Gpr3.

    Phylogenomic databases

    eggNOGi NOG320944.
    HOGENOMi HOG000294075.
    KOi K04311.
    PhylomeDBi Q8K1Q3.
    TreeFami TF330052.

    Miscellaneous databases

    NextBioi 624633.
    PROi Q8K1Q3.

    Gene expression databases

    Genevestigatori Q8K1Q3.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000984. GPR3.
    IPR000723. GPR_3/6/12_orphan.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00648. GPR3ORPHANR.
    PR00644. GPRORPHANR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system."
      Iismaa T.P., Kiefer J., Liu M.L., Baker E., Sutherland G.R., Shine J.
      Genomics 24:391-394(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-117.
      Strain: New England Deaconess Hospital.
      Tissue: Pancreas.
    3. "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors."
      Uhlenbrock K., Gassenhuber J., Kostenis E.
      Cell. Signal. 14:941-953(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-329.
    4. "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth."
      Tanaka S., Ishii K., Kasai K., Yoon S.O., Saeki Y.
      J. Biol. Chem. 282:10506-10515(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiGPR3_RAT
    AccessioniPrimary (citable) accession number: Q8K1Q3
    Secondary accession number(s): Q63230
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3