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Protein

Neuropeptide W

Gene

Npw

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress. When injected into the lateral cerebroventricle, it elevates prolactin (PRL) and corticosterone and lowers growth hormone (GH) release.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD

GO - Biological processi

  • feeding behavior Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: RGD
  • neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide W
Alternative name(s):
Preproprotein L8
Short name:
PPL8
Cleaved into the following 2 chains:
Neuropeptide W-23
Short name:
NPW23
Alternative name(s):
L8
Neuropeptide W-30
Short name:
NPW30
Alternative name(s):
L8C
Gene namesi
Name:Npw
Synonyms:Ppl8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi727858. Npw.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141Sequence analysisAdd
BLAST
Peptidei42 – 7130Neuropeptide W-30PRO_0000019849Add
BLAST
Peptidei42 – 6423Neuropeptide W-23PRO_0000019850Add
BLAST
Propeptidei74 – 185112Sequence analysisPRO_0000019851Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ8K1M5.
PRIDEiQ8K1M5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000012390.
GenevisibleiQ8K1M5. RN.

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016554.

Family & Domainsi

Sequence similaritiesi

Belongs to the neuropeptide B/W family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7Z8. Eukaryota.
ENOG41115MZ. LUCA.
GeneTreeiENSGT00510000049904.
HOGENOMiHOG000113846.
HOVERGENiHBG039581.
InParanoidiQ8K1M5.
OMAiASAWYKH.
OrthoDBiEOG091G0QS9.
PhylomeDBiQ8K1M5.
TreeFamiTF333179.

Family and domain databases

InterProiIPR013297. Neuropept_BW_pre.
IPR013299. Neuropept_W_pre.
[Graphical view]
PfamiPF15180. NPBW. 1 hit.
[Graphical view]
PRINTSiPR01888. NROPEPTIDEBW.
PR01890. PPNRPEPTIDEW.
ProDomiPD601995. Neuropept_W_pre. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K1M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLSALASSR EVRGPGPGAP VNRPLLPLLL LLLLLPLPAS AWYKHVASPR
60 70 80 90 100
YHTVGRASGL LMGLRRSPYL WRRALGGAAG PLVGLPGQMA RSALLLPSPG
110 120 130 140 150
QELWEVRSRS SPAGLPVHAT RSLRDLEGAG QPEQSLSFQS WTSAEPAARA
160 170 180
FGETLRAQPW FLQQIIFADP VRLDDRLKNR WRPRA
Length:185
Mass (Da):20,231
Last modified:October 1, 2002 - v1
Checksum:i2A4C82DFE0A8F6B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084278 mRNA. Translation: BAC07174.1.
RefSeqiNP_695206.1. NM_153294.1.
UniGeneiRn.14575.

Genome annotation databases

EnsembliENSRNOT00000016554; ENSRNOP00000016554; ENSRNOG00000012390.
GeneIDi259224.
KEGGirno:259224.
UCSCiRGD:727858. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084278 mRNA. Translation: BAC07174.1.
RefSeqiNP_695206.1. NM_153294.1.
UniGeneiRn.14575.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016554.

Proteomic databases

PaxDbiQ8K1M5.
PRIDEiQ8K1M5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016554; ENSRNOP00000016554; ENSRNOG00000012390.
GeneIDi259224.
KEGGirno:259224.
UCSCiRGD:727858. rat.

Organism-specific databases

CTDi283869.
RGDi727858. Npw.

Phylogenomic databases

eggNOGiENOG410J7Z8. Eukaryota.
ENOG41115MZ. LUCA.
GeneTreeiENSGT00510000049904.
HOGENOMiHOG000113846.
HOVERGENiHBG039581.
InParanoidiQ8K1M5.
OMAiASAWYKH.
OrthoDBiEOG091G0QS9.
PhylomeDBiQ8K1M5.
TreeFamiTF333179.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ8K1M5.

Gene expression databases

BgeeiENSRNOG00000012390.
GenevisibleiQ8K1M5. RN.

Family and domain databases

InterProiIPR013297. Neuropept_BW_pre.
IPR013299. Neuropept_W_pre.
[Graphical view]
PfamiPF15180. NPBW. 1 hit.
[Graphical view]
PRINTSiPR01888. NROPEPTIDEBW.
PR01890. PPNRPEPTIDEW.
ProDomiPD601995. Neuropept_W_pre. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiNPW_RAT
AccessioniPrimary (citable) accession number: Q8K1M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.