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Protein

Fatty acid desaturase 3

Gene

Fads3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transport

Chemistry

SwissLipidsiSLP:000001192.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid desaturase 3 (EC:1.14.19.-)
Gene namesi
Name:Fads3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628876. Fads3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 137137CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence analysisAdd
BLAST
Topological domaini159 – 1635LumenalSequence analysis
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Topological domaini185 – 26884CytoplasmicSequence analysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence analysisAdd
BLAST
Topological domaini290 – 31021LumenalSequence analysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence analysisAdd
BLAST
Topological domaini332 – 449118CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Fatty acid desaturase 3PRO_0000307110Add
BLAST

Proteomic databases

PaxDbiQ8K1P9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020385.
ExpressionAtlasiQ8K1P9. baseline.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027693.

Structurei

3D structure databases

ProteinModelPortaliQ8K1P9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 10178Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi186 – 1905Histidine box-1
Motifi223 – 2275Histidine box-2
Motifi387 – 3915Histidine box-3

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.

Sequence similaritiesi

Contains 1 cytochrome b5 heme-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4232. Eukaryota.
ENOG410XVSZ. LUCA.
HOGENOMiHOG000012997.
HOVERGENiHBG002839.
InParanoidiQ8K1P9.
KOiK10225.
OMAiPSLFIDW.
OrthoDBiEOG091G0E0W.
PhylomeDBiQ8K1P9.
TreeFamiTF313604.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR012171. Fatty_acid_desaturase.
IPR005804. Fatty_acid_desaturase_dom.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF00487. FA_desaturase. 1 hit.
[Graphical view]
PIRSFiPIRSF015921. FA_sphinglp_des. 1 hit.
PRINTSiPR00363. CYTOCHROMEB5.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiPS50255. CYTOCHROME_B5_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K1P9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGVGEPGGG PGPREGPAPL GAPLPIFRWE QIRQHDLPGD KWLVIERRVY
60 70 80 90 100
DISRWAQRHP GGSRLIGHHS AEDATDAFHA FHQDLHFVRK FLKPLLIGEL
110 120 130 140 150
APEEPSQDGA QNAQLIEDFR ALRQAAEDMK LFEADTTFFA LLLGHILAME
160 170 180 190 200
LLAWLLVYLL GPGWVSSVLA ALILAISQAQ CWCLQHDLGH ASIFPKSRWN
210 220 230 240 250
HVAQQFVMGQ LKGFSAHWWN FRHFQHHAKP NIFHKDPDVT VAPVFLLGES
260 270 280 290 300
SVEYGKKKRR YLPYNHQHLY FFLIGPPLLT LVNFEVENLA YMLVCMQWTD
310 320 330 340 350
LLWAASFYSR FFLSYSPFYG ATGTLLLFVA VRVLESHWFV WITQMNHIPK
360 370 380 390 400
EIGHEKHRDW ASSQLAATCN VEPSLFIDWF SGHLNFQIEH HLFPTMPRHN
410 420 430 440
YRRVAPLVKA FCAKHGLHYE VKPFLTALVD IIGSLKKSGD IWLDAYLHQ
Length:449
Mass (Da):51,467
Last modified:October 1, 2002 - v1
Checksum:iE2E33662095855AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ494720 mRNA. Translation: CAD38527.1.
RefSeqiNP_775160.1. NM_173137.1.
UniGeneiRn.35262.

Genome annotation databases

EnsembliENSRNOT00000027693; ENSRNOP00000027693; ENSRNOG00000020385.
GeneIDi286922.
KEGGirno:286922.
UCSCiRGD:628876. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ494720 mRNA. Translation: CAD38527.1.
RefSeqiNP_775160.1. NM_173137.1.
UniGeneiRn.35262.

3D structure databases

ProteinModelPortaliQ8K1P9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027693.

Chemistry

SwissLipidsiSLP:000001192.

Proteomic databases

PaxDbiQ8K1P9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027693; ENSRNOP00000027693; ENSRNOG00000020385.
GeneIDi286922.
KEGGirno:286922.
UCSCiRGD:628876. rat.

Organism-specific databases

CTDi3995.
RGDi628876. Fads3.

Phylogenomic databases

eggNOGiKOG4232. Eukaryota.
ENOG410XVSZ. LUCA.
HOGENOMiHOG000012997.
HOVERGENiHBG002839.
InParanoidiQ8K1P9.
KOiK10225.
OMAiPSLFIDW.
OrthoDBiEOG091G0E0W.
PhylomeDBiQ8K1P9.
TreeFamiTF313604.

Miscellaneous databases

PROiQ8K1P9.

Gene expression databases

BgeeiENSRNOG00000020385.
ExpressionAtlasiQ8K1P9. baseline.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR012171. Fatty_acid_desaturase.
IPR005804. Fatty_acid_desaturase_dom.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF00487. FA_desaturase. 1 hit.
[Graphical view]
PIRSFiPIRSF015921. FA_sphinglp_des. 1 hit.
PRINTSiPR00363. CYTOCHROMEB5.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiPS50255. CYTOCHROME_B5_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFADS3_RAT
AccessioniPrimary (citable) accession number: Q8K1P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.