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Protein

G-protein coupled receptor 3

Gene

Gpr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons (By similarity) and neurite outgrowth. Maintains also meiotic arrest in oocytes (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • positive regulation of cAMP metabolic process Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 3
Alternative name(s):
G-protein-coupled receptor R4
Gene namesi
Name:Gpr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628686. Gpr3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 73CytoplasmicSequence analysis9
Transmembranei74 – 94Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini95 – 108ExtracellularSequence analysisAdd BLAST14
Transmembranei109 – 129Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini130 – 153CytoplasmicSequence analysisAdd BLAST24
Transmembranei154 – 174Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini175 – 192ExtracellularSequence analysisAdd BLAST18
Transmembranei193 – 213Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini214 – 247CytoplasmicSequence analysisAdd BLAST34
Transmembranei248 – 268Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini269 – 277ExtracellularSequence analysis9
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 329CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003795971 – 329G-protein coupled receptor 3Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Lipidationi312S-palmitoyl cysteineBy similarity1
Modified residuei323PhosphoserineSequence analysis1
Modified residuei325PhosphoserineSequence analysis1
Modified residuei327PhosphoserineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

PTM databases

PhosphoSitePlusiQ8K1Q3.

Expressioni

Tissue specificityi

Abundantly expressed in granule neurons at all development stages.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8K1Q3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi311 – 314Poly-Cys4

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000294075.
InParanoidiQ8K1Q3.
KOiK04311.
PhylomeDBiQ8K1Q3.
TreeFamiTF330052.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000984. GPR3.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00648. GPR3ORPHANR.
PR00644. GPRORPHANR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K1Q3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMWGAGRSMA WFSAGSGSVN VSIDPAEEPT GPATLLPSPR AWDVVLCISG
60 70 80 90 100
TLVSCENALV VAIIVGTPAF RAPMFLLVGS LAVADLLAGL GLVLHFAADF
110 120 130 140 150
CIGSPEMSLV LVGVLATAFT ASIGSLLAIT VDRYLSLYNA LTYYSETTVT
160 170 180 190 200
RTYVMLALVW VGALGLGLVP VLAWNCRDGL TTCGVVYPLS KNHLVVLAIV
210 220 230 240 250
FFMVFGIMLQ LYAQICRIVC RHAQQIALQR HLLPASHYVA TRKGIATLAV
260 270 280 290 300
VLGAFAACWL PFTVYCLLGD ANSPPLYTYL TLLPATYNSM INPVIYAFRN
310 320
QDVQKVLWAI CCCCSTSKIP FRSRSPSDV
Length:329
Mass (Da):35,327
Last modified:July 28, 2009 - v2
Checksum:i96E347B2059BD85A
GO

Sequence cautioni

The sequence CAD20634 differs from that shown. Reason: Frameshift at positions 210, 224 and 225.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61V → M in AAA73559 (PubMed:7698767).Curated1
Sequence conflicti117T → M in AAA73559 (PubMed:7698767).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473968 Genomic DNA. Translation: EDL80660.1.
L32829 mRNA. Translation: AAA73559.1.
AJ427482 mRNA. Translation: CAD20634.1. Frameshift.
RefSeqiNP_714949.1. NM_153727.1.
XP_006239068.1. XM_006239006.3.
UniGeneiRn.83629.

Genome annotation databases

GeneIDi266769.
KEGGirno:266769.
UCSCiRGD:628686. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473968 Genomic DNA. Translation: EDL80660.1.
L32829 mRNA. Translation: AAA73559.1.
AJ427482 mRNA. Translation: CAD20634.1. Frameshift.
RefSeqiNP_714949.1. NM_153727.1.
XP_006239068.1. XM_006239006.3.
UniGeneiRn.83629.

3D structure databases

ProteinModelPortaliQ8K1Q3.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8K1Q3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi266769.
KEGGirno:266769.
UCSCiRGD:628686. rat.

Organism-specific databases

CTDi2827.
RGDi628686. Gpr3.

Phylogenomic databases

HOGENOMiHOG000294075.
InParanoidiQ8K1Q3.
KOiK04311.
PhylomeDBiQ8K1Q3.
TreeFamiTF330052.

Miscellaneous databases

PROiQ8K1Q3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000984. GPR3.
IPR000723. GPR_3/6/12_orphan.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00648. GPR3ORPHANR.
PR00644. GPRORPHANR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR3_RAT
AccessioniPrimary (citable) accession number: Q8K1Q3
Secondary accession number(s): Q63230
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 28, 2009
Last modified: November 2, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.