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Protein

Glycylpeptide N-tetradecanoyltransferase 1

Gene

Nmt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.By similarity

Catalytic activityi

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.97. 5301.
ReactomeiR-RNO-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-RNO-75108. Activation, myristolyation of BID and translocation to mitochondria.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferase 1 (EC:2.3.1.97By similarity)
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase 1
Short name:
NMT 1
Short name:
Type I N-myristoyltransferase
Peptide N-myristoyltransferase 1
Gene namesi
Name:Nmt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi628642. Nmt1.

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmcytosol By similarity
  • Membrane By similarity; Peripheral membrane protein By similarity

  • Note: Copurifies with ribosomes.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642241 – 496Glycylpeptide N-tetradecanoyltransferase 1Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineBy similarity1
Modified residuei47PhosphoserineCombined sources1
Modified residuei83PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8K1Q0.
PRIDEiQ8K1Q0.

PTM databases

iPTMnetiQ8K1Q0.
PhosphoSitePlusiQ8K1Q0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002989.
GenevisibleiQ8K1Q0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004046.

Structurei

3D structure databases

ProteinModelPortaliQ8K1Q0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni118 – 120Myristoyl-CoA bindingBy similarity3
Regioni248 – 250Myristoyl-CoA bindingBy similarity3
Regioni256 – 260Myristoyl-CoA bindingBy similarity5

Sequence similaritiesi

Belongs to the NMT family.Curated

Phylogenomic databases

eggNOGiKOG2779. Eukaryota.
COG5092. LUCA.
GeneTreeiENSGT00390000017837.
HOGENOMiHOG000189123.
HOVERGENiHBG003404.
InParanoidiQ8K1Q0.
KOiK00671.
OMAiEMCTEVY.
OrthoDBiEOG091G06JB.
PhylomeDBiQ8K1Q0.
TreeFamiTF300701.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K1Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADESETAVK LPAPSLPLMM EGNGNGHEHC SDCENEEDIS HNRGGLSPAN
60 70 80 90 100
DTGAKKKKKK QKKKKEKGND MDSTQDQPVK MNSLPAERIQ EIQKAIELFS
110 120 130 140 150
VGQGPAKTME EASKRSYQFW DTQPVPKLGE VVNTHGPVEP DKDNIRQEPY
160 170 180 190 200
TLPQGFTWDA LDLGDRGVLK ELYTLLNENY VEDDDNMFRF DYSPEFLLWA
210 220 230 240 250
LRPPGWLPQW HCGVRVVSSR KLVGFISAIP ANIHIYDTEK KMVEINFLCV
260 270 280 290 300
HKKLRSKRVA PVLIREITRR VHLEGIFQAV YTAGVVLPKP VGTCRYWHRS
310 320 330 340 350
LNPRKLIEVK FSHLSRNMTM QRTMKLYRLP ETPKTAGLRP MEKKDIPVVH
360 370 380 390 400
QLLSRYLKQF NLTPVMNQEE VEHWFYPQEN IIDTFVVENA NGEVTDFLSF
410 420 430 440 450
YTLPSTIMNH PTHKSLKAAY SFYNVHTQTP LLDLMSDALV LAKMKGFDVF
460 470 480 490
NALDLMENKT FLEKLKFGIG DGNLQYYLYN WKCPSMGAEK VGLVLQ
Length:496
Mass (Da):56,860
Last modified:October 1, 2002 - v1
Checksum:i3A7EE954E0D0156A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ492222 mRNA. Translation: CAD37349.1.
BC097277 mRNA. Translation: AAH97277.1.
RefSeqiNP_683689.1. NM_148891.2.
UniGeneiRn.830.

Genome annotation databases

EnsembliENSRNOT00000004046; ENSRNOP00000004046; ENSRNOG00000002989.
GeneIDi259274.
KEGGirno:259274.
UCSCiRGD:628642. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ492222 mRNA. Translation: CAD37349.1.
BC097277 mRNA. Translation: AAH97277.1.
RefSeqiNP_683689.1. NM_148891.2.
UniGeneiRn.830.

3D structure databases

ProteinModelPortaliQ8K1Q0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004046.

PTM databases

iPTMnetiQ8K1Q0.
PhosphoSitePlusiQ8K1Q0.

Proteomic databases

PaxDbiQ8K1Q0.
PRIDEiQ8K1Q0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004046; ENSRNOP00000004046; ENSRNOG00000002989.
GeneIDi259274.
KEGGirno:259274.
UCSCiRGD:628642. rat.

Organism-specific databases

CTDi4836.
RGDi628642. Nmt1.

Phylogenomic databases

eggNOGiKOG2779. Eukaryota.
COG5092. LUCA.
GeneTreeiENSGT00390000017837.
HOGENOMiHOG000189123.
HOVERGENiHBG003404.
InParanoidiQ8K1Q0.
KOiK00671.
OMAiEMCTEVY.
OrthoDBiEOG091G06JB.
PhylomeDBiQ8K1Q0.
TreeFamiTF300701.

Enzyme and pathway databases

BRENDAi2.3.1.97. 5301.
ReactomeiR-RNO-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-RNO-75108. Activation, myristolyation of BID and translocation to mitochondria.

Miscellaneous databases

PROiQ8K1Q0.

Gene expression databases

BgeeiENSRNOG00000002989.
GenevisibleiQ8K1Q0. RN.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNMT1_RAT
AccessioniPrimary (citable) accession number: Q8K1Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.