Reviewed, UniProtKB/Swiss-Prot Q8K1Q0 (NMT1_RAT)

Names and origin

Protein names

Recommended name:
    Glycylpeptide N-tetradecanoyltransferase 1
    EC=2.3.1.97
Alternative name(s):
    Peptide N-myristoyltransferase 1
    Myristoyl-CoA:protein N-myristoyltransferase 1
      Short name=NMT 1
      Short name=Type I N-myristoyltransferase

Gene names

Name:

Nmt1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	496 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins By similarity.
Catalytic activity	Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NMT family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycylpeptide N-tetradecanoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 496	496	Glycylpeptide N-tetradecanoyltransferase 1		PRO_0000064224
Amino acid modifications
	Modified residue	31	1	Phosphoserine By similarity
	Modified residue	47	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8K1Q0-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 3A7EE954E0D0156A	FASTA	496	56,860
	10 20 30 40 50 60 MADESETAVK LPAPSLPLMM EGNGNGHEHC SDCENEEDIS HNRGGLSPAN DTGAKKKKKK 70 80 90 100 110 120 QKKKKEKGND MDSTQDQPVK MNSLPAERIQ EIQKAIELFS VGQGPAKTME EASKRSYQFW 130 140 150 160 170 180 DTQPVPKLGE VVNTHGPVEP DKDNIRQEPY TLPQGFTWDA LDLGDRGVLK ELYTLLNENY 190 200 210 220 230 240 VEDDDNMFRF DYSPEFLLWA LRPPGWLPQW HCGVRVVSSR KLVGFISAIP ANIHIYDTEK 250 260 270 280 290 300 KMVEINFLCV HKKLRSKRVA PVLIREITRR VHLEGIFQAV YTAGVVLPKP VGTCRYWHRS 310 320 330 340 350 360 LNPRKLIEVK FSHLSRNMTM QRTMKLYRLP ETPKTAGLRP MEKKDIPVVH QLLSRYLKQF 370 380 390 400 410 420 NLTPVMNQEE VEHWFYPQEN IIDTFVVENA NGEVTDFLSF YTLPSTIMNH PTHKSLKAAY 430 440 450 460 470 480 SFYNVHTQTP LLDLMSDALV LAKMKGFDVF NALDLMENKT FLEKLKFGIG DGNLQYYLYN 490 WKCPSMGAEK VGLVLQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of rat liver NMT1." Daval S., Jan S., Guillou H., Legrand P., Rioux V. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ492222 mRNA. Translation: CAD37349.1. BC097277 mRNA. Translation: AAH97277.1.
IPI	IPI00200409.
RefSeq	NP_683689.1.
UniGene	Rn.830
3D structure databases
SMR	Q8K1Q0. Positions 115-495, 155-496.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8K1Q0.
Proteomic databases
PRIDE	Q8K1Q0.
Genome annotation databases
Ensembl	ENSRNOT00000004046; ENSRNOP00000004046; ENSRNOG00000002989; Rattus norvegicus. [Genome view]
GeneID	259274.
KEGG	rno:259274.
UCSC	NM_148891. rat.
Organism-specific databases
CTD	259274.
RGD	628642. Nmt1.
Phylogenomic databases
eggNOG	roNOG05621.
HOVERGEN	Q8K1Q0.
InParanoid	Q8K1Q0.
PhylomeDB	Q8K1Q0.
Enzyme and pathway databases
BRENDA	2.3.1.97. 248.
Gene expression databases
ArrayExpress	Q8K1Q0.
Genevestigator	Q8K1Q0.
GermOnline	ENSRNOG00000002989. Rattus norvegicus.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000903. Myristoyl_trans. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 2 hits.
PANTHER	PTHR11377. Myristoyl_trans. 1 hit.
Pfam	PF01233. NMT. 1 hit. PF02799. NMT_C. 1 hit. [Graphical view]
PIRSF	PIRSF015892. N-myristl_transf. 1 hit.
PROSITE	PS00975. NMT_1. 1 hit. PS00976. NMT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	624335.

Entry information

Entry name

NMT1_RAT

Accession

Primary (citable) accession number: Q8K1Q0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	October 1, 2002
Last modified:	January 19, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)