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Protein

Neuropeptide W

Gene

Npw

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress. When injected into the lateral cerebroventricle, it elevates prolactin (PRL) and corticosterone and lowers growth hormone (GH) release.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: RGD
  • neuropeptide signaling pathway Source: UniProtKB-KW

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide W
Alternative name(s):
Preproprotein L8
Short name:
PPL8
Cleaved into the following 2 chains:
Neuropeptide W-23
Short name:
NPW23
Alternative name(s):
L8
Neuropeptide W-30
Short name:
NPW30
Alternative name(s):
L8C
Gene namesi
Name:Npw
Synonyms:Ppl8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi727858 Npw

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 41Sequence analysisAdd BLAST41
PeptideiPRO_000001984942 – 71Neuropeptide W-30Add BLAST30
PeptideiPRO_000001985042 – 64Neuropeptide W-23Add BLAST23
PropeptideiPRO_000001985174 – 185Sequence analysisAdd BLAST112

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ8K1M5
PRIDEiQ8K1M5

Expressioni

Gene expression databases

BgeeiENSRNOG00000012390
GenevisibleiQ8K1M5 RN

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016554

Family & Domainsi

Sequence similaritiesi

Belongs to the neuropeptide B/W family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7Z8 Eukaryota
ENOG41115MZ LUCA
GeneTreeiENSGT00510000049904
HOGENOMiHOG000113846
HOVERGENiHBG039581
InParanoidiQ8K1M5
OMAiLPSGAWY
OrthoDBiEOG091G0QS9
PhylomeDBiQ8K1M5
TreeFamiTF333179

Family and domain databases

InterProiView protein in InterPro
IPR013297 Neuropept_BW_pre
IPR013299 Neuropept_W_pre
PANTHERiPTHR28553 PTHR28553, 1 hit
PfamiView protein in Pfam
PF15180 NPBW, 1 hit
PRINTSiPR01888 NROPEPTIDEBW
PR01890 PPNRPEPTIDEW
ProDomiView protein in ProDom or Entries sharing at least one domain
PD601995 Neuropept_W_pre, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K1M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLSALASSR EVRGPGPGAP VNRPLLPLLL LLLLLPLPAS AWYKHVASPR
60 70 80 90 100
YHTVGRASGL LMGLRRSPYL WRRALGGAAG PLVGLPGQMA RSALLLPSPG
110 120 130 140 150
QELWEVRSRS SPAGLPVHAT RSLRDLEGAG QPEQSLSFQS WTSAEPAARA
160 170 180
FGETLRAQPW FLQQIIFADP VRLDDRLKNR WRPRA
Length:185
Mass (Da):20,231
Last modified:October 1, 2002 - v1
Checksum:i2A4C82DFE0A8F6B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084278 mRNA Translation: BAC07174.1
RefSeqiNP_695206.1, NM_153294.1
UniGeneiRn.14575

Genome annotation databases

EnsembliENSRNOT00000016554; ENSRNOP00000016554; ENSRNOG00000012390
GeneIDi259224
KEGGirno:259224
UCSCiRGD:727858 rat

Similar proteinsi

Entry informationi

Entry nameiNPW_RAT
AccessioniPrimary (citable) accession number: Q8K1M5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health